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Volumn 131, Issue , 2016, Pages 42-47

Environmental enrichment as a method to improve cognitive function. What can we learn from animal models?

Author keywords

Alzheimer's disease; Environmental enrichment; Epigenetics; Histone acetylation; Memory; Neurodegeneration

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; COGNITION; DEGENERATIVE DISEASE; ENVIRONMENTAL ENRICHMENT; EXPERIMENTAL ANIMAL; HUMAN; HUNTINGTON CHOREA; LIFESTYLE MODIFICATION; MEMORY DISORDER; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; ANIMAL; COGNITIVE DEFECT; DISEASE MODEL; EVIDENCE BASED MEDICINE; KINESIOTHERAPY; PATHOPHYSIOLOGY; PROCEDURES; SPECIES DIFFERENCE; TREATMENT OUTCOME;

EID: 84950140685     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2015.11.039     Document Type: Article
Times cited : (68)

References (82)
  • 2
    • 59649121581 scopus 로고    scopus 로고
    • Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment
    • Arai J.A., Li S., Hartley D.M., Feig L.A. Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment. J. Neurosci. 2009, 29:1496-1502.
    • (2009) J. Neurosci. , vol.29 , pp. 1496-1502
    • Arai, J.A.1    Li, S.2    Hartley, D.M.3    Feig, L.A.4
  • 3
    • 4043147336 scopus 로고    scopus 로고
    • Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition
    • Arendash G.W., Garcia M.F., Costa D.A., Cracchiolo J.R., Wefes I.M., Potter H. Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition. Neuroreport 2004, 15:1751-1754.
    • (2004) Neuroreport , vol.15 , pp. 1751-1754
    • Arendash, G.W.1    Garcia, M.F.2    Costa, D.A.3    Cracchiolo, J.R.4    Wefes, I.M.5    Potter, H.6
  • 4
    • 33644934169 scopus 로고    scopus 로고
    • Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment
    • Artola A., von Frijtag J.C., Fermont P.C., Gispen W.H., Schrama L.H., Kamal A., Spruijt B.M. Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment. Eur. J. Neurosci. 2006, 23:261-272.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 261-272
    • Artola, A.1    von Frijtag, J.C.2    Fermont, P.C.3    Gispen, W.H.4    Schrama, L.H.5    Kamal, A.6    Spruijt, B.M.7
  • 5
    • 80053569697 scopus 로고    scopus 로고
    • Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?
    • Bekinschtein P., Oomen C.A., Saksida L.M., Bussey T.J. Effects of environmental enrichment and voluntary exercise on neurogenesis, learning and memory, and pattern separation: BDNF as a critical variable?. Semin. Cell Dev. Biol. 2011, 22:536-542.
    • (2011) Semin. Cell Dev. Biol. , vol.22 , pp. 536-542
    • Bekinschtein, P.1    Oomen, C.A.2    Saksida, L.M.3    Bussey, T.J.4
  • 7
    • 34447632448 scopus 로고    scopus 로고
    • Environmental enrichment delays the onset of memory deficits and reduces neuropathological hallmarks in a mouse model of Alzheimer-like neurodegeneration
    • Berardi N., Braschi C., Capsoni S., Cattaneo A., Maffei L. Environmental enrichment delays the onset of memory deficits and reduces neuropathological hallmarks in a mouse model of Alzheimer-like neurodegeneration. J. Alzheimers Dis. 2007, 11:359-370.
    • (2007) J. Alzheimers Dis. , vol.11 , pp. 359-370
    • Berardi, N.1    Braschi, C.2    Capsoni, S.3    Cattaneo, A.4    Maffei, L.5
  • 8
    • 33845190338 scopus 로고    scopus 로고
    • Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions
    • Bindu B., Alladi P.A., Mansooralikhan B.M., Srikumar B.N., Raju T.R., Kutty B.M. Short-term exposure to an enriched environment enhances dendritic branching but not brain-derived neurotrophic factor expression in the hippocampus of rats with ventral subicular lesions. Neuroscience 2007, 144:412-423.
    • (2007) Neuroscience , vol.144 , pp. 412-423
    • Bindu, B.1    Alladi, P.A.2    Mansooralikhan, B.M.3    Srikumar, B.N.4    Raju, T.R.5    Kutty, B.M.6
  • 9
    • 84899764910 scopus 로고    scopus 로고
    • Cognitive and emotional profiles of aged Alzheimer's disease (3×TgAD) mice: effects of environmental enrichment and sexual dimorphism
    • Blázquez G., Cañete T., Tobeña A., Giménez-Llort L., Fernández-Teruel A. Cognitive and emotional profiles of aged Alzheimer's disease (3×TgAD) mice: effects of environmental enrichment and sexual dimorphism. Behav. Brain Res. 2014, 15:185-201.
    • (2014) Behav. Brain Res. , vol.15 , pp. 185-201
    • Blázquez, G.1    Cañete, T.2    Tobeña, A.3    Giménez-Llort, L.4    Fernández-Teruel, A.5
  • 10
    • 0015799240 scopus 로고
    • Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
    • Bliss T.V., Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J. Physiol. Lond. 1973, 232:331-356.
    • (1973) J. Physiol. Lond. , vol.232 , pp. 331-356
    • Bliss, T.V.1    Lomo, T.2
  • 11
    • 1842785189 scopus 로고    scopus 로고
    • Signaling by insulin-like growth factor 1 in brain
    • Bondy C.A., Cheng C.M. Signaling by insulin-like growth factor 1 in brain. Eur. J. Pharmacol. 2004, 490:25-31.
    • (2004) Eur. J. Pharmacol. , vol.490 , pp. 25-31
    • Bondy, C.A.1    Cheng, C.M.2
  • 13
    • 81355133149 scopus 로고    scopus 로고
    • Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice
    • Cotel M.C., Jawhar S., Christensen D.Z., Bayer T.A., Wirths O. Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice. Neurobiol. Aging 2012, 33:96-107.
    • (2012) Neurobiol. Aging , vol.33 , pp. 96-107
    • Cotel, M.C.1    Jawhar, S.2    Christensen, D.Z.3    Bayer, T.A.4    Wirths, O.5
  • 14
    • 58149380028 scopus 로고    scopus 로고
    • The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches
    • Cotman C.W., Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J. Alzheimers Dis. 2008, 15:685-707.
    • (2008) J. Alzheimers Dis. , vol.15 , pp. 685-707
    • Cotman, C.W.1    Head, E.2
  • 15
    • 77952349119 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity
    • Cowansage K.K., LeDoux J.E., Monfils M.H. Brain-derived neurotrophic factor: a dynamic gatekeeper of neural plasticity. Curr. Mol. Pharmacol. 2010, 3:12-21.
    • (2010) Curr. Mol. Pharmacol. , vol.3 , pp. 12-21
    • Cowansage, K.K.1    LeDoux, J.E.2    Monfils, M.H.3
  • 16
    • 84870926527 scopus 로고    scopus 로고
    • Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice
    • Dong J., Zhou M., Wu X., Du M., Wang X. Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice. J. Biomed. Res. 2012, 26:439-447.
    • (2012) J. Biomed. Res. , vol.26 , pp. 439-447
    • Dong, J.1    Zhou, M.2    Wu, X.3    Du, M.4    Wang, X.5
  • 17
    • 33645865549 scopus 로고    scopus 로고
    • VEGF, a mediator of the effect of experience on hippocampal neurogenesis
    • During M.J., Cao L. VEGF, a mediator of the effect of experience on hippocampal neurogenesis. Curr. Alzheimer Res. 2006, 3:29-33.
    • (2006) Curr. Alzheimer Res. , vol.3 , pp. 29-33
    • During, M.J.1    Cao, L.2
  • 18
    • 84922257150 scopus 로고    scopus 로고
    • Adult neurogenesis in humans - common and unique traits in mammals
    • Ernst A., Frisén J. Adult neurogenesis in humans - common and unique traits in mammals. PLoS Biol. 2015, 13. e1002045.
    • (2015) PLoS Biol. , vol.13
    • Ernst, A.1    Frisén, J.2
  • 19
    • 0037436416 scopus 로고    scopus 로고
    • Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment
    • Faherty C.J., Kerley D., Smeyne R.J.A. Golgi-Cox morphological analysis of neuronal changes induced by environmental enrichment. Brain Res. Dev. Brain Res. 2003, 144:55-61.
    • (2003) Brain Res. Dev. Brain Res. , vol.144 , pp. 55-61
    • Faherty, C.J.1    Kerley, D.2    Smeyne, R.J.A.3
  • 22
    • 84899812044 scopus 로고    scopus 로고
    • Epigenetic memory: the Lamarckian brain
    • Fischer A. Epigenetic memory: the Lamarckian brain. EMBO J. 2014, 33:945-967.
    • (2014) EMBO J. , vol.33 , pp. 945-967
    • Fischer, A.1
  • 23
    • 28744449248 scopus 로고    scopus 로고
    • Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory
    • Fischer A., Sananbenesi F., Pang P.T., Lu B., Tsai L.H. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 2005, 48:825-838.
    • (2005) Neuron , vol.48 , pp. 825-838
    • Fischer, A.1    Sananbenesi, F.2    Pang, P.T.3    Lu, B.4    Tsai, L.H.5
  • 24
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning & memory after neuronal loss is associated with chromatin remodeling
    • Fischer A., Sananbenesi F., Wang X., Dobbin M., Tsai L.H. Recovery of learning & memory after neuronal loss is associated with chromatin remodeling. Nature 2007, 447:178-182.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.H.5
  • 26
    • 0037411533 scopus 로고    scopus 로고
    • Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice
    • Frick K.M., Fernandez S.M. Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice. Neurobiol. Aging 2003, 24:615-621.
    • (2003) Neurobiol. Aging , vol.24 , pp. 615-621
    • Frick, K.M.1    Fernandez, S.M.2
  • 27
    • 84920603403 scopus 로고    scopus 로고
    • Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia
    • Galeano P., Blanco E., Logica Tornatore T.M., Romero J.I., Holubiec M.I., Rodríguez de Fonseca F., Capani F. Life-long environmental enrichment counteracts spatial learning, reference and working memory deficits in middle-aged rats subjected to perinatal asphyxia. Front. Behav. Neurosci. 2015, 8. 10.3389.
    • (2015) Front. Behav. Neurosci. , vol.8 , pp. 10.3389
    • Galeano, P.1    Blanco, E.2    Logica Tornatore, T.M.3    Romero, J.I.4    Holubiec, M.I.5    Rodríguez de Fonseca, F.6    Capani, F.7
  • 29
    • 69149089036 scopus 로고    scopus 로고
    • Molecular pathogenesis of Parkinson disease: insights from genetic studies
    • Gasser T. Molecular pathogenesis of Parkinson disease: insights from genetic studies. Expert Rev. Mol. Med. 2009, 27. e22.
    • (2009) Expert Rev. Mol. Med. , vol.27
    • Gasser, T.1
  • 30
    • 78650743184 scopus 로고    scopus 로고
    • Enriched environment promotes similar neuronal and behavioral recovery in a young and aged mouse model of Parkinson's disease
    • Goldberg N.R., Haack A.K., Meshul C.K. Enriched environment promotes similar neuronal and behavioral recovery in a young and aged mouse model of Parkinson's disease. Neuroscience 2011, 13:443-452.
    • (2011) Neuroscience , vol.13 , pp. 443-452
    • Goldberg, N.R.1    Haack, A.K.2    Meshul, C.K.3
  • 31
    • 84856574257 scopus 로고    scopus 로고
    • Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
    • Goldberg N.R., Fields V., Pflibsen L., Salvatore M.F., Meshul C.K. Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Neurobiol. Dis. 2012, 45:1051-1067.
    • (2012) Neurobiol. Dis. , vol.45 , pp. 1051-1067
    • Goldberg, N.R.1    Fields, V.2    Pflibsen, L.3    Salvatore, M.F.4    Meshul, C.K.5
  • 32
    • 0015845931 scopus 로고
    • Pattern of dendritic branching in occipital cortex of rats reared in complex environments
    • Greenough W.T., Volkmar F.R. Pattern of dendritic branching in occipital cortex of rats reared in complex environments. Exp. Neurol. 1973, 40:491-504.
    • (1973) Exp. Neurol. , vol.40 , pp. 491-504
    • Greenough, W.T.1    Volkmar, F.R.2
  • 34
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 2007, 8:112-116.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 112-116
    • Haass, C.1    Selkoe, D.J.2
  • 36
    • 35148819275 scopus 로고    scopus 로고
    • Age-dependent effects of environmental enrichment on spatial reference memory in male mice
    • Harburger L.L., Lambert T.J., Frick K.M. Age-dependent effects of environmental enrichment on spatial reference memory in male mice. Behav. Brain Res. 2007, 185:43-48.
    • (2007) Behav. Brain Res. , vol.185 , pp. 43-48
    • Harburger, L.L.1    Lambert, T.J.2    Frick, K.M.3
  • 37
    • 84882792190 scopus 로고    scopus 로고
    • Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model
    • Harrison D.J., Busse M., Openshaw R., Rosser A.E., Dunnett S.B., Brooks S.P. Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model. Exp. Neurol. 2013, 248:457-469.
    • (2013) Exp. Neurol. , vol.248 , pp. 457-469
    • Harrison, D.J.1    Busse, M.2    Openshaw, R.3    Rosser, A.E.4    Dunnett, S.B.5    Brooks, S.P.6
  • 38
    • 0000152483 scopus 로고
    • The effects of early experience on problem-solving at maturity
    • Hebb D. The effects of early experience on problem-solving at maturity. Am. Psychol. 1947, 2:306-307.
    • (1947) Am. Psychol. , vol.2 , pp. 306-307
    • Hebb, D.1
  • 40
    • 38349147618 scopus 로고    scopus 로고
    • Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice
    • Herring A., Yasin H., Ambrée O., Sachser N., Paulus W., Keyvani K. Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice. Brain Pathol. 2008, 1:32-39.
    • (2008) Brain Pathol. , vol.1 , pp. 32-39
    • Herring, A.1    Yasin, H.2    Ambrée, O.3    Sachser, N.4    Paulus, W.5    Keyvani, K.6
  • 42
    • 33745267260 scopus 로고    scopus 로고
    • Enriched environment improves motor function in intact and unilateral dopamine-depleted rats
    • Jadavji N.M., Kolb B., Metz G.A. Enriched environment improves motor function in intact and unilateral dopamine-depleted rats. Neuroscience 2006, 140:1127-1138.
    • (2006) Neuroscience , vol.140 , pp. 1127-1138
    • Jadavji, N.M.1    Kolb, B.2    Metz, G.A.3
  • 43
    • 0344305380 scopus 로고    scopus 로고
    • Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease
    • Jankowsky J.L., Xu G., Fromholt D., Gonzales V., Borchelt D.R. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J. Neuropathol. Exp. Neurol. 2003, 62:1220-1227.
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 1220-1227
    • Jankowsky, J.L.1    Xu, G.2    Fromholt, D.3    Gonzales, V.4    Borchelt, D.R.5
  • 46
    • 68249134074 scopus 로고    scopus 로고
    • The role of apolipoprotein E in Alzheimer's disease
    • Kim J., Basak J.M., Holtzman D.M. The role of apolipoprotein E in Alzheimer's disease. Neuron 2009, 63:287-303.
    • (2009) Neuron , vol.63 , pp. 287-303
    • Kim, J.1    Basak, J.M.2    Holtzman, D.M.3
  • 51
    • 0042093508 scopus 로고    scopus 로고
    • ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory
    • Levi O., Jongen-Relo A.L., Feldon J., Roses A.D., Michaelson D.M. ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol. Dis. 2003, 13:273-283.
    • (2003) Neurobiol. Dis. , vol.13 , pp. 273-283
    • Levi, O.1    Jongen-Relo, A.L.2    Feldon, J.3    Roses, A.D.4    Michaelson, D.M.5
  • 52
    • 26844498655 scopus 로고    scopus 로고
    • The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies
    • Li J.Y., Popovic N., Brundin P. The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx 2005, 2:447-464.
    • (2005) NeuroRx , vol.2 , pp. 447-464
    • Li, J.Y.1    Popovic, N.2    Brundin, P.3
  • 53
    • 77952547357 scopus 로고    scopus 로고
    • Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour
    • Llorens-Martín M., Torres-Alemán I., Trejo J.L. Exercise modulates insulin-like growth factor 1-dependent and -independent effects on adult hippocampal neurogenesis and behaviour. Mol. Cell. Neurosci. 2010, 15:109-117.
    • (2010) Mol. Cell. Neurosci. , vol.15 , pp. 109-117
    • Llorens-Martín, M.1    Torres-Alemán, I.2    Trejo, J.L.3
  • 55
    • 77956194308 scopus 로고    scopus 로고
    • Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice
    • Madroñal N., López-Aracil C., Rangel A., del Río J.A., Delgado-García J.M., Gruart A. Effects of enriched physical and social environments on motor performance, associative learning, and hippocampal neurogenesis in mice. PLoS One 2010, 15. e11130.
    • (2010) PLoS One , vol.15
    • Madroñal, N.1    López-Aracil, C.2    Rangel, A.3    del Río, J.A.4    Delgado-García, J.M.5    Gruart, A.6
  • 56
    • 84925257158 scopus 로고    scopus 로고
    • Super-enrichment' reveals dose-dependent therapeutic effects of environmental stimulation in a transgenic mouse model of Huntington's disease
    • Mazarakis N.K., Mo C., Renoir T., van Dellen A., Deacon R., Blakemore C., Hannan A.J. Super-enrichment' reveals dose-dependent therapeutic effects of environmental stimulation in a transgenic mouse model of Huntington's disease. J. Huntingtons Dis. 2014, 3:299-309.
    • (2014) J. Huntingtons Dis. , vol.3 , pp. 299-309
    • Mazarakis, N.K.1    Mo, C.2    Renoir, T.3    van Dellen, A.4    Deacon, R.5    Blakemore, C.6    Hannan, A.J.7
  • 57
    • 84926349342 scopus 로고    scopus 로고
    • Huntington's disease: looking beyond the movement disorder
    • Morreale M.K. Huntington's disease: looking beyond the movement disorder. Adv. Psychosom. Med. 2015, 34:135-142.
    • (2015) Adv. Psychosom. Med. , vol.34 , pp. 135-142
    • Morreale, M.K.1
  • 58
    • 0042810917 scopus 로고    scopus 로고
    • Handling and environmental enrichment do not rescue learning and memory impairments in alphaCamKII(T286A) mutant mice
    • Need A.C., Giese K.P. Handling and environmental enrichment do not rescue learning and memory impairments in alphaCamKII(T286A) mutant mice. Genes Brain Behav. 2003, 2:132-139.
    • (2003) Genes Brain Behav. , vol.2 , pp. 132-139
    • Need, A.C.1    Giese, K.P.2
  • 59
    • 33747613561 scopus 로고    scopus 로고
    • Enriched environments, experience-dependent plasticity and disorders of the nervous system
    • Nithianantharajah J., Hannan A.J. Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat. Rev. Neurosci. 2006, 7:697-709.
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 697-709
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 60
    • 84916897532 scopus 로고    scopus 로고
    • BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment
    • Novkovic T., Mittmann T., Manahan-Vaughan D. BDNF contributes to the facilitation of hippocampal synaptic plasticity and learning enabled by environmental enrichment. Hippocampus 2015, 25:1-15.
    • (2015) Hippocampus , vol.25 , pp. 1-15
    • Novkovic, T.1    Mittmann, T.2    Manahan-Vaughan, D.3
  • 62
    • 84937043295 scopus 로고    scopus 로고
    • Protective effects of physical exercise in Alzheimer's disease and Parkinson's disease: a narrative review
    • Paillard T., Rolland Y., de Souto Barreto P. Protective effects of physical exercise in Alzheimer's disease and Parkinson's disease: a narrative review. J. Clin. Neurol. 2015, 11:212-219.
    • (2015) J. Clin. Neurol. , vol.11 , pp. 212-219
    • Paillard, T.1    Rolland, Y.2    de Souto Barreto, P.3
  • 66
    • 84921485077 scopus 로고    scopus 로고
    • Environmental enrichment is associated with rapid volumetric brain changes in adult mice
    • Scholz J., Allemang-Grand R., Dazai J., Lerch J.P. Environmental enrichment is associated with rapid volumetric brain changes in adult mice. Neuroimage 2015, 1:190-198.
    • (2015) Neuroimage , vol.1 , pp. 190-198
    • Scholz, J.1    Allemang-Grand, R.2    Dazai, J.3    Lerch, J.P.4
  • 67
    • 84910044957 scopus 로고    scopus 로고
    • Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease
    • Skillings E.A., Wood N.I., Morton A.J. Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease. Brain Behav. 2014, 4:675-686.
    • (2014) Brain Behav. , vol.4 , pp. 675-686
    • Skillings, E.A.1    Wood, N.I.2    Morton, A.J.3
  • 68
    • 1542286877 scopus 로고    scopus 로고
    • Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    • Spires T.L., Grote H.E., Varshney N.K., Cordery P.M., van Dellen A., Blakemore C., Hannan A.J. Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J. Neurosci. 2004, 24:2270-2276.
    • (2004) J. Neurosci. , vol.24 , pp. 2270-2276
    • Spires, T.L.1    Grote, H.E.2    Varshney, N.K.3    Cordery, P.M.4    van Dellen, A.5    Blakemore, C.6    Hannan, A.J.7
  • 69
    • 49249123273 scopus 로고    scopus 로고
    • Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis
    • Stam N.C., Nithianantharajah J., Howard M.L., Atkin J.D., Cheema S.S., Hannan A.J. Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis. Eur. J. Neurosci. 2008, 28:717-723.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 717-723
    • Stam, N.C.1    Nithianantharajah, J.2    Howard, M.L.3    Atkin, J.D.4    Cheema, S.S.5    Hannan, A.J.6
  • 70
    • 79958001269 scopus 로고    scopus 로고
    • The role of histone acetylation in age-associated memory impairment and Alzheimer's disease
    • Stilling R.M., Fischer A. The role of histone acetylation in age-associated memory impairment and Alzheimer's disease. Neurobiol. Learn. Mem. 2011, 96:19-26.
    • (2011) Neurobiol. Learn. Mem. , vol.96 , pp. 19-26
    • Stilling, R.M.1    Fischer, A.2
  • 71
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl B.D., Allis C.D. The language of covalent histone modifications. Nature 2000, 403:41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 72
    • 74449090471 scopus 로고    scopus 로고
    • Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle
    • Tang K., Xia F.C., Wagner P.D., Breen E.C. Exercise-induced VEGF transcriptional activation in brain, lung and skeletal muscle. Respir. Physiol. Neurobiol. 2010, 170:16-22.
    • (2010) Respir. Physiol. Neurobiol. , vol.170 , pp. 16-22
    • Tang, K.1    Xia, F.C.2    Wagner, P.D.3    Breen, E.C.4
  • 73
    • 38649115676 scopus 로고    scopus 로고
    • The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis
    • Trejo J.L., Llorens-Martin M.V., Torres-Aleman I. The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis. Mol. Cell. Neurosci. 2008, 37:402-411.
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 402-411
    • Trejo, J.L.1    Llorens-Martin, M.V.2    Torres-Aleman, I.3
  • 76
    • 0024436033 scopus 로고
    • Effects of preweaning environmental enrichment on basilar dendrites of pyramidal neurons in occipital cortex: a Golgi study
    • Venable N., Fernández V., Díaz E., Pinto-Hamuy T. Effects of preweaning environmental enrichment on basilar dendrites of pyramidal neurons in occipital cortex: a Golgi study. Brain Res. Dev. Brain Res. 1989, 49:140-144.
    • (1989) Brain Res. Dev. Brain Res. , vol.49 , pp. 140-144
    • Venable, N.1    Fernández, V.2    Díaz, E.3    Pinto-Hamuy, T.4
  • 78
    • 84891701025 scopus 로고    scopus 로고
    • All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
    • Vivar C., Potter M.C., van Praag H. All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis. Curr. Top. Behav. Neurosci. 2013, 15:189-205.
    • (2013) Curr. Top. Behav. Neurosci. , vol.15 , pp. 189-205
    • Vivar, C.1    Potter, M.C.2    van Praag, H.3
  • 80
    • 33751550928 scopus 로고    scopus 로고
    • Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease
    • Wolf S.A., Kronenberg G., Lehmann K., Blankenship A., Overall R., Staufenbiel M., G.K Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease. Biol. Psychiatry 2006, 15:1314-1323.
    • (2006) Biol. Psychiatry , vol.15 , pp. 1314-1323
    • Wolf, S.A.1    Kronenberg, G.2    Lehmann, K.3    Blankenship, A.4    Overall, R.5    Staufenbiel, M.6
  • 82
    • 84902189439 scopus 로고    scopus 로고
    • How to make a hippocampal dentate gyrus granule neuron
    • Yu D.X., Marchetto M.C., Gage F.H. How to make a hippocampal dentate gyrus granule neuron. Development 2014, 141:2366-2375.
    • (2014) Development , vol.141 , pp. 2366-2375
    • Yu, D.X.1    Marchetto, M.C.2    Gage, F.H.3


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