ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory

Neurobiology of Disease

Volumn 13, Issue 3, 2003, Pages 273-282

  Levi, Ofir ^a   Jongen Relo, Ana L ^b   Feldon, Joram ^b   Roses, Allen D ^c   Michaelson, Daniel M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b ETH ZURICH   (Switzerland)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Apolipoprotein E; Enriched environment; Learning; Synaptogenesis; Synaptophysin; Transgenic mice; Working memory

Indexed keywords

APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; SYNAPTOPHYSIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN NERVE CELL; COGNITION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; GENOTYPE; HIPPOCAMPUS; HUMAN; LEARNING; MEMORY; MOUSE; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNAPTOGENESIS; TRANSGENIC MOUSE;

EID: 0042093508     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-9961(03)00045-7     Document Type: Article

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