Handling and environmental enrichment do not rescue learning and memory impairments in αCamKIIT286A mutant mice

Genes, Brain and Behavior

Volumn 2, Issue 3, 2003, Pages 132-139

  Need, A C ^a   Giese, K P ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Calcium calmodulin dependent kinase II; Environmental enrichment; Hippocampus; Learning and memory; Postnatal handling

Indexed keywords

PROTEIN KINASE (CALCIUM,CALMODULIN) II; THREONINE;

AGE; ANIMAL EXPERIMENT; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DNA MODIFICATION; ENVIRONMENTAL FACTOR; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; HYBRID; LEARNING DISORDER; MAZE TEST; MEMORY DISORDER; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ENVIRONMENT; FEMALE; HANDLING (PSYCHOLOGY); MALE; MAZE LEARNING; MICE; MICE, MUTANT STRAINS; PHOSPHORYLATION; POINT MUTATION;

ANIMALIA;

EID: 0042810917     PISSN: 16011848     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1601-183X.2003.00020.x     Document Type: Article

References (36)

1. Angelo, M., Plattner, F., Irvine, E.E. & Giese, K.P. Improved reversal learning and altered fear conditioning in transgenic mice with regionally restriced p25 expression. Eur J Neurosci in press.
2. Cook, M.N., Bolivar, V.J., McFadyen, M.P. & Flaherty, L. (2002) Behavioral differences among 129 substrains: implications for knockout and transgenic mice. Behav Neurosci 116, 600-611.
3. Duffy, S.N., Craddock, K.J., Abel, T. & Nguyen, P.V. (2001) Environmental enrichment modifies the PKA-dependence of hippocampal LTP and improves hippocampus-dependent memory. Learn Mem 8, 26-34.
4. Faverjon, S., Silveira, D.C., Fu, D.D., Cha, B.H., Akman, C., Hu, Y. & Holmes, G.L. (2002) Beneficial effects of enriched environment following status epilepticus in immature rats. Neurology 59, 1356-1364.
5. Fernandez-Teruel, A., Gimenez-Llort, L., Escorihuela, R.M., Gil, L., Aguilar, R., Steimer, T. & Tobena, A. (2002) Early-life handling stimulation and environmental enrichment: are some of their effects mediated by similar neural mechanisms? Pharmacol Biochem Behav 73, 233-245.
6. 2+/calmodulin-dependent protein kinase II. Mutation of threonine 286 to alanine and aspartate. J Biol Chem 264, 16 759-16 763.
7. Gallagher, M., Burwell, R. & Burchinal, M. (1993) Severity of spatial learning impairment in ageing: development of a learning index for performance in the Morris water maze. Behav Neurosci 107, 618-626.
8. Gerlai, R.T., McNamara, A., Williams, S. & Phillips, H.S. (2002) Hippocampal dysfunction and behavioral deficit in the water maze in mice: an unresolved issue? Brain Res Bull 57, 3-9.
9. Giese, K.P., Fedorov, N.B., Filipkowski, R.K. & Silva, A.J. (1998) Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 279, 870-873.
10. 2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation. Neuron 3, 59-70.
11. Lisman, J., Schulman, H. & Cline, H. (2002) The molecular basis of CaMKII function in synaptic and behavioural memory. Nat Rev Neurosci 3, 175-190.
12. Martinez-Cue, C., Baamonde, C., Lumbreras, M., Paz, J., Davisson, M.T., Schmidt, C., Dierssen, M. & Florez, J. (2002) Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 134, 185-200.
13. Meaney, M.J., Aitken, D.H., van Berkel, C., Bhatnagar, S. & Sapolsky, R.M. (1988) Effect of neonatal handling on age-related impairments associated with the hippocampus. Science 239, 766-768.
14. 2+-triggered molecular switch. Cell 44, 861-870.
15. 2+-independent activity. Neuron 1, 593-604.
16. Morris, R.G., Garrud, P., Rawlins, J.N. & O'Keefe, J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683.
17. 2+-independent activity of calmodulin-dependent protein kinase II alpha subunit. J Biochem (Tokyo) 109, 137-143.
18. Owen, E.H., Logue, S.F., Rasmussen, D.L. & Wehner, J.M. (1997) Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience 80, 1087-1099.
19. Pham, T.M., Soderstrom, S., Winblad, B. & Mohammed, A.H. (1999) Effects of environmental enrichment on cognitive function and hippocampal NGF in the non-handled rats. Behav Brain Res 103, 63-70.
20. van Praag, H., Kempermann, G. & Gage, F.H. (2000) Neural consequences of environmental enrichment. Nat Rev Neurosci 1, 191-198.
21. Prusky, G.T., Reidel, C. & Douglas, R.M. (2000) Environmental enrichment from birth enhances visual acuity but not place learning in mice. Behav Brain Res 114, 11-15.
22. Rampon, C., Tang, Y.P., Goodhouse, J., Shimizu, E., Kyin, M. & Tsien, J.Z. (2000) Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice. Nat Neurosci 3, 238-244.
23. Rodgers, R.J., Boullier, E., Chatzimichalaki, P., Cooper, G.D. & Shorten, A. (2002) Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour. Physiol Behav 77, 301-310.
24. Schrijver, N.C., Bahr, N.I., Weiss, I.C. & Wurbel, H. (2002) Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats. Pharmacol Biochem Behav 73, 209-224.
25. Schrott, L.M., Denenberg, V.H., Sherman, G.F., Waters, N.S., Rosen, G.D. & Galaburda, A.M. (1992) Environmental enrichment, neocortical ectopias, and behavior in the autoimmune NZB mouse. Dev Brain Res 67, 85-93.
26. Simpson, E.M., Linder, C.C., Sargent, E.E., Davisson, M.T., Mobraaten, L.E. & Sharp, J.J. (1997) Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice. Nat Genet 16, 19-27.
27. Tan, S.E. & Liang, K.C. (1996) Spatial learning alters hippocampal calcium/calmodulin-dependent protein kinase II activity in rats. Brain Res 711, 234-240.
28. Tang, A.C. (2001) Neonatal exposure to novel environment enhances hippocampal-dependent memory function during infancy and adulthood. Learn Mem 8, 257-264.
29. Tang, Y.P., Wang, H., Feng, R., Kyin, M. & Tsien, J.Z. (2001) Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 41, 779-790.
30. Tees, R.C. (1999) The influences of rearing environment and neonatal choline dietary supplementation on spatial learning and memory in adult rats. Behav Brain Res 105, 173-188.
31. Threadgill, D.W., Yee, D., Matin, A., Nadeau, J.H. & Magnuson, T. (1997) Genealogy of the 129 inbred strains: 129/SvJ is a contaminated inbred strain. Mamm Genome 8, 390-393.
32. Tremml, P., Lipp, H.P., Muller, U. & Wolfer, D.P. (2002) Enriched early experiences of mice underexpressing the β-amyloid precursor protein restore spatial learning capabilities but not normal openfield begaviour of adult animals. Genes, Brain Behav 1, 230-241.
33. 2+/calmodulin-independent activity. Proc Natl Acad Sci USA 87, 1273-1277.
34. Williams, B.M., Luo, Y., Ward, C., Redd, K., Gibson, R., Kuczaj, S.A. & McCoy, J.G. (2001) Environmental enrichment: effects on spatial memory and hippocampal CREB immunoreactivity. Physiol Behav 73, 649-658.
35. Wolfer, D.P., Madani, R., Valenti, P. & Lipp, H.P. (2001) Extended analysis of path data from mutant mice using the public domain software Wintrack. Physiol Behav 73, 745-753.
36. Zaharia, M.D., Kulczycki, J., Shanks, N., Meaney, M.J. & Anisman, H. (1996) The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors. Psychopharmacology (Berl) 128, 227-239.