메뉴 건너뛰기




Volumn 888, Issue , 2015, Pages 237-252

MicroRNA and pulmonary hypertension

Author keywords

Lung; MicroRNA; PAEC; PAH; PASMC; Right ventricle

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; MICRORNA; MICRORNA 124; MICRORNA 126; MICRORNA 193; MICRORNA 208; MICRORNA 210; UNCLASSIFIED DRUG;

EID: 84949894825     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-22671-2_12     Document Type: Chapter
Times cited : (67)

References (73)
  • 4
    • 84874027652 scopus 로고    scopus 로고
    • Exercise intolerance in pulmonary arterial hypertension
    • Fowler RM, Gain KR, Gabbay E. Exercise intolerance in pulmonary arterial hypertension. Pulm Med. 2012;2012:359204
    • (2012) Pulm Med , vol.2012
    • Fowler, R.M.1    Gain, K.R.2    Gabbay, E.3
  • 5
    • 67649613565 scopus 로고    scopus 로고
    • Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension
    • Hoeper MM, Barberà JA, Channick RN, Hassoun PM, Lang IM, Manes A, et al. Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S85-96
    • (2009) J am Coll Cardiol , vol.54 , pp. S85-S96
    • Hoeper, M.M.1    Barberà, J.A.2    Channick, R.N.3    Hassoun, P.M.4    Lang, I.M.5    Manes, A.6
  • 7
    • 84880735860 scopus 로고    scopus 로고
    • Metabolic dysfunction in pulmonary hypertension: The expanding relevance of the Warburg effect
    • Cottrill KA, Chan SY. Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect. Eur J Clin Invest. 2013;43(8):855-65
    • (2013) Eur J Clin Invest , vol.43 , Issue.8 , pp. 855-865
    • Cottrill, K.A.1    Chan, S.Y.2
  • 8
    • 33745155785 scopus 로고    scopus 로고
    • An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxy-gen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: Similarities to human pulmonary arterial hypertension
    • Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, et al. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxy-gen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 2006;113(22):2630-41
    • (2006) Circulation , vol.113 , Issue.22 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3    Rade-Navarro, M.A.4    Thébaud, B.5    Bonnet, S.6
  • 9
    • 20444483234 scopus 로고    scopus 로고
    • Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
    • McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, et al. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest. 2005;115(6):1479-91
    • (2005) J Clin Invest , vol.115 , Issue.6 , pp. 1479-1491
    • McMurtry, M.S.1    Archer, S.L.2    Altieri, D.C.3    Bonnet, S.4    Haromy, A.5    Harry, G.6
  • 10
    • 33846002728 scopus 로고    scopus 로고
    • A mitochondria- K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    • Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, et al. A mitochondria- K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007;11(1):37-51
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 37-51
    • Bonnet, S.1    Archer, S.L.2    Allalunis-Turner, J.3    Haromy, A.4    Beaulieu, C.5    Thompson, R.6
  • 12
    • 84937146536 scopus 로고    scopus 로고
    • Therapeutic potential of microRNA modulation in pulmonary arterial hypertension
    • Meloche J, Paulin R, Provencher S, Bonnet S. Therapeutic potential of microRNA modulation in pulmonary arterial hypertension. Curr Vasc Pharmacol. 2015;13(3):331-40
    • (2015) Curr Vasc Pharmacol , vol.13 , Issue.3 , pp. 331-340
    • Meloche, J.1    Paulin, R.2    Provencher, S.3    Bonnet, S.4
  • 13
    • 84922236180 scopus 로고    scopus 로고
    • MicroRNAs in pulmonary arterial hypertension
    • Zhou G, Chen T, Raj JU. MicroRNAs in pulmonary arterial hypertension. Am J Respir Cell Mol Biol. 2015;52(2):139-51
    • (2015) Am J Respir Cell Mol Biol , vol.52 , Issue.2 , pp. 139-151
    • Zhou, G.1    Chen, T.2    Raj, J.U.3
  • 14
    • 77950878463 scopus 로고    scopus 로고
    • Dynamic changes in lung microRNA profi les during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline
    • Caruso P, MacLean MR, Khanin R, McClure J, Soon E, Southgate M, et al. Dynamic changes in lung microRNA profi les during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler Thromb Vasc Biol. 2010;30(4):716-23
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.4 , pp. 716-723
    • Caruso, P.1    Maclean, M.R.2    Khanin, R.3    McClure, J.4    Soon, E.5    Southgate, M.6
  • 15
    • 0033838125 scopus 로고    scopus 로고
    • Familial primary pulmonary hypertension (Gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
    • Deng Z, Morse JH, Slager SL, Cuervo N, Moore KJ, Venetos G, et al. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene. Am J Hum Genet. 2000;67(3):737-44
    • (2000) Am J Hum Genet , vol.67 , Issue.3 , pp. 737-744
    • Deng, Z.1    Morse, J.H.2    Slager, S.L.3    Cuervo, N.4    Moore, K.J.5    Venetos, G.6
  • 16
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension
    • Lane KB, Machado RD, Pauciulo MW, Thomson JR, Phillips JA, Loyd JE, et al. Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. Nat Genet. 2000;26(1):81-4
    • (2000) Nat Genet , vol.26 , Issue.1 , pp. 81-84
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3    Thomson, J.R.4    Phillips, J.A.5    Loyd, J.E.6
  • 17
    • 66249125359 scopus 로고    scopus 로고
    • A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension
    • Shintani M, Yagi H, Nakayama T, Saji T, Matsuoka R. A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. J Med Genet. 2009;46(5):331-7
    • (2009) J Med Genet , vol.46 , Issue.5 , pp. 331-337
    • Shintani, M.1    Yagi, H.2    Nakayama, T.3    Saji, T.4    Matsuoka, R.5
  • 18
    • 65649128937 scopus 로고    scopus 로고
    • Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents
    • Izikki M, Guignabert C, Fadel E, Humbert M, Tu L, Zadigue P, et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest. 2009;119(3):512-23
    • (2009) J Clin Invest , vol.119 , Issue.3 , pp. 512-523
    • Izikki, M.1    Guignabert, C.2    Fadel, E.3    Humbert, M.4    Tu, L.5    Zadigue, P.6
  • 19
    • 33644865928 scopus 로고    scopus 로고
    • Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: Implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension
    • Teichert-Kuliszewska K, Kutryk MJB, Kuliszewski MA, Karoubi G, Courtman DW, Zucco L, et al. Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension. Circ Res. 2006;98(2):209-17
    • (2006) Circ Res , vol.98 , Issue.2 , pp. 209-217
    • Teichert-Kuliszewska, K.1    Kutryk, M.2    Kuliszewski, M.A.3    Karoubi, G.4    Courtman, D.W.5    Zucco, L.6
  • 20
    • 85019401678 scopus 로고    scopus 로고
    • Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells
    • Yang X, Long L, Reynolds PN, Morrell NW. Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells. Pulm Circ. 2011;1(1):103-10
    • (2011) Pulm Circ , vol.1 , Issue.1 , pp. 103-110
    • Yang, X.1    Long, L.2    Reynolds, P.N.3    Morrell, N.W.4
  • 21
    • 80052348254 scopus 로고    scopus 로고
    • Disruption of PPARγ/β- - catenin- mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
    • Alastalo T-P, Li M, Perez Vde J, Pham D, Sawada H, Wang JK, et al. Disruption of PPARγ/β- - catenin- mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J Clin Invest. 2011;121(9):3735-46
    • (2011) J Clin Invest , vol.121 , Issue.9 , pp. 3735-3746
    • Alastalo, T.-P.1    Li, M.2    Perez Vde, J.3    Pham, D.4    Sawada, H.5    Wang, J.K.6
  • 22
    • 84872078405 scopus 로고    scopus 로고
    • An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension
    • Kim J, Kang Y, Kojima Y, Lighthouse JK, Hu X, Aldred MA, et al. An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension. Nat Med. 2013;19(1):74-82
    • (2013) Nat Med , vol.19 , Issue.1 , pp. 74-82
    • Kim, J.1    Kang, Y.2    Kojima, Y.3    Lighthouse, J.K.4    Hu, X.5    Aldred, M.A.6
  • 23
    • 84905454459 scopus 로고    scopus 로고
    • Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension
    • Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, et al. Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. J Clin Invest. 2014;124(8):3514-28
    • (2014) J Clin Invest , vol.124 , Issue.8 , pp. 3514-3528
    • Bertero, T.1    Lu, Y.2    Annis, S.3    Hale, A.4    Bhat, B.5    Saggar, R.6
  • 24
    • 0038389113 scopus 로고    scopus 로고
    • Peroxisome proliferator- activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth
    • Ameshima S, Golpon H, Cool CD, Chan D, Vandivier RW, Gardai SJ, et al. Peroxisome proliferator- activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res. 2003;92(10):1162-9
    • (2003) Circ Res , vol.92 , Issue.10 , pp. 1162-1169
    • Ameshima, S.1    Golpon, H.2    Cool, C.D.3    Chan, D.4    Vandivier, R.W.5    Gardai, S.J.6
  • 26
    • 66949118228 scopus 로고    scopus 로고
    • Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3- microRNA cluster 17/92 pathway
    • Brock M, Trenkmann M, Gay RE, Michel BA, Gay S, Fischler M, et al. Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3- microRNA cluster 17/92 pathway. Circ Res. 2009;104(10):1184-91
    • (2009) Circ Res , vol.104 , Issue.10 , pp. 1184-1191
    • Brock, M.1    Trenkmann, M.2    Gay, R.E.3    Michel, B.A.4    Gay, S.5    Fischler, M.6
  • 27
    • 84872674552 scopus 로고    scopus 로고
    • The role of infl ammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension
    • Kherbeck N, Tamby MC, Bussone G, Dib H, Perros F, Humbert M, et al. The role of infl ammation and autoimmunity in the pathophysiology of pulmonary arterial hypertension. Clin Rev Allergy Immunol. 2013;44(1):31-8
    • (2013) Clin Rev Allergy Immunol , vol.44 , Issue.1 , pp. 31-38
    • Kherbeck, N.1    Tamby, M.C.2    Bussone, G.3    Dib, H.4    Perros, F.5    Humbert, M.6
  • 29
    • 84906039533 scopus 로고    scopus 로고
    • Inhibition of microRNA-125a promotes human endothelial cell proliferation and viability through an antiapoptotic mechanism
    • Svensson D, Gidlöf O, Turczyńska KM, Erlinge D, Albinsson S, Nilsson B-O. Inhibition of microRNA-125a promotes human endothelial cell proliferation and viability through an antiapoptotic mechanism. J Vasc Res. 2014;51(3):239-45
    • (2014) J Vasc Res , vol.51 , Issue.3 , pp. 239-245
    • Svensson, D.1    Gidlöf, O.2    Turczyńska, K.M.3    Erlinge, D.4    Albinsson, S.5    Nilsson, B.-O.6
  • 30
    • 84862777565 scopus 로고    scopus 로고
    • MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: Results of a network bioinformatics approach
    • Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, et al. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 2012;125(12):1520-32
    • (2012) Circulation , vol.125 , Issue.12 , pp. 1520-1532
    • Parikh, V.N.1    Jin, R.C.2    Rabello, S.3    Gulbahce, N.4    White, K.5    Hale, A.6
  • 31
    • 84455168708 scopus 로고    scopus 로고
    • Altered microRNA processing in heritable pulmonary arterial hypertension: An important role for Smad-8
    • Drake KM, Zygmunt D, Mavrakis L, Harbor P, Wang L, Comhair SA, et al. Altered microRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8. Am J Respir Crit Care Med. 2011;184(12):1400-8
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.12 , pp. 1400-1408
    • Drake, K.M.1    Zygmunt, D.2    Mavrakis, L.3    Harbor, P.4    Wang, L.5    Comhair, S.A.6
  • 32
    • 84863293692 scopus 로고    scopus 로고
    • Abraham E, et al. MiR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling
    • Yang S, Banerjee S, de Freitas A, Cui H, Xie N, Abraham E, et al. miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol. 2012;302(6):L521-9
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , Issue.6 , pp. L521-L529
    • Yang, S.1    Banerjee, S.2    De Freitas, A.3    Cui, H.4    Xie, N.5
  • 33
    • 84902549732 scopus 로고    scopus 로고
    • Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase- 3 axis
    • White K, Dempsie Y, Caruso P, Wallace E, McDonald RA, Stevens H, et al. Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase- 3 axis. Hypertension. 2014;64(1):185-94
    • (2014) Hypertension , vol.64 , Issue.1 , pp. 185-194
    • White, K.1    Dempsie, Y.2    Caruso, P.3    Wallace, E.4    McDonald, R.A.5    Stevens, H.6
  • 34
    • 70349478990 scopus 로고    scopus 로고
    • MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2
    • Chan SY, Zhang Y-Y, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009;10(4):273-84
    • (2009) Cell Metab , vol.10 , Issue.4 , pp. 273-284
    • Chan, S.Y.1    Zhang, Y.-Y.2    Hemann, C.3    Mahoney, C.E.4    Zweier, J.L.5    Loscalzo, J.6
  • 36
    • 84936153104 scopus 로고    scopus 로고
    • Emerging concepts in the molecular basis of pulmonary arterial hypertension: Part I: Metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension
    • Ryan JJ, Archer SL. Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension. Circulation. 2015;131(19):1691-702
    • (2015) Circulation , vol.131 , Issue.19 , pp. 1691-1702
    • Ryan, J.J.1    Archer, S.L.2
  • 37
    • 84934945418 scopus 로고    scopus 로고
    • Iron homeostasis and pulmonary hypertension: Iron deficiency leads to pulmonary vascular remodeling in the rat
    • Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res. 2015;116(10):1680-90
    • (2015) Circ Res , vol.116 , Issue.10 , pp. 1680-1690
    • Cotroneo, E.1    Ashek, A.2    Wang, L.3    Wharton, J.4    Dubois, O.5    Bozorgi, S.6
  • 38
    • 84930160765 scopus 로고    scopus 로고
    • Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension
    • White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, et al. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015;7(6):695-713
    • (2015) EMBO Mol Med , vol.7 , Issue.6 , pp. 695-713
    • White, K.1    Lu, Y.2    Annis, S.3    Hale, A.E.4    Chau, B.N.5    Dahlman, J.E.6
  • 39
    • 84904260870 scopus 로고    scopus 로고
    • STAT3 signaling in pulmonary arterial hypertension
    • Paulin R, Meloche J, Bonnet S. STAT3 signaling in pulmonary arterial hypertension. JAKSTAT. 2012;1(4):223-33
    • (2012) JAKSTAT , vol.1 , Issue.4 , pp. 223-233
    • Paulin, R.1    Meloche, J.2    Bonnet, S.3
  • 40
    • 79953043420 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension
    • Paulin R, Courboulin A, Meloche J, Mainguy V, Dumas de la Roque E, Saksouk N, et al. Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. Circulation. 2011;123(11):1205-15
    • (2011) Circulation , vol.123 , Issue.11 , pp. 1205-1215
    • Paulin, R.1    Courboulin, A.2    Meloche, J.3    Mainguy, V.4    Dumas De La Roque, E.5    Saksouk, N.6
  • 42
    • 80053351689 scopus 로고    scopus 로고
    • Krüppellike factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension
    • Courboulin A, Tremblay VL, Barrier M, Meloche J, Jacob MH, Chapolard M, et al. Krüppellike factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension. Respir Res. 2011;12:128
    • (2011) Respir Res , vol.12
    • Courboulin, A.1    Tremblay, V.L.2    Barrier, M.3    Meloche, J.4    Jacob, M.H.5    Chapolard, M.6
  • 43
    • 34547456414 scopus 로고    scopus 로고
    • The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted
    • Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, et al. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A. 2007;104(27):11418-23
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.27 , pp. 11418-11423
    • Bonnet, S.1    Rochefort, G.2    Sutendra, G.3    Archer, S.L.4    Haromy, A.5    Webster, L.6
  • 45
    • 84941671128 scopus 로고    scopus 로고
    • MiR-223 reverses experimental pulmonary arterial hypertension
    • Meloche J, Le Guen M, Potus F, et al. miR-223 reverses experimental pulmonary arterial hypertension. Am J Physiol Cell Physiol 2015;309:C363-72. doi: 10.1152/ajpcell.00149.2015
    • (2015) Am J Physiol Cell Physiol , vol.309 , pp. C363-C372
    • Meloche, J.1    Le Guen, M.2    Potus, F.3
  • 46
    • 84928386929 scopus 로고    scopus 로고
    • MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression
    • Xing Y, Zheng X, Li G, Liao L, Cao W, Xing H, et al. MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression. Int J Biochem Cell Biol. 2015;64:155-66
    • (2015) Int J Biochem Cell Biol , vol.64 , pp. 155-166
    • Xing, Y.1    Zheng, X.2    Li, G.3    Liao, L.4    Cao, W.5    Xing, H.6
  • 50
    • 70449109145 scopus 로고    scopus 로고
    • Notch3 signaling promotes the development of pulmonary arterial hypertension
    • Li X, Zhang X, Leathers R, Makino A, Huang C, Parsa P, et al. Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med. 2009;15(11):1289-97
    • (2009) Nat Med , vol.15 , Issue.11 , pp. 1289-1297
    • Li, X.1    Zhang, X.2    Leathers, R.3    Makino, A.4    Huang, C.5    Parsa, P.6
  • 51
    • 84864229176 scopus 로고    scopus 로고
    • A role for miR-145 in pulmonary arterial hypertension: Evidence from mouse models and patient samples
    • Caruso P, Dempsie Y, Stevens HC, McDonald RA, Long L, Lu R, et al. A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circ Res. 2012;111(3):290-300
    • (2012) Circ Res , vol.111 , Issue.3 , pp. 290-300
    • Caruso, P.1    Dempsie, Y.2    Stevens, H.C.3    McDonald, R.A.4    Long, L.5    Lu, R.6
  • 52
    • 78649892620 scopus 로고    scopus 로고
    • MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
    • Sarkar J, Gou D, Turaka P, Viktorova E, Ramchandran R, Raj JU. MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am J Physiol Lung Cell Mol Physiol. 2010;299(6):L861-71
    • (2010) Am J Physiol Lung Cell Mol Physiol , vol.299 , Issue.6 , pp. L861-L871
    • Sarkar, J.1    Gou, D.2    Turaka, P.3    Viktorova, E.4    Ramchandran, R.5    Raj, J.U.6
  • 54
    • 84922347131 scopus 로고    scopus 로고
    • AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodeling in hypoxia-induced pulmonary hypertension
    • Brock M, Samillan VJ, Trenkmann M, Schwarzwald C, Ulrich S, Gay RE, et al. AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodeling in hypoxia-induced pulmonary hypertension. Eur Heart J. 2014;35(45):3203-11
    • (2014) Eur Heart J , vol.35 , Issue.45 , pp. 3203-3211
    • Brock, M.1    Samillan, V.J.2    Trenkmann, M.3    Schwarzwald, C.4    Ulrich, S.5    Gay, R.E.6
  • 55
    • 84924755766 scopus 로고    scopus 로고
    • Loss of microRNA-17 ∼ 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5
    • Chen T, Zhou G, Zhou Q, Tang H, Ibe JCF, Cheng H, et al. Loss of microRNA-17 ∼ 92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5. Am J Respir Crit Care Med. 2015;191(6):678-92
    • (2015) Am J Respir Crit Care Med , vol.191 , Issue.6 , pp. 678-692
    • Chen, T.1    Zhou, G.2    Zhou, Q.3    Tang, H.4    Ibe, J.5    Cheng, H.6
  • 56
    • 0036461644 scopus 로고    scopus 로고
    • Role of K+ channels in pulmonary hypertension
    • Mandegar M, Yuan JXJ. Role of K+ channels in pulmonary hypertension. Vascul Pharmacol. 2002;38(1):25-33
    • (2002) Vascul Pharmacol , vol.38 , Issue.1 , pp. 25-33
    • Mandegar, M.1    Yuan, J.X.J.2
  • 57
    • 84903590362 scopus 로고    scopus 로고
    • MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K + channel in arterial smooth muscle cells
    • Li S-S, Ran Y-J, Zhang D-D, Li S-Z, Zhu D. MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K + channel in arterial smooth muscle cells. J Cell Biochem. 2014;115(6):1196-205
    • (2014) J Cell Biochem , vol.115 , Issue.6 , pp. 1196-1205
    • Li, S.-S.1    Ran, Y.-J.2    Zhang, D.-D.3    Li, S.-Z.4    Zhu, D.5
  • 58
    • 84949910019 scopus 로고    scopus 로고
    • MicroRNA 29b is upregulated in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension and inhibits K+ channel expression and function
    • Pohl NM, Yamamura A, Yamamura H, Makino A, Yuan JX-J. MicroRNA 29b is upregulated in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension and inhibits K+ channel expression and function. FASEB J. 2012;26:884
    • (2012) FASEB J , vol.26
    • Pohl, N.M.1    Yamamura, A.2    Yamamura, H.3    Makino, A.4    Yuan, J.-J.5
  • 59
    • 84863419659 scopus 로고    scopus 로고
    • The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C
    • Guo L, Qiu Z, Wei L, Yu X, Gao X, Jiang S, et al. The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C. Hypertension. 2012;59(5):1006-13
    • (2012) Hypertension , vol.59 , Issue.5 , pp. 1006-1013
    • Guo, L.1    Qiu, Z.2    Wei, L.3    Yu, X.4    Gao, X.5    Jiang, S.6
  • 60
    • 77955281323 scopus 로고    scopus 로고
    • 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90
    • Zhang L, Ma J, Li Y, Guo L, Ran Y, Liu S, et al. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90. Life Sci. 2010;87(7-8):223-31
    • (2010) Life Sci , vol.87 , Issue.7-8 , pp. 223-231
    • Zhang, L.1    Ma, J.2    Li, Y.3    Guo, L.4    Ran, Y.5    Liu, S.6
  • 61
    • 80053574010 scopus 로고    scopus 로고
    • Key role of 15-lipoxygenase/15- hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension
    • Ma C, Li Y, Ma J, Liu Y, Li Q, Niu S, et al. Key role of 15-lipoxygenase/15- hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension. Hypertension. 2011;58(4):679-88
    • (2011) Hypertension , vol.58 , Issue.4 , pp. 679-688
    • Ma, C.1    Li, Y.2    Ma, J.3    Liu, Y.4    Li, Q.5    Niu, S.6
  • 62
    • 77951492263 scopus 로고    scopus 로고
    • Apolipoprotein A-I mimetic peptides: A potential new therapy for the prevention of atherosclerosis
    • Sherman CB, Peterson SJ, Frishman WH. Apolipoprotein A-I mimetic peptides: a potential new therapy for the prevention of atherosclerosis. Cardiol Rev. 2010;18(3):141-7
    • (2010) Cardiol Rev , vol.18 , Issue.3 , pp. 141-147
    • Sherman, C.B.1    Peterson, S.J.2    Frishman, W.H.3
  • 63
    • 84907376787 scopus 로고    scopus 로고
    • ApoA-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p
    • Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, et al. ApoA-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p. Circulation. 2014;130(9): 776-85
    • (2014) Circulation , vol.130 , Issue.9 , pp. 776-785
    • Sharma, S.1    Umar, S.2    Potus, F.3    Iorga, A.4    Wong, G.5    Meriwether, D.6
  • 64
    • 84873693794 scopus 로고    scopus 로고
    • Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change
    • Stenmark KR, Frid MG, Yeager M, Li M, Riddle S, McKinsey T, et al. Targeting the adventitial microenvironment in pulmonary hypertension: a potential approach to therapy that considers epigenetic change. Pulm Circ. 2012;2(1):3-14
    • (2012) Pulm Circ , vol.2 , Issue.1 , pp. 3-14
    • Stenmark, K.R.1    Frid, M.G.2    Yeager, M.3    Li, M.4    Riddle, S.5    McKinsey, T.6
  • 65
    • 84892930632 scopus 로고    scopus 로고
    • MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts
    • Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, et al. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014;114(1):67-78
    • (2014) Circ Res , vol.114 , Issue.1 , pp. 67-78
    • Wang, D.1    Zhang, H.2    Li, M.3    Frid, M.G.4    Flockton, A.R.5    McKeon, B.A.6
  • 66
    • 62149104001 scopus 로고    scopus 로고
    • The right ventricle under pressure: Cellular and molecular mechanisms of right-heart failure in pulmonary hypertension
    • Bogaard HJ, Abe K, Vonk Noordegraaf A, Voelkel NF. The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest. 2009;135(3):794-804
    • (2009) Chest , vol.135 , Issue.3 , pp. 794-804
    • Bogaard, H.J.1    Abe, K.2    Vonk Noordegraaf, A.3    Voelkel, N.F.4
  • 67
    • 41649100266 scopus 로고    scopus 로고
    • Right ventricular function in cardiovascular disease, part II: Pathophysiology, clinical importance, and management of right ventricular failure
    • Haddad F, Doyle R, Murphy DJ, Hunt SA. Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation. 2008;117(13):1717-31
    • (2008) Circulation , vol.117 , Issue.13 , pp. 1717-1731
    • Haddad, F.1    Doyle, R.2    Murphy, D.J.3    Hunt, S.A.4
  • 68
    • 85026338603 scopus 로고    scopus 로고
    • MicroRNAs in right ventricular (Dys)function (2013 Grover conference series)
    • Thum T, Batkai S. MicroRNAs in right ventricular (dys)function (2013 Grover conference series). Pulm Circ. 2014;4(2):185-90
    • (2014) Pulm Circ , vol.4 , Issue.2 , pp. 185-190
    • Thum, T.1    Batkai, S.2
  • 69
    • 84920789459 scopus 로고    scopus 로고
    • A miR-208- Mef2 axis drives the de-compensation of right ventricular function in pulmonary hypertension
    • Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy AS, Provencher S, et al. A miR-208- Mef2 axis drives the de-compensation of right ventricular function in pulmonary hypertension. Circ Res. 2015;116(1):56-69
    • (2015) Circ Res , vol.116 , Issue.1 , pp. 56-69
    • Paulin, R.1    Sutendra, G.2    Gurtu, V.3    Dromparis, P.4    Haromy, A.S.5    Provencher, S.6
  • 70
    • 85026335947 scopus 로고    scopus 로고
    • Vascular remodeling process in pulmonary arterial hypertension, with focus on miR-204 and miR-126 (2013 Grover conference series)
    • Potus F, Graydon C, Provencher S, Bonnet S. Vascular remodeling process in pulmonary arterial hypertension, with focus on miR-204 and miR-126 (2013 Grover conference series). Pulm Circ. 2014;4(2):175-84
    • (2014) Pulm Circ , vol.4 , Issue.2 , pp. 175-184
    • Potus, F.1    Graydon, C.2    Provencher, S.3    Bonnet, S.4
  • 71
    • 84905831453 scopus 로고    scopus 로고
    • Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension
    • Potus F, Malenfant S, Graydon C, Mainguy V, Tremblay E, Breuils-Bonnet S, et al. Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2014;190(3):318-28
    • (2014) Am J Respir Crit Care Med , vol.190 , Issue.3 , pp. 318-328
    • Potus, F.1    Malenfant, S.2    Graydon, C.3    Mainguy, V.4    Tremblay, E.5    Breuils-Bonnet, S.6
  • 72
    • 84941360761 scopus 로고    scopus 로고
    • Downregulation of miR-126 contributes to the Failing right ventricle in pulmonary arterial hypertension
    • Potus F, Ruffenach G, Dahou A, et al. Downregulation of miR-126 contributes to the Failing right ventricle in pulmonary arterial hypertension. circulation 2015;132:932-43. doi: 10.1161/CIRCULATIONAHA.115.016382
    • (2015) Circulation , vol.132 , pp. 932-943
    • Potus, F.1    Ruffenach, G.2    Dahou, A.3
  • 73
    • 84878140094 scopus 로고    scopus 로고
    • Circulating miRNAs as potential marker for pulmonary hypertension
    • Wei C, Henderson H, Spradley C, Li L, Kim I-K, Kumar S, et al. Circulating miRNAs as potential marker for pulmonary hypertension. PLoS One. 2013;8(5), e64396
    • (2013) Plos One , vol.8 , Issue.5
    • Wei, C.1    Henderson, H.2    Spradley, C.3    Li, L.4    Kim, I.-K.5    Kumar, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.