Super-low Dose Endotoxin Pre-conditioning Exacerbates Sepsis Mortality

EBioMedicine

Volumn 2, Issue 4, 2015, Pages 324-333

  Chen, Keqiang ^a   Geng, Shuo ^a   Yuan, Ruoxi ^a   Diao, Na ^a   Upchurch, Zachary ^a   Li, Liwu ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

Innate immunity; Neutrophil; Polymicrobial sepsis; Pre conditioning dynamics; Super low dose endotoxin

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; CXCL1 CHEMOKINE; ENDOTOXIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; TAUROURSODEOXYCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CHEMOTAXIS ASSAY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR TRAP; FLOW CYTOMETRY; HISTOLOGY; IMMUNOFLUORESCENCE; INFLAMMATION; INNATE IMMUNITY; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TISSUE INJURY;

EID: 84949668034     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.03.001     Document Type: Article

References (58)

1. Ancuta P., Kamat A., Kunstman K.J., Kim E.Y., Autissier P., Wurcel A., Zaman T., Stone D., Mefford M., Morgello S., et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One 2008, 3:e2516.
2. Arany I., Megyesi J.K., Kaneto H., Tanaka S., Safirstein R.L. Activation of ERK or inhibition of JNK ameliorates H(2)O(2) cytotoxicity in mouse renal proximal tubule cells. Kidney Int. 2004, 65:1231-1239.
3. Bakal C., Linding R., Llense F., Heffern E., Martin-Blanco E., Pawson T., Perrimon N. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science 2008, 322:453-456.
4. Campbell A.M., Kashgarian M., Shlomchik M.J. NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus. Sci. Transl. Med. 2012, 4:1-7. 157ra141.
5. Cani P.D., Bibiloni R., Knauf C., Waget A., Neyrinck A.M., Delzenne N.M., Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008, 57:1470-1481.
6. Colak A., Kelten B., Sagmanligil A., Akdemir O., Karaoglan A., Sahan E., Celik O., Barut S. Tauroursodeoxycholic acid and secondary damage after spinal cord injury in rats. J. Clin. Neurosci. 2008, 15:665-671.
7. Deng H., Maitra U., Morris M., Li L. Molecular mechanism responsible for the priming of macrophage activation. J. Biol. Chem. 2013, 288:3897-3906.
8. Engin F., Yermalovich A., Nguyen T., Hummasti S., Fu W., Eizirik D.L., Mathis D., Hotamisligil G.S. Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Sci. Transl. Med. 2013, 5:1-14. 211ra156.
9. Foster S.L., Hargreaves D.C., Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 2007, 447:972-978.
10. Fu Y., Glaros T., Zhu M., Wang P., Wu Z., Tyson J.J., Li L., Xing J. Network topologies and dynamics leading to endotoxin tolerance and priming in innate immune cells. PLoS Comput. Biol. 2012, 8:e1002526.
11. Godshall C.J., Scott M.J., Peyton J.C., Gardner S.A., Cheadle W.G. Genetic background determines susceptibility during murine septic peritonitis. J. Surg. Res. 2002, 102:45-49.
12. Goto T., Eden S., Nordenstam G., Sundh V., Svanborg-Eden C., Mattsby-Baltzer I. Endotoxin levels in sera of elderly individuals. Clin. Diagn. Lab. Immunol. 1994, 1:684-688.
13. Hakkim A., Fuchs T.A., Martinez N.E., Hess S., Prinz H., Zychlinsky A., Waldmann H. Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation. Nat. Chem. Biol. 2011, 7:75-77.
14. Henricson B.E., Manthey C.L., Perera P.Y., Hamilton T.A., Vogel S.N. Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A. Infect. Immun. 1993, 61:2325-2333.
15. Hirohashi N., Morrison D.C. Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro. Infect. Immun. 1996, 64:1011-1015.
16. Hong T., X., J., Li L., Tyson J. A mathematical model for the reciprocal differentiation of T helper 17 cells and induced regulatory T cells. PLoS Comput. Biol. 2011, 7:1-13.
17. Jacinto R., Hartung T., McCall C., Li L. Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J. Immunol. 2002, 168:6136-6141.
18. Junttila M.R., Li S.P., Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J. 2008, 22:954-965.
19. Kawai T., Akira S. TLR signaling. Semin. Immunol. 2007, 19:24-32.
20. Kopanakis K., Tzepi I.M., Pistiki A., Carrer D.P., Netea M.G., Georgitsi M., Lymperi M., Droggiti D.I., Liakakos T., Machairas A., et al. Pre-treatment with low-dose endotoxin prolongs survival from experimental lethal endotoxic shock: benefit for lethal peritonitis by Escherichia coli. Cytokine 2013, 62:382-388.
21. Landoni V.I., Chiarella P., Martire-Greco D., Schierloh P., van-Rooijen N., Rearte B., Palermo M.S., Isturiz M.A., Fernandez G.C. Tolerance to lipopolysaccharide promotes an enhanced neutrophil extracellular traps formation leading to a more efficient bacterial clearance in mice. Clin. Exp. Immunol. 2012, 168:153-163.
22. Li L., Cousart S., Hu J., McCall C.E. Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J. Biol. Chem. 2000, 275:23340-23345.
23. Lira F.S., Rosa J.C., Pimentel G.D., Souza H.A., Caperuto E.C., Carnevali L.C., Seelaender M., Damaso A.R., Oyama L.M., de Mello M.T., et al. Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects. Lipids Health Dis. 2010, 9:82.
24. Maitra U., Gan L., Chang S., Li L. Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein delta. J. Immunol. 2011, 186:4467-4473.
25. Maitra U., Deng H., Glaros T., Baker B., Capelluto D.G., Li Z., Li L. Molecular mechanisms responsible for the selective and low-grade induction of proinflammatory mediators in murine macrophages by lipopolysaccharide. J. Immunol. 2012, 189:1014-1023.
26. Martinez F.O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization. Front. Biosci. 2008, 13:453-461.
27. Mayadas T.N., Cullere X., Lowell C.A. The multifaceted functions of neutrophils. Annu. Rev. Pathol. 2014, 9:181-218.
28. Medvedev A.E., Lentschat A., Wahl L.M., Golenbock D.T., Vogel S.N. Dysregulation of LPS-induced toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J. Immunol. 2002, 169:5209-5216.
29. Meng X., Ao L., Brown J.M., Meldrum D.R., Sheridan B.C., Cain B.S., Banerjee A., Harken A.H. LPS induces late cardiac functional protection against ischemia independent of cardiac and circulating TNF-alpha. Am. J. Physiol. 1997, 273:H1894-1902.
30. Meng W., Paunel-Gorgulu A., Flohe S., Hoffmann A., Witte I., Mackenzie C., Baldus S.E., Windolf J., Logters T.T. Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice. Crit. Care 2012, 16:R137.
31. Morris M., Li L. Molecular mechanisms and pathological consequences of endotoxin tolerance and priming. Arch. Immunol. Ther. Exp. (Warsz) 2012, 60:13-18.
32. Morris M., Gilliams E., Li L. Innate immune programming by endotoxin and its pathological consequences. Front. Immunol. 2015, 5(680):1-8.
33. Ness T.L., Hogaboam C.M., Strieter R.M., Kunkel S.L. Immunomodulatory role of CXCR2 during experimental septic peritonitis. J. Immunol. 2003, 171:3775-3784.
34. Netea M.G., Quintin J., van der Meer J.W. Trained immunity: a memory for innate host defense. Cell Host Microbe 2011, 9:355-361.
35. Quintin J., Saeed S., Martens J.H., Giamarellos-Bourboulis E.J., Ifrim D.C., Logie C., Jacobs L., Jansen T., Kullberg B.J., Wijmenga C., et al. Candida albicans infection affords protection against reinfection via functional reprogramming of monocytes. Cell Host Microbe 2012, 12:223-232.
36. Rao R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 2009, 50:638-644.
37. Rocksen D., Koch B., Sandstrom T., Bucht A. Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. Shock 2004, 22:482-490.
38. Sabroe I., Prince L.R., Jones E.C., Horsburgh M.J., Foster S.J., Vogel S.N., Dower S.K., Whyte M.K. Selective roles for toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span. J. Immunol. 2003, 170:5268-5275.
39. Salmond R.J., Brownlie R.J., Morrison V.L., Zamoyska R. The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals. Nat. Immunol. 2014, 15:875-883.
40. Schauer C., Janko C., Munoz L.E., Zhao Y., Kienhofer D., Frey B., Lell M., Manger B., Rech J., Naschberger E., et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat. Med. 2014, 20:511-517.
41. Schliess F., Kurz A.K., vom Dahl S., Haussinger D. Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. Gastroenterology 1997, 113:1306-1314.
42. Shen Y.H., Godlewski J., Zhu J., Sathyanarayana P., Leaner V., Birrer M.J., Rana A., Tzivion G. Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors. J. Biol. Chem. 2003, 278:26715-26721.
43. Shirey K.A., Lai W., Scott A.J., Lipsky M., Mistry P., Pletneva L.M., Karp C.L., McAlees J., Gioannini T.L., Weiss J., et al. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature 2013, 497:498-502.
44. Srivastava N., Sudan R., Saha B. CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection. J. Immunol. 2011, 186:5863-5872.
45. Stearns-Kurosawa D.J., Osuchowski M.F., Valentine C., Kurosawa S., Remick D.G. The pathogenesis of sepsis. Annu. Rev. Pathol. 2011, 6:19-48.
46. Sunil V.R., Patel K.J., Nilsen-Hamilton M., Heck D.E., Laskin J.D., Laskin D.L. Acute endotoxemia is associated with upregulation of lipocalin 24p3/Lcn2 in lung and liver. Exp. Mol. Pathol. 2007, 83:177-187.
47. Szeto C.C., Kwan B.C., Chow K.M., Lai K.B., Chung K.Y., Leung C.B., Li P.K. Endotoxemia is related to systemic inflammation and atherosclerosis in peritoneal dialysis patients. Clin. J. Am. Soc. Nephrol. 2008, 3:431-436.
48. Tancevski I., Nairz M., Duwensee K., Auer K., Schroll A., Heim C., Feistritzer C., Hoefer J., Gerner R.R., Moschen A.R., et al. Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2. EMBO Mol. Med. 2014, 6:810-820.
49. Terawaki H., Yokoyama K., Yamada Y., Maruyama Y., Iida R., Hanaoka K., Yamamoto H., Obata T., Hosoya T. Low-grade endotoxemia contributes to chronic inflammation in hemodialysis patients: examination with a novel lipopolysaccharide detection method. Ther. Apher. Dial. 2010, 14:477-482.
50. Toscano M.G., Ganea D., Gamero A.M. Cecal ligation puncture procedure. JoVE 2011, 51:e2860.
51. Tyson J.J., Chen K., Novak B. Network dynamics and cell physiology. Nat. Rev. Mol. Cell Biol. 2001, 2:908-916.
52. van Panhuys N., Klauschen F., Germain R.N. T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization in vivo. Immunity 2014, 41:63-74.
53. Wang S.C., Klein R.D., Wahl W.L., Alarcon W.H., Garg R.J., Remick D.G., Su G.L. Tissue coexpression of LBP and CD14 mRNA in a mouse model of sepsis. J. Surg. Res. 1998, 76:67-73.
54. West M.A., Heagy W. Endotoxin tolerance: a review. Crit. Care Med. 2002, 30:S64-S73.
55. Wiedermann C.J., Kiechl S., Dunzendorfer S., Schratzberger P., Egger G., Oberhollenzer F., Willeit J. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J. Am. Coll. Cardiol. 1999, 34:1975-1981.
56. Yoo D.G., Winn M., Pang L., Moskowitz S.M., Malech H.L., Leto T.L., Rada B. Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation. J. Immunol. 2014, 192:4728-4738.
57. Zhang X., Morrison D.C. Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages. J. Exp. Med. 1993, 177:511-516.
58. Zhang X., Morrison D.C. Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages. J. Leukoc. Biol. 1993, 54:444-450.