메뉴 건너뛰기




Volumn 60, Issue 1, 2012, Pages 13-18

Molecular mechanisms and pathological consequences of endotoxin tolerance and priming

Author keywords

Endotoxin; Inflammatory diseases; Priming; Sepsis; Tolerance

Indexed keywords

ENDOTOXIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MKP 1; TRANSCRIPTION FACTOR RELB; UNCLASSIFIED DRUG;

EID: 84858797878     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-011-0155-9     Document Type: Review
Times cited : (98)

References (51)
  • 1
    • 60549106442 scopus 로고    scopus 로고
    • Tolerance induced via TLR2 and TLR4 in human dendritic cells: Role of IRAK-1
    • Albrecht V, Hofer TP, Foxwell B et al (2008) Tolerance induced via TLR2 and TLR4 in human dendritic cells: role of IRAK-1. BMC Immunol 9:69
    • (2008) BMC Immunol , vol.9 , pp. 69
    • Albrecht, V.1    Hofer, T.P.2    Foxwell, B.3
  • 2
    • 79958056948 scopus 로고    scopus 로고
    • LPS-induced CD11b(+) Gr1(int)F4/80(+) regulatory myeloid cells suppress allergen-induced airway inflammation
    • Arora M, Poe SL, Ray A et al (2011) LPS-induced CD11b(+) Gr1(int)F4/80(+) regulatory myeloid cells suppress allergen-induced airway inflammation. Int Immunopharmacol 11:827-832
    • (2011) Int Immunopharmacol , vol.11 , pp. 827-832
    • Arora, M.1    Poe, S.L.2    Ray, A.3
  • 3
    • 0028815553 scopus 로고
    • Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
    • Berg DJ, Kühn R, Rajewsky K et al (1995) Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest 96:2339-2347
    • (1995) J Clin Invest , vol.96 , pp. 2339-2347
    • Berg, D.J.1    Kühn, R.2    Rajewsky, K.3
  • 4
    • 70349559403 scopus 로고    scopus 로고
    • Endotoxin tolerance: New mechanisms, molecules and clinical significance
    • Biswas SK, Lopez-Collazo E (2009) Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol 30:475-487
    • (2009) Trends Immunol , vol.30 , pp. 475-487
    • Biswas, S.K.1    Lopez-Collazo, E.2
  • 6
    • 77956627302 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages
    • Chaurasia B, Mauer J, Koch L et al (2010) Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol 30:4354-4366
    • (2010) Mol Cell Biol , vol.30 , pp. 4354-4366
    • Chaurasia, B.1    Mauer, J.2    Koch, L.3
  • 7
    • 58149396443 scopus 로고    scopus 로고
    • RelB sustains IkappaBalpha expression during endotoxin tolerance
    • Chen X, Yoza BK, El Gazzar M et al (2009) RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol 16:104-110
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 104-110
    • Chen, X.1    Yoza, B.K.2    El Gazzar, M.3
  • 8
    • 24944586285 scopus 로고    scopus 로고
    • Achieving stability of lipopolysaccharide-induced NF-kappaB activation
    • DOI 10.1126/science.1112304
    • Covert MW, Leung TH, Gaston JE et al (2005) Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309:1854-1857 (Pubitemid 41325095)
    • (2005) Science , vol.309 , Issue.5742 , pp. 1854-1857
    • Covert, M.W.1    Leung, T.H.2    Gaston, J.E.3    Baltimore, D.4
  • 9
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth SC, Piggott Da, Huleatt JW et al (2002) Lipopolysaccharide- enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 196:1645-1651
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Da, P.2    Huleatt, J.W.3
  • 10
    • 78650059543 scopus 로고    scopus 로고
    • Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent antiinflammatory pathway in macrophages
    • Eken C, Martin PJ, Sadallah S et al (2010) Ectosomes released by polymorphonuclear neutrophils induce a MerTK-dependent antiinflammatory pathway in macrophages. J Biol Chem 285:39914-39921
    • (2010) J Biol Chem , vol.285 , pp. 39914-39921
    • Eken, C.1    Martin, P.J.2    Sadallah, S.3
  • 11
    • 78650266432 scopus 로고    scopus 로고
    • FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
    • Fan W, Morinaga H, Kim JJ et al (2010) FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 29:4223-4236
    • (2010) EMBO J , vol.29 , pp. 4223-4236
    • Fan, W.1    Morinaga, H.2    Kim, J.J.3
  • 12
    • 0027407363 scopus 로고    scopus 로고
    • Ferrero E, Jiai D, Tsuberi BZ et al (1993) Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide. Proc Natl Acad Sci USA 90:2380-2384
    • Proc Natl Acad Sci USA , vol.90 , pp. 2380-2384
  • 13
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • DOI 10.1038/nature05836, PII NATURE05836
    • Foster SL, Hargreaves DC, Medzhitov R (2007) Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 447:972-978 (Pubitemid 46975746)
    • (2007) Nature , vol.447 , Issue.7147 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 15
    • 70249137268 scopus 로고    scopus 로고
    • RelB/p50 regulates CCL19 production, but fails to promote human DC maturation
    • Gasparini C, Foxwell BM, Feldmann M (2009) RelB/p50 regulates CCL19 production, but fails to promote human DC maturation. Eur J Immunol 39:2215-2223
    • (2009) Eur J Immunol , vol.39 , pp. 2215-2223
    • Gasparini, C.1    Foxwell, B.M.2    Feldmann, M.3
  • 16
    • 33646547951 scopus 로고    scopus 로고
    • Systems biology approaches identify ATF3 as a negative regulator of toll-like receptor 4
    • Gilchrist M, Thorsson V, Li B et al (2006) Systems biology approaches identify ATF3 as a negative regulator of toll-like receptor 4. Nature 441:173-178
    • (2006) Nature , vol.441 , pp. 173-178
    • Gilchrist, M.1    Thorsson, V.2    Li, B.3
  • 17
    • 75649147911 scopus 로고    scopus 로고
    • TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
    • González-Navajas JM, Fine S, Law JE et al (2010) TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest 120:570-581
    • (2010) J Clin Invest , vol.120 , pp. 570-581
    • González-Navajas, J.M.1    Fine, S.2    Law, J.E.3
  • 18
    • 0027159611 scopus 로고
    • Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A
    • Henricson BE, Manthey CL, Perera PY et al (1993) Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A. Infect Immun 61:2325-2333 (Pubitemid 23159218)
    • (1993) Infection and Immunity , vol.61 , Issue.6 , pp. 2325-2333
    • Henricson, B.E.1    Manthey, C.L.2    Perera, P.Y.3    Hamilton, T.A.4    Vogel, S.N.5
  • 19
    • 0025365576 scopus 로고
    • Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice
    • DOI 10.1084/jem.171.6.1853
    • Heremans H, Van Damme J, Dillen C et al (1990) Interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice. J Exp Med 171:1853-1869 (Pubitemid 20200228)
    • (1990) Journal of Experimental Medicine , vol.171 , Issue.6 , pp. 1853-1869
    • Heremans, H.1    Van Damme, J.2    Dillen, C.3    Dijkmans, R.4    Billiau, A.5
  • 20
    • 0030051294 scopus 로고    scopus 로고
    • Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro
    • Hirohashi N, Morrison DC (1996) Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro. Infect Immun 64:1011-1015 (Pubitemid 26065580)
    • (1996) Infection and Immunity , vol.64 , Issue.3 , pp. 1011-1015
    • Hirohashi, N.1    Morrison, D.C.2
  • 22
    • 67649668789 scopus 로고    scopus 로고
    • Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint
    • Huang W, Ghisletti S, Perissi V et al (2009) Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell 35:48-57
    • (2009) Mol Cell , vol.35 , pp. 48-57
    • Huang, W.1    Ghisletti, S.2    Perissi, V.3
  • 23
    • 0037097519 scopus 로고    scopus 로고
    • Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: Distinct alterations in IL-1 receptor-associated kinase
    • Jacinto R, Hartung T, McCall C, Li L (2002) Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J Immunol 168:6136-6141 (Pubitemid 34620031)
    • (2002) Journal of Immunology , vol.168 , Issue.12 , pp. 6136-6141
    • Jacinto, R.1    Hartung, T.2    McCall, C.3    Li, L.4
  • 25
    • 0035029189 scopus 로고    scopus 로고
    • Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery
    • Kawasaki T, Ogata M, Kawasaki C et al (2001) Surgical stress induces endotoxin hyporesponsiveness and an early decrease of monocyte mCD14 and HLA-DR expression during surgery. Anesth Analg 92:1322-1326 (Pubitemid 32385966)
    • (2001) Anesthesia and Analgesia , vol.92 , Issue.5 , pp. 1322-1326
    • Kawasaki, T.1    Ogata, M.2    Kawasaki, C.3    Tomihisa, T.4    Okamoto, K.5    Shigematsu, A.6
  • 26
    • 68949134285 scopus 로고    scopus 로고
    • Lipopolysaccharide "two-hit" induced refractory hypoxemia acute respiratory distress model in rats
    • Li Y, Wei H (2009) Lipopolysaccharide "two-hit" induced refractory hypoxemia acute respiratory distress model in rats. J Huazhong Univ Sci Technolog Med Sci 29:470-475
    • (2009) J Huazhong Univ Sci Technolog Med Sci , vol.29 , pp. 470-475
    • Li, Y.1    Wei, H.2
  • 27
    • 0034725584 scopus 로고    scopus 로고
    • Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells
    • DOI 10.1074/jbc.M001950200
    • Li L, Cousart S, Hu J et al (2000) Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J Biol Chem 275:23340-23345 (Pubitemid 30646236)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.30 , pp. 23340-23345
    • Li, L.1    Cousart, S.2    Hu, J.3    McCall, C.E.4
  • 28
    • 79955045367 scopus 로고    scopus 로고
    • Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein {delta}
    • Maitra U, Gan L, Chang S et al (2011) Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein {delta}. J Immunol 186:4467-4473
    • (2011) J Immunol , vol.186 , pp. 4467-4473
    • Maitra, U.1    Gan, L.2    Chang, S.3
  • 29
    • 0021360476 scopus 로고
    • The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals
    • McPhail LC, Clayton CC, Snyderman R (1984) The NADPH oxidase of human polymorphonuclear leukocytes. Evidence for regulation by multiple signals. J Biol Chem 259:5768-5775 (Pubitemid 14145044)
    • (1984) Journal of Biological Chemistry , vol.259 , Issue.9 , pp. 5768-5775
    • McPhail, L.C.1    Clayton, C.C.2    Snyderman, R.3
  • 30
    • 78650642949 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
    • Medina EA, Morris IR, Berton MT (2010) Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain. J Immunol 185:7562-7572
    • (2010) J Immunol , vol.185 , pp. 7562-7572
    • Medina, E.A.1    Morris, I.R.2    Berton, M.T.3
  • 31
    • 0034043956 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: Dysregulation of cytokine, chemokine, and Toll-like receptor 2 and 4 gene expression
    • Medvedev AE, Kopydlowski KM, Vogel SN (2000) Inhibition of lipopolysaccharide-induced signal transduction in endotoxin-tolerized mouse macrophages: dysregulation of cytokine, chemokine, and toll-like receptor 2 and 4 gene expression. J Immunol 164:5564-5574 (Pubitemid 30389795)
    • (2000) Journal of Immunology , vol.164 , Issue.11 , pp. 5564-5574
    • Medvedev, A.E.1    Kopydlowski, K.M.2    Vogel, S.N.3
  • 33
    • 75649139205 scopus 로고    scopus 로고
    • Murine responses to endotoxin: Another dirty little secret?
    • Munford RS (2010) Murine responses to endotoxin: another dirty little secret? J Infect Dis 201:175-177
    • (2010) J Infect Dis , vol.201 , pp. 175-177
    • Munford, R.S.1
  • 35
    • 60549093454 scopus 로고    scopus 로고
    • Mobilization and margination of bone marrow Gr-1 high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury
    • O'Dea KP, Wilson MR, Dokpesi JO et al (2009) Mobilization and margination of bone marrow Gr-1 high monocytes during subclinical endotoxemia predisposes the lungs toward acute injury. J Immunol 182:1155-1166
    • (2009) J Immunol , vol.182 , pp. 1155-1166
    • O'Dea, K.P.1    Wilson, M.R.2    Dokpesi, J.O.3
  • 37
    • 70349275277 scopus 로고    scopus 로고
    • Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB
    • Porta C, Rimoldi M, Raes G et al (2009) Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci USA 106:14978-14983
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14978-14983
    • Porta, C.1    Rimoldi, M.2    Raes, G.3
  • 38
    • 8144230703 scopus 로고    scopus 로고
    • Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E
    • DOI 10.1097/01.shk.0000142254.38630.36
    • Rocksén D, Koch B, Sandström T et al (2004) Lung effects during a generalized Shwartzman reaction and therapeutic intervention with dexamethasone or vitamin E. Shock 22:482-490 (Pubitemid 39472575)
    • (2004) Shock , vol.22 , Issue.5 , pp. 482-490
    • Rocksen, D.1    Koch, B.2    Sandstrom, T.3    Bucht, A.4
  • 40
    • 36849033963 scopus 로고    scopus 로고
    • TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response
    • DOI 10.1016/j.cell.2007.10.034, PII S0092867407013529
    • Rothlin CV, Ghosh S, Zuniga EI et al (2007) TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131:1124-1136 (Pubitemid 350235020)
    • (2007) Cell , vol.131 , Issue.6 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.A.4    Lemke, G.5
  • 41
    • 81155157952 scopus 로고    scopus 로고
    • Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study
    • Sivapalaratnam S, Farrugia R, Nieuwdorp M et al (2011) Identification of candidate genes linking systemic inflammation to atherosclerosis; results of a human in vivo LPS infusion study. BMC Med Genomics 4:64
    • (2011) BMC Med Genomics , vol.4 , pp. 64
    • Sivapalaratnam, S.1    Farrugia, R.2    Nieuwdorp, M.3
  • 42
    • 33748765793 scopus 로고    scopus 로고
    • Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction
    • Slofstra SH, ten Cate H, Spek CA (2006) Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. Thromb J 4:13
    • (2006) Thromb J , vol.4 , pp. 13
    • Slofstra, S.H.1    Ten Cate, H.2    Spek, C.A.3
  • 43
    • 4143102310 scopus 로고    scopus 로고
    • LPS-induced upregulation of SHIP is essential for endotoxin tolerance
    • DOI 10.1016/j.immuni.2004.07.010, PII S1074761304001931
    • Sly LM, Rauh MJ, Kalesnikoff J et al (2004) LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21:227-239 (Pubitemid 39094052)
    • (2004) Immunity , vol.21 , Issue.2 , pp. 227-239
    • Sly, L.M.1    Rauh, M.J.2    Kalesnikoff, J.3    Song, C.H.4    Krystal, G.5
  • 44
    • 34247548450 scopus 로고    scopus 로고
    • Leptin: At the crossroads of energy balance and systemic inflammation
    • DOI 10.1016/j.plipres.2006.11.001, PII S0163782706000634
    • Steiner AA, Romanovsky AA (2007) Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res 46:89-107 (Pubitemid 46654230)
    • (2007) Progress in Lipid Research , vol.46 , Issue.2 , pp. 89-107
    • Steiner, A.A.1    Romanovsky, A.A.2
  • 45
    • 77957346206 scopus 로고    scopus 로고
    • Low-grade endotoxemia contributes to chronic inflammation in hemodialysis patients: Examination with a novel lipopolysaccharide detection method
    • Terawaki H, Yokoyama K, Yamada Y et al (2010) Low-grade endotoxemia contributes to chronic inflammation in hemodialysis patients: examination with a novel lipopolysaccharide detection method. Ther Apher Dial 14:477-482
    • (2010) Ther Apher Dial , vol.14 , pp. 477-482
    • Terawaki, H.1    Yokoyama, K.2    Yamada, Y.3
  • 46
    • 38949181003 scopus 로고    scopus 로고
    • A common pathway mediated through Toll-like receptors leads to T- and natural killer-cell immunosuppression
    • DOI 10.1182/blood-2007-07-100404
    • Vaknin I, Blinder L, Wang L et al (2008) A common pathway mediated through toll-like receptors leads to T- and natural killer-cell immunosuppression. Blood 111:1437-1447 (Pubitemid 351213431)
    • (2008) Blood , vol.111 , Issue.3 , pp. 1437-1447
    • Vaknin, I.1    Blinder, L.2    Wang, L.3    Gazit, R.4    Shapira, E.5    Genina, O.6    Pines, M.7    Pikarsky, E.8    Baniyash, M.9
  • 47
    • 67650401419 scopus 로고    scopus 로고
    • Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis)
    • Wiersinga WJ, van't Veer C, van den Pangaart PS et al (2009) Immunosuppression associated with interleukin-1R-associated-kinase-M upregulation predicts mortality in Gram-negative sepsis (melioidosis). Crit Care Med 37:569-576
    • (2009) Crit Care Med , vol.37 , pp. 569-576
    • Wiersinga, W.J.1    Van'T Veer, C.2    Van Den Pangaart, P.S.3
  • 48
    • 79953143905 scopus 로고    scopus 로고
    • Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
    • Xiong Y, Qiu F, Piao W et al (2011) Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem 286:7905-7916
    • (2011) J Biol Chem , vol.286 , pp. 7905-7916
    • Xiong, Y.1    Qiu, F.2    Piao, W.3
  • 49
    • 78651101982 scopus 로고    scopus 로고
    • Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis
    • Yoza BK,McCall CE (2011) Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis. Cytokine 53:145-152
    • (2011) Cytokine , vol.53 , pp. 145-152
    • Yoza, B.K.1    McCall, C.E.2
  • 51
    • 46449132224 scopus 로고    scopus 로고
    • Decrease in toll-like receptors 2 and 4 in the spleen of mouse with endotoxic tolerance
    • Zhong B, Ma HY, Yang Q et al (2008) Decrease in toll-like receptors 2 and 4 in the spleen of mouse with endotoxic tolerance. Inflamm Res 57:252-259
    • (2008) Inflamm Res , vol.57 , pp. 252-259
    • Zhong, B.1    Ma, H.Y.2    Yang, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.