-
1
-
-
2442635429
-
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
-
Mathur, R. K., A. Awasthi, P. Wadhone, B. Ramanamurthy, and B. Saha. 2004. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat. Med. 10:540-544.
-
(2004)
Nat. Med.
, vol.10
, pp. 540-544
-
-
Mathur, R.K.1
Awasthi, A.2
Wadhone, P.3
Ramanamurthy, B.4
Saha, B.5
-
2
-
-
33344472043
-
The conundrum of CD40 function: Host protection or disease promotion?
-
Mathur, R. K., A. Awasthi, and B. Saha. 2006. The conundrum of CD40 function: host protection or disease promotion? Trends Parasitol. 22:117-122.
-
(2006)
Trends Parasitol.
, vol.22
, pp. 117-122
-
-
Mathur, R.K.1
Awasthi, A.2
Saha, B.3
-
3
-
-
65749102081
-
Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. [Published erratum appears in 1037-10432009 Nat. Immunol. 10:665.]
-
Rub, A., R. Dey, M. Jadhav, R. Kamat, S. Chakkaramakkil, S. Majumdar, R. Mukhopadhyaya, and B. Saha. 2009. Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. [Published erratum appears in 1037-10432009 Nat. Immunol. 10:665.] Nat. Immunol. 10:273-280.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 273-280
-
-
Rub, A.1
Dey, R.2
Jadhav, M.3
Kamat, R.4
Chakkaramakkil, S.5
Majumdar, S.6
Mukhopadhyaya, R.7
Saha, B.8
-
4
-
-
0037460059
-
CD40 signaling is impaired in L. Major-infected macrophages and is rescued by a p38MAPK activator establishing a hostprotective memory T cell response
-
Awasthi, A., R. K. Mathur, A. Khan, B. N. Joshi, N. Jain, S. Sawant, R. Boppana, D. Mitra, and B. Saha. 2003. CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a hostprotective memory T cell response. J. Exp. Med. 197:1037-1043.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 1037-1043
-
-
Awasthi, A.1
Mathur, R.K.2
Khan, A.3
Joshi, B.N.4
Jain, N.5
Sawant, S.6
Boppana, R.7
Mitra, D.8
Saha, B.9
-
5
-
-
0032744175
-
Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-g-triggered JAK2 activation
-
Blanchette, J., N. R. Racette, R. Faure, K. A. Siminovitch, and M. Olivier. 1999. Leishmania-induced increases in activation of macrophage SHP-1 tyrosine phosphatase are associated with impaired IFN-g-triggered JAK2 activation. Eur. J. Immunol. 29:3737-3744.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 3737-3744
-
-
Blanchette, J.1
Racette, N.R.2
Faure, R.3
Siminovitch, K.A.4
Olivier, M.5
-
6
-
-
0037146607
-
Leishmania EF-1a activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 leading to macrophage deactivation
-
Nandan, D., T. Yi, M. Lopez, C. Lai, and N. E. Reiner. 2002. Leishmania EF-1a activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 leading to macrophage deactivation. J. Biol. Chem. 277:50190-50197.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50190-50197
-
-
Nandan, D.1
Yi, T.2
Lopez, M.3
Lai, C.4
Reiner, N.E.5
-
7
-
-
17444420714
-
Subversion mechanisms by which Leishmania parasites can escape the host immune response: A signaling point of view
-
Olivier, M., D. J. Gregory, and G. Forget. 2005. Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view. Clin. Microbiol. Rev. 18:293-305.
-
(2005)
Clin. Microbiol. Rev.
, vol.18
, pp. 293-305
-
-
Olivier, M.1
Gregory, D.J.2
Forget, G.3
-
8
-
-
63849109119
-
Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)
-
Blanchette, J., I. Abu-Dayyeh, K. Hassani, L. Whitcombe, and M. Olivier. 2009. Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1). Immunology 127:123-133.
-
(2009)
Immunology
, vol.127
, pp. 123-133
-
-
Blanchette, J.1
Abu-Dayyeh, I.2
Hassani, K.3
Whitcombe, L.4
Olivier, M.5
-
9
-
-
20844444211
-
Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1
-
Forget, G., C. Matte, K. A. Siminovitch, S. Rivest, P. Pouliot, and M. Olivier. 2005. Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. Eur. J. Immunol. 35:1906-1917.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 1906-1917
-
-
Forget, G.1
Matte, C.2
Siminovitch, K.A.3
Rivest, S.4
Pouliot, P.5
Olivier, M.6
-
10
-
-
0034096201
-
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
-
Keyse, S. M. 2000. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12:186-192.
-
(2000)
Curr. Opin. Cell Biol.
, vol.12
, pp. 186-192
-
-
Keyse, S.M.1
-
12
-
-
33847176551
-
MAPK phosphatases: Regulating the immune response
-
Liu, Y., E. G. Shepherd, and L. D. Nelin. 2007. MAPK phosphatases: regulating the immune response. Nat. Rev. Immunol. 7:202-212.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 202-212
-
-
Liu, Y.1
Shepherd, E.G.2
Nelin, L.D.3
-
13
-
-
31344475056
-
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
-
Hammer, M., J. Mages, H. Dietrich, A. Servatius, N. Howells, A. C. Cato, and R. Lang. 2006. Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock. J. Exp. Med. 203:15-20.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 15-20
-
-
Hammer, M.1
Mages, J.2
Dietrich, H.3
Servatius, A.4
Howells, N.5
Cato, A.C.6
Lang, R.7
-
14
-
-
0036884621
-
Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages
-
Chen, P., J. Li, J. Barnes, G. C. Kokkonen, J. C. Lee, and Y. Liu. 2002. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J. Immunol. 169:6408-6416.
-
(2002)
J. Immunol.
, vol.169
, pp. 6408-6416
-
-
Chen, P.1
Li, J.2
Barnes, J.3
Kokkonen, G.C.4
Lee, J.C.5
Liu, Y.6
-
15
-
-
31144452241
-
Essential role of MAPK phosphatase-1 in the negative control of innate immune responses
-
Salojin, K. V., I. B. Owusu, K. A. Millerchip, M. Potter, K. A. Platt, and T. Oravecz. 2006. Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J. Immunol. 176:1899-1907.
-
(2006)
J. Immunol.
, vol.176
, pp. 1899-1907
-
-
Salojin, K.V.1
Owusu, I.B.2
Millerchip, K.A.3
Potter, M.4
Platt, K.A.5
Oravecz, T.6
-
16
-
-
33144460185
-
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
-
Chi, H., S. P. Barry, R. J. Roth, J. J. Wu, E. A. Jones, A. M. Bennett, and R. A. Flavell. 2006. Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc. Natl. Acad. Sci. USA 103:2274-2279.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2274-2279
-
-
Chi, H.1
Barry, S.P.2
Roth, R.J.3
Wu, J.J.4
Jones, E.A.5
Bennett, A.M.6
Flavell, R.A.7
-
17
-
-
57649198454
-
DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility
-
Maillet, M., N. H. Purcell, M. A. Sargent, A. J. York, O. F. Bueno, and J. D. Molkentin. 2008. DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J. Biol. Chem. 283:31246-31255.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31246-31255
-
-
Maillet, M.1
Purcell, N.H.2
Sargent, M.A.3
York, A.J.4
Bueno, O.F.5
Molkentin, J.D.6
-
18
-
-
0025865103
-
A Tyr/Ser protein phosphatase encoded by vaccinia virus
-
Guan, K. L., S. S. Broyles, and J. E. Dixon. 1991. A Tyr/Ser protein phosphatase encoded by vaccinia virus. Nature 350:359-362.
-
(1991)
Nature
, vol.350
, pp. 359-362
-
-
Guan, K.L.1
Broyles, S.S.2
Dixon, J.E.3
-
19
-
-
11144238602
-
The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages
-
Shepherd, E. G., Q. Zhao, S. E. Welty, T. N. Hansen, C. V. Smith, and Y. Liu. 2004. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. J. Biol. Chem. 279:54023-54031.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 54023-54031
-
-
Shepherd, E.G.1
Zhao, Q.2
Welty, S.E.3
Hansen, T.N.4
Smith, C.V.5
Liu, Y.6
-
20
-
-
0033557291
-
Macrophage microbicidal mechanisms in vivo: Reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani
-
Murray, H. W., and C. F. Nathan. 1999. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J. Exp. Med. 189:741-746.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 741-746
-
-
Murray, H.W.1
Nathan, C.F.2
-
21
-
-
0030021084
-
Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice
-
Carrera, L., R. T. Gazzinelli, R. Badolato, S. Hieny, W. Muller, R. Kuhn, and D. L. Sacks. 1996. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 183:515-526.
-
(1996)
J. Exp. Med.
, vol.183
, pp. 515-526
-
-
Carrera, L.1
Gazzinelli, R.T.2
Badolato, R.3
Hieny, S.4
Muller, W.5
Kuhn, R.6
Sacks, D.L.7
-
22
-
-
0032898950
-
Experimental Leishmania major infection in mice: Role of IL-10
-
Chatelain, R., S. Mauze, and R. L. Coffman. 1999. Experimental Leishmania major infection in mice: role of IL-10. Parasite Immunol. 21:211-218.
-
(1999)
Parasite Immunol.
, vol.21
, pp. 211-218
-
-
Chatelain, R.1
Mauze, S.2
Coffman, R.L.3
-
23
-
-
0030028222
-
MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
-
Muda, M., U. Boschert, R. Dickinson, J. C. Martinou, I. Martinou, M. Camps, W. Schlegel, and S. Arkinstall. 1996. MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J. Biol. Chem. 271:4319-4326.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4319-4326
-
-
Muda, M.1
Boschert, U.2
Dickinson, R.3
Martinou, J.C.4
Martinou, I.5
Camps, M.6
Schlegel, W.7
Arkinstall, S.8
-
24
-
-
0027358722
-
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
-
Sun, H., C. H. Charles, L. F. Lau, and N. K. Tonks. 1993. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75:487-493.
-
(1993)
Cell
, vol.75
, pp. 487-493
-
-
Sun, H.1
Charles, C.H.2
Lau, L.F.3
Tonks, N.K.4
-
25
-
-
31344442772
-
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
-
Zhao, Q., X. Wang, L. D. Nelin, Y. Yao, R. Matta, M. E. Manson, R. S. Baliga, X. Meng, C. V. Smith, J. A. Bauer, et al. 2006. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock. J. Exp. Med. 203:131-140.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 131-140
-
-
Zhao, Q.1
Wang, X.2
Nelin, L.D.3
Yao, Y.4
Matta, R.5
Manson, M.E.6
Baliga, R.S.7
Meng, X.8
Smith, C.V.9
Bauer, J.A.10
-
26
-
-
0035863867
-
The role of IL-10 in promoting disease progression in leishmaniasis
-
Kane, M. M., and D. M. Mosser. 2001. The role of IL-10 in promoting disease progression in leishmaniasis. J. Immunol. 166:1141-1147.
-
(2001)
J. Immunol.
, vol.166
, pp. 1141-1147
-
-
Kane, M.M.1
Mosser, D.M.2
-
27
-
-
34548543615
-
Interleukin-10 and the pathogenesis of human visceral leishmaniasis
-
Nylén, S., and D. Sacks. 2007. Interleukin-10 and the pathogenesis of human visceral leishmaniasis. Trends Immunol. 28:378-384.
-
(2007)
Trends Immunol.
, vol.28
, pp. 378-384
-
-
Nylén, S.1
Sacks, D.2
-
28
-
-
33846203839
-
Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages
-
Yang, Z., D. M. Mosser, and X. Zhang. 2007. Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages. J. Immunol. 178:1077-1085.
-
(2007)
J. Immunol.
, vol.178
, pp. 1077-1085
-
-
Yang, Z.1
Mosser, D.M.2
Zhang, X.3
-
29
-
-
0038832564
-
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation
-
Brondello, J. M., J. Pouysségur, and F. R. McKenzie. 1999. Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science 286:2514-2517.
-
(1999)
Science
, vol.286
, pp. 2514-2517
-
-
Brondello, J.M.1
Pouysségur, J.2
McKenzie, F.R.3
-
30
-
-
11844294679
-
Extracellular signal-regulated kinases phosphorylate mitogenactivated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation
-
Marchetti, S., C. Gimond, J. C. Chambard, T. Touboul, D. Roux, J. Pouysségur, and G. Pagès. 2005. Extracellular signal-regulated kinases phosphorylate mitogenactivated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation. Mol. Cell. Biol. 25:854-864.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 854-864
-
-
Marchetti, S.1
Gimond, C.2
Chambard, J.C.3
Touboul, T.4
Roux, D.5
Pouysségur, J.6
Pagès, G.7
-
31
-
-
34547756859
-
MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge
-
Nelin, L. D., X. Wang, Q. Zhao, L. G. Chicoine, T. L. Young, D. M. Hatch, B. K. English, and Y. Liu. 2007. MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge. Am. J. Physiol. Cell Physiol. 293:C632-C640.
-
(2007)
Am. J. Physiol. Cell Physiol.
, vol.293
, pp. C632-C640
-
-
Nelin, L.D.1
Wang, X.2
Zhao, Q.3
Chicoine, L.G.4
Young, T.L.5
Hatch, D.M.6
English, B.K.7
Liu, Y.8
-
32
-
-
34247142019
-
Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria
-
Wang, X., X. Meng, J. R. Kuhlman, L. D. Nelin, K. K. Nicol, B. K. English, and Y. Liu. 2007. Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria. J. Immunol. 178:5312-5320.
-
(2007)
J. Immunol.
, vol.178
, pp. 5312-5320
-
-
Wang, X.1
Meng, X.2
Kuhlman, J.R.3
Nelin, L.D.4
Nicol, K.K.5
English, B.K.6
Liu, Y.7
-
33
-
-
4844231880
-
Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice
-
Sacks, D., and C. Anderson. 2004. Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice. Immunol. Rev. 201:225-238.
-
(2004)
Immunol. Rev.
, vol.201
, pp. 225-238
-
-
Sacks, D.1
Anderson, C.2
-
34
-
-
27644506964
-
Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10
-
Hammer, M., J. Mages, H. Dietrich, F. Schmitz, F. Striebel, P. J. Murray, H. Wagner, and R. Lang. 2005. Control of dual-specificity phosphatase-1 expression in activated macrophages by IL-10. Eur. J. Immunol. 35:2991-3001.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2991-3001
-
-
Hammer, M.1
Mages, J.2
Dietrich, H.3
Schmitz, F.4
Striebel, F.5
Murray, P.J.6
Wagner, H.7
Lang, R.8
-
35
-
-
0037058703
-
Expression of mitogenactivated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma
-
Denkert, C., W. D. Schmitt, S. Berger, A. Reles, S. Pest, A. Siegert, W. Lichtenegger, M. Dietel, and S. Hauptmann. 2002. Expression of mitogenactivated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Int. J. Cancer 102:507-513.
-
(2002)
Int. J. Cancer
, vol.102
, pp. 507-513
-
-
Denkert, C.1
Schmitt, W.D.2
Berger, S.3
Reles, A.4
Pest, S.5
Siegert, A.6
Lichtenegger, W.7
Dietel, M.8
Hauptmann, S.9
-
36
-
-
2542637306
-
Mitogenactivated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients
-
Vicent, S., M. Garayoa, J. M. López-Picazo, M. D. Lozano, G. Toledo, F. B. Thunnissen, R. G. Manzano, and L. M. Montuenga. 2004. Mitogenactivated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients. Clin. Cancer Res. 10:3639-3649.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3639-3649
-
-
Vicent, S.1
Garayoa, M.2
López-Picazo, J.M.3
Lozano, M.D.4
Toledo, G.5
Thunnissen, F.B.6
Manzano, R.G.7
Montuenga, L.M.8
-
37
-
-
33748995966
-
Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance
-
Wang, Z., J. Xu, J. Y. Zhou, Y. Liu, and G. S. Wu. 2006. Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance. Cancer Res. 66:8870-8877.
-
(2006)
Cancer Res.
, vol.66
, pp. 8870-8877
-
-
Wang, Z.1
Xu, J.2
Zhou, J.Y.3
Liu, Y.4
Wu, G.S.5
-
38
-
-
4043182010
-
Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras
-
Warmka, J. K., L. J. Mauro, and E. V. Wattenberg. 2004. Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras. J. Biol. Chem. 279:33085-33092.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 33085-33092
-
-
Warmka, J.K.1
Mauro, L.J.2
Wattenberg, E.V.3
-
39
-
-
18844448016
-
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer
-
Xu, S., T. Furukawa, N. Kanai, M. Sunamura, and A. Horii. 2005. Abrogation of DUSP6 by hypermethylation in human pancreatic cancer. J. Hum. Genet. 50:159-167.
-
(2005)
J. Hum. Genet.
, vol.50
, pp. 159-167
-
-
Xu, S.1
Furukawa, T.2
Kanai, N.3
Sunamura, M.4
Horii, A.5
-
40
-
-
43049101029
-
Dual-specificity MAP kinase phosphatases (MKPs) and cancer
-
Keyse, S. M. 2008. Dual-specificity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 27:253-261.
-
(2008)
Cancer Metastasis Rev.
, vol.27
, pp. 253-261
-
-
Keyse, S.M.1
-
41
-
-
77954686146
-
MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: Involvement of distinct protein kinase C isoforms
-
Kar, S., A. Ukil, G. Sharma, and P. K. Das. 2010. MAPK-directed phosphatases preferentially regulate pro- and anti-inflammatory cytokines in experimental visceral leishmaniasis: involvement of distinct protein kinase C isoforms. J. Leukoc. Biol. 88:9-20.
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 9-20
-
-
Kar, S.1
Ukil, A.2
Sharma, G.3
Das, P.K.4
|