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Volumn 16, Issue 2, 2004, Pages 174-179

Notch signaling in T- and B-cell development

Author keywords

Antigen presenting cell; APC; BM; Bone marrow; FoB; Follicular B cell; Hematopoietic stem cell; HSC; Marginal zone B cell; MINT; Msx2 interacting nuclear target protein; MZB; Narp; Notch IC; Notch regulated ankyrin repeat protein

Indexed keywords

BINDING PROTEIN; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2 RECEPTOR; LIGAND; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN DERIVATIVE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR PAX5;

EID: 1542351331     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2004.01.002     Document Type: Review
Times cited : (89)

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    • + peripheral T cells was able to bias Th1 over Th2 cytokine production in vitro. In addition, anti-sense Notch3-IC was able to inhibit Th1 development in the presence of Delta1-Fc, also suggesting that Notch3 mediates a Th1 response in vitro. More importantly, Delta1-induced Notch signaling promoted a Th1 response in vivo in a Th2-prone L. major model.
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