-
1
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas S., Rand M.D., Lake R.J. Notch signaling: cell fate control and signal integration in development. Science. 284:1999;770-776.
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
2
-
-
0037137482
-
Modulation of receptor signaling by glycosylation: Fringe is an O-fucose-β1,3-N-acetylglucosaminyltransferase
-
Haltiwanger R.S., Stanley P. Modulation of receptor signaling by glycosylation: fringe is an O-fucose-β1,3-N-acetylglucosaminyltransferase. Biochim Biophys Acta. 1573:2002;328-335.
-
(2002)
Biochim Biophys Acta
, vol.1573
, pp. 328-335
-
-
Haltiwanger, R.S.1
Stanley, P.2
-
3
-
-
0029047609
-
Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
-
Matsuno K., Diederich R.J., Go M.J., Blaumueller C.M., Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development. 121:1995;2633-2644.
-
(1995)
Development
, vol.121
, pp. 2633-2644
-
-
Matsuno, K.1
Diederich, R.J.2
Go, M.J.3
Blaumueller, C.M.4
Artavanis-Tsakonas, S.5
-
4
-
-
0029909203
-
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
-
Frise E., Knoblich J.A., Younger-Shepherd S., Jan L.Y., Jan Y.N. The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A. 93:1996;11925-11932.
-
(1996)
Proc Natl Acad Sci U S a
, vol.93
, pp. 11925-11932
-
-
Frise, E.1
Knoblich, J.A.2
Younger-Shepherd, S.3
Jan, L.Y.4
Jan, Y.N.5
-
5
-
-
0037606092
-
Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: Multiple Notch1 signaling pathways involved in T cell development
-
Yun T.J., Bevan M.J. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J Immunol. 170:2003;5834-5841.
-
(2003)
J Immunol
, vol.170
, pp. 5834-5841
-
-
Yun, T.J.1
Bevan, M.J.2
-
6
-
-
0037332254
-
Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway
-
In a search for RBP-J binding proteins, the authors identified MINT, which functions as a negative regulator of Notch activity. MINT competes with Notch-IC for binding to RBP-J, thereby inhibiting Notch signaling. MINT is principally expressed in FoB cells; consequently MINT inactivation causes preferential differentiation of B cells into MZB cells at the expense of FoB cells.
-
Kuroda K., Han H., Tani S., Tanigaki K., Tun T., Furukawa T., Taniguchi Y., Kurooka H., Hamada Y., Toyokuni S.et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. 18:2003;301-312 In a search for RBP-J binding proteins, the authors identified MINT, which functions as a negative regulator of Notch activity. MINT competes with Notch-IC for binding to RBP-J, thereby inhibiting Notch signaling. MINT is principally expressed in FoB cells; consequently MINT inactivation causes preferential differentiation of B cells into MZB cells at the expense of FoB cells.
-
(2003)
Immunity
, vol.18
, pp. 301-312
-
-
Kuroda, K.1
Han, H.2
Tani, S.3
Tanigaki, K.4
Tun, T.5
Furukawa, T.6
Taniguchi, Y.7
Kurooka, H.8
Hamada, Y.9
Toyokuni, S.10
-
7
-
-
0033136717
-
Deficient T cell fate specification in mice with an induced inactivation of Notch1
-
Radtke F., Wilson A., Stark G., Bauer M., van Meerwijk J., MacDonald H.R., Aguet M. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 10:1999;547-558.
-
(1999)
Immunity
, vol.10
, pp. 547-558
-
-
Radtke, F.1
Wilson, A.2
Stark, G.3
Bauer, M.4
Van Meerwijk, J.5
MacDonald, H.R.6
Aguet, M.7
-
8
-
-
0034669907
-
Cutting edge: An essential role for Notch-1 in the development of both thymus-independent and -dependent T cells in the gut
-
Wilson A., Ferrero I., MacDonald H.R., Radtke F. Cutting edge: an essential role for Notch-1 in the development of both thymus-independent and -dependent T cells in the gut. J Immunol. 165:2000;5397-5400.
-
(2000)
J Immunol
, vol.165
, pp. 5397-5400
-
-
Wilson, A.1
Ferrero, I.2
MacDonald, H.R.3
Radtke, F.4
-
9
-
-
0035477668
-
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
-
Wilson A., MacDonald H.R., Radtke F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med. 194:2001;1003-1012.
-
(2001)
J Exp Med
, vol.194
, pp. 1003-1012
-
-
Wilson, A.1
MacDonald, H.R.2
Radtke, F.3
-
10
-
-
0035988246
-
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
-
Inactivation of RBP-J in the BM blocks T-cell development at an early stage, and promotes B-cell development in the thymus in a cell autonomous fashion. Myeloid development is, however, unaffected. This study provides confirmation of the role of RBP-J as a downstream effector of Notch1 signaling in the T-cell lineage and raises the question of whether Notch receptors play any role in the development of other blood lineages in the BM.
-
Han H., Tanigaki K., Yamamoto N., Kuroda K., Yoshimoto M., Nakahata T., Ikuta K., Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol. 14:2002;637-645 Inactivation of RBP-J in the BM blocks T-cell development at an early stage, and promotes B-cell development in the thymus in a cell autonomous fashion. Myeloid development is, however, unaffected. This study provides confirmation of the role of RBP-J as a downstream effector of Notch1 signaling in the T-cell lineage and raises the question of whether Notch receptors play any role in the development of other blood lineages in the BM.
-
(2002)
Int Immunol
, vol.14
, pp. 637-645
-
-
Han, H.1
Tanigaki, K.2
Yamamoto, N.3
Kuroda, K.4
Yoshimoto, M.5
Nakahata, T.6
Ikuta, K.7
Honjo, T.8
-
11
-
-
0038742790
-
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
-
+ T2 B cells. This study shows conclusively that Notch2 regulates MZB cell development in a dose-dependent manner.
-
+ T2 B cells. This study shows conclusively that Notch2 regulates MZB cell development in a dose-dependent manner.
-
(2003)
Immunity
, vol.18
, pp. 675-685
-
-
Saito, T.1
Chiba, S.2
Ichikawa, M.3
Kunisato, A.4
Asai, T.5
Shimizu, K.6
Yamaguchi, T.7
Yamamoto, G.8
Seo, S.9
Kumano, K.10
-
12
-
-
20244389684
-
Notch1 expression in early lymphopoiesis influences B versus T lineage determination
-
Pui J.C., Allman D., Xu L., DeRocco S., Karnell F.G., Bakkour S., Lee J.Y., Kadesch T., Hardy R.R., Aster J.C.et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 11:1999;299-308.
-
(1999)
Immunity
, vol.11
, pp. 299-308
-
-
Pui, J.C.1
Allman, D.2
Xu, L.3
Derocco, S.4
Karnell, F.G.5
Bakkour, S.6
Lee, J.Y.7
Kadesch, T.8
Hardy, R.R.9
Aster, J.C.10
-
13
-
-
0035895087
-
A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer
-
Yan X.Q., Sarmiento U., Sun Y., Huang G., Guo J., Juan T., Van G., Qi M.Y., Scully S., Senaldi G.et al. A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. Blood. 98:2001;3793-3799.
-
(2001)
Blood
, vol.98
, pp. 3793-3799
-
-
Yan, X.Q.1
Sarmiento, U.2
Sun, Y.3
Huang, G.4
Guo, J.5
Juan, T.6
Van, G.7
Qi, M.Y.8
Scully, S.9
Senaldi, G.10
-
14
-
-
0037105544
-
Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease
-
Dorsch M., Zheng G., Yowe D., Rao P., Wang Y., Shen Q., Murphy C., Xiong X., Shi Q., Gutierrez-Ramos J.C.et al. Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. Blood. 100:2002;2046-2055.
-
(2002)
Blood
, vol.100
, pp. 2046-2055
-
-
Dorsch, M.1
Zheng, G.2
Yowe, D.3
Rao, P.4
Wang, Y.5
Shen, Q.6
Murphy, C.7
Xiong, X.8
Shi, Q.9
Gutierrez-Ramos, J.C.10
-
15
-
-
0037198653
-
Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations
-
Kawamata S., Du C., Li K., Lavau C. Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene. 21:2002;3855-3863.
-
(2002)
Oncogene
, vol.21
, pp. 3855-3863
-
-
Kawamata, S.1
Du, C.2
Li, K.3
Lavau, C.4
-
16
-
-
0036906546
-
Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
-
Pax5 expression in hematopoietic stem cells and progenitors under the control of the endogenous Ikaros locus promotes B-cell development at the expense of T-cell development, but has no effect on myeloid or natural killer cell development. These results further confirm and restrict the role of Pax5 as a master regulator of B-cell development. Pax5 represses transcription of Notch1, providing a possible mechanism to allow B-cell development in the BM despite expression of Notch1.
-
Souabni A., Cobaleda C., Schebesta M., Busslinger M. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 17:2002;781-793 Pax5 expression in hematopoietic stem cells and progenitors under the control of the endogenous Ikaros locus promotes B-cell development at the expense of T-cell development, but has no effect on myeloid or natural killer cell development. These results further confirm and restrict the role of Pax5 as a master regulator of B-cell development. Pax5 represses transcription of Notch1, providing a possible mechanism to allow B-cell development in the BM despite expression of Notch1.
-
(2002)
Immunity
, vol.17
, pp. 781-793
-
-
Souabni, A.1
Cobaleda, C.2
Schebesta, M.3
Busslinger, M.4
-
17
-
-
0038819130
-
Pax5 determines B- versus T-cell fate and does not block early myeloid-lineage development
-
•] - inhibiting T-cell development and promoting B-cell development in BM chimeras.
-
•] - inhibiting T-cell development and promoting B-cell development in BM chimeras.
-
(2003)
Blood
, vol.101
, pp. 4342-4346
-
-
Cotta, C.V.1
Zhang, Z.2
Kim, H.G.3
Klug, C.A.4
-
18
-
-
0034869258
-
Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1
-
Koch U., Lacombe T.A., Holland D., Bowman J.L., Cohen B.L., Egan S.E., Guidos C.J. Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity. 15:2001;225-236.
-
(2001)
Immunity
, vol.15
, pp. 225-236
-
-
Koch, U.1
Lacombe, T.A.2
Holland, D.3
Bowman, J.L.4
Cohen, B.L.5
Egan, S.E.6
Guidos, C.J.7
-
19
-
-
18344388633
-
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1
-
Izon D.J., Aster J.C., He Y., Weng A., Karnell F.G., Patriub V., Xu L., Bakkour S., Rodriguez C., Allman D.et al. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity. 16:2002;231-243.
-
(2002)
Immunity
, vol.16
, pp. 231-243
-
-
Izon, D.J.1
Aster, J.C.2
He, Y.3
Weng, A.4
Karnell, F.G.5
Patriub, V.6
Xu, L.7
Bakkour, S.8
Rodriguez, C.9
Allman, D.10
-
20
-
-
0036533568
-
Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification
-
French M.B., Koch U., Shaye R.E., McGill M.A., Dho S.E., Guidos C.J., McGlade C.J. Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification. J Immunol. 168:2002;3173-3180.
-
(2002)
J Immunol
, vol.168
, pp. 3173-3180
-
-
French, M.B.1
Koch, U.2
Shaye, R.E.3
McGill, M.A.4
Dho, S.E.5
Guidos, C.J.6
McGlade, C.J.7
-
21
-
-
0035476891
-
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation
-
Jaleco A.C., Neves H., Hooijberg E., Gameiro P., Clode N., Haury M., Henrique D., Parreira L. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med. 194:2001;991-1002.
-
(2001)
J Exp Med
, vol.194
, pp. 991-1002
-
-
Jaleco, A.C.1
Neves, H.2
Hooijberg, E.3
Gameiro, P.4
Clode, N.5
Haury, M.6
Henrique, D.7
Parreira, L.8
-
22
-
-
0037105423
-
Active form of Notch imposes T cell fate in human progenitor cells
-
De Smedt M., Reynvoet K., Kerre T., Taghon T., Verhasselt B., Vandekerckhove B., Leclercq G., Plum J. Active form of Notch imposes T cell fate in human progenitor cells. J Immunol. 169:2002;3021-3029.
-
(2002)
J Immunol
, vol.169
, pp. 3021-3029
-
-
De Smedt, M.1
Reynvoet, K.2
Kerre, T.3
Taghon, T.4
Verhasselt, B.5
Vandekerckhove, B.6
Leclercq, G.7
Plum, J.8
-
23
-
-
0141816703
-
Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a γδ T-cell fate in fetal thymus organ culture
-
Garcia-Peydro M., de Yebenes V.G., Toribio M.L. Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a γδ T-cell fate in fetal thymus organ culture. Blood. 102:2003;2444-2451.
-
(2003)
Blood
, vol.102
, pp. 2444-2451
-
-
Garcia-Peydro, M.1
De Yebenes, V.G.2
Toribio, M.L.3
-
24
-
-
0037310525
-
Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors
-
Harman B.C., Jenkinson E.J., Anderson G. Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors. J Immunol. 170:2003;1299-1303.
-
(2003)
J Immunol
, vol.170
, pp. 1299-1303
-
-
Harman, B.C.1
Jenkinson, E.J.2
Anderson, G.3
-
25
-
-
0032054238
-
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
-
Jiang R., Lan Y., Chapman H.D., Shawber C., Norton C.R., Serreze D.V., Weinmaster G., Gridley T. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12:1998;1046-1057.
-
(1998)
Genes Dev
, vol.12
, pp. 1046-1057
-
-
Jiang, R.1
Lan, Y.2
Chapman, H.D.3
Shawber, C.4
Norton, C.R.5
Serreze, D.V.6
Weinmaster, G.7
Gridley, T.8
-
26
-
-
0036916440
-
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
-
In vitro ectopic expression of the Notch ligand Delta1 on the OP9 BM stromal cell line renders these cells incapable of supporting B-cell development but confers the capacity to support differentiation of immature fetal liver progenitors into T-lineage cells in vitro. This is accompanied by stage-specific T-cell expansion and TCR gene rearrangement and expression. Consequently, this study shows that the Delta1-Notch interaction is able to support T-lineage commitment and development in the absence of a conventional thymic microenvironment.
-
Schmitt T.M., Zuniga-Pflucker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity. 17:2002;749-756 In vitro ectopic expression of the Notch ligand Delta1 on the OP9 BM stromal cell line renders these cells incapable of supporting B-cell development but confers the capacity to support differentiation of immature fetal liver progenitors into T-lineage cells in vitro. This is accompanied by stage-specific T-cell expansion and TCR gene rearrangement and expression. Consequently, this study shows that the Delta1-Notch interaction is able to support T-lineage commitment and development in the absence of a conventional thymic microenvironment.
-
(2002)
Immunity
, vol.17
, pp. 749-756
-
-
Schmitt, T.M.1
Zuniga-Pflucker, J.C.2
-
27
-
-
0037651063
-
Active form of Notch members can enforce T lymphopoiesis on lymphoid progenitors in the monolayer culture specific for B cell development
-
•], these authors show that retroviral transfection of fetal liver progenitors with Notch1-IC and subsequent culture on OP9 BM stromal cells can also induce the development of committed T-lineage cells. Interestingly, both Notch2-IC and Notch3-IC were able to induce T-cell development similar to Notch1-IC. Moreover, in addition to Notch-IC, other stromal-derived factors were necessary for T-lineage induction.
-
•], these authors show that retroviral transfection of fetal liver progenitors with Notch1-IC and subsequent culture on OP9 BM stromal cells can also induce the development of committed T-lineage cells. Interestingly, both Notch2-IC and Notch3-IC were able to induce T-cell development similar to Notch1-IC. Moreover, in addition to Notch-IC, other stromal-derived factors were necessary for T-lineage induction.
-
(2003)
J Immunol
, vol.170
, pp. 4973-4979
-
-
Hozumi, K.1
Abe, N.2
Chiba, S.3
Hirai, H.4
Habu, S.5
-
28
-
-
0031001247
-
Notch activity influences the αβ versus γδ T cell lineage decision
-
Washburn T., Schweighoffer E., Gridley T., Chang D., Fowlkes B.J., Cado D., Robey E. Notch activity influences the αβ versus γδ T cell lineage decision. Cell. 88:1997;833-843.
-
(1997)
Cell
, vol.88
, pp. 833-843
-
-
Washburn, T.1
Schweighoffer, E.2
Gridley, T.3
Chang, D.4
Fowlkes, B.J.5
Cado, D.6
Robey, E.7
-
29
-
-
0036070308
-
Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes
-
Lineage-specific deletion of Notch1 in the thymus before pre-TCR expression severely perturbs αβ but not γδ T-cell development. This effect is due to impaired TCR VDJβ but not DJβ rearrangement. In addition, pre-TCR independent survival of immature thymocytes occurs, demonstrating that Notch1 controls several non-redundant functions necessary for αβ lineage development.
-
Wolfer A., Wilson A., Nemir M., MacDonald H.R., Radtke F. Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity. 16:2002;869-879 Lineage-specific deletion of Notch1 in the thymus before pre-TCR expression severely perturbs αβ but not γδ T-cell development. This effect is due to impaired TCR VDJβ but not DJβ rearrangement. In addition, pre-TCR independent survival of immature thymocytes occurs, demonstrating that Notch1 controls several non-redundant functions necessary for αβ lineage development.
-
(2002)
Immunity
, vol.16
, pp. 869-879
-
-
Wolfer, A.1
Wilson, A.2
Nemir, M.3
MacDonald, H.R.4
Radtke, F.5
-
30
-
-
0035911172
-
Evidence that γδ versus αβ T cell fate determination is initiated independently of T cell receptor signaling
-
Kang J., Volkmann A., Raulet D.H. Evidence that γδ versus αβ T cell fate determination is initiated independently of T cell receptor signaling. J Exp Med. 193:2001;689-698.
-
(2001)
J Exp Med
, vol.193
, pp. 689-698
-
-
Kang, J.1
Volkmann, A.2
Raulet, D.H.3
-
31
-
-
0034161282
-
FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor
-
Newton K., Harris A.W., Strasser A. FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor. EMBO J. 19:2000;931-941.
-
(2000)
EMBO J
, vol.19
, pp. 931-941
-
-
Newton, K.1
Harris, A.W.2
Strasser, A.3
-
32
-
-
0030297895
-
An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
-
Robey E., Chang D., Itano A., Cado D., Alexander H., Lans D., Weinmaster G., Salmon P. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. 87:1996;483-492.
-
(1996)
Cell
, vol.87
, pp. 483-492
-
-
Robey, E.1
Chang, D.2
Itano, A.3
Cado, D.4
Alexander, H.5
Lans, D.6
Weinmaster, G.7
Salmon, P.8
-
33
-
-
0033681301
-
Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
-
Deftos M.L., Huang E., Ojala E.W., Forbush K.A., Bevan M.J. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity. 13:2000;73-84.
-
(2000)
Immunity
, vol.13
, pp. 73-84
-
-
Deftos, M.L.1
Huang, E.2
Ojala, E.W.3
Forbush, K.A.4
Bevan, M.J.5
-
34
-
-
0037103148
-
A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development
-
Fowlkes B.J., Robey E.A. A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development. J Immunol. 169:2002;1817-1821.
-
(2002)
J Immunol
, vol.169
, pp. 1817-1821
-
-
Fowlkes, B.J.1
Robey, E.A.2
-
35
-
-
12144288151
-
Tissue specific inactivation of Notch1 in immature thymocytes does not perturb lineage commitment, maturation or survival of CD4 and CD8 T cells
-
Wolfer A., Bakker T., Wilson A., Ioannidis V., Littman D.R., Lee P.P., Wilson C.B., Held W., MacDonald H.R., Radtke F. Tissue specific inactivation of Notch1 in immature thymocytes does not perturb lineage commitment, maturation or survival of CD4 and CD8 T cells. Nat Immunol. 3:2000;235-241.
-
(2000)
Nat Immunol
, vol.3
, pp. 235-241
-
-
Wolfer, A.1
Bakker, T.2
Wilson, A.3
Ioannidis, V.4
Littman, D.R.5
Lee, P.P.6
Wilson, C.B.7
Held, W.8
MacDonald, H.R.9
Radtke, F.10
-
36
-
-
0041428109
-
Surface expression of Notch1 on thymocytes: Correlation with the double-negative to double-positive transition
-
Huang E.Y., Gallegos A.M., Richards S.M., Lehar S.M., Bevan M.J. Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition. J Immunol. 171:2003;2296-2304.
-
(2003)
J Immunol
, vol.171
, pp. 2296-2304
-
-
Huang, E.Y.1
Gallegos, A.M.2
Richards, S.M.3
Lehar, S.M.4
Bevan, M.J.5
-
37
-
-
0036094254
-
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells
-
Using CD19-cre mediated deletion of RBP-J, this group clearly demonstrates that Notch/RBP-J signaling determines the fate of mature B cells. In the absence of RBP-J, T2 B cells are directed towards the FoB cell fate at the expense of MZB cells. Interestingly, B1 B-cell development appears unaffected by Notch/RBP-J signaling.
-
Tanigaki K., Han H., Yamamoto N., Tashiro K., Ikegawa M., Kuroda K., Suzuki A., Nakano T., Honjo T. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol. 3:2002;443-450 Using CD19-cre mediated deletion of RBP-J, this group clearly demonstrates that Notch/RBP-J signaling determines the fate of mature B cells. In the absence of RBP-J, T2 B cells are directed towards the FoB cell fate at the expense of MZB cells. Interestingly, B1 B-cell development appears unaffected by Notch/RBP-J signaling.
-
(2002)
Nat Immunol
, vol.3
, pp. 443-450
-
-
Tanigaki, K.1
Han, H.2
Yamamoto, N.3
Tashiro, K.4
Ikegawa, M.5
Kuroda, K.6
Suzuki, A.7
Nakano, T.8
Honjo, T.9
-
38
-
-
0041331751
-
Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells
-
Witt C.M., Won W.J., Hurez V., Klug C.A. Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J Immunol. 171:2003;2783-2788.
-
(2003)
J Immunol
, vol.171
, pp. 2783-2788
-
-
Witt, C.M.1
Won, W.J.2
Hurez, V.3
Klug, C.A.4
-
39
-
-
0033950375
-
Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells
-
Hoyne G.F., Le Roux I., Corsin-Jimenez M., Tan K., Dunne J., Forsyth L.M., Dallman M.J., Owen M.J., Ish-Horowicz D., Lamb J.R. Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int Immunol. 12:2000;177-185.
-
(2000)
Int Immunol
, vol.12
, pp. 177-185
-
-
Hoyne, G.F.1
Le Roux, I.2
Corsin-Jimenez, M.3
Tan, K.4
Dunne, J.5
Forsyth, L.M.6
Dallman, M.J.7
Owen, M.J.8
Ish-Horowicz, D.9
Lamb, J.R.10
-
40
-
-
0242493801
-
Over expression of the Notch ligand, Jagged-1 induces alloantigen-specific human regulatory T cells
-
in press.
-
Yvon ES, Vigouroux S, Rousseau RF, Biagi E, Amrolia P, Dotti G, Wagner HJ, Brenner MK: Over expression of the Notch ligand, Jagged-1 induces alloantigen-specific human regulatory T cells. Blood 2003, in press.
-
(2003)
Blood
-
-
Yvon, E.S.1
Vigouroux, S.2
Rousseau, R.F.3
Biagi, E.4
Amrolia, P.5
Dotti, G.6
Wagner, H.J.7
Brenner, M.K.8
-
41
-
-
0141566334
-
Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes
-
Vigouroux S., Yvon E., Wagner H.J., Biagi E., Dotti G., Sili U., Lira C., Rooney C.M., Brenner M.K. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol. 77:2003;10872-10880.
-
(2003)
J Virol
, vol.77
, pp. 10872-10880
-
-
Vigouroux, S.1
Yvon, E.2
Wagner, H.J.3
Biagi, E.4
Dotti, G.5
Sili, U.6
Lira, C.7
Rooney, C.M.8
Brenner, M.K.9
-
42
-
-
10744222828
-
Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
-
Anastasi E., Campese A., Bellavia D., Bulotta A., Balestri A., Pascucci M., Checquolo S., Gradini R., Lendahl U., Frati L.et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol. 171:2003;4504-4511.
-
(2003)
J Immunol
, vol.171
, pp. 4504-4511
-
-
Anastasi, E.1
Campese, A.2
Bellavia, D.3
Bulotta, A.4
Balestri, A.5
Pascucci, M.6
Checquolo, S.7
Gradini, R.8
Lendahl, U.9
Frati, L.10
-
43
-
-
0036885067
-
The lineage decisions of helper T cells
-
Murphy K.M., Reiner S.L. The lineage decisions of helper T cells. Nat Rev Immunol. 2:2002;933-944.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 933-944
-
-
Murphy, K.M.1
Reiner, S.L.2
-
44
-
-
0142157141
-
Delta1-Notch3 interactions bias the functional differentiation of activated CD4(+) T cells
-
+ peripheral T cells was able to bias Th1 over Th2 cytokine production in vitro. In addition, anti-sense Notch3-IC was able to inhibit Th1 development in the presence of Delta1-Fc, also suggesting that Notch3 mediates a Th1 response in vitro. More importantly, Delta1-induced Notch signaling promoted a Th1 response in vivo in a Th2-prone L. major model.
-
+ peripheral T cells was able to bias Th1 over Th2 cytokine production in vitro. In addition, anti-sense Notch3-IC was able to inhibit Th1 development in the presence of Delta1-Fc, also suggesting that Notch3 mediates a Th1 response in vitro. More importantly, Delta1-induced Notch signaling promoted a Th1 response in vivo in a Th2-prone L. major model.
-
(2003)
Immunity
, vol.19
, pp. 549-559
-
-
Maekawa, Y.1
Tsukumo, S.2
Chiba, S.3
Hirai, H.4
Hayashi, Y.5
Okada, H.6
Kishihara, K.7
Yasutomo, K.8
-
45
-
-
0042834334
-
Notch signaling augments T cell responsiveness by enhancing CD25 expression
-
Adler S.H., Chiffoleau E., Xu L., Dalton N.M., Burg J.M., Wells A.D., Wolfe M.S., Turka L.A., Pear W.S. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol. 171:2003;2896-2903.
-
(2003)
J Immunol
, vol.171
, pp. 2896-2903
-
-
Adler, S.H.1
Chiffoleau, E.2
Xu, L.3
Dalton, N.M.4
Burg, J.M.5
Wells, A.D.6
Wolfe, M.S.7
Turka, L.A.8
Pear, W.S.9
-
46
-
-
0041331708
-
TCR-mediated notch signaling regulates proliferation and IFN-gamma production in peripheral T cells
-
Palaga T., Miele L., Golde T.E., Osborne B.A. TCR-mediated notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol. 171:2003;3019-3024.
-
(2003)
J Immunol
, vol.171
, pp. 3019-3024
-
-
Palaga, T.1
Miele, L.2
Golde, T.E.3
Osborne, B.A.4
-
47
-
-
0036749748
-
The role of Notch signaling during hematopoietic lineage commitment
-
Radtke F., Wilson A., Ernst B., MacDonald H.R. The role of Notch signaling during hematopoietic lineage commitment. Immunol Rev. 187:2002;65-74.
-
(2002)
Immunol Rev
, vol.187
, pp. 65-74
-
-
Radtke, F.1
Wilson, A.2
Ernst, B.3
MacDonald, H.R.4
|