Extended release microparticle-in-gel formulation of octreotide: Effect of polymer type on acylation of peptide during in vitro release

International Journal of Pharmaceutics

Volumn 496, Issue 2, 2015, Pages 676-688

  Vaishya, Ravi D ^a,b   Mandal, Abhirup ^a   Patel, Sulabh ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b INSYS Therapeutics Inc   (United States)

Author keywords

Drug delivery; Hydrogel; Microparticles; Peptide; Peptide chemical stability; Polycaprolactone; Polyglycolic acid; Polylactic acid; Sustained delivery

Indexed keywords

MACROGOL; METHANOL; OCTREOTIDE; OIL; POLYCAPROLACTONE; POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYMER; WATER; DELAYED RELEASE FORMULATION; GEL; LACTIC ACID; MICROSPHERE; PEPTIDE FRAGMENT; POLYESTER; POLYLACTIDE;

ACYLATION; ARTICLE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; IN VITRO STUDY; MASS SPECTROMETRY; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE FORMULATION; ULTRAVIOLET SPECTROSCOPY; X RAY POWDER DIFFRACTION; CHEMISTRY; DELAYED RELEASE FORMULATION; GEL; MEDICINAL CHEMISTRY; PHARMACOKINETICS;

ACYLATION; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; GELS; LACTIC ACID; MICROSPHERES; OCTREOTIDE; PEPTIDE FRAGMENTS; POLYESTERS; POLYGLYCOLIC ACID; POLYMERS;

EID: 84949580211     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.11.002     Document Type: Article

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