PEGylation of octreotide: II. Effect of N-terminal mono-PEGylation on biological activity and pharmacokinetics

Pharmaceutical Research

Volumn 22, Issue 5, 2005, Pages 743-749

  Na, Dong Hee ^a   Lee, Kang Choon ^b   DeLuca, Patrick P ^a,c  

^a Kyungsung University   (South Korea)

^b Sungkyunkwan University   (South Korea)

^c University of Kentucky   (United States)

Author keywords

Biological activity; Octreotide; Pharmacokinetics; Site specific PEGylation; Stability

Indexed keywords

MACROGOL; OCTREOTIDE; PROPIONIC ACID DERIVATIVE; SUCCINIMIDE DERIVATIVE;

ACYLATION; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG ACTIVITY; EVALUATION; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CIRCULAR DICHROISM; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; HALF-LIFE; INJECTIONS, SUBCUTANEOUS; LACTIC ACID; MALE; OCTREOTIDE; POLYETHYLENE GLYCOLS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; TECHNOLOGY, PHARMACEUTICAL;

EID: 20044390237     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-005-2590-y     Document Type: Article

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