Novel thermosensitive pentablock copolymers for sustained delivery of proteins in the treatment of posterior segment diseases

Protein and Peptide Letters

Volumn 21, Issue 11, 2014, Pages 1185-1200

  Patel, Sulabh P ^a   Vaishya, Ravi ^a   Yang, Xiaoyan ^a   Pal, Dhananjay ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Block copolymers; Controlled drug delivery; In situ gelling system; Intravitreal; Ocular delivery; Pentablock copolymers; Posterior segment; Sol gel transition; Sustained drug delivery; Thermosensitive gel

Indexed keywords

BIOMATERIAL; COPOLYMER; IMMUNOGLOBULIN G; MACROGOL; POLYCAPROLACTONE; HYDROGEL; POLYMER; PROTEIN;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; CELL SIZE; CELL VIABILITY; DRUG DEGRADATION; DRUG SYNTHESIS; EYE DISEASE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; HYDROGEL; HYDROPHOBICITY; IN VITRO STUDY; MACROPHAGE; MICELLE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHASE TRANSITION; PIGMENT EPITHELIUM; SUSTAINED DRUG RELEASE; SYRINGE; VISCOSITY; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICAL PHENOMENA; CHEMISTRY; CYTOLOGY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; INTRAOCULAR DRUG ADMINISTRATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TEMPERATURE;

ADMINISTRATION, OPHTHALMIC; ANIMALS; CELL LINE; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGELS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MOLECULAR WEIGHT; PHASE TRANSITION; POLYMERS; PROTEINS; RETINAL PIGMENT EPITHELIUM; TEMPERATURE; VISCOSITY;

EID: 84925604890     PISSN: 09298665     EISSN: 18755305     Source Type: Journal    
DOI: 10.2174/092986652111141001122054     Document Type: Article

References (22)

1. Kulkarni, A. D.; Kuppermann, B. D. Wet age-related macular degeneration. Adv. Drug Deliv. Rev., 2005, 57(14), 1994-2009.
2. Barot, M.; Gokulgandhi, M. R.; Patel, S.; Mitra, A. K. Microvascular complications and diabetic retinopathy: recent advances and future implications. Future Med. Chem., 2013, 5(3), 301-14.
3. Leung, D. W.; Cachianes, G.; Kuang, W. J.; Goeddel, D. V.; Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 1989, 246(4935), 1306-9.
4. Ishida, S.; Usui, T.; Yamashiro, K.; Kaji, Y.; Amano, S.; Ogura, Y.; Hida, T.; Oguchi, Y.; Ambati, J.; Miller, J. W.; Gragoudas, E. S.; Ng, Y. S.; D'Amore, P. A.; Shima, D. T.; Adamis, A. P. VEGF164-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J. Exp. Med., 2003, 198(3), 483-9.
5. Bock, F.; Onderka, J.; Dietrich, T.; Bachmann, B.; Kruse, F. E.; Paschke, M.; Zahn, G.; Cursiefen, C., Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest. Ophthalmol. Vis. Sci., 2007, 48(6), 2545-52.
6. Alforja, M. S.; Sabater, N.; Giralt, J.; Adan, A.; Pelegrin, L.; Casaroli-Marano, R., Intravitreal bevacizumab injection for peripheral exudative hemorrhagic chorioretinopathy. Jpn. J. Ophthalmol., 2011, 55(4), 425-7.
7. Peyman, G. A.; Lad, E. M.; Moshfeghi, D. M. Intravitreal injection of therapeutic agents. Retina, 2009, 29(7), 875-912.
8. Jager, R. D.; Aiello, L. P.; Patel, S. C.; Cunningham, E. T., Jr. Risks of intravitreous injection: a comprehensive review. Retina, 2004, 24(5), 676-98.
9. Sampat, K. M.; Garg, S. J. Complications of intravitreal injections. Curr. Opin. Ophthalmol., 2010, 21(3), 178-83.
10. Van Tomme, S. R.; Storm, G.; Hennink, W. E. In situ gelling hydrogels for pharmaceutical and biomedical applications. Int. J. Pharm., 2008, 355(1-2), 1-18.
11. Gou, M.; Gong, C.; Zhang, J.; Wang, X.; Gu, Y.; Guo, G.; Chen, L.; Luo, F.; Zhao, X.; Wei, Y.; Qian, Z., Polymeric matrix for drug delivery: honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel. J. Biomed. Mater. Res. A, 2010, 93(1), 219-26.
12. Jeong, B.; Bae, Y. H.; Kim, S. W. In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J. Biomed. Mater. Res., 2000, 50(2), 171-7.
13. Singh, S.; Webster, D. C.; Singh, J. Thermosensitive polymers: synthesis, characterization, and delivery of proteins. Int. J. Pharm., 2007, 341(1-2), 68-77.
14. Liu, C. B.; Gong, C. Y.; Huang, M. J.; Wang, J. W.; Pan, Y. F.; Zhang, Y. D.; Li, G. Z.; Gou, M. L.; Wang, K.; Tu, M. J.; Wei, Y. Q.; Qian, Z. Y. Thermoreversible gel-sol behavior of biodegradable PCL-PEG-PCL triblock copolymer in aqueous solutions. J. Biomed. Mater. Res. B Appl. Biomater., 2008, 84(1), 165-75.
15. Gong, C.; Shi, S.; Wu, L.; Gou, M.; Yin, Q.; Guo, Q.; Dong, P.; Zhang, F.; Luo, F.; Zhao, X.; Wei, Y.; Qian, Z., Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel. Part 2: sol-gel-sol transition and drug delivery behavior. Acta Biomater., 2009, 5(9), 3358-70.
16. Huang, M.-H.; Li, S.; Vert, M. Synthesis and degradation of PLA-PCL-PLA triblock copolymer prepared by successive polymerization of 3-caprolactone and DL-lactide. Polymer, 2004, 45, 8675-8681.
17. Houchin, M. L.; Topp, E. M. Chemical degradation of peptides and proteins in PLGA: a review of reactions and mechanisms. J. Pharm. Sci., 2008, 97(7), 2395-404.
18. Zhang, Y.; Schwendeman, S. P. Minimizing acylation of peptides in PLGA microspheres. J. Control. Release, 2012, 162(1), 119-26.
19. Hwang, M. J.; Suh, J. M.; Bae, Y. H.; Kim, S. W.; Jeong, B. Caprolactonic poloxamer analog: PEG-PCL-PEG. Biomacromolecules, 2005, 6(2), 885-90.
20. Prabhu, A.; Shelburne, C. E.; Gibbons, D. F. Cellular proliferation and cytokine responses of murine macrophage cell line J774A.1 to polymethylmethacrylate and cobalt-chrome alloy particles. J. Biomed. Mater. Res., 1998, 42(4), 655-63.
21. Lee, D.; Shim, M.; Kim, S.; Lee, H.; Park, I.; Chang, T. Novel thermoreversible gelation of biodegradable PLGA-block-PEOblock-PLGA triblock copolymers in aqueous solution. Macromol. Rapid. Commun., 2001, 22, 587-592.
22. Jeong, B.; Bae, Y. H.; Kim, S. W. Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers. J. Control. Release, 2000, 63(1-2), 155-63.