Reversible blocking of amino groups of octreotide for the inhibition of formation of acylated peptide impurities in poly(lactide-co-glycolide) delivery systems

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1220-1226

  Ahn, Jae Hwa ^a   Park, Eun Ji ^a   Lee, Hye Suk ^b   Lee, Kang Choon ^c   Na, Dong Hee ^a  

^a Kyungsung University   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

maleic anhydride; octreotide; peptide acylation; poly(lactide co glycolide); reversible blocking

Indexed keywords

AMINO ACID; MALEIC ANHYDRIDE; OCTREOTIDE; PEPTIDE; POLYGLACTIN;

ACYLATION; ARTICLE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; HYDROLYSIS; PH; PRIORITY JOURNAL; PROTEIN PURIFICATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACYLATION; BUFFERS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG CARRIERS; DRUG COMPOUNDING; DRUG CONTAMINATION; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MALEIC ANHYDRIDES; OCTREOTIDE; POLYGLACTIN 910; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 83555162563     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9694-y     Document Type: Article

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