A single amino acid mutation (R104P) in the E/DRY motif of GPR40 impairs receptor function

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Guo, Shimeng ^a,b   Zhang, Jiandong ^b,c   Zhang, Shuyong ^c   Li, Jing ^c  

^a SHANGHAI UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM; G PROTEIN COUPLED RECEPTOR 40; LINOLEIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROLINE; FFAR1 PROTEIN, HUMAN; G PROTEIN COUPLED RECEPTOR; GLUCOSE; INSULIN;

ARTICLE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EC50; ENZYME PHOSPHORYLATION; GENETIC VARIABILITY; GPR40 GENE; HUMAN; HUMAN CELL; INTERNALIZATION; MUTATIONAL ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOGENESIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; GENETICS; HEK293 CELL LINE; INSULIN RESISTANCE; METABOLISM; MUTATION; PANCREAS ISLET BETA CELL; PATHOLOGY; SECRETION (PROCESS);

AMINO ACID MOTIFS; ARGININE; CALCIUM; DIABETES MELLITUS, TYPE 2; GLUCOSE; HEK293 CELLS; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MUTATION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84949553005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0141303     Document Type: Article

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