Molecular matchmaking between the popular weight-loss herb hoodia gordonii and GPR119, a potential drug target for metabolic disorder

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 40, 2014, Pages 14571-14576

  Zhang, Shuyong ^a,b   Ma, Yuyong ^c   Li, Jing ^b   Ma, Junjun ^c   Yu, Biao ^c   Xie, Xin ^a,b  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLYCOSIDE; GORDONOSIDE F; GPR119 PROTEIN, MOUSE; INSULIN; PLANT EXTRACT; STEROID;

AGONISTS; ANIMAL; APOCYNACEAE; C57BL MOUSE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; EATING; GENETICS; GLUCOSE TOLERANCE TEST; HEK293 CELL LINE; HUMAN; KNOCKOUT MOUSE; MALE; MEDICINAL PLANT; METABOLIC DISEASES; METABOLISM; MOLECULARLY TARGETED THERAPY; PANCREAS ISLET BETA CELL; PHYTOTHERAPY; PROCEDURES; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; WEIGHT REDUCTION;

ANIMALS; ASCLEPIADACEAE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; GLUCOSE TOLERANCE TEST; GLYCOSIDES; HEK293 CELLS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; METABOLIC DISEASES; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; STEROIDS; WEIGHT LOSS;

EID: 84907704823     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1324130111     Document Type: Article

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