Discovery and characterization of novel smallmolecule agonists of G protein-coupled receptor 119

Acta Pharmacologica Sinica

Volumn 35, Issue 4, 2014, Pages 540-548

  Zhang, Shu Yong ^a   Li, Jing ^b   Xie, Xin ^a,b  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

AR231453; cAMP; GPCR; GPR119; High throughput screening; Insulin; Obesity; PSN632408; Type 2 diabetes mellitus; cell

Indexed keywords

1 [[4 (5 CYCLOPROPYL 1,2,4 OXADIAZOL 3 YL)PHENYL]SULFONYL] N [(TETRAHYDROFURAN 2 YL)METHYL]PIPERIDINE 4 CARBOXAMIDE; 4 ETHYL 2 [3 (4 PHENYLPIPERAZINE 1 CARBONYL)PIPERIDIN 1 YL]PYRIDO[2,3 B]PYRAZIN 3(4H) ONE; 4 ETHYL 2 [3 [4 (4 METHOXYPHENYL)PIPERAZINE 1 CARBONYL]PIPERIDIN 1 YL]PYRIDO[2,3 B]PYRAZIN 3(4H) ONE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; G PROTEIN COUPLED RECEPTOR 119 AGONIST; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG; ZSY 04; ZSY 06; ZSY 13; ANTIDIABETIC AGENT; GLUCOSE; GPR119 PROTEIN, HUMAN; GPR119 PROTEIN, MOUSE; INSULIN; MOLECULAR LIBRARY;

AGONIST; ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; AGONISTS; ANIMAL; CALCIUM SIGNALING; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; METABOLISM; MOLECULAR LIBRARY; PANCREAS ISLET; REPRODUCIBILITY; SECOND MESSENGER; SECRETION (PROCESS); STRUCTURE ACTIVITY RELATION; TIME; TISSUE CULTURE TECHNIQUE;

ANIMALS; CALCIUM SIGNALING; CHO CELLS; CRICETULUS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; GLUCOSE; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; REPRODUCIBILITY OF RESULTS; SECOND MESSENGER SYSTEMS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TISSUE CULTURE TECHNIQUES; TRANSFECTION;

EID: 84898744571     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2014.8     Document Type: Article

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