메뉴 건너뛰기




Volumn 15, Issue 12, 2015, Pages 1631-1644

Testing for oncogenic molecular aberrations in cell-free DNA-based liquid biopsies in the clinic: Are we there yet?

Author keywords

advanced cancer; cell free DNA; Liquid biopsy; personalized medicine; targeted therapy

Indexed keywords

CELL DNA; DNA; TUMOR MARKER;

EID: 84949535312     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/14737159.2015.1110021     Document Type: Review
Times cited : (52)

References (120)
  • 1
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147 (2):275-292.
    • (2011) Cell. , vol.147 , Issue.2 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 2
    • 84867744264 scopus 로고    scopus 로고
    • Evolution of the cancer genome
    • Yates LR, Campbell PJ. Evolution of the cancer genome. Nat Rev Genet. 2012;13 (11):795-806.
    • (2012) Nat Rev Genet. , vol.13 , Issue.11 , pp. 795-806
    • Yates, L.R.1    Campbell, P.J.2
  • 3
    • 84891434380 scopus 로고    scopus 로고
    • The evolution of the unstable cancer genome
    • Burrell RA, Swanton C. The evolution of the unstable cancer genome. Curr Opin Genet Dev. 2014;24:61-67.
    • (2014) Curr Opin Genet Dev. , vol.24 , pp. 61-67
    • Burrell, R.A.1    Swanton, C.2
  • 5
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366 (10):883-892.
    • (2012) N Engl J Med. , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 7
    • 84957852098 scopus 로고
    • Les acides nucleiques du plasma sanguin chez l'homme [in French]
    • Mandel P, Metais P. Les acides nucleiques du plasma sanguin chez l'homme [in French]. Comptes Rendus Séances Société Biol Ses Fil. 1948;142(3-4):241-243.
    • (1948) Comptes Rendus Séances Société Biol Ses Fil. , vol.142 , Issue.3-4 , pp. 241-243
    • Mandel, P.1    Metais, P.2
  • 8
    • 84898542288 scopus 로고    scopus 로고
    • Liquid biopsies: Genotyping circulating tumor DNA
    • Diaz LA, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 2014;32(6):579-586.
    • (2014) J Clin Oncol. , vol.32 , Issue.6 , pp. 579-586
    • Diaz, L.A.1    Bardelli, A.2
  • 9
    • 84879487413 scopus 로고    scopus 로고
    • Noninvasive prenatal testing for aneuploidy: Current status and future prospects
    • Benn P, Cuckle H, Pergament E. Noninvasive prenatal testing for aneuploidy: current status and future prospects. Ultrasound Obstet Gynecol. 2013;42 (1):15-33.
    • (2013) Ultrasound Obstet Gynecol. , vol.42 , Issue.1 , pp. 15-33
    • Benn, P.1    Cuckle, H.2    Pergament, E.3
  • 10
    • 84865310601 scopus 로고    scopus 로고
    • Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury
    • Macher H, Egea-Guerrero JJ, Revuelto-Rey J, et al. Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury. Clin Chim Acta. 2012;414:12-17.
    • (2012) Clin Chim Acta. , vol.414 , pp. 12-17
    • Macher, H.1    Egea-Guerrero, J.J.2    Revuelto-Rey, J.3
  • 11
    • 80051700805 scopus 로고    scopus 로고
    • A sensitive method to quantify human cellfree circulating DNA in blood: Relevance to myocardial infarction screening
    • Jing-R-R, Wang H-M, Cui M, et al. A sensitive method to quantify human cellfree circulating DNA in blood: relevance to myocardial infarction screening. Clin Biochem. 2011;44(13):1074-1079.
    • (2011) Clin Biochem. , vol.44 , Issue.13 , pp. 1074-1079
    • Jing, R.-R.1    Wang, H.-M.2    Cui, M.3
  • 12
    • 78650868368 scopus 로고    scopus 로고
    • The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke
    • Tsai N-W, Lin T-K, Chen S-D, et al. The value of serial plasma nuclear and mitochondrial DNA levels in patients with acute ischemic stroke. Clin Chim Acta. 2011;412(5-6):476-479.
    • (2011) Clin Chim Acta. , vol.412 , Issue.5-6 , pp. 476-479
    • Tsai, N.-W.1    Lin, T.-K.2    Chen, S.-D.3
  • 13
    • 84869491426 scopus 로고    scopus 로고
    • The value of serial plasma nuclear and mitochondrial DNA levels in acute spontaneous intra-cerebral haemorrhage
    • Wang H-C, Lin Y-J, Lin W-C, et al. The value of serial plasma nuclear and mitochondrial DNA levels in acute spontaneous intra-cerebral haemorrhage. Eur J Neurol. 2012;19(12):1532-1538.
    • (2012) Eur J Neurol. , vol.19 , Issue.12 , pp. 1532-1538
    • Wang, H.-C.1    Lin, Y.-J.2    Lin, W.-C.3
  • 14
    • 84881479047 scopus 로고    scopus 로고
    • Liquid biopsy: Monitoring cancer-genetics in the blood
    • Crowley E, Di Nicolantonio F, Loupakis F, et al. Liquid biopsy: monitoring cancer-genetics in the blood. Nat Rev Clin Oncol. 2013;10(8):472-484.
    • (2013) Nat Rev Clin Oncol. , vol.10 , Issue.8 , pp. 472-484
    • Crowley, E.1    Di Nicolantonio, F.2    Loupakis, F.3
  • 15
    • 51349141191 scopus 로고    scopus 로고
    • Circulating mutant DNA to assess tumor dynamics
    • Diehl F, Schmidt K, Choti MA, et al. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008;14 (9):985-990.
    • (2008) Nat Med. , vol.14 , Issue.9 , pp. 985-990
    • Diehl, F.1    Schmidt, K.2    Choti, M.A.3
  • 16
    • 84863000299 scopus 로고    scopus 로고
    • The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    • Diaz LA, Williams RT, Wu J, et al. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature. 2012;486(7404):537-540.
    • (2012) Nature. , vol.486 , Issue.7404 , pp. 537-540
    • Diaz, L.A.1    Williams, R.T.2    Wu, J.3
  • 17
    • 84903512238 scopus 로고    scopus 로고
    • BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease
    • Janku F, Vibat CRT, Kosco K, et al. BRAF V600E mutations in urine and plasma cell-free DNA from patients with Erdheim-Chester disease. Oncotarget. 2014;5(11):3607-3610.
    • (2014) Oncotarget. , vol.5 , Issue.11 , pp. 3607-3610
    • Janku, F.1    Vibat, C.R.T.2    Kosco, K.3
  • 18
    • 84922372527 scopus 로고    scopus 로고
    • Prospective blinded study of BRAFV600E mutation detection in cellfree DNA of patients with systemic histiocytic disorders
    • Hyman DM, Diamond EL, Vibat CRT, et al. Prospective blinded study of BRAFV600E mutation detection in cellfree DNA of patients with systemic histiocytic disorders. Cancer Discov. 2015;5 (1):64-71.
    • (2015) Cancer Discov. , vol.5 , Issue.1 , pp. 64-71
    • Hyman, D.M.1    Diamond, E.L.2    Vibat, C.R.T.3
  • 19
    • 84923869755 scopus 로고    scopus 로고
    • Brain tumor mutations detected in cerebral spinal fluid
    • Pan W, Gu W, Nagpal S, et al. Brain tumor mutations detected in cerebral spinal fluid. Clin Chem. 2015;61 (3):514-522.
    • (2015) Clin Chem. , vol.61 , Issue.3 , pp. 514-522
    • Pan, W.1    Gu, W.2    Nagpal, S.3
  • 20
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • Misale S, Yaeger R, Hobor S, et al. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012;486 (7404):532-536.
    • (2012) Nature. , vol.486 , Issue.7404 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3
  • 21
    • 84949532663 scopus 로고    scopus 로고
    • Cell-free DNA derived from ascites: Detection of copy number and somatic mutations using OncoScan FFPE Assay [abstract]
    • Apr 18-22, Washington, DC. Philadelphia (PA): AACR; 2015. Abstract nr 2410
    • Husain H, Venkatapathy S, Gomez G, et al. Cell-free DNA derived from ascites: detection of copy number and somatic mutations using OncoScan FFPE Assay [abstract]. Proc Annu Meet Am Assoc Cancer Res; 2015 Apr 18-22, Washington, DC. Philadelphia (PA): AACR; 2015. Abstract nr 2410.
    • (2015) Proc Annu Meet Am Assoc Cancer Res
    • Husain, H.1    Venkatapathy, S.2    Gomez, G.3
  • 22
    • 33845476677 scopus 로고    scopus 로고
    • Circulating nucleic acids (CNAs) and cancer - A survey
    • Fleischhacker M, Schmidt B. Circulating nucleic acids (CNAs) and cancer-a survey. Biochim Biophys Acta. 2007;1775 (1):181-232.
    • (2007) Biochim Biophys Acta , vol.1775 , Issue.1 , pp. 181-232
    • Fleischhacker, M.1    Schmidt, B.2
  • 23
    • 79957458567 scopus 로고    scopus 로고
    • Cell-free nucleic acids as biomarkers in cancer patients
    • Schwarzenbach H, Hoon DSB, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer. 2011;11 (6):426-437.
    • (2011) Nat Rev Cancer. , vol.11 , Issue.6 , pp. 426-437
    • Schwarzenbach, H.1    Hoon, D.S.B.2    Pantel, K.3
  • 24
    • 61449150588 scopus 로고    scopus 로고
    • Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer
    • Paci M, Maramotti S, Bellesia E, et al. Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer. Lung Cancer. 2009;64(1):92-97.
    • (2009) Lung Cancer. , vol.64 , Issue.1 , pp. 92-97
    • Paci, M.1    Maramotti, S.2    Bellesia, E.3
  • 25
    • 84874463234 scopus 로고    scopus 로고
    • Multiple marker detection in peripheral blood for NSCLC diagnosis
    • Ulivi P, Mercatali L, Casoni G-L, et al. Multiple marker detection in peripheral blood for NSCLC diagnosis. PloS One. 2013;8(2):e57401.
    • (2013) PloS One. , vol.8 , Issue.2 , pp. e57401
    • Ulivi, P.1    Mercatali, L.2    Casoni, G.-L.3
  • 26
    • 67149087399 scopus 로고    scopus 로고
    • Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls
    • Yoon K-A, Park S, Lee SH, et al. Comparison of circulating plasma DNA levels between lung cancer patients and healthy controls. J Mol Diagn. 2009;11 (3):182-185.
    • (2009) J Mol Diagn. , vol.11 , Issue.3 , pp. 182-185
    • Yoon, K.-A.1    Park, S.2    Lee, S.H.3
  • 27
    • 51649092604 scopus 로고    scopus 로고
    • Quantification of free circulating tumor DNA as a diagnostic marker for breast cancer
    • Catarino R, Ferreira MM, Rodrigues H, et al. Quantification of free circulating tumor DNA as a diagnostic marker for breast cancer. DNA Cell Biol. 2008;27 (8):415-421.
    • (2008) DNA Cell Biol. , vol.27 , Issue.8 , pp. 415-421
    • Catarino, R.1    Ferreira, M.M.2    Rodrigues, H.3
  • 28
    • 84869051782 scopus 로고    scopus 로고
    • Free circulating tumor DNA as a diagnostic marker for breast cancer
    • Hashad D, Sorour A, Ghazal A, et al. Free circulating tumor DNA as a diagnostic marker for breast cancer. J Clin Lab Anal. 2012;26(6):467-472.
    • (2012) J Clin Lab Anal. , vol.26 , Issue.6 , pp. 467-472
    • Hashad, D.1    Sorour, A.2    Ghazal, A.3
  • 29
    • 84863146536 scopus 로고    scopus 로고
    • Cell-free DNA in blood is a potential diagnostic biomarker of breast cancer
    • Gong B, Xue J, Yu J, et al. Cell-free DNA in blood is a potential diagnostic biomarker of breast cancer. Oncol Lett. 2012;3(4):897-900.
    • (2012) Oncol Lett. , vol.3 , Issue.4 , pp. 897-900
    • Gong, B.1    Xue, J.2    Yu, J.3
  • 30
    • 77951016854 scopus 로고    scopus 로고
    • Plasma cell-free DNA in ovarian cancer: An independent prognostic biomarker
    • Kamat AA, Baldwin M, Urbauer D, et al. Plasma cell-free DNA in ovarian cancer: An independent prognostic biomarker. Cancer. 2010;116(8):1918-1925.
    • (2010) Cancer. , vol.116 , Issue.8 , pp. 1918-1925
    • Kamat, A.A.1    Baldwin, M.2    Urbauer, D.3
  • 31
    • 55449106087 scopus 로고    scopus 로고
    • Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors
    • Zachariah RR, Schmid S, Buerki N, et al, Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors. Obstet Gynecol. 2008;112(4):843-850.
    • (2008) Obstet Gynecol , vol.112 , Issue.4 , pp. 843-850
    • Zachariah, R.R.1    Schmid, S.2    Buerki, N.3
  • 32
    • 52249087563 scopus 로고    scopus 로고
    • Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer
    • Schwarzenbach H, Stoehlmacher J, Pantel K, et al. Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer. Ann N Y Acad Sci. 2008;1137:190-196.
    • (2008) Ann N y Acad Sci. , vol.1137 , pp. 190-196
    • Schwarzenbach, H.1    Stoehlmacher, J.2    Pantel, K.3
  • 33
    • 36649009176 scopus 로고    scopus 로고
    • Free circulating DNA as possible tumour marker in colorectal cancer
    • Boni L, Cassinotti E, Canziani M, et al. Free circulating DNA as possible tumour marker in colorectal cancer. Surg Oncol. 2007;16(Suppl 1):S29-31.
    • (2007) Surg Oncol. , vol.16 , pp. S29-31
    • Boni, L.1    Cassinotti, E.2    Canziani, M.3
  • 34
    • 78751605806 scopus 로고    scopus 로고
    • Real-time polymerase chain reaction quantification of free DNA in serum of patients with polyps and colorectal cancers
    • Danese E, Montagnana M, Minicozzi AM, et al. Real-time polymerase chain reaction quantification of free DNA in serum of patients with polyps and colorectal cancers. Clin Chem Lab Med. 2010;48(11):1665-1668.
    • (2010) Clin Chem Lab Med. , vol.48 , Issue.11 , pp. 1665-1668
    • Danese, E.1    Montagnana, M.2    Minicozzi, A.M.3
  • 35
    • 84887327972 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients
    • Marzese DM, Hirose H, Hoon DSB. Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients. Expert Rev Mol Diagn. 2013;13 (8):827-844.
    • (2013) Expert Rev Mol Diagn. , vol.13 , Issue.8 , pp. 827-844
    • Marzese, D.M.1    Hirose, H.2    Hoon, D.S.B.3
  • 36
    • 0035866393 scopus 로고    scopus 로고
    • DNA fragments in the blood plasma of cancer patients: Quantitations and evidence for their origin from apoptotic and necrotic cells
    • Jahr S, Hentze H, Englisch S, et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 2001;61(4):1659-1665.
    • (2001) Cancer Res. , vol.61 , Issue.4 , pp. 1659-1665
    • Jahr, S.1    Hentze, H.2    Englisch, S.3
  • 37
    • 0242669382 scopus 로고    scopus 로고
    • Degradation of chromosomal DNA during apoptosis
    • Nagata S, Nagase H, Kawane K, et al. Degradation of chromosomal DNA during apoptosis. Cell Death Differ. 2003;10 (1):108-116.
    • (2003) Cell Death Differ. , vol.10 , Issue.1 , pp. 108-116
    • Nagata, S.1    Nagase, H.2    Kawane, K.3
  • 38
    • 80052436485 scopus 로고    scopus 로고
    • High fragmentation characterizes tumour-derived circulating DNA
    • Mouliere F, Robert B, Arnau Peyrotte E, et al. High fragmentation characterizes tumour-derived circulating DNA. PloS One. 2011;6(9):e23418.
    • (2011) PloS One. , vol.6 , Issue.9 , pp. e23418
    • Mouliere, F.1    Robert, B.2    Arnau Peyrotte, E.3
  • 39
    • 0042173180 scopus 로고    scopus 로고
    • Increased plasma DNA integrity in cancer patients
    • Wang BG, Huang H-Y, Chen Y-C, et al. Increased plasma DNA integrity in cancer patients. Cancer Res. 2003;63(14):3966-3968.
    • (2003) Cancer Res. , vol.63 , Issue.14 , pp. 3966-3968
    • Wang, B.G.1    Huang, H.-Y.2    Chen, Y.-C.3
  • 40
    • 78049435890 scopus 로고    scopus 로고
    • Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts
    • Thierry AR, Mouliere F, Gongora C, et al. Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts. Nucleic Acids Res. 2010;38(18):6159-6175.
    • (2010) Nucleic Acids Res. , vol.38 , Issue.18 , pp. 6159-6175
    • Thierry, A.R.1    Mouliere, F.2    Gongora, C.3
  • 41
    • 84875320887 scopus 로고    scopus 로고
    • Biological role of cell-free nucleic acids in cancer: The theory of genometastasis
    • García-Olmo DC, García-Olmo D. Biological role of cell-free nucleic acids in cancer: the theory of genometastasis. Crit Rev Oncog. 2013;18(1-2):153-161.
    • (2013) Crit Rev Oncog. , vol.18 , Issue.1-2 , pp. 153-161
    • García-Olmo, D.C.1    García-Olmo, D.2
  • 42
    • 84861432560 scopus 로고    scopus 로고
    • Transformation of non-tumor host cells during tumor progression: Theories and evidence
    • García-Olmo DC, Picazo MG, García-Olmo D. Transformation of non-tumor host cells during tumor progression: theories and evidence. Expert Opin Biol Ther. 2012;12(Suppl 1):S199-207.
    • (2012) Expert Opin Biol Ther. , vol.12 , pp. S199-207
    • García-Olmo, D.C.1    Picazo, M.G.2    García-Olmo, D.3
  • 43
    • 76549132066 scopus 로고    scopus 로고
    • Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
    • García-Olmo DC, Domínguez C, García-Arranz M, et al. Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res. 2010;70(2):560-567.
    • (2010) Cancer Res. , vol.70 , Issue.2 , pp. 560-567
    • García-Olmo, D.C.1    Domínguez, C.2    García-Arranz, M.3
  • 44
    • 0021326637 scopus 로고
    • Effect of DNA size and strandedness on the in vivo clearance and organ localization of DNA
    • Emlen W, Mannik M. Effect of DNA size and strandedness on the in vivo clearance and organ localization of DNA. Clin Exp Immunol. 1984;56(1):185-192.
    • (1984) Clin Exp Immunol. , vol.56 , Issue.1 , pp. 185-192
    • Emlen, W.1    Mannik, M.2
  • 45
    • 84880375472 scopus 로고    scopus 로고
    • Circulating cell free DNA: Preanalytical considerations
    • El Messaoudi S, Rolet F, Mouliere F, et al. Circulating cell free DNA: preanalytical considerations. Clin Chim Acta. 2013;424:222-230.
    • (2013) Clin Chim Acta. , vol.424 , pp. 222-230
    • El Messaoudi, S.1    Rolet, F.2    Mouliere, F.3
  • 46
    • 84926459432 scopus 로고    scopus 로고
    • Circulating tumor cells and circulating tumor DNA for precision medicine: Dream or reality
    • Ignatiadis M, Dawson S-J. Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality? Ann Oncol. 2014;25(12):2304-2313.
    • (2014) Ann Oncol , vol.25 , Issue.12 , pp. 2304-2313
    • Ignatiadis, M.1    Dawson, S.-J.2
  • 47
    • 84880610837 scopus 로고    scopus 로고
    • Optimizing blood collection, transport and storage conditions for cell free DNA increases access to prenatal testing
    • Wong D, Moturi S, Angkachatchai V, et al. Optimizing blood collection, transport and storage conditions for cell free DNA increases access to prenatal testing. Clin Biochem. 2013;46(12):1099-1104.
    • (2013) Clin Biochem. , vol.46 , Issue.12 , pp. 1099-1104
    • Wong, D.1    Moturi, S.2    Angkachatchai, V.3
  • 48
    • 84884538715 scopus 로고    scopus 로고
    • A novel blood collection device stabilizes cell-free RNA in blood during sample shipping and storage
    • Qin J, Williams TL, Fernando MR. A novel blood collection device stabilizes cell-free RNA in blood during sample shipping and storage. BMC Res Notes. 2013;6:380.
    • (2013) BMC Res Notes. , vol.6 , pp. 380
    • Qin, J.1    Williams, T.L.2    Fernando, M.R.3
  • 49
    • 52249098637 scopus 로고    scopus 로고
    • The origin of elevated levels of circulating DNA in blood plasma of premature neonates
    • Tuaeva NO, Abramova ZI, Sofronov VV. The origin of elevated levels of circulating DNA in blood plasma of premature neonates. Ann N Y Acad Sci. 2008;1137:27-30.
    • (2008) Ann N y Acad Sci. , vol.1137 , pp. 27-30
    • Tuaeva, N.O.1    Abramova, Z.I.2    Sofronov, V.V.3
  • 50
    • 0038378834 scopus 로고    scopus 로고
    • The use of fluorometric assays to assess the immune response to DNA in murine systemic lupus erythematosus
    • Björkman L, Reich CF, Pisetsky DS. The use of fluorometric assays to assess the immune response to DNA in murine systemic lupus erythematosus. Scand J Immunol. 2003;57(6):525-533.
    • (2003) Scand J Immunol. , vol.57 , Issue.6 , pp. 525-533
    • Björkman, L.1    Reich, C.F.2    Pisetsky, D.S.3
  • 51
    • 64549135075 scopus 로고    scopus 로고
    • Evaluation of fluorescence-based methods for total vs amplifiable DNA quantification in plasma of lung cancer patients
    • Szpechcinski A, Struniawska R, Zaleska J, et al. Evaluation of fluorescence-based methods for total vs. amplifiable DNA quantification in plasma of lung cancer patients. J Physiol Pharmacol. 2008;59 (Suppl 6):675-681.
    • (2008) J Physiol Pharmacol. , vol.59 , pp. 675-681
    • Szpechcinski, A.1    Struniawska, R.2    Zaleska, J.3
  • 52
    • 73449088712 scopus 로고    scopus 로고
    • A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids
    • Goldshtein H, Hausmann MJ, Douvdevani A. A rapid direct fluorescent assay for cell-free DNA quantification in biological fluids. Ann Clin Biochem. 2009;46(Pt 6):488-494.
    • (2009) Ann Clin Biochem. , vol.46 , pp. 488-494
    • Goldshtein, H.1    Hausmann, M.J.2    Douvdevani, A.3
  • 53
    • 84949533344 scopus 로고    scopus 로고
    • Whole genome bisulfite sequencing from plasma of patients with metastatic breast cancer identifies putative biomarkers [abstract]
    • Abstract nr 3825
    • Legendre C, Gooden G, Johnson K, et al. Whole genome bisulfite sequencing from plasma of patients with metastatic breast cancer identifies putative biomarkers [abstract]. Cancer Res 2015;75:Abstract nr 3825.
    • (2015) Cancer Res , vol.75
    • Legendre, C.1    Gooden, G.2    Johnson, K.3
  • 54
    • 28044468634 scopus 로고    scopus 로고
    • Detection and quantification of mutations in the plasma of patients with colorectal tumors
    • Diehl F, Li M, Dressman D, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci. 2005;102(45):16368-16373.
    • (2005) Proc Natl Acad Sci. , vol.102 , Issue.45 , pp. 16368-16373
    • Diehl, F.1    Li, M.2    Dressman, D.3
  • 55
    • 77950689916 scopus 로고    scopus 로고
    • Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer
    • Board RE, Wardley AM, Dixon JM, et al. Detection of PIK3CA mutations in circulating free DNA in patients with breast cancer. Breast Cancer Res Treat. 2010;120(2):461-467.
    • (2010) Breast Cancer Res Treat. , vol.120 , Issue.2 , pp. 461-467
    • Board, R.E.1    Wardley, A.M.2    Dixon, J.M.3
  • 56
    • 70349696342 scopus 로고    scopus 로고
    • Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: Monitoring of therapy or recurrence in non-metastatic breast cancer
    • Chen Z, Feng J, Buzin CH, et al. Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: monitoring of therapy or recurrence in non-metastatic breast cancer. PloS One. 2009;4(9):e7220.
    • (2009) PloS One. , vol.4 , Issue.9 , pp. e7220
    • Chen, Z.1    Feng, J.2    Buzin, C.H.3
  • 57
    • 4143133293 scopus 로고    scopus 로고
    • Molecular detection of APC, K-ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers
    • Wang J-Y, Hsieh J-S, Chang M-Y, et al. Molecular detection of APC, K-ras, and p53 mutations in the serum of colorectal cancer patients as circulating biomarkers. World J Surg. 2004;28(7):721-726.
    • (2004) World J Surg. , vol.28 , Issue.7 , pp. 721-726
    • Wang, J.-Y.1    Hsieh, J.-S.2    Chang, M.-Y.3
  • 58
    • 41649114743 scopus 로고    scopus 로고
    • Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer
    • Frattini M, Gallino G, Signoroni S, et al. Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer. Cancer Lett. 2008;263(2):170-181.
    • (2008) Cancer Lett. , vol.263 , Issue.2 , pp. 170-181
    • Frattini, M.1    Gallino, G.2    Signoroni, S.3
  • 59
    • 17344377380 scopus 로고    scopus 로고
    • Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: Correlation with clinicopathological features
    • Yamada T, Nakamori S, Ohzato H, et al. Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features. Clin Cancer Res. 1998;4(6):1527-1532.
    • (1998) Clin Cancer Res. , vol.4 , Issue.6 , pp. 1527-1532
    • Yamada, T.1    Nakamori, S.2    Ohzato, H.3
  • 60
    • 0033050166 scopus 로고    scopus 로고
    • K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: Diagnostic utility and prognostic significance
    • Castells A, Puig P, Móra J, et al. K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance. J Clin Oncol. 1999;17 (2):578-584.
    • (1999) J Clin Oncol. , vol.17 , Issue.2 , pp. 578-584
    • Castells, A.1    Puig, P.2    Móra, J.3
  • 61
    • 84900992934 scopus 로고    scopus 로고
    • Detection of cancer DNA in plasma of patients with early-stage breast cancer
    • Beaver JA, Jelovac D, Balukrishna S, et al. Detection of cancer DNA in plasma of patients with early-stage breast cancer. Clin Cancer Res. 2014;20(10):2643-2650.
    • (2014) Clin Cancer Res. , vol.20 , Issue.10 , pp. 2643-2650
    • Beaver, J.A.1    Jelovac, D.2    Balukrishna, S.3
  • 62
    • 84862537727 scopus 로고    scopus 로고
    • Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood
    • Higgins MJ, Jelovac D, Barnathan E, et al. Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood. Clin Cancer Res. 2012;18 (12):3462-3469.
    • (2012) Clin Cancer Res. , vol.18 , Issue.12 , pp. 3462-3469
    • Higgins, M.J.1    Jelovac, D.2    Barnathan, E.3
  • 63
    • 84875520648 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA to monitor metastatic breast cancer
    • Dawson S-J, Tsui DWY, Murtaza M, et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med. 2013;368(13):1199-1209.
    • (2013) N Engl J Med. , vol.368 , Issue.13 , pp. 1199-1209
    • Dawson, S.-J.1    Tsui, D.W.Y.2    Murtaza, M.3
  • 64
    • 63449103435 scopus 로고    scopus 로고
    • Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non-small cell lung cancer patients
    • Yung TKF, Chan KCA, Mok TSK, et al. Single-molecule detection of epidermal growth factor receptor mutations in plasma by microfluidics digital PCR in non-small cell lung cancer patients. Clin Cancer Res. 2009;15(6):2076-2084.
    • (2009) Clin Cancer Res. , vol.15 , Issue.6 , pp. 2076-2084
    • Yung, T.K.F.1    Chan, K.C.A.2    Mok, T.S.K.3
  • 65
    • 84907285681 scopus 로고    scopus 로고
    • Tumor clone dynamics in lethal prostate cancer
    • Carreira S, Romanel A, Goodall J, et al. Tumor clone dynamics in lethal prostate cancer. Sci Transl Med. 2014;6 (254):254ra125.
    • (2014) Sci Transl Med. , vol.6 , Issue.254 , pp. 254ra125
    • Carreira, S.1    Romanel, A.2    Goodall, J.3
  • 66
    • 84896371874 scopus 로고    scopus 로고
    • Detection of circulating tumor DNA in early-and late-stage human malignancies
    • Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor DNA in early-and late-stage human malignancies. Sci Transl Med. 2014;6(224):224ra24.
    • (2014) Sci Transl Med. , vol.6 , Issue.224 , pp. 224ra24
    • Bettegowda, C.1    Sausen, M.2    Leary, R.J.3
  • 67
    • 84903218109 scopus 로고    scopus 로고
    • An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
    • Newman AM, Bratman SV, To J, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20(5):548-554.
    • (2014) Nat Med. , vol.20 , Issue.5 , pp. 548-554
    • Newman, A.M.1    Bratman, S.V.2    To, J.3
  • 68
    • 84877579861 scopus 로고    scopus 로고
    • Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
    • Murtaza M, Dawson S-J, Tsui DWY, et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature. 2013;497 (7447):108-112.
    • (2013) Nature. , vol.497 , Issue.7447 , pp. 108-112
    • Murtaza, M.1    Dawson, S.-J.2    Tsui, D.W.Y.3
  • 69
    • 84872020299 scopus 로고    scopus 로고
    • Cancer genome scanning in plasma: Detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing
    • Chan KCA, Jiang P, Zheng YWL, et al. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem. 2013;59 (1):211-224.
    • (2013) Clin Chem. , vol.59 , Issue.1 , pp. 211-224
    • Chan, K.C.A.1    Jiang, P.2    Zheng, Y.W.L.3
  • 70
    • 84875824898 scopus 로고    scopus 로고
    • Tumorassociated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
    • Heitzer E, Ulz P, Belic J, et al. Tumorassociated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing. Genome Med. 2013;5(4):30.
    • (2013) Genome Med. , vol.5 , Issue.4 , pp. 30
    • Heitzer, E.1    Ulz, P.2    Belic, J.3
  • 71
    • 84898476658 scopus 로고    scopus 로고
    • Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
    • Thierry AR, Mouliere F, El Messaoudi S, et al. Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA. Nat Med. 2014;20 (4):430-435.
    • (2014) Nat Med. , vol.20 , Issue.4 , pp. 430-435
    • Thierry, A.R.1    Mouliere, F.2    El Messaoudi, S.3
  • 72
    • 84921758615 scopus 로고    scopus 로고
    • Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer
    • Rothé F, Laes J-F, Lambrechts D, et al. Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer. Ann Oncol. 2014;25(10):1959-1965.
    • (2014) Ann Oncol. , vol.25 , Issue.10 , pp. 1959-1965
    • Rothé, F.1    Laes, J.-F.2    Lambrechts, D.3
  • 73
    • 84898786810 scopus 로고    scopus 로고
    • Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system
    • Aung KL, Donald E, Ellison G, et al. Analytical validation of BRAF mutation testing from circulating free DNA using the amplification refractory mutation testing system. J Mol Diagn. 2014;16 (3):343-349.
    • (2014) J Mol Diagn. , vol.16 , Issue.3 , pp. 343-349
    • Aung, K.L.1    Donald, E.2    Ellison, G.3
  • 74
    • 84918505173 scopus 로고    scopus 로고
    • Clinical utility of a blood-based BRAF(V600E) mutation assay in melanoma
    • Panka DJ, Buchbinder E, Giobbie-Hurder A, et al. Clinical utility of a blood-based BRAF(V600E) mutation assay in melanoma. Mol Cancer Ther. 2014;13(12):3210-3218.
    • (2014) Mol Cancer Ther. , vol.13 , Issue.12 , pp. 3210-3218
    • Panka, D.J.1    Buchbinder, E.2    Giobbie-Hurder, A.3
  • 75
    • 84943303014 scopus 로고    scopus 로고
    • Cell-free DNA next-generation sequencing in pancreatobiliary carcinomas
    • Zill OA, Greene C, Sebisanovic D, et al. Cell-free DNA next-generation sequencing in pancreatobiliary carcinomas. Cancer Discov. 2015. doi:10.1158/2159-8290.CD-15-0274.
    • (2015) Cancer Discov.
    • Zill, O.A.1    Greene, C.2    Sebisanovic, D.3
  • 76
    • 84949530997 scopus 로고    scopus 로고
    • Rapid, automated BRAF mutation testing of cellfree DNA from plasma of patients with advanced cancers using the novel Idylla platform [abstract]
    • Abstract nr 2413
    • Janku F, Huang H, Claes B, et al. Rapid, automated BRAF mutation testing of cellfree DNA from plasma of patients with advanced cancers using the novel Idylla platform [abstract]. Cancer Res 2015;75: Abstract nr 2413.
    • (2015) Cancer Res , vol.75
    • Janku, F.1    Huang, H.2    Claes, B.3
  • 77
    • 84930025659 scopus 로고    scopus 로고
    • Actionable mutations in plasma cellfree DNA in patients with advanced cancers referred for experimental targeted therapies
    • Janku F, Angenendt P, Tsimberidou AM, et al. Actionable mutations in plasma cellfree DNA in patients with advanced cancers referred for experimental targeted therapies. Oncotarget. 2015;6 (14):12809-12821.
    • (2015) Oncotarget. , vol.6 , Issue.14 , pp. 12809-12821
    • Janku, F.1    Angenendt, P.2    Tsimberidou, A.M.3
  • 78
    • 84881514906 scopus 로고    scopus 로고
    • Circulating BRAFV600E in the diagnosis and follow-up of differentiated papillary thyroid carcinoma
    • Pupilli C, Pinzani P, Salvianti F, et al. Circulating BRAFV600E in the diagnosis and follow-up of differentiated papillary thyroid carcinoma. J Clin Endocrinol Metab. 2013;98(8):3359-3365.
    • (2013) J Clin Endocrinol Metab. , vol.98 , Issue.8 , pp. 3359-3365
    • Pupilli, C.1    Pinzani, P.2    Salvianti, F.3
  • 79
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
    • Forshew T, Murtaza M, Parkinson C, et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med. 2012;4(136):136ra68.
    • (2012) Sci Transl Med. , vol.4 , Issue.136 , pp. 136ra68
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3
  • 80
    • 84857076207 scopus 로고    scopus 로고
    • Quantitative cell-free DNA, KRAS, and BRAF mutations in plasma from patients with metastatic colorectal cancer during treatment with cetuximab and irinotecan
    • Spindler K-LG, Pallisgaard N, Vogelius I, et al. Quantitative cell-free DNA, KRAS, and BRAF mutations in plasma from patients with metastatic colorectal cancer during treatment with cetuximab and irinotecan. Clin Cancer Res. 2012;18 (4):1177-1185.
    • (2012) Clin Cancer Res. , vol.18 , Issue.4 , pp. 1177-1185
    • Spindler, K.-L.G.1    Pallisgaard, N.2    Vogelius, I.3
  • 81
    • 84873207633 scopus 로고    scopus 로고
    • The prognostic value of KRAS mutated plasma DNA in advanced non-small cell lung cancer
    • Nygaard AD, Garm Spindler K-L, Pallisgaard N, et al, The prognostic value of KRAS mutated plasma DNA in advanced non-small cell lung cancer. Lung Cancer. 2013;79(3):312-317.
    • (2013) Lung Cancer , vol.79 , Issue.3 , pp. 312-317
    • Nygaard, A.D.1    Garm Spindler, K.-L.2    Pallisgaard, N.3
  • 82
    • 69249194732 scopus 로고    scopus 로고
    • Circulating hTERT DNA in early breast cancer
    • Divella R, Tommasi S, Lacalamita R, et al. Circulating hTERT DNA in early breast cancer. Anticancer Res. 2009;29 (7):2845-2849.
    • (2009) Anticancer Res. , vol.29 , Issue.7 , pp. 2845-2849
    • Divella, R.1    Tommasi, S.2    Lacalamita, R.3
  • 83
    • 76749151984 scopus 로고    scopus 로고
    • Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer
    • Wang S, An T, Wang J, et al. Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer. Clin Cancer Res. 2010;16(4):1324-1330.
    • (2010) Clin Cancer Res. , vol.16 , Issue.4 , pp. 1324-1330
    • Wang, S.1    An, T.2    Wang, J.3
  • 84
    • 34247537858 scopus 로고    scopus 로고
    • Utility of circulating B-RAF DNA mutation in serum for monitoring melanoma patients receiving biochemotherapy
    • Shinozaki M, O'Day SJ, Kitago M, et al. Utility of circulating B-RAF DNA mutation in serum for monitoring melanoma patients receiving biochemotherapy. Clin Cancer Res. 2007;13(7):2068-2074.
    • (2007) Clin Cancer Res. , vol.13 , Issue.7 , pp. 2068-2074
    • Shinozaki, M.1    O'Day, S.J.2    Kitago, M.3
  • 85
    • 0036897543 scopus 로고    scopus 로고
    • Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival
    • Silva JM, Silva J, Sanchez A, et al. Tumor DNA in plasma at diagnosis of breast cancer patients is a valuable predictor of disease-free survival. Clin Cancer Res. 2002;8(12):3761-3766.
    • (2002) Clin Cancer Res. , vol.8 , Issue.12 , pp. 3761-3766
    • Silva, J.M.1    Silva, J.2    Sanchez, A.3
  • 86
    • 77449138591 scopus 로고    scopus 로고
    • Prognostic value of circulating mutant DNA in unresectable metastatic colorectal cancer
    • Lefebure B, Charbonnier F, Di Fiore F, et al. Prognostic value of circulating mutant DNA in unresectable metastatic colorectal cancer. Ann Surg. 2010;251 (2):275-280.
    • (2010) Ann Surg. , vol.251 , Issue.2 , pp. 275-280
    • Lefebure, B.1    Charbonnier, F.2    Di Fiore, F.3
  • 87
    • 33846537534 scopus 로고    scopus 로고
    • Prognostic value of circulating KRAS2 gene mutations in colorectal cancer with distant metastases
    • Trevisiol C, Di Fabio F, Nascimbeni R, et al. Prognostic value of circulating KRAS2 gene mutations in colorectal cancer with distant metastases. Int J Biol Markers. 2006;21(4):223-228.
    • (2006) Int J Biol Markers. , vol.21 , Issue.4 , pp. 223-228
    • Trevisiol, C.1    Di Fabio, F.2    Nascimbeni, R.3
  • 88
    • 24344497920 scopus 로고    scopus 로고
    • Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer
    • Swisher EM, Wollan M, Mahtani SM, et al. Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer. Am J Obstet Gynecol. 2005;193(3 Pt 1):662-667.
    • (2005) Am J Obstet Gynecol. , vol.193 , Issue.3 , pp. 662-667
    • Swisher, E.M.1    Wollan, M.2    Mahtani, S.M.3
  • 89
    • 84867509213 scopus 로고    scopus 로고
    • Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression
    • Schwarzenbach H, Eichelser C, Kropidlowski J, et al. Loss of heterozygosity at tumor suppressor genes detectable on fractionated circulating cell-free tumor DNA as indicator of breast cancer progression. Clin Cancer Res. 2012;18 (20):5719-5730.
    • (2012) Clin Cancer Res. , vol.18 , Issue.20 , pp. 5719-5730
    • Schwarzenbach, H.1    Eichelser, C.2    Kropidlowski, J.3
  • 90
    • 84864331647 scopus 로고    scopus 로고
    • LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival
    • Kuhlmann JD, Schwarzenbach H, Wimberger P, et al. LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival. BMC Cancer. 2012;12:325.
    • (2012) BMC Cancer. , vol.12 , pp. 325
    • Kuhlmann, J.D.1    Schwarzenbach, H.2    Wimberger, P.3
  • 91
    • 3042582102 scopus 로고    scopus 로고
    • Allelic imbalance on 12q22-23 in serum circulating DNA of melanoma patients predicts disease outcome
    • Fujimoto A, O'Day SJ, Taback B, et al. Allelic imbalance on 12q22-23 in serum circulating DNA of melanoma patients predicts disease outcome. Cancer Res. 2004;64(12):4085-4088.
    • (2004) Cancer Res. , vol.64 , Issue.12 , pp. 4085-4088
    • Fujimoto, A.1    O'Day, S.J.2    Taback, B.3
  • 92
    • 0035875037 scopus 로고    scopus 로고
    • Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients
    • Sozzi G, Conte D, Mariani L, et al. Analysis of circulating tumor DNA in plasma at diagnosis and during follow-up of lung cancer patients. Cancer Res. 2001;61(12):4675-4678.
    • (2001) Cancer Res. , vol.61 , Issue.12 , pp. 4675-4678
    • Sozzi, G.1    Conte, D.2    Mariani, L.3
  • 93
    • 0032894125 scopus 로고    scopus 로고
    • Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients
    • Esteller M, Sanchez-Cespedes M, Rosell R, et al. Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res. 1999;59 (1):67-70.
    • (1999) Cancer Res. , vol.59 , Issue.1 , pp. 67-70
    • Esteller, M.1    Sanchez-Cespedes, M.2    Rosell, R.3
  • 94
    • 0033026117 scopus 로고    scopus 로고
    • Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients
    • Silva JM, Dominguez G, Villanueva MJ, et al. Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients. Br J Cancer. 1999;80 (8):1262-1264.
    • (1999) Br J Cancer. , vol.80 , Issue.8 , pp. 1262-1264
    • Silva, J.M.1    Dominguez, G.2    Villanueva, M.J.3
  • 95
    • 0032893755 scopus 로고    scopus 로고
    • Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
    • Wong IH, Lo YM, Zhang J, et al. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients. Cancer Res. 1999;59(1):71-73.
    • (1999) Cancer Res. , vol.59 , Issue.1 , pp. 71-73
    • Wong, I.H.1    Lo, Y.M.2    Zhang, J.3
  • 96
    • 77954247556 scopus 로고    scopus 로고
    • Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients
    • Sharma G, Mirza S, Parshad R, et al. Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients. Life Sci. 2010;87(3-4):83-91.
    • (2010) Life Sci. , vol.87 , Issue.3-4 , pp. 83-91
    • Sharma, G.1    Mirza, S.2    Parshad, R.3
  • 97
    • 84865853256 scopus 로고    scopus 로고
    • Methylated DNA and total DNA in serum detected by one-step methylation-specific PCR is predictive of poor prognosis for breast cancer patients
    • Fujita N, Nakayama T, Yamamoto N, et al. Methylated DNA and total DNA in serum detected by one-step methylation-specific PCR is predictive of poor prognosis for breast cancer patients. Oncology. 2012;83(5):273-282.
    • (2012) Oncology. , vol.83 , Issue.5 , pp. 273-282
    • Fujita, N.1    Nakayama, T.2    Yamamoto, N.3
  • 98
    • 82455218972 scopus 로고    scopus 로고
    • Prognostic significance of methylated RASSF1A and PITX2 genes in bloodand bone marrow plasma of breast cancer patients
    • Göbel G, Auer D, Gaugg I, et al. Prognostic significance of methylated RASSF1A and PITX2 genes in bloodand bone marrow plasma of breast cancer patients. Breast Cancer Res Treat. 2011;130(1):109-117.
    • (2011) Breast Cancer Res Treat. , vol.130 , Issue.1 , pp. 109-117
    • Göbel, G.1    Auer, D.2    Gaugg, I.3
  • 99
    • 84867088990 scopus 로고    scopus 로고
    • Prognostic role of methylated free circulating DNA in colorectal cancer
    • Philipp AB, Stieber P, Nagel D, et al. Prognostic role of methylated free circulating DNA in colorectal cancer. Int J Cancer. 2012;131(10):2308-2319.
    • (2012) Int J Cancer. , vol.131 , Issue.10 , pp. 2308-2319
    • Philipp, A.B.1    Stieber, P.2    Nagel, D.3
  • 100
    • 84882941753 scopus 로고    scopus 로고
    • Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival
    • Balgkouranidou I, Karayiannakis A, Matthaios D, et al. Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival. Clin Chem Lab Med. 2013;51(7):1505-1510.
    • (2013) Clin Chem Lab Med. , vol.51 , Issue.7 , pp. 1505-1510
    • Balgkouranidou, I.1    Karayiannakis, A.2    Matthaios, D.3
  • 101
    • 84876668560 scopus 로고    scopus 로고
    • Detection of TFPI2 methylation in the serum of hepatocellular carcinoma patients
    • Sun F-K, Fan Y-C, Zhao J, et al. Detection of TFPI2 methylation in the serum of hepatocellular carcinoma patients. Dig Dis Sci. 2013;58(4):1010-1015.
    • (2013) Dig Dis Sci. , vol.58 , Issue.4 , pp. 1010-1015
    • Sun, F.-K.1    Fan, Y.-C.2    Zhao, J.3
  • 102
    • 84906250256 scopus 로고    scopus 로고
    • Gefitinib treatment in EGFR mutated Caucasian NSCLC: Circulating-free tumor DNA as a surrogate for determination of EGFR status
    • Douillard J-Y, Ostoros G, Cobo M, et al. Gefitinib treatment in EGFR mutated Caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status. J Thorac Oncol. 2014;9(9):1345-1353.
    • (2014) J Thorac Oncol. , vol.9 , Issue.9 , pp. 1345-1353
    • Douillard, J.-Y.1    Ostoros, G.2    Cobo, M.3
  • 103
    • 84938289394 scopus 로고    scopus 로고
    • Dynamic plasma EGFR mutation status as a predictor of EGFR-TKI efficacy in patients with EGFR-mutant lung adenocarcinoma
    • Tseng J-S, Yang T-Y, Tsai C-R, et al. Dynamic plasma EGFR mutation status as a predictor of EGFR-TKI efficacy in patients with EGFR-mutant lung adenocarcinoma. J Thorac Oncol. 2015;10 (4):603-610.
    • (2015) J Thorac Oncol. , vol.10 , Issue.4 , pp. 603-610
    • Tseng, J.-S.1    Yang, T.-Y.2    Tsai, C.-R.3
  • 104
    • 84896539307 scopus 로고    scopus 로고
    • Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA
    • Oxnard GR, Paweletz CP, Kuang Y, et al. Noninvasive detection of response and resistance in EGFR-mutant lung cancer using quantitative next-generation genotyping of cell-free plasma DNA. Clin Cancer Res. 2014;20(6):1698-1705.
    • (2014) Clin Cancer Res. , vol.20 , Issue.6 , pp. 1698-1705
    • Oxnard, G.R.1    Paweletz, C.P.2    Kuang, Y.3
  • 105
    • 84872777716 scopus 로고    scopus 로고
    • Molecular diagnostics and personalized medicine in oncology: Challenges and opportunities
    • Normanno N, Rachiglio AM, Roma C, et al. Molecular diagnostics and personalized medicine in oncology: challenges and opportunities. J Cell Biochem. 2013;114(3):514-524.
    • (2013) J Cell Biochem. , vol.114 , Issue.3 , pp. 514-524
    • Normanno, N.1    Rachiglio, A.M.2    Roma, C.3
  • 106
    • 84938367162 scopus 로고    scopus 로고
    • Mechanismbased cancer therapy: Resistance to therapy, therapy for resistance
    • Ramos P, Bentires-Alj M. Mechanismbased cancer therapy: resistance to therapy, therapy for resistance. Oncogene. 2015;34(28):3617-3626.
    • (2015) Oncogene. , vol.34 , Issue.28 , pp. 3617-3626
    • Ramos, P.1    Bentires-Alj, M.2
  • 107
    • 84890566680 scopus 로고    scopus 로고
    • Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia
    • Soverini S, Branford S, Nicolini FE, et al. Implications of BCR-ABL1 kinase domain-mediated resistance in chronic myeloid leukemia. Leuk Res. 2014;38 (1):10-20.
    • (2014) Leuk Res. , vol.38 , Issue.1 , pp. 10-20
    • Soverini, S.1    Branford, S.2    Nicolini, F.E.3
  • 108
    • 84914182003 scopus 로고    scopus 로고
    • Acquired resistance to EGFR-targeted therapies in colorectal cancer
    • Van Emburgh BO, Sartore-Bianchi A, Di Nicolantonio F, et al. Acquired resistance to EGFR-targeted therapies in colorectal cancer. Mol Oncol. 2014;8(6):1084-1094.
    • (2014) Mol Oncol. , vol.8 , Issue.6 , pp. 1084-1094
    • Van Emburgh, B.O.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 109
    • 40049099220 scopus 로고    scopus 로고
    • The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
    • Yun C-H, Mengwasser KE, Toms AV, et al. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci. 2008;105(6):2070-2075.
    • (2008) Proc Natl Acad Sci. , vol.105 , Issue.6 , pp. 2070-2075
    • Yun, C.-H.1    Mengwasser, K.E.2    Toms, A.V.3
  • 110
    • 84863011443 scopus 로고    scopus 로고
    • Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer
    • Su K-Y, Chen H-Y, K-C L, et al. Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J Clin Oncol. 2012;30(4):433-440.
    • (2012) J Clin Oncol. , vol.30 , Issue.4 , pp. 433-440
    • Su, K.-Y.1    Chen, H.-Y.2
  • 111
    • 78049426513 scopus 로고    scopus 로고
    • EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors
    • Choi YL, Soda M, Yamashita Y, et al. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors. N Engl J Med. 2010;363(18):1734-1739.
    • (2010) N Engl J Med. , vol.363 , Issue.18 , pp. 1734-1739
    • Choi, Y.L.1    Soda, M.2    Yamashita, Y.3
  • 112
    • 84903159476 scopus 로고    scopus 로고
    • Targeting RAF kinases for cancer therapy: BRAFmutated melanoma and beyond
    • Holderfield M, Deuker MM, McCormick F, et al. Targeting RAF kinases for cancer therapy: BRAFmutated melanoma and beyond. Nat Rev Cancer. 2014;14(7):455-467.
    • (2014) Nat Rev Cancer. , vol.14 , Issue.7 , pp. 455-467
    • Holderfield, M.1    Deuker, M.M.2    McCormick, F.3
  • 113
    • 81855208762 scopus 로고    scopus 로고
    • Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas
    • Taniguchi K, Uchida J, Nishino K, et al. Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas. Clin Cancer Res. 2011;17(24):7808-7815.
    • (2011) Clin Cancer Res. , vol.17 , Issue.24 , pp. 7808-7815
    • Taniguchi, K.1    Uchida, J.2    Nishino, K.3
  • 114
    • 84914703538 scopus 로고    scopus 로고
    • Quantification and dynamic monitoring of EGFR T790M in plasma cell-free DNA by digital PCR for prognosis of EGFR-TKI treatment in advanced NSCLC
    • Wang Z, Chen R, Wang S, et al. Quantification and dynamic monitoring of EGFR T790M in plasma cell-free DNA by digital PCR for prognosis of EGFR-TKI treatment in advanced NSCLC. PloS One. 2014;9(11):e110780.
    • (2014) PloS One. , vol.9 , Issue.11 , pp. e110780
    • Wang, Z.1    Chen, R.2    Wang, S.3
  • 115
    • 84926431987 scopus 로고    scopus 로고
    • Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment
    • Morelli MP, Overman MJ, Dasari A, et al. Characterizing the patterns of clonal selection in circulating tumor DNA from patients with colorectal cancer refractory to anti-EGFR treatment. Ann Oncol. 2015;26(4):731-736.
    • (2015) Ann Oncol. , vol.26 , Issue.4 , pp. 731-736
    • Morelli, M.P.1    Overman, M.J.2    Dasari, A.3
  • 116
    • 4143094988 scopus 로고    scopus 로고
    • Circulating tumor cells, disease progression, and survival in metastatic breast cancer
    • Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med. 2004;351 (8):781-791.
    • (2004) N Engl J Med. , vol.351 , Issue.8 , pp. 781-791
    • Cristofanilli, M.1    Budd, G.T.2    Ellis, M.J.3
  • 117
    • 33846814619 scopus 로고    scopus 로고
    • Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival
    • Hayes DF, Cristofanilli M, Budd GT, et al. Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res. 2006;12(14 Pt 1):4218-4224.
    • (2006) Clin Cancer Res. , vol.12 , Issue.14 , pp. 4218-4224
    • Hayes, D.F.1    Cristofanilli, M.2    Budd, G.T.3
  • 118
    • 58149165081 scopus 로고    scopus 로고
    • Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
    • De Bono JS, Scher HI, Montgomery RB, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res. 2008;14(19):6302-6309.
    • (2008) Clin Cancer Res. , vol.14 , Issue.19 , pp. 6302-6309
    • De Bono, J.S.1    Scher, H.I.2    Montgomery, R.B.3
  • 119
    • 49249130844 scopus 로고    scopus 로고
    • Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
    • Cohen SJ, Punt CJA, Iannotti N, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(19):3213-3221.
    • (2008) J Clin Oncol. , vol.26 , Issue.19 , pp. 3213-3221
    • Cohen, S.J.1    Punt, C.J.A.2    Iannotti, N.3
  • 120
    • 84894189683 scopus 로고    scopus 로고
    • Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer
    • Kahlert C, Melo SA, Protopopov A, et al. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J Biol Chem. 2014;289 (7):3869-3875.
    • (2014) J Biol Chem. , vol.289 , Issue.7 , pp. 3869-3875
    • Kahlert, C.1    Melo, S.A.2    Protopopov, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.