Real-time polymerase chain reaction quantification of free DNA in serum of patients with polyps and colorectal cancers

Clinical Chemistry and Laboratory Medicine

Volumn 48, Issue 11, 2010, Pages 1665-1668

  Danese, Elisa ^a   Montagnana, Martina ^a   Minicozzi, Anna Maria ^a   De Matteis, Giovanna ^a   Scudo, Giovanni ^a   Salvagno, Gian Luca ^a   Cordiano, Claudio ^a   Lippi, Giuseppe ^b   Guidi, Gian Cesare ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY HOSPITAL OF PARMA   (Italy)

Author keywords

Cell free DNA; Colorectal cancer; Laboratory markers; Polyps

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; DNA;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; COLORECTAL CANCER; COLORECTAL POLYP; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA DETERMINATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYP; PRIORITY JOURNAL; RANK SUM TEST; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC;

ADENOMATOUS POLYPS; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DNA; FEMALE; HUMANS; INTESTINAL POLYPS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 78751605806     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2010.301     Document Type: Article

References (15)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.
2. Verdecchia A, Francisci S, Brenner H, Gatta G, Micheli A, Mangone L, et al. Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol 2007;8:784-96.
3. van Rijn JC, Reitsma JB, Stoker J, Bossuyt PM, van Deventer SJ, Dekker E. Polyp miss rate determined by tandem colonoscopy: a systematic review. Am J Gastroenterol 2006;101:343-50.
4. Sturgeon CM, Duffy MJ, Stenman UH, Lilja H, Brünner N, Chan DW, et al. National academy of clinical biochemistry laboratory medicine practice guidelines for use of tumor markers in testicular, prostate, colorectal, breast, and ovarian cancers. Clin Chem 2008;54: e11-79.
5. Gormally E, Caboux E, Vineis P, Hainaut P. Circulating free DNA in plasma or serum as biomarker of carcinogenesis: practical aspects and biological significance. Mut Res 2007;635:105-17.
6. Johnson PJ, Lo YM. Plasma nucleic acids in the diagnosis and management of malignant disease. Clin Chem 2002;48:1186-93.
7. Boni L, Cassinotti E, Canziani M, Dionigi G, Rovera F, Dionigi R. Free circulating DNA as possible tumour marker in colorectal cancer. Surg Oncol 2007;16(Suppl 1): S29-31.
8. Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG, et al. AJCC cancer staging manual, 6th ed. Springer-Verlag, 2002:435.
9. Swaminathan R, Butt AN. Circulating nucleic acids in plasma and serum: recent developments. Ann NY Acad Sci 2006;1075:1-9.
10. Flamini E, Mercatali L, Nanni O, Calistri D, Nunziatini R, Zoli W, et al. Free DNA and carcinoembryonic antigen serum levels: an important combination for diagnosis of colorectal cancer. Clin Cancer Res 2006;12:6985-8.
11. Leslie A, Carey FA, Pratt NR, Steele RJ. The colorectal adenoma-carcinoma sequence. Br J Surg 2002;89:845-60.
12. Winawer SJ, Zauber AG, Ho MN, O'Brien MJ, Gottlieb LS, Sternberg SS, et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993;329:1977-81.
13. Bauer VP, Papaconstantinou HT. Management of serrated adenomas and hyperplastic polyps. Clin Colon Rectal Surg 2008;21:273-9.
14. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001;61:1659-65.
15. Stroun M, Lyautey J, Lederrey C, Olson-Sand A, Anker P. About the possible origin and mechanism of circulating DNA apoptosis and active DNA release. Clin Chim Acta 2001;313:139-42.