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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 6, 2015, Pages 1163-1170

Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function

(5) Skolnick, Jeffrey a Gao, Mu a Roy, Ambrish a Srinivasan, Bharath a Zhou, Hongyi a

a GEORGIA INSTITUTE OF TECHNOLOGY (United States)

Author keywords

Drug repurposing; Drug side effects; Kinases proteases phosphatases; Ligand binding pockets; Virtual ligand screening

Indexed keywords

AMINO ACID; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN TYROSINE PHOSPHATASE; REV PROTEIN; LIGAND; PROTEIN BINDING; PROTEIN KINASE;

AMINO ACID SEQUENCE; ARTICLE; BIOCHEMISTRY; COMPUTER SIMULATION; DRUG BINDING; FOOD AND DRUG ADMINISTRATION; GENETIC CONSERVATION; LIGAND BINDING; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; BINDING SITE; CHEMISTRY; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; PRECLINICAL STUDY; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; DRUG EVALUATION, PRECLINICAL; EVOLUTION, MOLECULAR; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEINS;

EID: 84949324877 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.01.059 Document Type: Review

Times cited : (25)

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