Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

Acta Oncologica

Volumn 53, Issue 3, 2014, Pages 427-428

  Nygren, Peter ^a   Larsson, Rolf ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BEVACIZUMAB; CAPECITABINE; IRINOTECAN; MEBENDAZOLE; OXALIPLATIN;

ABNORMAL SUBSTRATE CONCENTRATION IN BLOOD; ABSENCE OF SIDE EFFECTS; ADENOCARCINOMA; ADVANCED CANCER; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTINEOPLASTIC ACTIVITY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER COMBINATION CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CANCER REGRESSION; CANCER SIZE; CANCER SURGERY; CASE REPORT; COLON CANCER; COMPUTER ASSISTED TOMOGRAPHY; DRUG REPOSITIONING; DRUG SCREENING; EMERGENCY SURGERY; GENE MUTATION; HISTOPATHOLOGY; HUMAN; ILEUS; LETTER; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MAINTENANCE THERAPY; MALE; METASTASIS; MULTIMODALITY CANCER THERAPY; NEUROPATHY; ONCOGENE K RAS; PARAAORTIC LYMPH NODE; PRIORITY JOURNAL; SIGMOID; HEALTH CARE COST; SIGMOID CARCINOMA; TUMOR REGRESSION;

AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLONIC NEOPLASMS; DRUG REPOSITIONING; HUMANS; LIVER; MALE; MEBENDAZOLE;

EID: 84894168314     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2013.844359     Document Type: Letter

References (4)

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3. Mukhopadhyay T, Sasaki J, Ramesh R, Roth JA. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo. Clin Cancer Res 2002;8:2963-9.
4. Dobrosotskaya IY, Hammer GD, Schteingart DE, Maturen KE, Worden FP. Mebendazole montherapy and long-term disease control in metastatic adrenocortical carcinoma. Endocrine Practice 2011;17:e59-62.