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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 10, 2015, Pages 2019-2027

Design strategies to address kinetics of drug binding and residence time

(6) Cusack, Kevin P a Wang, Ying a Hoemann, Michael Z a Marjanovic, Jasmina a Heym, Roland G a Vasudevan, Anil a

a ABBVIE INC (United States)

Author keywords

Design; Kinetics; Modeling; Residence time; Structure kinetic relationship (SKR)

Indexed keywords

CHEMOKINE RECEPTOR CCR2; DORAMAPIMOD; NAPHTHALENE DERIVATIVE; PYRAZOLE DERIVATIVE;

ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; KINETICS; METABOLISM; TIME FACTOR;

BINDING SITES; DRUG DESIGN; KINETICS; MOLECULAR STRUCTURE; NAPHTHALENES; PYRAZOLES; RECEPTORS, CCR2; TIME FACTORS;

EID: 84949324412 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.02.027 Document Type: Review

Times cited : (69)

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