The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)2, d(CGATCG)2 and d(CGCGCG)2 shows a strong but reversible binding to G:C base pairs

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 24, 2012, Pages 6979-6988

  Mazzini, Stefania ^a   Scaglioni, Leonardo ^a   Mondelli, Rosanna ^a   Caruso, Michele ^b   Sirtori, Federico Riccardi ^b  

^a DeFENS Department of Food Environmental and Nutritional Sciences   (Italy)

^b NERVIANO MEDICAL SCIENCES   (Italy)

Author keywords

Drug DNA interactions; Nemorubicin; NMR spectroscopy; Topoisomerase inhibitors

Indexed keywords

3' DEAMINO 3'',4' ANHYDRO [2'' METHOXY 3'' OXY 4 MORPHOLINYL]DOXORUBICIN; ANTINEOPLASTIC AGENT; CYTOSINE; DNA FRAGMENT; DOXORUBICIN; DRUG METABOLITE; ENDONUCLEASE; GUANINE; NEMORUBICIN; OLIGONUCLEOTIDE; PHOSPHORUS; PNU 159682; PROTON; UNCLASSIFIED DRUG;

ACCURACY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASE PAIRING; COMPLEX FORMATION; COVALENT BOND; DISSOCIATION CONSTANT; DNA DENATURATION; DNA HELIX; DRUG CONFORMATION; DRUG DNA INTERACTION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERCALATION COMPLEX; KINETICS; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOLECULAR STABILITY; NUCLEAR OVERHAUSER EFFECT; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PROTON NUCLEAR MAGNETIC RESONANCE; TANDEM MASS SPECTROMETRY; TEMPERATURE SENSITIVITY; ULTRAVIOLET SPECTROSCOPY;

ANTIBIOTICS, ANTINEOPLASTIC; BASE PAIRING; CYTOSINE; DNA; DOXORUBICIN; GUANINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGONUCLEOTIDES; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS; TOPOISOMERASE II INHIBITORS;

EID: 84870038799     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.10.033     Document Type: Article

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