Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

Journal of Medicinal Chemistry

Volumn 57, Issue 8, 2014, Pages 3213-3222

  Louvel, Julien ^a   Guo, Dong ^a   Agliardi, Marta ^a   Mocking, Tamara A M ^a   Kars, Roland ^a   Pham, Tan Phát ^a   Xia, Lizi ^a   De Vries, Henk ^a   Brussee, Johannes ^a   Heitman, Laura H ^a   Ijzerman, Adriaan P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 6 (BENZO[D][1,3]DIOXOL 5 YL) 2 [[2 (4 CHLOROPHENYL)THIAZOL 4 YL]METHYLTHIO]PYRIMIDINE 5 CARBONITRILE; ADENOSINE A1 RECEPTOR AGONIST; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CHEMICAL PROCEDURES; DRUG BINDING; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; RECEPTOR BINDING ASSAY; STRUCTURE ACTIVITY RELATION; STRUCTURE KINETIC RELATIONSHIP; ANIMAL; CHO CELL LINE; CRICETULUS; DRUG DEVELOPMENT; HEK293 CELL LINE; HUMAN; METABOLISM; RADIOASSAY; SYNTHESIS;

ADENOSINE A1 RECEPTOR AGONISTS; ANIMALS; CHO CELLS; CRICETULUS; DRUG DISCOVERY; HEK293 CELLS; HUMANS; PYRIMIDINES; RADIOLIGAND ASSAY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899562267     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401643m     Document Type: Article

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