Steroids and endocrine disruptors - History, recent state of art and open questions

Journal of Steroid Biochemistry and Molecular Biology

Volumn 155, Issue , 2016, Pages 217-223

  Hampl, Richard ^a   Kubátová, Jana ^a   Stárka, Luboslav ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

Author keywords

Endocrine disruptors; Overreview; Sites of action; Steroids

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AROMATASE; ENDOCRINE DISRUPTOR; G PROTEIN COUPLED RECEPTOR 54; KISSPEPTIN; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; STEROID; STEROID 5ALPHA REDUCTASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE 17BETA DEHYDROGENASE; TRANSCORTIN; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; HYDROXYSTEROID DEHYDROGENASE; STEROID RECEPTOR;

CIRCULATION; COMPUTER MODEL; GONADOTROPIN RELEASE; HORMONE RELEASE; HUMAN; MITOCHONDRION; MOLECULAR DOCKING; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; STEROID BINDING; STEROID METABOLISM; STEROIDOGENESIS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HIGH THROUGHPUT SCREENING; HISTORY; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

17-HYDROXYSTEROID DEHYDROGENASES; 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE; ENDOCRINE DISRUPTORS; GENE EXPRESSION REGULATION; GONADAL STEROID HORMONES; HIGH-THROUGHPUT SCREENING ASSAYS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MOLECULAR DOCKING SIMULATION; PITUITARY-ADRENAL SYSTEM; RECEPTORS, STEROID; SEX HORMONE-BINDING GLOBULIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCORTIN;

EID: 84949321687     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.04.013     Document Type: Review

References (80)

1. A.K. Hotchkiss, C.V. Rider, C.R. Blystone, V.S. Wilson, P.C. Hartig, G.T. Ankley, P.M. Foster, C.L. Gray, and L.E. Gray Fifteen years after Wingspread - environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go Toxicol. Sci. 105 2 2008 235 259
2. A.C. Gore A.C. Gore, Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2010 Humana Press Totowa, NJ
3. M. Hill, J. Vrbikova, J. Zarubova, R. Kancheva, M. Velikova, L. Kancheva, J. Kubatova, M. Duskova, P. Marusic, A. Parizek, and L. Starka The steroid metabolome in lamotrigine-treated women with epilepsy Steroids 76 12 2011 1351 1357
4. J.T. Sanderson The steroid hormone biosynthesis pathway as a target for endocrine-disrupting chemicals Toxicol. Sci. 94 1 2006 3 21
5. S.A. Whitehead, and S. Rice Endocrine-disrupting chemicals as modulators of sex steroid synthesis Best Pract. Res. Clin. Endocrinol. Metab. 20 1 2006 45 61
6. K. Svechnikov, G. Izzo, L. Landreh, J. Weisser, and O. Soder Endocrine disruptors and Leydig cell function J. Biomed. Biotechnol. 2010 2010 (pii: 684504)
7. Z.R. Craig, W. Wang, and J.A. Flaws Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling Reproduction 142 5 2011 633 646
8. E.C. Bonefeld-Jorgensen, M. Long, M.V. Hofmeister, and A.M. Vinggaard Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review Environ. Health Perspect. 115 Suppl. 1 2007 69 76
9. L. Ye, Z.J. Su, and R.S. Ge Inhibitors of testosterone biosynthetic and metabolic activation enzymes Molecules 16 12 2011 9983 10001
10. K. Cheshenko, F. Pakdel, H. Segner, O. Kah, and R.I. Eggen Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish Gen. Comp. Endocrinol. 155 1 2008 31 62
11. B. Castro, P. Sanchez, J.M. Torres, O. Preda, R.G. del Moral, and E. Ortega Bisphenol A exposure during adulthood alters expression of aromatase and 5alpha-reductase isozymes in rat prostate PLoS One 8 2 2013 e55905
12. S. Lo, I. King, A. Allera, and D. Klingmuller Effects of various pesticides on human 5alpha-reductase activity in prostate and LNCaP cells Toxicol. In Vitro 21 3 2007 502 508
13. A. Bali, and A.S. Jaggi Multifunctional aspects of allopregnanolone in stress and related disorders Prog. Neuropsychopharmacol. Biol. Psychiatry 48 2014 64 78
14. K. Yuan, B. Zhao, X.W. Li, G.X. Hu, Y. Su, Y. Chu, B.T. Akingbemi, Q.Q. Lian, and R.S. Ge Effects of phthalates on 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities in human and rat testes Chem. Biol. Interact. 195 3 2012 180 188
15. B. Zhao, Y. Chu, D.O. Hardy, X.K. Li, and R.S. Ge Inhibition of 3beta- and 17beta-hydroxysteroid dehydrogenase activities in rat Leydig cells by perfluorooctane acid J. Steroid Biochem. Mol. Biol. 118 1-2 2010 13 17
16. G.X. Hu, Q.Q. Lian, H. Lin, S.A. Latif, D.J. Morris, M.P. Hardy, and R.S. Ge Rapid mechanisms of glucocorticoid signaling in the Leydig cell Steroids 73 9-10 2008 1018 1024
17. M. Ohshima, S. Ohno, and S. Nakajin Inhibitory effects of some possible endocrine-disrupting chemicals on the isozymes of human 11beta-hydroxysteroid dehydrogenase and expression of their mRNA in gonads and adrenal glands Environ. Sci. 12 4 2005 219 230
18. J. Guo, X. Yuan, L. Qiu, W. Zhu, C. Wang, G. Hu, Y. Chu, L. Ye, Y. Xu, and R.S. Ge Inhibition of human and rat 11beta-hydroxysteroid dehydrogenases activities by bisphenol A Toxicol. Lett. 215 2 2012 126 130
19. R.H. Waring, S. Ayers, A.J. Gescher, H.R. Glatt, W. Meinl, P. Jarratt, C.J. Kirk, T. Pettitt, D. Rea, and R.M. Harris Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption J. Steroid Biochem. Mol. Biol. 108 3-5 2008 213 220
20. R. Harris, N. Turan, C. Kirk, D. Ramsden, and R. Waring Effects of endocrine disruptors on dehydroepiandrosterone sulfotransferase and enzymes involved in PAPS synthesis: genomic and nongenomic pathways Environ. Health Perspect. 115 Suppl. 1 2007 51 54
21. R.M. Harris, and R.H. Waring Sulfotransferase inhibition: potential impact of diet and environmental chemicals on steroid metabolism and drug detoxification Curr. Drug Metab. 9 4 2008 269 275
22. B.J. Clark, J. Wells, S.R. King, and D.M. Stocco The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR) J. Biol. Chem. 269 45 1994 28314 28322
23. K.M. Caron, S.C. Soo, and K.L. Parker Targeted disruption of StAR provides novel insights into congenital adrenal hyperplasia Endocr. Res. 24 3-4 1998 827 834
24. B.J. Clark, and R.K. Cochrum The steroidogenic acute regulatory protein as a target of endocrine disruption in male reproduction Drug Metab. Rev. 39 2-3 2007 353 370
25. V. Kumar, C. Balomajumder, and P. Roy Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action Toxicology 250 2-3 2008 124 131
26. N. Sandhu, and M.M. Vijayan Cadmium-mediated disruption of cortisol biosynthesis involves suppression of corticosteroidogenic genes in rainbow trout Aquat. Toxicol. 103 1-2 2011 92 100
27. H. Shibata, T.E. Spencer, S.A. Onate, G. Jenster, S.Y. Tsai, M.J. Tsai, and B.W. O'Malley Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action Recent Prog. Horm. Res. 52 1997 141 164 discussion 164-145
28. D. Ratman, W. Vanden Berghe, L. Dejager, C. Libert, J. Tavernier, I.M. Beck, and K. De Bosscher How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering Mol. Cell. Endocrinol. 380 1-2 2013 41 54
29. P. Thomas Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models Gen. Comp. Endocrinol. 175 3 2012 367 383
30. S.L. Tilghman, E.N. Nierth-Simpson, R. Wallace, M.E. Burow, and J.A. McLachlan Environmental hormones: multiple pathways for response may lead to multiple disease outcomes Steroids 75 8-9 2010 520 523
31. S. De Coster, and N. van Larebeke Endocrine-disrupting chemicals: associated disorders and mechanisms of action J. Environ. Public Health 2012 2012 713696
32. I. Quesada, E. Fuentes, M.C. Viso-Leon, B. Soria, C. Ripoll, and A. Nadal Low doses of the endocrine disruptor bisphenol-A and the native hormone 17beta-estradiol rapidly activate transcription factor CREB FASEB J. 16 12 2002 1671 1673
33. D. Grove-Strawser, M.I. Boulware, and P.G. Mermelstein Membrane estrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to bidirectionally regulate CREB phosphorylation in female rat striatal neurons Neuroscience 170 4 2010 1045 1055
34. C. Teng, B. Goodwin, K. Shockley, M. Xia, R. Huang, J. Norris, B.A. Merrick, A.M. Jetten, C.P. Austin, and R.R. Tice Bisphenol A affects androgen receptor function via multiple mechanisms Chem. Biol. Interact. 203 3 2013 556 564
35. S.R. Adler Cellular mechanism of endocrine disruption A.C. Gore, Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2010 Humana Press Totowa 135 174
36. L.G. Nashev, A. Vuorinen, L. Praxmarer, B. Chantong, D. Cereghetti, R. Winiger, D. Schuster, and A. Odermatt Virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action PLoS One 7 10 2012 e46958
37. A. Vuorinen, A. Odermatt, and D. Schuster In silico methods in the discovery of endocrine disrupting chemicals J. Steroid Biochem. Mol. Biol. 137 2013 18 26
38. L. Gagliardi, J.T. Ho, and D.J. Torpy Corticosteroid-binding globulin: the clinical significance of altered levels and heritable mutations Mol. Cell. Endocrinol. 316 1 2010 24 34
39. H.Y. Lin, Y.A. Muller, and G.L. Hammond Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin Mol. Cell. Endocrinol. 316 1 2010 3 12
40. G.V. Avvakumov, A. Cherkasov, Y.A. Muller, and G.L. Hammond Structural analyses of sex hormone-binding globulin reveal novel ligands and function Mol. Cell. Endocrinol. 316 1 2010 13 23
41. S.M. Kahn, D.J. Hryb, A.M. Nakhla, N.A. Romas, and W. Rosner Sex hormone-binding globulin is synthesized in target cells J. Endocrinol. 175 1 2002 113 120
42. D. Montes-Grajales, and J. Olivero-Verbel Computer-aided identification of novel protein targets of bisphenol A Toxicol. Lett. 222 3 2013 312 320
43. K.E. Tollefsen Binding of alkylphenols and alkylated non-phenolics to the rainbow trout (Oncorhynchus mykiss) plasma sex steroid-binding protein Ecotoxicol. Environ. Saf. 68 1 2007 40 48
44. M. Montano, E. Cocco, C. Guignard, G. Marsh, L. Hoffmann, A. Bergman, A.C. Gutleb, and A.J. Murk New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors Toxicol. Sci. 130 1 2012 94 105
45. D.M. Walker, and A.C. Gore Endocrine-disrupting chemicals and the brain A.C. Gore, Endocrine-Disrupting Chemicals: From Basic Research to Clinical Practice 2010 Humana Press Totowa, NJ 63 109
46. J. Cao, M.E. Rebuli, J. Rogers, K.L. Todd, S.M. Leyrer, S.A. Ferguson, and H.B. Patisaul Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala Toxicol. Sci. 133 1 2013 157 173
47. L. Monje, J. Varayoud, M. Munoz-de-Toro, E.H. Luque, and J.G. Ramos Exposure of neonatal female rats to bisphenol A disrupts hypothalamic LHRH pre-mRNA processing and estrogen receptor alpha expression in nuclei controlling estrous cyclicity Reprod. Toxicol. 30 4 2010 625 634
48. S.M. Dickerson, S.L. Cunningham, and A.C. Gore Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus Toxicol. Appl. Pharmacol. 252 1 2011 36 46
49. R. Vinas, and C.S. Watson Bisphenol S disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: effects on cell functions Environ. Health Perspect. 121 3 2013 352 358
50. L.F. Silveira, M.G. Teles, E.B. Trarbach, and A.C. Latronico Role of kisspeptin/GPR54 system in human reproductive axis Front. Horm. Res. 39 2010 13 24
51. M. Bellingham, P.A. Fowler, M.R. Amezaga, S.M. Rhind, C. Cotinot, B. Mandon-Pepin, R.M. Sharpe, and N.P. Evans Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin/GPR54 system in ovine hypothalamus and pituitary gland Environ. Health Perspect. 117 10 2009 1556 1562
52. M. Tena-Sempere Kisspeptin/GPR54 system as potential target for endocrine disruption of reproductive development and function Int. J. Androl. 33 2 2010 360 368
53. G. Rasier, A.S. Parent, A. Gerard, R. Denooz, M.C. Lebrethon, C. Charlier, and J.P. Bourguignon Mechanisms of interaction of endocrine-disrupting chemicals with glutamate-evoked secretion of gonadotropin-releasing hormone Toxicol. Sci. 102 1 2008 33 41
54. J.P. Hinson, and P.W. Raven Effects of endocrine-disrupting chemicals on adrenal function Best Pract. Res. Clin. Endocrinol. Metab. 20 1 2006 111 120
55. C.D. Foradori, L.R. Hinds, A.M. Quihuis, A.F. Lacagnina, C.B. Breckenridge, and R.J. Handa The differential effect of atrazine on luteinizing hormone release in adrenalectomized adult female Wistar rats Biol. Reprod. 85 4 2011 684 689
56. H. Gallart-Ayala, E. Moyano, and M.T. Galceran Recent advances in mass spectrometry analysis of phenolic endocrine disruptors and related compounds Mass Spectrom. Rev. 29 5 2010 776 805
57. A. Goncharov, R. Rej, S. Negoita, M. Schymura, A. Santiago-Rivera, G. Morse, and D.O. Carpenter Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men Environ. Health Perspect. 117 9 2009 1454 1460
58. M. Chen, L. Tao, E.M. Collins, C. Austin, and C. Lu Simultaneous determination of multiple phthalate metabolites and bisphenol-A in human urine by liquid chromatography-tandem mass spectrometry J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 904 2012 73 80
59. E. Carlsen, A. Giwercman, N. Keiding, and N.E. Skakkebaek Evidence for decreasing quality of semen during past 50 years Br. Med. J. 305 6854 1992 609 613
60. R. Hauser, J.S. Barthold, and J.D. Meeker Epidemiologic evidence on the relationship between environmental endocrine disruptors and male reproductive and developmental health A.C. Gore, Endocrine Disrupting Chemicals: From Basic Research to Clinical Practice 2010 Humana Press Totowa, NJ 225 251
61. F. Brucker-Davis, B. Ducot, K. Wagner-Mahler, C. Tommasi, P. Ferrari, P. Pacini, M. Boda-Buccino, A. Bongain, P. Azuar, and P. Fenichel Environmental pollutants in maternal milk and cryptorchidism Gynecol. Obstet. Fertil. 36 9 2008 840 847
62. H. Kadar, B. Veyrand, A. Barbarossa, G. Pagliuca, A. Legrand, C. Bosher, C.Y. Boquien, S. Durand, F. Monteau, J.P. Antignac, and B. Le Bizec Development of an analytical strategy based on liquid chromatography-high resolution mass spectrometry for measuring perfluorinated compounds in human breast milk: application to the generation of preliminary data regarding perinatal exposure in France Chemosphere 85 3 2011 473 480
63. T.H. Kim, Y. Bang du, H.J. Lim, A.J. Won, M.Y. Ahn, N. Patra, K.K. Chung, S.J. Kwack, K.L. Park, S.Y. Han, W.S. Choi, J.Y. Han, B.M. Lee, J.E. Oh, J.H. Yoon, J. Lee, and H.S. Kim Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples Chemosphere 87 1 2012 97 104
64. E.M. Petro, J.L. Leroy, A. Covaci, E. Fransen, D. De Neubourg, A.C. Dirtu, I. De Pauw, and P.E. Bols Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence Hum. Reprod. 27 4 2012 1025 1033
65. T. Takeuchi, O. Tsutsumi, Y. Ikezuki, Y. Takai, and Y. Taketani Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction Endocr. J. 51 2 2004 165 169
66. E. Kandaraki, A. Chatzigeorgiou, S. Livadas, E. Palioura, F. Economou, M. Koutsilieris, S. Palimeri, D. Panidis, and E. Diamanti-Kandarakis Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS J. Clin. Endocrinol. Metab. 96 3 2011 E480 E484
67. G. Tarantino, R. Valentino, C. Di Somma, V. D'Esposito, F. Passaretti, G. Pizza, V. Brancato, F. Orio, P. Formisano, A. Colao, and S. Savastano Bisphenol A in polycystic ovary syndrome and its association with liver-spleen axis Clin. Endocrinol. (Oxf.). 78 3 2013 447 453
68. S.L. Wang, Y.C. Chang, H.R. Chao, C.M. Li, L.A. Li, L.Y. Lin, and O. Papke Body burdens of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls and their relations to estrogen metabolism in pregnant women Environ. Health Perspect. 114 5 2006 740 745
69. Y. Wan, K. Choi, S. Kim, K. Ji, H. Chang, S. Wiseman, P.D. Jones, J.S. Khim, S. Park, J. Park, M.H. Lam, and J.P. Giesy Hydroxylated polybrominated diphenyl ethers and bisphenol A in pregnant women and their matching fetuses: placental transfer and potential risks Environ. Sci. Technol. 44 13 2010 5233 5239
70. U.N. Joensen, B. Veyrand, J.P. Antignac, M. Blomberg Jensen, J.H. Petersen, P. Marchand, N.E. Skakkebaek, A.M. Andersson, B. Le Bizec, and N. Jorgensen PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men Hum. Reprod. 28 3 2013 599 608
71. R. Hampl, J. Kubátová, V. Sobotka, and J. Heráček Steroids in semen, their role in spermatogenesis and the possible impact of endocrine disruptors Horm. Mol. Biol. Clin. Invest. 13 2013 1 5
72. P. Mocarelli, P.M. Gerthoux, D.G. Patterson Jr., S. Milani, G. Limonta, M. Bertona, S. Signorini, P. Tramacere, L. Colombo, C. Crespi, P. Brambilla, C. Sarto, V. Carreri, E.J. Sampson, W.E. Turner, and L.L. Needham Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen quality Environ. Health Perspect. 116 1 2008 70 77
73. T. Bushnik, D. Haines, P. Levallois, J. Levesque, J. Van Oostdam, and C. Viau Lead and bisphenol A concentrations in the Canadian population Health Rep. 21 3 2010 7 18
74. T. Galloway, R. Cipelli, J. Guralnik, L. Ferrucci, S. Bandinelli, A.M. Corsi, C. Money, P. McCormack, and D. Melzer Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study Environ. Health Perspect. 118 11 2010 1603 1608
75. R.H. Weldon, M. Webster, K.G. Harley, A. Bradman, L. Fenster, M.D. Davis, A. Hubbard, D.B. Barr, N. Holland, and B. Eskenazi Serum persistent organic pollutants and duration of lactation among Mexican-American women J. Environ. Public Health 2010 2010 861757
76. X. Ye, X. Zhou, L.Y. Wong, and A.M. Calafat Concentrations of bisphenol A and seven other phenols in pooled sera from 3-11 year old children: 2001-2002 National Health and Nutrition Examination Survey Environ. Sci. Technol. 46 22 2012 12664 12671
77. I. Gyllenhammar, A. Glynn, P.O. Darnerud, S. Lignell, R. van Delft, and M. Aune 4-Nonylphenol and bisphenol A in Swedish food and exposure in Swedish nursing women Environ. Int. 43 2012 21 28
78. L. Meijer, A. Martijn, J. Melessen, A. Brouwer, J. Weiss, F.H. de Jong, and P.J. Sauer Influence of prenatal organohalogen levels on infant male sexual development: sex hormone levels, testes volume and penile length Hum. Reprod. 27 3 2012 867 872
79. U.N. Joensen, H. Frederiksen, M.B. Jensen, M.P. Lauritsen, I.A. Olesen, T.H. Lassen, A.M. Andersson, and N. Jorgensen Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men Environ. Health Perspect. 120 10 2012 1397 1403
80. G. Toft, B.A. Jonsson, C.H. Lindh, A. Giwercman, M. Spano, D. Heederik, V. Lenters, R. Vermeulen, L. Rylander, H.S. Pedersen, J.K. Ludwicki, V. Zviezdai, and J.P. Bonde Exposure to perfluorinated compounds and human semen quality in Arctic and European populations Hum. Reprod. 27 8 2012 2532 2540