PFOS (perfluorooctanesulfonate) in serum is negatively associated with testosterone levels, but not with semen quality, in healthy men

Human Reproduction

Volumn 28, Issue 3, 2013, Pages 599-608

  Joensen, Ulla Nordström ^a   Veyrand, Bruno ^b   Antignac, Jean Philippe ^b   Blomberg Jensen, Martin ^a   Petersen, Jørgen Holm ^a   Marchand, Philippe ^b   Skakkebæk, Niels Erik ^a   Andersson, Anna Maria ^a   Le Bizec, Bruno ^b   Jørgensen, Niels ^a  

^a Rigshospitalet   (Denmark)

^b LUNAM UNIVERSITÉ   (France)

Author keywords

PFC; PFOA; PFOS; semen quality; testosterone

Indexed keywords

ESTRADIOL; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; PERFLUOROOCTANESULFONIC ACID; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; CALCULATED FREE TESTOSTERONE; CROSS-SECTIONAL STUDY; FREE ANDROGEN INDEX; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; SEMEN ANALYSIS; SEX HORMONE DETERMINATION; SPERMATOZOON DENSITY; STATISTICAL ANALYSIS; TESTIS FUNCTION; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

EID: 84874309586     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/des425     Document Type: Article

References (37)

1. Beesoon S, Webster GM, Shoeib M, Harner T, Benskin JP, Martin JW. Isomer profiles of perfluorochemicals in matched maternal, cord, and house dust samples: manufacturing sources and transplacental transfer. Environ Health Perspect 2011;119: 1659-1664.
2. Begley TH, Hsu W, Noonan G, Diachenko G. Migration of fluorochemical paper additives from food-contact paper into foods and food simulants. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2008; 25: 384-390.
3. Benninghoff AD, Bisson WH, Koch DC, Ehresman DJ, Kolluri SK, Williams DE. Estrogen-like activity of perfluoroalkyl acids in vivo and interaction with human and rainbow trout estrogen receptors in vitro. Toxicol Sci 2011;120: 42-58.
4. Biegel LB, Liu RC, Hurtt ME, Cook JC. Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies. Toxicol Appl Pharmacol 1995;134: 18-25.
5. Butenhoff J, Costa G, Elcombe C, Farrar D, Hansen K, Iwai H, Jung R, Kennedy G Jr, Lieder P, Olsen G et al. Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. Toxicol Sci 2002;69: 244-257.
6. Cook JC, Murray SM, Frame SR, Hurtt ME. Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrinerelated mechanism. Toxicol Appl Pharmacol 1992;113: 209-217.
7. Department of Growth and Reproduction, Copenhagen University Hospital, 2012 Normal ranges for reproductive hormones in Danish men [Danish] http://www.rigshospitalet.dk/NR/rdonlyres/BF045 510-9714-4A44-9906-FD5B02E5CD13/ 0/Referencem%c3%a6nd.pdf. (8 December 2012, date last accessed).
8. European Food Safety Authority. Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts. Scientific opinion of the panel on contaminants in the food chain, 2012. http://www.efsa .europa.eu/en/ efsajournal/doc/653.pdf. (8 December 2012, date last accessed).
9. Gilliland FD. Fluorocarbons and Human Health: Studies in an Occupational Cohort. Minneapolis, MN: University of Minnesota, 1992.
10. Han X, Snow TA, Kemper RA, JepsonGW. Binding of perfluorooctanoic acid to rat and human plasma proteins. Chem Res Toxicol 2003;16: 775-781.
11. Hu W, Jones PD, Decoen W, King L, Fraker P, Newsted J, Giesy JP. Alterations in cell membrane properties caused by perfluorinated compounds. Comp Biochem Physiol C Toxicol Pharmacol 2003;135: 77-88.
12. Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebæk NE, Jørgensen N. Do perfluoroalkyl compounds impair human semen quality? Environ Health Perspect 2009;117: 923-927.
13. Jones PD, Hu W, De CW, Newsted JL, Giesy JP. Binding of perfluorinated fatty acids to serum proteins. Environ Toxicol Chem 2003;22: 2639-2649.
14. Jørgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, Andersson AM, Haugen TB, Horte A, Jensen TK et al. East-West gradient in semen quality in the Nordic-Baltic area: a study of men from the general population in Denmark, Norway, Estonia and Finland. Hum Reprod 2002;17: 2199-2208.
15. Kannan K, Corsolini S, Falandysz J, Fillmann G, Kumar KS, Loganathan BG, Mohd MA, Olivero J, Van Wouwe N, Yang JH et al. Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries. Environ Sci Technol 2004;38: 4489-4495.
16. Kato K, Wong LY, Jia LT, Kuklenyik Z, Calafat AM. Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008. Environ Sci Technol 2011;45: 8037-8045.
17. Kissa E. Fluorinated Surfactants and Repellents, 2nd edn. Surfactant Science Series, Vol. 97. CRC Press, 2001.
18. Kortenkamp A, Faust M. Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment. Int J Androl 2010; 33: 463-474.
19. Loccisano AE, Campbell JL Jr, Andersen ME, Clewell HJ III. Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model. Regul Toxicol Pharmacol 2011;59: 157-175.
20. Menkveld R, Stander FS, Kotze TJ, Kruger TF, van Zyl JA. The evaluation of morphological characteristics of human spermatozoa according to stricter criteria. Hum Reprod 1990;5: 586-592.
21. O'Brien JM, Kennedy SW, Chu S, Letcher RJ. Isomer-specific accumulation of perfluorooctane sulfonate in the liver of chicken embryos exposed in ovo to a technical mixture. Environ Toxicol Chem 2011;30: 226-231.
22. Olsen GW, Gilliland FD, Burlew MM, Burris JM, Mandel JS, Mandel JH. An epidemiologic investigation of reproductive hormones in men with occupational exposure to perfluorooctanoic acid. J Occup Environ Med 1998;40: 614-622.
23. Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL, Zobel LR. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 2007;115: 1298-1305.
24. Ravnborg TL, Jensen TK, Andersson AM, Toppari J, Skakkebæk NE, Jørgensen N. Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index. Hum Reprod 2011;26: 1000-1011.
25. Raymer JH, Michael LC, Studabaker WB, Olsen GW, Sloan CS, Wilcosky T, Walmer DK. Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements. Reprod Toxicol 2012;33: 419-427.
26. Shi Z, Zhang H, Liu Y, Xu M, Dai J. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Toxicol Sci 2007;98: 206-215.
27. Søeborg T, Frederiksen H, Andersson AM. Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach. Int J Androl 2012;35: 245-252.
28. Specht IO, Hougaard KS, Spano M, Bizzaro D, Manicardi GC, Lindh CH, Toft G, Jonsson BA, Giwercman A, Bonde JP. Sperm DNA integrity in relation to exposure to environmental perfluoroalkyl substances-a study of spouses of pregnant women in three geographical regions. Reprod Toxicol 2012;33: 577-583.
29. Steenland K, Fletcher T, Savitz DA. Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA). Environ Health Perspect 2010; 118: 1100-1108.
30. Stockholm Convention, 2009 http://chm.pops.int/Convention/The POPs/ListingofPOPs/tabid/2509/Default.aspx. (8 December 2012, date last accessed).
31. Toft G, Jonsson BA, Lindh CH, Giwercman A, Spano M, Heederik D, Lenters V, Vermeulen R, Rylander L, Pedersen HS et al. Exposure to perfluorinated compounds and human semen quality in arctic and European populations. Hum Reprod 2012;27: 2532-2540.
32. Trier X, Granby K, Christensen JH. Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging. Environ Sci Pollut Res Int 2011;18: 1108-1120.
33. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999;84: 3666-3672.
34. Weiss JM, Andersson PL, Lamoree MH, Leonards PE, van Leeuwen SP, Hamers T. Competitive binding of poly-and perfluorinated compounds to the thyroid hormone transport protein transthyretin. Toxicol Sci 2009;109: 206-216.
35. White SS, Fenton SE, Hines EP. Endocrine disrupting properties of perfluorooctanoic acid. J Steroid Biochem Mol Biol 2011;127: 16-26.
36. World Health Organization. WHO Laboratory Manual for the Examination and Processing Of Human Semen, 5th edn, 2010. http://whqlibdoc.who .int/publications/2010/9789241547789-eng.pdf. (8 December 2012, date last accessed).
37. Zhao B, Hu GX, Chu Y, Jin X, Gong S, Akingbemi BT, Zhang Z, Zirkin BR, Ge RS. Inhibition of human and rat 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase 3 activities by perfluoroalkylated substances. Chem Biol Interact 2010; 188: 38-43.