Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: Probable mechanism of action

Toxicology

Volumn 250, Issue 2-3, 2008, Pages 124-131

  Kumar, Vikas ^a   Balomajumder, Chandrajeet ^a   Roy, Partha ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

Adenylyl cyclase; Leydig cells; Steroidogenesis; Triclosan

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ADENYLATE CYCLASE; CYCLIC AMP; CYTOCHROME P450 CHAIN CLEAVAGE; CYTOCHROME P450 ISOENZYME; FORSKOLIN; LUTEINIZING HORMONE; MESSENGER RNA; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TRICLOSAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; LEYDIG CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURINE SYNTHESIS; RAT; REPRODUCTIVE TOXICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSLATION; STEROIDOGENESIS; TESTIS; TESTOSTERONE METABOLISM; TESTOSTERONE SYNTHESIS; WESTERN BLOTTING;

17-HYDROXYSTEROID DEHYDROGENASES; 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); ADENYLATE CYCLASE; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; BLOTTING, WESTERN; CELL SEPARATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TESTOSTERONE; TETRAZOLIUM SALTS; THIAZOLES; TRICLOSAN;

RATTUS;

EID: 49849095979     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.06.012     Document Type: Article

References (41)

1. Andrew S., June Liu, Barry R.Z., and Haolin C. Effect of myxothiazol on Leydig cell steroidogenesis: inhibition of luteinizing hormone mediated testosterone synthesis but stimulation of basal steroidogenesis. Endocrinology 148 6 (2007) 2583-2590
2. Beavo J.A., and Brunton L.L. Cyclic nucleotide research -- still expanding after half a century. Nat. Rev. Mol. Cell. Biol. 3 (2002) 710-718
3. Black J.G., and Howes D.R.T. Percutaneous absorption and metabolism of Irgasan DP 300. Toxicology 3 (1975) 33-47
4. Cabana H., Jiwan J.L., Rozenberg R., Elisashvili V., Penninckx M., Agathos S.N., and Jones J.P. Elimination of endocrine disrupting chemicals nonylphenol and bisphenol A and personal care product ingredient triclosan using enzyme preparation from the white rot fungus Coriolopsis polyzona. Chemosphere 67 (2007) 770-778
5. Chen J., Ahn K.C., Gee N.A., Gee S.J., Hammock B.D., and Lasley B.L. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol. Appl. Pharmacol. 221 (2007) 278-284
6. Chomczynski P., and Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162 (1987) 156-159
7. Darbre P.D. Environmental oestrogens, cosmetics and breast cancer. Res. Clin. Endocrinol. Metab. 20 (2006) 121-143
8. Darney Jr. K.J., Wing T.Y., and Ewing L.L. Simultaneous measurement of four testicular ketosteroids by isocratic high-performance liquid chromatography with on-line ultraviolet absorbance detection. J. Chromatogr. 257 (1983) 81-90
9. Dayan A.D. Response to: ethics, data and the pharmaceutical physician. Int. J. Clin. Pract. 60 (2006) 1009
10. Dufau M.L. Endocrine regulation and communicating functions of the Leydig cell. Ann. Rev. Physiol. 50 (1988) 483-508
11. Fauser B.C.J.M. Molecular biology of steroidogenesis. Molecular Biology in the Reproductive Medicine vol. 234 (1999), Parthenon Publishing, New York pp. 234-251
12. Foran C.M., Bennett E.R., and Benson W.H. Developmental evaluation of a potential non-steroidal estrogen: triclosan. Mar. Environ. Res. 50 1-5 (2000) 153-156
13. Gail P.R., and Hedger M.P. Adult rat Leydig cell cultures: minimum requirements for maintenance of luteinizing hormone responsiveness and testosterone production. Mol. Cell. Endocrinol. 83 (1992) 128-132
14. Guillette L.J. Endocrine disrupting contaminants-beyond the dogma. Environ. Health Perspect. 114 1 (2006) 9-12
15. Harper J., and Brooker G. Femtomole sensitive radioimmunoassay for cyclic-AMP and cyclic GMP after 2′-O-acetylation by acetic anhydride in aqueous solution. J. Cycl. Nucleotide Res. 4 (1975) 207-218
16. Heidler J., Sapkota A., and Halden R.U. Partitioning, persistence and accumulation in digested sludge of the topical antiseptic triclocarban during wastewater treatment. Environ. Sci. Technol. 40 (2006) 3634-3639
17. Indarto D., and Izawa M. Steroid hormones and endocrine disruptors: recent advances in receptor-mediated actions. Yonago Acta Med. 44 (2001) 1-6
18. Ishibashi H., Matsumura N., Hirano M., Matsuoka M., Shiratsuchi H., Ishibashi Y., Takao Y., and Arizono K. Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin. Aquat. Toxicol. 67 (2004) 167-179
19. Kanetoshi A., Ogawa H., Katsura E., Kaneshima H., and Miura T. Formation of polychlorinated dibenzo-p-dioxins upon combustion of commercial textile products containing 2,4,4-trichloro-2-hydroxydiphenyl ether (Irgasan DP300). J. Chromatogr. 442 (1998) 289-299
20. Kanetoshi A., Ogawa H., Katsura E., Kaneshima H., and Miura T. Formation of polychlorinated dibenzo-p-dioxins from 2,4,4 trichloro-2β-hydroxydiphenyl ether (Irgasan DP300) and its chlorinated derivatives by exposure to sunlight. J. Chromatogr. 454 (1998) 145-155
21. Kumar V., Chakraborty A., Gunda V., and Roy P. Androgenic endocrine disruptors in wastewater treatment plant effluents in India: their influence on reproductive processes and systemic toxicity in male rats. Toxicol. Appl. Pharmacol. 226 1 (2008) 60-63
22. Lakeram M., Lockley D.J., Sanders D.J., Pendlington R., and Forbes B. Paraben transport and metabolism in the biomimetic artificial membrane permeability assay (BAMPA) and 3-day and 21-day Caco-2 cell systems. J. Biomol. Screen. 12 (2006) 84-91
23. Lin Ho., Wang S.W., Wang R.Y., and Paulus S. Stimulatory effect of lactate on testosterone production by rat Leydig cells. J. Cell Biochem. 83 (2001) 147-154
24. Lin T.C., Chien S.C., Hsu P.C., and Li L.A. Mechanistic study of polychlorinated biphenyl 126-induced CYP 11B1 and CYP 11B2 up-regulation. Endocrinology 147 (2006) 1536-1544
25. Lyssimachou A., Jessen B.M., and Arukew A. Brain cytochrome P450 aromatase gene isoforms and activity levels in atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynylestradiol and antifoulant tributyltin. Toxicol. Sci. 91 (2006) 82-92
26. Marinero M.J., Colas B., Prieto J.C., and López-Ruiz M.P. Different sites of action of arachidonic acid on steroidogenesis in rat Leydig cells. Mol. Cell. Endocrinol. 118 1-2 (1996) 193-200
27. Miller W.L. Molecular biology of steroid hormone synthesis. Endocr. Rev. 9 (1988) 295-318
28. Murugesan P., Muthusamy T., Balasubramanian K., and Arunakaran J. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Toxicology 232 (2007) 170-182
29. Nakada N., Tanishima T., Shinohara H., Kiri K., and Takada H. Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Res. 40 (2006) 3297-3303
30. Ohsako S., Kubota K., Kurosawa S., Takeda K., Qing W., Ishimura R., and Tohyma C. Alterations of gene expression in adult male rat testis and pituitary shortly after sub-acute administration of the antiandrogen flutmide. J. Reprod. Dev. 49 (2003) 275-290
31. Omura T., and Morohashi K. Gene regulation of steroidogenesis. J. Steroid Biochem. Mol. Biol. 53 (1995) 19-25
32. Privalle C.T., Crivello J.F., and Jefcoate C.R. Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P450scc in rat adrenal gland. Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 702-706
33. Rice S., Mason H.D., and Whitehead S.A. Phytoestrogens and their low dose combinations inhibit mRNA expression and activity of aromatase in human granulosa-luteal cells. J. Steroid Biochem. Mol. Biol. 101 (2006) 216-225
34. Roy P., and Pereira B.M.J. A treatise on hazards of endocrine disruptors and tool to evaluate them. Indian J. Exp. Biol. 43 (2005) 975-992
35. Sanderson T., and Vanden B.M. Interactions of xenobiotics with the steroid hormone biosynthesis pathway. Pure Appl. Chem. 75 (2003) 1957-1971
36. Sharpe R.M., and Irvine D.S. How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health?. Br. Med. J. 328 (2004) 447-451
37. Solomon Y., Londos C., and Rodbell M. A highly sensitive adenylate cyclase assay. Anal. Biochem. 58 (1974) 541-548
38. Stocco D.M., and Clark B.J. The role of the steroidogenic acute regulatory protein in steroidogenesis. Steroids 62 29 (1997) 36
39. Tatarazako N., Ishibashi H., Teshima K., Kishi K., and Arizono K. Effects of triclosan on various aquatic organisms. Environ. Sci. 11 2 (2004) 133-140
40. Vuorento T., Lahti A., Hovatta O., and Huhtaniemi I.T. Daily measurements of salivary progesterone reveal a high rate of anovulation in healthy students. Scand. J. Clin. Lab. Invest. 49 (1989) 395-401
41. West L.A., Horvat R.D., Roess D.A., Barisas B.G., Juengel J.L., and Niswender G.D. Steroidogenic acute regulatory protein and peripheral-type benzodiazepine receptor associate at the mitochondrial membrane. Endocrinology 142 (2001) 502-505