High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism

Human Molecular Genetics

Volumn 24, Issue 22, 2015, Pages 6301-6313

  Aarabi, Mahmoud ^a,b   San Gabrie, Maria C ^a,b   Chan, Donovan ^b   Behan, Nathalie A ^c   Caron, Maxime ^a   Pastinen, Tomi ^a   Bourque, Guillaume ^a   MacFarlane, Amanda J ^c   Zini, Armand ^a,b   Trasler, Jacquetta ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FOLIC ACID; FOLLITROPIN; HOMOCYSTEINE; LUTEINIZING HORMONE; PROLACTIN; PROTEIN TYROSINE PHOSPHATASE SHP 1; REPETITIVE DNA; RNA H19; SODIUM GLUCOSE COTRANSPORTER 2; TESTOSTERONE; THYROTROPIN; DNA; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CPG ISLAND; DIET SUPPLEMENTATION; DNA METHYLATION; DNA POLYMORPHISM; DRUG MEGADOSE; EPIGENETICS; EXON; FOLATE METABOLISM; FOLIC ACID BLOOD LEVEL; FOLLITROPIN BLOOD LEVEL; GENE LOCUS; GENE SEQUENCE; HOMOZYGOSITY; HUMAN; HUMAN CELL; IDIOPATHIC DISEASE; INTRON; LONG TERMINAL REPEAT; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE INFERTILITY; NEXT GENERATION SEQUENCING; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROMOTER REGION; REDUCED REPRESENTATION BISULFITE SEQUENCING; SHORT INTERSPERSED REPEAT; SPERM; SPERMATOZOON DENSITY; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; TRANSCRIPTION TERMINATION; TRANSPOSON; TREATMENT DURATION; VITAMIN BLOOD LEVEL; BLOOD; DIETARY SUPPLEMENT; DRUG EFFECTS; ENZYMOLOGY; GENETIC EPIGENESIS; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; METABOLISM; PHYSIOLOGY; REGULATOR GENE; SPERMATOZOON;

ADULT; DIETARY SUPPLEMENTS; DNA; DNA METHYLATION; EPIGENESIS, GENETIC; FOLIC ACID; GENES, REGULATOR; GENOTYPE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; SNRNP CORE PROTEINS; SPERMATOZOA;

EID: 84949057868     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv338     Document Type: Article

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