-
1
-
-
34249895023
-
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
-
DOI 10.1126/science.1142364
-
Zeggini E, Weedon MN, Lindgren CM et al (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341 (Pubitemid 46871654)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
Frayling, T.M.4
Elliott, K.S.5
Lango, H.6
Timpson, N.J.7
Perry, J.R.B.8
Rayner, N.W.9
Freathy, R.M.10
Barrett, J.C.11
Shields, B.12
Morris, A.P.13
Ellard, S.14
Groves, C.J.15
Harries, L.W.16
Marchini, J.L.17
Owen, K.R.18
Knight, B.19
Cardon, L.R.20
Walker, M.21
Hitman, G.A.22
Morris, A.D.23
Doney, A.S.F.24
McCarthy, M.I.25
Hattersley, A.T.26
Bruce, I.N.27
Donovan, H.28
Eyre, S.29
Gilbert, P.D.30
Hider, S.L.31
Hinks, A.M.32
John, S.L.33
Potter, C.34
Silman, A.J.35
Symmons, D.P.M.36
Thomson, W.37
Worthington, J.38
more..
-
2
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
-
DOI 10.1126/science.1142382
-
Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345 (Pubitemid 46871655)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
Willer, C.J.4
Li, Y.5
Duren, W.L.6
Erdos, M.R.7
Stringham, H.M.8
Chines, P.S.9
Jackson, A.U.10
Prokunina-Olsson, L.11
Ding, C.-J.12
Swift, A.J.13
Narisu14
Hu, T.15
Pruim, R.16
Xiao, R.17
Li, X.-Y.18
Conneely, K.N.19
Riebow, N.L.20
Sprau, A.G.21
Tong, M.22
White, P.P.23
Hetrick, K.N.24
Barnhart, M.W.25
Bark, C.W.26
Goldstein, J.L.27
Watkins, L.28
Xiang, F.29
Saramies, J.30
Buchanan, T.A.31
Watanabe, R.M.32
Valle, T.T.33
Kinnunen, L.34
Abecasis, G.R.35
Pugh, E.W.36
Doheny, K.F.37
Bergman, R.N.38
Tuomilehto, J.39
Collins, F.S.40
Boehnke, M.41
more..
-
3
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
DOI 10.1126/science.1142358
-
Saxena R, Voight BF, Lyssenko V et al (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336 (Pubitemid 46871653)
-
(2007)
Science
, vol.316
, Issue.5829
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
Burtt, N.P.4
De Bakker, P.I.W.5
Chen, H.6
Roix, J.J.7
Kathiresan, S.8
Hirschhorn, J.N.9
Daly, M.J.10
Hughes, T.E.11
Groop, L.12
Altshuler, D.13
-
4
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
DOI 10.1038/ng.120, PII NG120
-
Zeggini E, Scott LJ, Saxena R et al (2008)Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638-645 (Pubitemid 351601209)
-
(2008)
Nature Genetics
, vol.40
, Issue.5
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
Voight, B.F.4
-
5
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
Dupuis J, Langenberg C, Prokopenko I et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105-116
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
-
6
-
-
75749091912
-
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
-
Saxena R, Hivert MF, Langenberg C et al (2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet 42:142-148
-
(2010)
Nat Genet
, vol.42
, pp. 142-148
-
-
Saxena, R.1
Hivert, M.F.2
Langenberg, C.3
-
7
-
-
72449122779
-
Parental origin of sequence variants associated with complex diseases
-
Kong A, Steinthorsdottir V, Masson G et al (2009) Parental origin of sequence variants associated with complex diseases. Nature 462:868-874
-
(2009)
Nature
, vol.462
, pp. 868-874
-
-
Kong, A.1
Steinthorsdottir, V.2
Masson, G.3
-
8
-
-
77954143522
-
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
-
Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579-589
-
(2010)
Nat Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
-
9
-
-
56349096931
-
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
-
Lango H, Palmer CN, Morris AD et al (2008) Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes 57:3129-3135
-
(2008)
Diabetes
, vol.57
, pp. 3129-3135
-
-
Lango, H.1
Palmer, C.N.2
Morris, A.D.3
-
10
-
-
65249131713
-
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
-
Nejentsev S, Walker N, Riches D, Egholm M, Todd JA (2009) Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 324:387-389
-
(2009)
Science
, vol.324
, pp. 387-389
-
-
Nejentsev, S.1
Walker, N.2
Riches, D.3
Egholm, M.4
Todd, J.A.5
-
11
-
-
41149139275
-
Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young
-
Ellard S, Bellanne-Chantelot C, Hattersley AT (2008) Best practice guidelines for the molecular genetic diagnosis of maturity-onset diabetes of the young. Diabetologia 51:546-553
-
(2008)
Diabetologia
, vol.51
, pp. 546-553
-
-
Ellard, S.1
Bellanne-Chantelot, C.2
Hattersley, A.T.3
-
12
-
-
0037135622
-
Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4α
-
DOI 10.1074/jbc.M201582200
-
Bartoov-Shifman R, Hertz R, Wang H, Wollheim CB, Bar-Tana J, Walker MD (2002) Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4α. J Biol Chem 277:25914-25919 (Pubitemid 34967071)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.29
, pp. 25914-25919
-
-
Bartoov-Shifman, R.1
Hertz, R.2
Wang, H.3
Wollheim, C.B.4
Bar-Tana, J.5
Walker, M.D.6
-
13
-
-
0242349197
-
Regulation of hepatic fasting response by PPARg coactivator-1α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
-
DOI 10.1073/pnas.0730870100
-
Rhee J, Inoue Y, Yoon JC et al (2003) Regulation of hepatic fasting response by PPARg coactivator-1α (PGC-1): requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc Natl Acad Sci USA 100:4012-4017 (Pubitemid 36418148)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4012-4017
-
-
Rhee, J.1
Inoue, Y.2
Yoon, J.C.3
Puigserver, P.4
Fan, M.5
Gonzalez, F.J.6
Spiegelman, B.M.7
-
14
-
-
7044229728
-
Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population
-
Weedon MN, Owen KR, Shields B et al (2004) Common variants of the hepatocyte nuclear factor-4α P2 promoter are associated with type 2 diabetes in the U.K. population. Diabetes 53:3002-3006
-
(2004)
Diabetes
, vol.53
, pp. 3002-3006
-
-
Weedon, M.N.1
Owen, K.R.2
Shields, B.3
-
15
-
-
0030907295
-
New susceptibility locus for NIDDM is localized to human chromosome 20q
-
Ji L, Malecki M, Warram JH, Yang Y, Rich SS, Krolewski AS (1997) New susceptibility locus for NIDDM is localized to human chromosome 20q. Diabetes 46:876-881 (Pubitemid 27188267)
-
(1997)
Diabetes
, vol.46
, Issue.5
, pp. 876-881
-
-
Ji, L.1
Malecki, M.2
Warram, J.H.3
Yang, Y.4
Rich, S.S.5
Krolewski, A.S.6
-
16
-
-
0030766446
-
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene
-
DOI 10.1093/hmg/6.9.1401
-
Zouali H, Hani EH, Philippi A et al (1997) A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum Mol Genet 6:1401-1408 (Pubitemid 27397014)
-
(1997)
Human Molecular Genetics
, vol.6
, Issue.9
, pp. 1401-1408
-
-
Zouali, H.1
Hani, E.H.2
Philippi, A.3
Vionnet, N.4
Beckmann, J.S.5
Demenais, F.6
Froguel, P.7
-
17
-
-
1842422877
-
A Common Polymorphism in the Upstream Promoter Region of the Hepatocyte Nuclear Factor-4α Gene on Chromosome 20q Is Associated with Type 2 Diabetes and Appears to Contribute to the Evidence for Linkage in an Ashkenazi Jewish Population
-
DOI 10.2337/diabetes.53.4.1134
-
Love-Gregory LD, Wasson J, Ma J et al (2004) A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4α gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population. Diabetes 53:1134-1140 (Pubitemid 38436629)
-
(2004)
Diabetes
, vol.53
, Issue.4
, pp. 1134-1140
-
-
Love-Gregory, L.D.1
Wasson, J.2
Ma, J.3
Jin, C.H.4
Glaser, B.5
Suarez, B.K.6
Permutt, M.A.7
-
18
-
-
12144291217
-
Genetic Variation Near the Hepatocyte Nuclear Factor-4α Gene Predicts Susceptibility to Type 2 Diabetes
-
DOI 10.2337/diabetes.53.4.1141
-
Silander K, Mohlke KL, Scott LJ et al (2004) Genetic variation near the hepatocyte nuclear factor-4α gene predicts susceptibility to type 2 diabetes. Diabetes 53:1141-1149 (Pubitemid 38436630)
-
(2004)
Diabetes
, vol.53
, Issue.4
, pp. 1141-1149
-
-
Silander, K.1
Mohlke, K.L.2
Scott, L.J.3
Peck, E.C.4
Hollstein, P.5
Skol, A.D.6
Jackson, A.U.7
Delonkas, P.8
Hunt, S.9
Stavrides, G.10
Chines, P.S.11
Erdos, M.R.12
Narisu, N.13
Conneely, K.N.14
Li, C.15
Fingerlin, T.E.16
Dhanjal, S.K.17
Valle, T.T.18
Bergman, R.N.19
Tuomilehto, J.20
Watanabe, R.M.21
Boehnke, M.22
Collins, F.S.23
more..
-
19
-
-
67349167388
-
Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies
-
Lillioja S, Wilton A (2009) Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies. Diabetologia 52:1061-1074
-
(2009)
Diabetologia
, vol.52
, pp. 1061-1074
-
-
Lillioja, S.1
Wilton, A.2
-
20
-
-
18844442012
-
The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4α (HNF4A): Gene associations with type 2 diabetes or altered beta-cell function among danes
-
DOI 10.1210/jc.2004-2159
-
Ek J, Rose CS, Jensen DP et al (2005) The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4α (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes. J Clin Endocrinol Metab 90:3054-3059 (Pubitemid 40686363)
-
(2005)
Journal of Clinical Endocrinology and Metabolism
, vol.90
, Issue.5
, pp. 3054-3059
-
-
Ek, J.1
Rose, C.S.2
Jensen, D.P.3
Glumer, C.4
Borch-Johnsen, K.5
Jorgensen, T.6
Pedersen, O.7
Hansen, T.8
-
21
-
-
20044365215
-
Association testing of variants in the hepatocyte nuclear factor 4α gene with risk of type 2 diabetes in 7,888 people
-
DOI 10.2337/diabetes.54.3.886
-
Winckler W, Graham RR, de Bakker PI et al (2005) Association testing of variants in the hepatocyte nuclear factor 4α gene with risk of type 2 diabetes in 7,883 people. Diabetes 54:886-892 (Pubitemid 40322095)
-
(2005)
Diabetes
, vol.54
, Issue.3
, pp. 886-892
-
-
Winckler, W.1
Graham, R.R.2
De Bakker, P.I.W.3
Sun, M.4
Almgren, P.5
Tuomi, T.6
Gaudet, D.7
Hudson, T.J.8
Ardlie, K.G.9
Daly, M.J.10
Hirschhorn, J.N.11
Groop, L.12
Altshuler, D.13
-
22
-
-
71649108660
-
Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: A meta-analysis in 49,577 individuals
-
Sookoian S, Gemma C, Pirola CJ (2010) Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: a meta-analysis in 49,577 individuals. Mol Genet Metab 99:80-89
-
(2010)
Mol Genet Metab
, vol.99
, pp. 80-89
-
-
Sookoian, S.1
Gemma, C.2
Pirola, C.J.3
-
23
-
-
58149163149
-
Common variants at 30 loci contribute to polygenic dyslipidemia
-
Kathiresan S,Willer CJ, Peloso GMet al (2009) Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41:56-65
-
(2009)
Nat Genet
, vol.41
, pp. 56-65
-
-
Kathiresan, S.1
Willer, C.J.2
Peloso, G.M.3
-
24
-
-
0038632115
-
T130I mutation in HNF-4α gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects
-
Zhu Q, Yamagata K, Miura A et al (2003) T130I mutation in HNF-4α gene is a loss-of-function mutation in hepatocytes and is associated with late-onset type 2 diabetes mellitus in Japanese subjects. Diabetologia 46:567-573 (Pubitemid 36577802)
-
(2003)
Diabetologia
, vol.46
, Issue.4
, pp. 567-573
-
-
Zhu, Q.1
Yamagata, K.2
Miura, A.3
Shihara, N.4
Horikawa, Y.5
Takeda, J.6
Miyagawa, J.7
Matsuzawa, Y.8
-
25
-
-
0030798068
-
Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4α in Caucasians with maturity onset NIDDM
-
DOI 10.1007/s001250050778
-
Moller AM, Urhammer SA, Dalgaard LT et al (1997) Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4α in Caucasians with maturity onset NIDDM. Diabetologia 40:980-983 (Pubitemid 27316582)
-
(1997)
Diabetologia
, vol.40
, Issue.8
, pp. 980-983
-
-
Moller, A.M.1
Urhammer, S.A.2
Dalgaard, L.T.3
Reneland, R.4
Berglund, L.5
Hansen, T.6
Clausen, J.O.7
Lithell, H.8
Pedersen, O.9
-
26
-
-
0033028606
-
Functional characterization of the MODY1 gene mutations HNF4(R127W), HNF4(V255M), and HNF4(E276Q)
-
DOI 10.2337/diabetes.48.7.1459
-
Navas MA, Munoz-Elias EJ, Kim J, Shih D, Stoffel M (1999) Functional characterization of the MODY1 gene mutations HNF4 (R127W), HNF4(V255M), and HNF4(E276Q). Diabetes 48:1459-1465 (Pubitemid 29297311) (Pubitemid 29297311)
-
(1999)
Diabetes
, vol.48
, Issue.7
, pp. 1459-1465
-
-
Navas, M.A.1
Munoz-Elias, E.J.2
Kim, J.3
Shih, D.4
Stoffel, M.5
-
27
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447:661-678
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
28
-
-
0034893106
-
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (The diabetes UK Warren 2 repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q
-
DOI 10.1086/323249
-
Wiltshire S, Hattersley AT, Hitman GA et al (2001) A genome-wide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet 69:553-569 (Pubitemid 32777694) (Pubitemid 32777694)
-
(2001)
American Journal of Human Genetics
, vol.69
, Issue.3
, pp. 553-569
-
-
Wiltshire, S.1
Hattersley, A.T.2
Hitman, G.A.3
Walker, M.4
Levy, J.C.5
Sampson, M.6
O'Rahilly, S.7
Frayling, T.M.8
Bell, J.I.9
Lathrop, G.M.10
Bennett, A.11
Dhillon, R.12
Fletcher, C.13
Groves, C.J.14
Jones, E.15
Prestwich, P.16
Simecek, N.17
Subba, R.P.V.18
Wishart, M.19
Foxon, R.20
Howell, S.21
Smedley, D.22
Cardon, L.R.23
Menzel, S.24
McCarthy, M.I.25
more..
-
29
-
-
0033808127
-
The ADDITION study: Proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with type 2 diabetes detected by screening
-
Lauritzen T, Griffin S, Borch-Johnsen K, Wareham NJ, Wolffenbuttel BH, Rutten G (2000) The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with type 2 diabetes detected by screening. Int J Obes Relat Metab Disord 24(Suppl 3):S6-S11
-
(2000)
Int J Obes Relat Metab Disord
, vol.24
, Issue.SUPPL. 3
-
-
Lauritzen, T.1
Griffin, S.2
Borch-Johnsen, K.3
Wareham, N.J.4
Wolffenbuttel, B.H.5
Rutten, G.6
-
30
-
-
65549163338
-
Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men
-
Stancakova A, Javorsky M, Kuulasmaa T, Haffner SM, Kuusisto J, LaaksoM(2009) Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men. Diabetes 58:1212-1221
-
(2009)
Diabetes
, vol.58
, pp. 1212-1221
-
-
Stancakova, A.1
Javorsky, M.2
Kuulasmaa, T.3
Haffner, S.M.4
Kuusisto, J.5
Laakso, M.6
-
31
-
-
25844509429
-
Variants in hepatocyte nuclear factor 4α are modestly associated with type 2 diabetes in Pima Indians
-
DOI 10.2337/diabetes.54.10.3035
-
Muller YL, Infante AM, Hanson RL et al (2005) Variants in hepatocyte nuclear factor 4α are modestly associated with type 2 diabetes in Pima Indians. Diabetes 54:3035-3039 (Pubitemid 41401105) (Pubitemid 41401105)
-
(2005)
Diabetes
, vol.54
, Issue.10
, pp. 3035-3039
-
-
Muller, Y.L.1
Infante, A.M.2
Hanson, R.L.3
Love-Gregory, L.4
Knowler, W.5
Bogardus, C.6
Baier, L.J.7
-
32
-
-
38349194536
-
High frequency of T130I mutation of HNF4A gene in Mexican patients with early-onset type 2 diabetes
-
MenjivarM, Granados-SilvestreMA,Montufar-Robles I et al (2008) High frequency of T130I mutation of HNF4A gene in Mexican patients with early-onset type 2 diabetes. Clin Genet 73:185-187
-
(2008)
Clin Genet
, vol.73
, pp. 185-187
-
-
Menjivar, M.1
Granados-Silvestre, M.A.2
Montufar-Robles, I.3
|