-
1
-
-
67349176115
-
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
-
Ahren, B., Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat. Rev. Drug Discov. 8 (2009), 369–385.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 369-385
-
-
Ahren, B.1
-
2
-
-
10744226187
-
Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene
-
Bacchelli, E., Blasi, F., Biondolillo, M., Lamb, J.A., Bonora, E., Barnby, G., Parr, J., Beyer, K.S., Klauck, S.M., Poustka, A., Bailey, A.J., Monaco, A.P., Maestrini, E., Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene. Mol. Psychiatry 8 (2003), 916–924.
-
(2003)
Mol. Psychiatry
, vol.8
, pp. 916-924
-
-
Bacchelli, E.1
Blasi, F.2
Biondolillo, M.3
Lamb, J.A.4
Bonora, E.5
Barnby, G.6
Parr, J.7
Beyer, K.S.8
Klauck, S.M.9
Poustka, A.10
Bailey, A.J.11
Monaco, A.P.12
Maestrini, E.13
-
3
-
-
0036310678
-
2 + channels accounts for first-phase insulin secretion in mouse beta-cells
-
2 + channels accounts for first-phase insulin secretion in mouse beta-cells. Diabetes 51:Suppl. 1 (2002), S74–S82.
-
(2002)
Diabetes
, vol.51
, pp. S74-S82
-
-
Barg, S.1
Eliasson, L.2
Renstrom, E.3
Rorsman, P.4
-
4
-
-
0032491319
-
PIP2 and PIP as determinants for ATP inhibition of KATP channels
-
Baukrowitz, T., Schulte, U., Oliver, D., Herlitze, S., Krauter, T., Tucker, S.J., Ruppersberg, J.P., Fakler, B., PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 282 (1998), 1141–1144.
-
(1998)
Science
, vol.282
, pp. 1141-1144
-
-
Baukrowitz, T.1
Schulte, U.2
Oliver, D.3
Herlitze, S.4
Krauter, T.5
Tucker, S.J.6
Ruppersberg, J.P.7
Fakler, B.8
-
5
-
-
0036729478
-
Cyclic nucleotide research — still expanding after half a century
-
Beavo, J.A., Brunton, L.L., Cyclic nucleotide research — still expanding after half a century. Nat. Rev. Mol. Cell Biol. 3 (2002), 710–718.
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 710-718
-
-
Beavo, J.A.1
Brunton, L.L.2
-
6
-
-
43549098268
-
Calcium cycling and signaling in cardiac myocytes
-
Bers, D.M., Calcium cycling and signaling in cardiac myocytes. Annu. Rev. Physiol. 70 (2008), 23–49.
-
(2008)
Annu. Rev. Physiol.
, vol.70
, pp. 23-49
-
-
Bers, D.M.1
-
7
-
-
33751241720
-
Epac proteins: multi-purpose cAMP targets
-
Bos, J.L., Epac proteins: multi-purpose cAMP targets. Trends Biochem. Sci. 31 (2006), 680–686.
-
(2006)
Trends Biochem. Sci.
, vol.31
, pp. 680-686
-
-
Bos, J.L.1
-
8
-
-
0036310679
-
Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion
-
Bratanova-Tochkova, T.K., Cheng, H., Daniel, S., Gunawardana, S., Liu, Y.J., Mulvaney-Musa, J., Schermerhorn, T., Straub, S.G., Yajima, H., Sharp, G.W., Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion. Diabetes 51:Suppl. 1 (2002), S83–S90.
-
(2002)
Diabetes
, vol.51
, pp. S83-S90
-
-
Bratanova-Tochkova, T.K.1
Cheng, H.2
Daniel, S.3
Gunawardana, S.4
Liu, Y.J.5
Mulvaney-Musa, J.6
Schermerhorn, T.7
Straub, S.G.8
Yajima, H.9
Sharp, G.W.10
-
9
-
-
0041315574
-
cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension
-
Christensen, A.E., Selheim, F., de Rooij, J., Dremier, S., Schwede, F., Dao, K.K., Martinez, A., Maenhaut, C., Bos, J.L., Genieser, H.G., Doskeland, S.O., cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J. Biol. Chem. 278 (2003), 35394–35402.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35394-35402
-
-
Christensen, A.E.1
Selheim, F.2
de Rooij, J.3
Dremier, S.4
Schwede, F.5
Dao, K.K.6
Martinez, A.7
Maenhaut, C.8
Bos, J.L.9
Genieser, H.G.10
Doskeland, S.O.11
-
10
-
-
84857947890
-
cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane
-
Consonni, S.V., Gloerich, M., Spanjaard, E., Bos, J.L., cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Proc. Natl. Acad. Sci. U. S. A. 109 (2012), 3814–3819.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
, pp. 3814-3819
-
-
Consonni, S.V.1
Gloerich, M.2
Spanjaard, E.3
Bos, J.L.4
-
11
-
-
0014336473
-
Dynamics of insulin secretion by the perfused rat pancreas
-
Curry, D.L., Bennett, L.L., Grodsky, G.M., Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 83 (1968), 572–584.
-
(1968)
Endocrinology
, vol.83
, pp. 572-584
-
-
Curry, D.L.1
Bennett, L.L.2
Grodsky, G.M.3
-
12
-
-
55649108863
-
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas
-
de Heer, J., Rasmussen, C., Coy, D.H., Holst, J.J., Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia 51 (2008), 2263–2270.
-
(2008)
Diabetologia
, vol.51
, pp. 2263-2270
-
-
de Heer, J.1
Rasmussen, C.2
Coy, D.H.3
Holst, J.J.4
-
13
-
-
77956399106
-
2 + channel-dependent exocytosis
-
2 + channel-dependent exocytosis. Cell Metab. 11 (2010), 543–553.
-
(2010)
Cell Metab.
, vol.11
, pp. 543-553
-
-
De Marinis, Y.Z.1
Salehi, A.2
Ward, C.E.3
Zhang, Q.4
Abdulkader, F.5
Bengtsson, M.6
Braha, O.7
Braun, M.8
Ramracheya, R.9
Amisten, S.10
Habib, A.M.11
Moritoh, Y.12
Zhang, E.13
Reimann, F.14
Rosengren, A.H.15
Shibasaki, T.16
Gribble, F.17
Renstrom, E.18
Seino, S.19
Eliasson, L.20
Rorsman, P.21
more..
-
14
-
-
0034617282
-
Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs
-
de Rooij, J., Rehmann, H., van Triest, M., Cool, R.H., Wittinghofer, A., Bos, J.L., Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. J. Biol. Chem. 275 (2000), 20829–20836.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 20829-20836
-
-
de Rooij, J.1
Rehmann, H.2
van Triest, M.3
Cool, R.H.4
Wittinghofer, A.5
Bos, J.L.6
-
15
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
-
de Rooij, J., Zwartkruis, F.J., Verheijen, M.H., Cool, R.H., Nijman, S.M., Wittinghofer, A., Bos, J.L., Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396 (1998), 474–477.
-
(1998)
Nature
, vol.396
, pp. 474-477
-
-
de Rooij, J.1
Zwartkruis, F.J.2
Verheijen, M.H.3
Cool, R.H.4
Nijman, S.M.5
Wittinghofer, A.6
Bos, J.L.7
-
16
-
-
33644618433
-
The biology of incretin hormones
-
Drucker, D.J., The biology of incretin hormones. Cell Metab. 3 (2006), 153–165.
-
(2006)
Cell Metab.
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
17
-
-
78650090455
-
Epac2-dependent mobilization of intracellular Ca(2)+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice
-
Dzhura, I., Chepurny, O.G., Kelley, G.G., Leech, C.A., Roe, M.W., Dzhura, E., Afshari, P., Malik, S., Rindler, M.J., Xu, X., Lu, Y., Smrcka, A.V., Holz, G.G., Epac2-dependent mobilization of intracellular Ca(2)+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice. J. Physiol. 588 (2010), 4871–4889.
-
(2010)
J. Physiol.
, vol.588
, pp. 4871-4889
-
-
Dzhura, I.1
Chepurny, O.G.2
Kelley, G.G.3
Leech, C.A.4
Roe, M.W.5
Dzhura, E.6
Afshari, P.7
Malik, S.8
Rindler, M.J.9
Xu, X.10
Lu, Y.11
Smrcka, A.V.12
Holz, G.G.13
-
18
-
-
79955793555
-
Phospholipase C-epsilon links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
-
Dzhura, I., Chepurny, O.G., Leech, C.A., Roe, M.W., Dzhura, E., Xu, X., Lu, Y., Schwede, F., Genieser, H.G., Smrcka, A.V., Holz, G.G., Phospholipase C-epsilon links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets 3 (2011), 121–128.
-
(2011)
Islets
, vol.3
, pp. 121-128
-
-
Dzhura, I.1
Chepurny, O.G.2
Leech, C.A.3
Roe, M.W.4
Dzhura, E.5
Xu, X.6
Lu, Y.7
Schwede, F.8
Genieser, H.G.9
Smrcka, A.V.10
Holz, G.G.11
-
19
-
-
70449116100
-
Beta-adrenergic stimulation and myocardial function in the failing heart
-
El-Armouche, A., Eschenhagen, T., Beta-adrenergic stimulation and myocardial function in the failing heart. Heart Fail. Rev. 14 (2009), 225–241.
-
(2009)
Heart Fail. Rev.
, vol.14
, pp. 225-241
-
-
El-Armouche, A.1
Eschenhagen, T.2
-
20
-
-
84898062722
-
Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells
-
Emery, A.C., Eiden, M.V., Eiden, L.E., Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells. J. Biol. Chem. 289 (2014), 10126–10139.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 10126-10139
-
-
Emery, A.C.1
Eiden, M.V.2
Eiden, L.E.3
-
21
-
-
85006314494
-
A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
-
Enserink, J.M., Christensen, A.E., de Rooij, J., van Triest, M., Schwede, F., Genieser, H.G., Doskeland, S.O., Blank, J.L., Bos, J.L., A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat. Cell Biol. 4 (2002), 901–906.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 901-906
-
-
Enserink, J.M.1
Christensen, A.E.2
de Rooij, J.3
van Triest, M.4
Schwede, F.5
Genieser, H.G.6
Doskeland, S.O.7
Blank, J.L.8
Bos, J.L.9
-
22
-
-
84929353459
-
Epac2 mediates cAMP-dependent potentiation of neurotransmission in the hippocampus
-
Fernandes, H.B., Riordan, S., Nomura, T., Remmers, C.L., Kraniotis, S., Marshall, J.J., Kukreja, L., Vassar, R., Contractor, A., Epac2 mediates cAMP-dependent potentiation of neurotransmission in the hippocampus. J. Neurosci. 35 (2015), 6544–6553.
-
(2015)
J. Neurosci.
, vol.35
, pp. 6544-6553
-
-
Fernandes, H.B.1
Riordan, S.2
Nomura, T.3
Remmers, C.L.4
Kraniotis, S.5
Marshall, J.J.6
Kukreja, L.7
Vassar, R.8
Contractor, A.9
-
23
-
-
77649191184
-
Rap1, a mercenary among the Ras-like GTPases
-
Frische, E.W., Zwartkruis, F.J., Rap1, a mercenary among the Ras-like GTPases. Dev. Biol. 340 (2010), 1–9.
-
(2010)
Dev. Biol.
, vol.340
, pp. 1-9
-
-
Frische, E.W.1
Zwartkruis, F.J.2
-
24
-
-
79952133231
-
Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway
-
Fu, D., Wakabayashi, Y., Lippincott-Schwartz, J., Arias, I.M., Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 1403–1408.
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
, pp. 1403-1408
-
-
Fu, D.1
Wakabayashi, Y.2
Lippincott-Schwartz, J.3
Arias, I.M.4
-
25
-
-
0037184610
-
2 + sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis
-
2 + sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. J. Biol. Chem. 277 (2002), 50497–50502.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50497-50502
-
-
Fujimoto, K.1
Shibasaki, T.2
Yokoi, N.3
Kashima, Y.4
Matsumoto, M.5
Sasaki, T.6
Tajima, N.7
Iwanaga, T.8
Seino, S.9
-
26
-
-
51149084357
-
Application of an Epac activator enhances neurotransmitter release at excitatory central synapses
-
Gekel, I., Neher, E., Application of an Epac activator enhances neurotransmitter release at excitatory central synapses. J. Neurosci. 28 (2008), 7991–8002.
-
(2008)
J. Neurosci.
, vol.28
, pp. 7991-8002
-
-
Gekel, I.1
Neher, E.2
-
27
-
-
44649103989
-
Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus
-
Gelinas, J.N., Banko, J.L., Peters, M.M., Klann, E., Weeber, E.J., Nguyen, P.V., Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learn. Mem. 15 (2008), 403–411.
-
(2008)
Learn. Mem.
, vol.15
, pp. 403-411
-
-
Gelinas, J.N.1
Banko, J.L.2
Peters, M.M.3
Klann, E.4
Weeber, E.J.5
Nguyen, P.V.6
-
28
-
-
80053111149
-
Regulating Rap small G-proteins in time and space
-
Gloerich, M., Bos, J.L., Regulating Rap small G-proteins in time and space. Trends Cell Biol. 21 (2011), 615–623.
-
(2011)
Trends Cell Biol.
, vol.21
, pp. 615-623
-
-
Gloerich, M.1
Bos, J.L.2
-
29
-
-
0029149848
-
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization
-
Gromada, J., Dissing, S., Bokvist, K., Renstrom, E., Frokjaer-Jensen, J., Wulff, B.S., Rorsman, P., Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization. Diabetes 44 (1995), 767–774.
-
(1995)
Diabetes
, vol.44
, pp. 767-774
-
-
Gromada, J.1
Dissing, S.2
Bokvist, K.3
Renstrom, E.4
Frokjaer-Jensen, J.5
Wulff, B.S.6
Rorsman, P.7
-
30
-
-
0033760442
-
Triggering and amplifying pathways of regulation of insulin secretion by glucose
-
Henquin, J.C., Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 49 (2000), 1751–1760.
-
(2000)
Diabetes
, vol.49
, pp. 1751-1760
-
-
Henquin, J.C.1
-
31
-
-
84879806575
-
DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms
-
Hoivik, E.A., Witsoe, S.L., Bergheim, I.R., Xu, Y., Jakobsson, I., Tengholm, A., Doskeland, S.O., Bakke, M., DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms. PLoS One, 8, 2013, e67925.
-
(2013)
PLoS One
, vol.8
-
-
Hoivik, E.A.1
Witsoe, S.L.2
Bergheim, I.R.3
Xu, Y.4
Jakobsson, I.5
Tengholm, A.6
Doskeland, S.O.7
Bakke, M.8
-
32
-
-
33750730215
-
Cell physiology of cAMP sensor Epac
-
Holz, G.G., Kang, G., Harbeck, M., Roe, M.W., Chepurny, O.G., Cell physiology of cAMP sensor Epac. J. Physiol. 577 (2006), 5–15.
-
(2006)
J. Physiol.
, vol.577
, pp. 5-15
-
-
Holz, G.G.1
Kang, G.2
Harbeck, M.3
Roe, M.W.4
Chepurny, O.G.5
-
34
-
-
56649083642
-
Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart
-
Hothi, S.S., Gurung, I.S., Heathcote, J.C., Zhang, Y., Booth, S.W., Skepper, J.N., Grace, A.A., Huang, C.L., Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart. Pflugers Arch. 457 (2008), 253–270.
-
(2008)
Pflugers Arch.
, vol.457
, pp. 253-270
-
-
Hothi, S.S.1
Gurung, I.S.2
Heathcote, J.C.3
Zhang, Y.4
Booth, S.W.5
Skepper, J.N.6
Grace, A.A.7
Huang, C.L.8
-
35
-
-
84885160578
-
Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop beta-cell dysfunction and metabolic syndrome
-
Kai, A.K., Lam, A.K., Chen, Y., Tai, A.C., Zhang, X., Lai, A.K., Yeung, P.K., Tam, S., Wang, J., Lam, K.S., Vanhoutte, P.M., Bos, J.L., Chung, S.S., Xu, A., Chung, S.K., Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop beta-cell dysfunction and metabolic syndrome. FASEB J. 27 (2013), 4122–4135.
-
(2013)
FASEB J.
, vol.27
, pp. 4122-4135
-
-
Kai, A.K.1
Lam, A.K.2
Chen, Y.3
Tai, A.C.4
Zhang, X.5
Lai, A.K.6
Yeung, P.K.7
Tam, S.8
Wang, J.9
Lam, K.S.10
Vanhoutte, P.M.11
Bos, J.L.12
Chung, S.S.13
Xu, A.14
Chung, S.K.15
-
37
-
-
33744939752
-
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells
-
Kang, G., Chepurny, O.G., Malester, B., Rindler, M.J., Rehmann, H., Bos, J.L., Schwede, F., Coetzee, W.A., Holz, G.G., cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J. Physiol. 573 (2006), 595–609.
-
(2006)
J. Physiol.
, vol.573
, pp. 595-609
-
-
Kang, G.1
Chepurny, O.G.2
Malester, B.3
Rindler, M.J.4
Rehmann, H.5
Bos, J.L.6
Schwede, F.7
Coetzee, W.A.8
Holz, G.G.9
-
38
-
-
0037424363
-
2 + release and exocytosis in pancreatic beta-cells
-
2 + release and exocytosis in pancreatic beta-cells. J. Biol. Chem. 278 (2003), 8279–8285.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8279-8285
-
-
Kang, G.1
Joseph, J.W.2
Chepurny, O.G.3
Monaco, M.4
Wheeler, M.B.5
Bos, J.L.6
Schwede, F.7
Genieser, H.G.8
Holz, G.G.9
-
39
-
-
0035824548
-
Critical role of cAMP-GEFII–Rim2 complex in incretin-potentiated insulin secretion
-
Kashima, Y., Miki, T., Shibasaki, T., Ozaki, N., Miyazaki, M., Yano, H., Seino, S., Critical role of cAMP-GEFII–Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 276 (2001), 46046–46053.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46046-46053
-
-
Kashima, Y.1
Miki, T.2
Shibasaki, T.3
Ozaki, N.4
Miyazaki, M.5
Yano, H.6
Seino, S.7
-
40
-
-
0032545328
-
A family of cAMP-binding proteins that directly activate Rap1
-
Kawasaki, H., Springett, G.M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D.E., Graybiel, A.M., A family of cAMP-binding proteins that directly activate Rap1. Science 282 (1998), 2275–2279.
-
(1998)
Science
, vol.282
, pp. 2275-2279
-
-
Kawasaki, H.1
Springett, G.M.2
Mochizuki, N.3
Toki, S.4
Nakaya, M.5
Matsuda, M.6
Housman, D.E.7
Graybiel, A.M.8
-
41
-
-
0035865293
-
Phospholipase C(epsilon): a novel Ras effector
-
Kelley, G.G., Reks, S.E., Ondrako, J.M., Smrcka, A.V., Phospholipase C(epsilon): a novel Ras effector. EMBO J. 20 (2001), 743–754.
-
(2001)
EMBO J.
, vol.20
, pp. 743-754
-
-
Kelley, G.G.1
Reks, S.E.2
Ondrako, J.M.3
Smrcka, A.V.4
-
42
-
-
28644449041
-
Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells
-
Kiermayer, S., Biondi, R.M., Imig, J., Plotz, G., Haupenthal, J., Zeuzem, S., Piiper, A., Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells. Mol. Biol. Cell 16 (2005), 5639–5648.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5639-5648
-
-
Kiermayer, S.1
Biondi, R.M.2
Imig, J.3
Plotz, G.4
Haupenthal, J.5
Zeuzem, S.6
Piiper, A.7
-
43
-
-
84877317750
-
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure
-
Kim, M., Platt, M.J., Shibasaki, T., Quaggin, S.E., Backx, P.H., Seino, S., Simpson, J.A., Drucker, D.J., GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat. Med. 19 (2013), 567–575.
-
(2013)
Nat. Med.
, vol.19
, pp. 567-575
-
-
Kim, M.1
Platt, M.J.2
Shibasaki, T.3
Quaggin, S.E.4
Backx, P.H.5
Seino, S.6
Simpson, J.A.7
Drucker, D.J.8
-
44
-
-
33646366678
-
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane
-
Li, Y., Asuri, S., Rebhun, J.F., Castro, A.F., Paranavitana, N.C., Quilliam, L.A., The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane. J. Biol. Chem. 281 (2006), 2506–2514.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 2506-2514
-
-
Li, Y.1
Asuri, S.2
Rebhun, J.F.3
Castro, A.F.4
Paranavitana, N.C.5
Quilliam, L.A.6
-
45
-
-
57349150591
-
Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2
-
Liu, C., Takahashi, M., Li, Y., Song, S., Dillon, T.J., Shinde, U., Stork, P.J., Ras is required for the cyclic AMP-dependent activation of Rap1 via Epac2. Mol. Cell. Biol. 28 (2008), 7109–7125.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 7109-7125
-
-
Liu, C.1
Takahashi, M.2
Li, Y.3
Song, S.4
Dillon, T.J.5
Shinde, U.6
Stork, P.J.7
-
46
-
-
77954532839
-
Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway
-
Metrich, M., Laurent, A.C., Breckler, M., Duquesnes, N., Hmitou, I., Courillau, D., Blondeau, J.P., Crozatier, B., Lezoualc'h, F., Morel, E., Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway. Cell. Signal. 22 (2010), 1459–1468.
-
(2010)
Cell. Signal.
, vol.22
, pp. 1459-1468
-
-
Metrich, M.1
Laurent, A.C.2
Breckler, M.3
Duquesnes, N.4
Hmitou, I.5
Courillau, D.6
Blondeau, J.P.7
Crozatier, B.8
Lezoualc'h, F.9
Morel, E.10
-
47
-
-
42549128214
-
Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy
-
Metrich, M., Lucas, A., Gastineau, M., Samuel, J.L., Heymes, C., Morel, E., Lezoualc'h, F., Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Circ. Res. 102 (2008), 959–965.
-
(2008)
Circ. Res.
, vol.102
, pp. 959-965
-
-
Metrich, M.1
Lucas, A.2
Gastineau, M.3
Samuel, J.L.4
Heymes, C.5
Morel, E.6
Lezoualc'h, F.7
-
48
-
-
0015390201
-
The mode of action of adenosine 3′:5′-cyclic monophosphate in mammalian islets of Langerhans. Preparation and properties of islet-cell protein phosphokinase
-
Montague, W., Howell, S.L., The mode of action of adenosine 3′:5′-cyclic monophosphate in mammalian islets of Langerhans. Preparation and properties of islet-cell protein phosphokinase. Biochem. J. 129 (1972), 551–560.
-
(1972)
Biochem. J.
, vol.129
, pp. 551-560
-
-
Montague, W.1
Howell, S.L.2
-
49
-
-
33644667603
-
cAMP-binding protein Epac induces cardiomyocyte hypertrophy
-
Morel, E., Marcantoni, A., Gastineau, M., Birkedal, R., Rochais, F., Garnier, A., Lompre, A.M., Vandecasteele, G., Lezoualc'h, F., cAMP-binding protein Epac induces cardiomyocyte hypertrophy. Circ. Res. 97 (2005), 1296–1304.
-
(2005)
Circ. Res.
, vol.97
, pp. 1296-1304
-
-
Morel, E.1
Marcantoni, A.2
Gastineau, M.3
Birkedal, R.4
Rochais, F.5
Garnier, A.6
Lompre, A.M.7
Vandecasteele, G.8
Lezoualc'h, F.9
-
50
-
-
47749143964
-
Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration
-
Murray, A.J., Shewan, D.A., Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration. Mol. Cell. Neurosci. 38 (2008), 578–588.
-
(2008)
Mol. Cell. Neurosci.
, vol.38
, pp. 578-588
-
-
Murray, A.J.1
Shewan, D.A.2
-
51
-
-
67049155251
-
Unraveling the science of incretin biology
-
Nauck, M.A., Unraveling the science of incretin biology. Am. J. Med. 122 (2009), S3–S10.
-
(2009)
Am. J. Med.
, vol.122
, pp. S3-S10
-
-
Nauck, M.A.1
-
52
-
-
64549105338
-
Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function
-
Niimura, M., Miki, T., Shibasaki, T., Fujimoto, W., Iwanaga, T., Seino, S., Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function. J. Cell. Physiol. 219 (2009), 652–658.
-
(2009)
J. Cell. Physiol.
, vol.219
, pp. 652-658
-
-
Niimura, M.1
Miki, T.2
Shibasaki, T.3
Fujimoto, W.4
Iwanaga, T.5
Seino, S.6
-
53
-
-
49549107515
-
Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation
-
Nijholt, I.M., Dolga, A.M., Ostroveanu, A., Luiten, P.G., Schmidt, M., Eisel, U.L., Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation. Cell. Signal. 20 (2008), 1715–1724.
-
(2008)
Cell. Signal.
, vol.20
, pp. 1715-1724
-
-
Nijholt, I.M.1
Dolga, A.M.2
Ostroveanu, A.3
Luiten, P.G.4
Schmidt, M.5
Eisel, U.L.6
-
54
-
-
77956831579
-
Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval
-
Ostroveanu, A., van der Zee, E.A., Eisel, U.L., Schmidt, M., Nijholt, I.M., Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus 20 (2010), 1018–1026.
-
(2010)
Hippocampus
, vol.20
, pp. 1018-1026
-
-
Ostroveanu, A.1
van der Zee, E.A.2
Eisel, U.L.3
Schmidt, M.4
Nijholt, I.M.5
-
55
-
-
0033769693
-
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
-
Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Matsuura, Y., Iwanaga, T., Takai, Y., Seino, S., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat. Cell Biol. 2 (2000), 805–811.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 805-811
-
-
Ozaki, N.1
Shibasaki, T.2
Kashima, Y.3
Miki, T.4
Takahashi, K.5
Ueno, H.6
Sunaga, Y.7
Yano, H.8
Matsuura, Y.9
Iwanaga, T.10
Takai, Y.11
Seino, S.12
-
56
-
-
84862945912
-
Glucagon-like peptide-1 enhances glucokinase activity in pancreatic beta-cells through the association of Epac2 with Rim2 and Rab3A
-
Park, J.H., Kim, S.J., Park, S.H., Son, D.G., Bae, J.H., Kim, H.K., Han, J., Song, D.K., Glucagon-like peptide-1 enhances glucokinase activity in pancreatic beta-cells through the association of Epac2 with Rim2 and Rab3A. Endocrinology 153 (2012), 574–582.
-
(2012)
Endocrinology
, vol.153
, pp. 574-582
-
-
Park, J.H.1
Kim, S.J.2
Park, S.H.3
Son, D.G.4
Bae, J.H.5
Kim, H.K.6
Han, J.7
Song, D.K.8
-
57
-
-
84939971446
-
The future of EPAC-targeted therapies: agonism versus antagonism
-
Parnell, E., Palmer, T.M., Yarwood, S.J., The future of EPAC-targeted therapies: agonism versus antagonism. Trends Pharmacol. Sci. 36 (2015), 203–214.
-
(2015)
Trends Pharmacol. Sci.
, vol.36
, pp. 203-214
-
-
Parnell, E.1
Palmer, T.M.2
Yarwood, S.J.3
-
58
-
-
78751703574
-
Epac2-mediated dendritic spine remodeling: implications for disease
-
Penzes, P., Woolfrey, K.M., Srivastava, D.P., Epac2-mediated dendritic spine remodeling: implications for disease. Mol. Cell. Neurosci. 46 (2011), 368–380.
-
(2011)
Mol. Cell. Neurosci.
, vol.46
, pp. 368-380
-
-
Penzes, P.1
Woolfrey, K.M.2
Srivastava, D.P.3
-
59
-
-
84874472807
-
2 + leak and arrhythmia
-
2 + leak and arrhythmia. Circulation 127 (2013), 913–922.
-
(2013)
Circulation
, vol.127
, pp. 913-922
-
-
Pereira, L.1
Cheng, H.2
Lao, D.H.3
Na, L.4
van Oort, R.J.5
Brown, J.H.6
Wehrens, X.H.7
Chen, J.8
Bers, D.M.9
-
60
-
-
84961374070
-
Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes
-
Pereira, L., Rehmann, H., Lao, D.H., Erickson, J.R., Bossuyt, J., Chen, J., Bers, D.M., Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 3991–3996.
-
(2015)
Proc. Natl. Acad. Sci. U. S. A.
, vol.112
, pp. 3991-3996
-
-
Pereira, L.1
Rehmann, H.2
Lao, D.H.3
Erickson, J.R.4
Bossuyt, J.5
Chen, J.6
Bers, D.M.7
-
61
-
-
84155186284
-
Epac enhances excitation-transcription coupling in cardiac myocytes
-
Pereira, L., Ruiz-Hurtado, G., Morel, E., Laurent, A.C., Metrich, M., Dominguez-Rodriguez, A., Lauton-Santos, S., Lucas, A., Benitah, J.P., Bers, D.M., Lezoualc'h, F., Gomez, A.M., Epac enhances excitation-transcription coupling in cardiac myocytes. J. Mol. Cell. Cardiol. 52 (2012), 283–291.
-
(2012)
J. Mol. Cell. Cardiol.
, vol.52
, pp. 283-291
-
-
Pereira, L.1
Ruiz-Hurtado, G.2
Morel, E.3
Laurent, A.C.4
Metrich, M.5
Dominguez-Rodriguez, A.6
Lauton-Santos, S.7
Lucas, A.8
Benitah, J.P.9
Bers, D.M.10
Lezoualc'h, F.11
Gomez, A.M.12
-
62
-
-
0037135592
-
Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP
-
Qiao, J., Mei, F.C., Popov, V.L., Vergara, L.A., Cheng, X., Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. J. Biol. Chem. 277 (2002), 26581–26586.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26581-26586
-
-
Qiao, J.1
Mei, F.C.2
Popov, V.L.3
Vergara, L.A.4
Cheng, X.5
-
63
-
-
55049124487
-
Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes
-
Quesada, I., Tuduri, E., Ripoll, C., Nadal, A., Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. J. Endocrinol. 199 (2008), 5–19.
-
(2008)
J. Endocrinol.
, vol.199
, pp. 5-19
-
-
Quesada, I.1
Tuduri, E.2
Ripoll, C.3
Nadal, A.4
-
64
-
-
84856285651
-
Epac2: a sulfonylurea receptor?
-
Rehmann, H., Epac2: a sulfonylurea receptor?. Biochem. Soc. Trans. 40 (2012), 6–10.
-
(2012)
Biochem. Soc. Trans.
, vol.40
, pp. 6-10
-
-
Rehmann, H.1
-
65
-
-
51349150613
-
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B
-
Rehmann, H., Arias-Palomo, E., Hadders, M.A., Schwede, F., Llorca, O., Bos, J.L., Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature 455 (2008), 124–127.
-
(2008)
Nature
, vol.455
, pp. 124-127
-
-
Rehmann, H.1
Arias-Palomo, E.2
Hadders, M.A.3
Schwede, F.4
Llorca, O.5
Bos, J.L.6
-
66
-
-
31844447089
-
Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state
-
Rehmann, H., Das, J., Knipscheer, P., Wittinghofer, A., Bos, J.L., Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature 439 (2006), 625–628.
-
(2006)
Nature
, vol.439
, pp. 625-628
-
-
Rehmann, H.1
Das, J.2
Knipscheer, P.3
Wittinghofer, A.4
Bos, J.L.5
-
67
-
-
0030792753
-
Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic β-cells
-
Renstrom, E., Eliasson, L., Rorsman, P., Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic β-cells. J. Physiol. 502:Pt 1 (1997), 105–118.
-
(1997)
J. Physiol.
, vol.502
, pp. 105-118
-
-
Renstrom, E.1
Eliasson, L.2
Rorsman, P.3
-
68
-
-
44449135977
-
Epac: effectors and biological functions
-
Roscioni, S.S., Elzinga, C.R., Schmidt, M., Epac: effectors and biological functions. Naunyn Schmiedeberg's Arch. Pharmacol. 377 (2008), 345–357.
-
(2008)
Naunyn Schmiedeberg's Arch. Pharmacol.
, vol.377
, pp. 345-357
-
-
Roscioni, S.S.1
Elzinga, C.R.2
Schmidt, M.3
-
69
-
-
0035793039
-
Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held
-
Sakaba, T., Neher, E., Preferential potentiation of fast-releasing synaptic vesicles by cAMP at the calyx of Held. Proc. Natl. Acad. Sci. U. S. A. 98 (2001), 331–336.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 331-336
-
-
Sakaba, T.1
Neher, E.2
-
70
-
-
84926648779
-
Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease
-
Sandoval, D.A., D'Alessio, D.A., Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol. Rev. 95 (2015), 513–548.
-
(2015)
Physiol. Rev.
, vol.95
, pp. 513-548
-
-
Sandoval, D.A.1
D'Alessio, D.A.2
-
71
-
-
84880939628
-
Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions
-
Schmidt, M., Dekker, F.J., Maarsingh, H., Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol. Rev. 65 (2013), 670–709.
-
(2013)
Pharmacol. Rev.
, vol.65
, pp. 670-709
-
-
Schmidt, M.1
Dekker, F.J.2
Maarsingh, H.3
-
72
-
-
0035735452
-
A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase
-
Schmidt, M., Evellin, S., Weernink, P.A., von Dorp, F., Rehmann, H., Lomasney, J.W., Jakobs, K.H., A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat. Cell Biol. 3 (2001), 1020–1024.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 1020-1024
-
-
Schmidt, M.1
Evellin, S.2
Weernink, P.A.3
von Dorp, F.4
Rehmann, H.5
Lomasney, J.W.6
Jakobs, K.H.7
-
73
-
-
84922235719
-
Structure-guided design of selective Epac1 and Epac2 agonists
-
Schwede, F., Bertinetti, D., Langerijs, C.N., Hadders, M.A., Wienk, H., Ellenbroek, J.H., de Koning, E.J., Bos, J.L., Herberg, F.W., Genieser, H.G., Janssen, R.A., Rehmann, H., Structure-guided design of selective Epac1 and Epac2 agonists. PLoS Biol., 13, 2015, e1002038.
-
(2015)
PLoS Biol.
, vol.13
-
-
Schwede, F.1
Bertinetti, D.2
Langerijs, C.N.3
Hadders, M.A.4
Wienk, H.5
Ellenbroek, J.H.6
de Koning, E.J.7
Bos, J.L.8
Herberg, F.W.9
Genieser, H.G.10
Janssen, R.A.11
Rehmann, H.12
-
74
-
-
79957900616
-
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
-
Seino, S., Shibasaki, T., Minami, K., Dynamics of insulin secretion and the clinical implications for obesity and diabetes. J. Clin. Invest. 121 (2011), 2118–2125.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 2118-2125
-
-
Seino, S.1
Shibasaki, T.2
Minami, K.3
-
75
-
-
78650903000
-
GIP and GLP-1, the two incretin hormones: similarities and differences
-
Seino, Y., Fukushima, M., Yabe, D., GIP and GLP-1, the two incretin hormones: similarities and differences. J. Diabetes Investig. 1 (2010), 8–23.
-
(2010)
J. Diabetes Investig.
, vol.1
, pp. 8-23
-
-
Seino, Y.1
Fukushima, M.2
Yabe, D.3
-
77
-
-
37649002935
-
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
-
Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J., Seino, S., Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc. Natl. Acad. Sci. U. S. A. 104 (2007), 19333–19338.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 19333-19338
-
-
Shibasaki, T.1
Takahashi, H.2
Miki, T.3
Sunaga, Y.4
Matsumura, K.5
Yamanaka, M.6
Zhang, C.7
Tamamoto, A.8
Satoh, T.9
Miyazaki, J.10
Seino, S.11
-
78
-
-
0037153376
-
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon
-
Song, C., Satoh, T., Edamatsu, H., Wu, D., Tadano, M., Gao, X., Kataoka, T., Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. Oncogene 21 (2002), 8105–8113.
-
(2002)
Oncogene
, vol.21
, pp. 8105-8113
-
-
Song, C.1
Satoh, T.2
Edamatsu, H.3
Wu, D.4
Tadano, M.5
Gao, X.6
Kataoka, T.7
-
79
-
-
84865221702
-
Social, communication, and cortical structural impairments in Epac2-deficient mice
-
Srivastava, D.P., Jones, K.A., Woolfrey, K.M., Burgdorf, J., Russell, T.A., Kalmbach, A., Lee, H., Yang, C., Bradberry, M.M., Wokosin, D., Moskal, J.R., Casanova, M.F., Waters, J., Penzes, P., Social, communication, and cortical structural impairments in Epac2-deficient mice. J. Neurosci. 32 (2012), 11864–11878.
-
(2012)
J. Neurosci.
, vol.32
, pp. 11864-11878
-
-
Srivastava, D.P.1
Jones, K.A.2
Woolfrey, K.M.3
Burgdorf, J.4
Russell, T.A.5
Kalmbach, A.6
Lee, H.7
Yang, C.8
Bradberry, M.M.9
Wokosin, D.10
Moskal, J.R.11
Casanova, M.F.12
Waters, J.13
Penzes, P.14
-
80
-
-
84863668613
-
An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice
-
Srivastava, D.P., Woolfrey, K.M., Jones, K.A., Anderson, C.T., Smith, K.R., Russell, T.A., Lee, H., Yasvoina, M.V., Wokosin, D.L., Ozdinler, P.H., Shepherd, G.M., Penzes, P., An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol., 10, 2012, e1001350.
-
(2012)
PLoS Biol.
, vol.10
-
-
Srivastava, D.P.1
Woolfrey, K.M.2
Jones, K.A.3
Anderson, C.T.4
Smith, K.R.5
Russell, T.A.6
Lee, H.7
Yasvoina, M.V.8
Wokosin, D.L.9
Ozdinler, P.H.10
Shepherd, G.M.11
Penzes, P.12
-
81
-
-
58149295113
-
Epac mediates PACAP-dependent long-term depression in the hippocampus
-
Ster, J., de Bock, F., Bertaso, F., Abitbol, K., Daniel, H., Bockaert, J., Fagni, L., Epac mediates PACAP-dependent long-term depression in the hippocampus. J. Physiol. 587 (2009), 101–113.
-
(2009)
J. Physiol.
, vol.587
, pp. 101-113
-
-
Ster, J.1
de Bock, F.2
Bertaso, F.3
Abitbol, K.4
Daniel, H.5
Bockaert, J.6
Fagni, L.7
-
82
-
-
84928907433
-
Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion
-
Takahashi, H., Shibasaki, T., Park, J.H., Hidaka, S., Takahashi, T., Ono, A., Song, D.K., Seino, S., Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion. Diabetes 64 (2015), 1262–1272.
-
(2015)
Diabetes
, vol.64
, pp. 1262-1272
-
-
Takahashi, H.1
Shibasaki, T.2
Park, J.H.3
Hidaka, S.4
Takahashi, T.5
Ono, A.6
Song, D.K.7
Seino, S.8
-
83
-
-
84886737102
-
Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A
-
Takahashi, T., Shibasaki, T., Takahashi, H., Sugawara, K., Ono, A., Inoue, N., Furuya, T., Seino, S., Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A. Sci. Signal., 6, 2013, ra94.
-
(2013)
Sci. Signal.
, vol.6
-
-
Takahashi, T.1
Shibasaki, T.2
Takahashi, H.3
Sugawara, K.4
Ono, A.5
Inoue, N.6
Furuya, T.7
Seino, S.8
-
84
-
-
0026775150
-
Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1
-
Thorens, B., Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc. Natl. Acad. Sci. U. S. A. 89 (1992), 8641–8645.
-
(1992)
Proc. Natl. Acad. Sci. U. S. A.
, vol.89
, pp. 8641-8645
-
-
Thorens, B.1
-
85
-
-
79951696645
-
Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs
-
Tsalkova, T., Gribenko, A.V., Cheng, X., Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs. Assay Drug Dev. Technol. 9 (2011), 88–91.
-
(2011)
Assay Drug Dev. Technol.
, vol.9
, pp. 88-91
-
-
Tsalkova, T.1
Gribenko, A.V.2
Cheng, X.3
-
87
-
-
84883681341
-
Actin dynamics regulated by the balance of neuronal Wiskott–Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion
-
Uenishi, E., Shibasaki, T., Takahashi, H., Seki, C., Hamaguchi, H., Yasuda, T., Tatebe, M., Oiso, Y., Takenawa, T., Seino, S., Actin dynamics regulated by the balance of neuronal Wiskott–Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion. J. Biol. Chem. 288 (2013), 25851–25864.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 25851-25864
-
-
Uenishi, E.1
Shibasaki, T.2
Takahashi, H.3
Seki, C.4
Hamaguchi, H.5
Yasuda, T.6
Tatebe, M.7
Oiso, Y.8
Takenawa, T.9
Seino, S.10
-
88
-
-
0034759763
-
Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform
-
Ueno, H., Shibasaki, T., Iwanaga, T., Takahashi, K., Yokoyama, Y., Liu, L.M., Yokoi, N., Ozaki, N., Matsukura, S., Yano, H., Seino, S., Characterization of the gene EPAC2: structure, chromosomal localization, tissue expression, and identification of the liver-specific isoform. Genomics 78 (2001), 91–98.
-
(2001)
Genomics
, vol.78
, pp. 91-98
-
-
Ueno, H.1
Shibasaki, T.2
Iwanaga, T.3
Takahashi, K.4
Yokoyama, Y.5
Liu, L.M.6
Yokoi, N.7
Ozaki, N.8
Matsukura, S.9
Yano, H.10
Seino, S.11
-
89
-
-
34548385746
-
Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy
-
Ulucan, C., Wang, X., Baljinnyam, E., Bai, Y., Okumura, S., Sato, M., Minamisawa, S., Hirotani, S., Ishikawa, Y., Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am. J. Physiol. Heart Circ. Physiol. 293 (2007), H1662–H1672.
-
(2007)
Am. J. Physiol. Heart Circ. Physiol.
, vol.293
, pp. H1662-H1672
-
-
Ulucan, C.1
Wang, X.2
Baljinnyam, E.3
Bai, Y.4
Okumura, S.5
Sato, M.6
Minamisawa, S.7
Hirotani, S.8
Ishikawa, Y.9
-
90
-
-
0027136670
-
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
-
Usdin, T.B., Mezey, E., Button, D.C., Brownstein, M.J., Bonner, T.I., Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133 (1993), 2861–2870.
-
(1993)
Endocrinology
, vol.133
, pp. 2861-2870
-
-
Usdin, T.B.1
Mezey, E.2
Button, D.C.3
Brownstein, M.J.4
Bonner, T.I.5
-
91
-
-
54349106705
-
8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue
-
Vliem, M.J., Ponsioen, B., Schwede, F., Pannekoek, W.J., Riedl, J., Kooistra, M.R., Jalink, K., Genieser, H.G., Bos, J.L., Rehmann, H., 8-pCPT-2′-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem 9 (2008), 2052–2054.
-
(2008)
Chembiochem
, vol.9
, pp. 2052-2054
-
-
Vliem, M.J.1
Ponsioen, B.2
Schwede, F.3
Pannekoek, W.J.4
Riedl, J.5
Kooistra, M.R.6
Jalink, K.7
Genieser, H.G.8
Bos, J.L.9
Rehmann, H.10
-
92
-
-
34248219593
-
Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
-
Wang, Z., Oh, E., Thurmond, D.C., Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion. J. Biol. Chem. 282 (2007), 9536–9546.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9536-9546
-
-
Wang, Z.1
Oh, E.2
Thurmond, D.C.3
-
93
-
-
70349559570
-
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines
-
Woolfrey, K.M., Srivastava, D.P., Photowala, H., Yamashita, M., Barbolina, M.V., Cahill, M.E., Xie, Z., Jones, K.A., Quilliam, L.A., Prakriya, M., Penzes, P., Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. Nat. Neurosci. 12 (2009), 1275–1284.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 1275-1284
-
-
Woolfrey, K.M.1
Srivastava, D.P.2
Photowala, H.3
Yamashita, M.4
Barbolina, M.V.5
Cahill, M.E.6
Xie, Z.7
Jones, K.A.8
Quilliam, L.A.9
Prakriya, M.10
Penzes, P.11
-
94
-
-
0028847462
-
Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA
-
Yamada, Y., Hayami, T., Nakamura, K., Kaisaki, P.J., Someya, Y., Wang, C.Z., Seino, S., Seino, Y., Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA. Genomics 29 (1995), 773–776.
-
(1995)
Genomics
, vol.29
, pp. 773-776
-
-
Yamada, Y.1
Hayami, T.2
Nakamura, K.3
Kaisaki, P.J.4
Someya, Y.5
Wang, C.Z.6
Seino, S.7
Seino, Y.8
-
95
-
-
84863154673
-
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation
-
Yang, Y., Shu, X., Liu, D., Shang, Y., Wu, Y., Pei, L., Xu, X., Tian, Q., Zhang, J., Qian, K., Wang, Y.X., Petralia, R.S., Tu, W., Zhu, L.Q., Wang, J.Z., Lu, Y., EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron 73 (2012), 774–788.
-
(2012)
Neuron
, vol.73
, pp. 774-788
-
-
Yang, Y.1
Shu, X.2
Liu, D.3
Shang, Y.4
Wu, Y.5
Pei, L.6
Xu, X.7
Tian, Q.8
Zhang, J.9
Qian, K.10
Wang, Y.X.11
Petralia, R.S.12
Tu, W.13
Zhu, L.Q.14
Wang, J.Z.15
Lu, Y.16
-
96
-
-
79957904659
-
Rim2alpha determines docking and priming states in insulin granule exocytosis
-
Yasuda, T., Shibasaki, T., Minami, K., Takahashi, H., Mizoguchi, A., Uriu, Y., Numata, T., Mori, Y., Miyazaki, J., Miki, T., Seino, S., Rim2alpha determines docking and priming states in insulin granule exocytosis. Cell Metab. 12 (2010), 117–129.
-
(2010)
Cell Metab.
, vol.12
, pp. 117-129
-
-
Yasuda, T.1
Shibasaki, T.2
Minami, K.3
Takahashi, H.4
Mizoguchi, A.5
Uriu, Y.6
Numata, T.7
Mori, Y.8
Miyazaki, J.9
Miki, T.10
Seino, S.11
-
97
-
-
68149136367
-
The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs
-
Zhang, C.L., Katoh, M., Shibasaki, T., Minami, K., Sunaga, Y., Takahashi, H., Yokoi, N., Iwasaki, M., Miki, T., Seino, S., The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 325 (2009), 607–610.
-
(2009)
Science
, vol.325
, pp. 607-610
-
-
Zhang, C.L.1
Katoh, M.2
Shibasaki, T.3
Minami, K.4
Sunaga, Y.5
Takahashi, H.6
Yokoi, N.7
Iwasaki, M.8
Miki, T.9
Seino, S.10
-
98
-
-
12144255117
-
cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction
-
Zhong, N., Zucker, R.S., cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange protein to regulate transmitter release at the crayfish neuromuscular junction. J. Neurosci. 25 (2005), 208–214.
-
(2005)
J. Neurosci.
, vol.25
, pp. 208-214
-
-
Zhong, N.1
Zucker, R.S.2
|