Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Nature Neuroscience

Volumn 12, Issue 10, 2009, Pages 1275-1284

  Woolfrey, Kevin M ^a   Srivastava, Deepak P ^a   Photowala, Huzefa ^a   Yamashita, Megumi ^a   Barbolina, Maria V ^b   Cahill, Michael E ^a   Xie, Zhong ^a   Jones, Kelly A ^a   Quilliam, Lawrence A ^c   Prakriya, Murali ^a   Penzes, Peter ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 1 RECEPTOR; GLUTAMATE RECEPTOR 2; MEMBRANE PROTEIN; NEUROLIGIN; PROTEIN EPAC2; RAP PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; COMPLEX FORMATION; CONTROLLED STUDY; MISSENSE MUTATION; MORPHOGENESIS; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SPINE MOBILITY; SYNAPSE; SYNAPTIC TRANSMISSION;

ANIMALS; CELL ADHESION MOLECULES; CELL MOVEMENT; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CEREBRAL CORTEX; DENDRITIC SPINES; DEPRESSION; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; POINT MUTATION; RAP1 GTP-BINDING PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; RNA, SMALL INTERFERING; SYNAPSES; SYNAPTIC TRANSMISSION; THEOPHYLLINE; TRANSFECTION;

EID: 70349559570     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2386     Document Type: Article

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