-
1
-
-
79955770162
-
Scaffold proteins: Hubs for controlling the flow of cellular information
-
Good, M. C., Zalatan, J. G. & Lim, W. A. Scaffold proteins: hubs for controlling the flow of cellular information. Science 332, 680-686 (2011).
-
(2011)
Science
, vol.332
, pp. 680-686
-
-
Good, M.C.1
Zalatan, J.G.2
Lim, W.A.3
-
2
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
Lemmon, M. A. & Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell 141, 1117-1134 (2010).
-
(2010)
Cell
, vol.141
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
3
-
-
9644268238
-
Structural and evolutionary division of phosphotyrosine binding (PTB) domains
-
Uhlik, M. T. et al. Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J. Mol. Biol. 345, 1-20 (2005).
-
(2005)
J. Mol. Biol.
, vol.345
, pp. 1-20
-
-
Uhlik, M.T.1
-
4
-
-
0033669885
-
Evolutionof Shc functions from nematode to human
-
Luzi, L.,Confalonieri, S., Di Fiore, P. P.&Pelicci, P. G. EvolutionofShc functions from nematode to human. Curr. Opin. Genet. Dev. 10, 668-674 (2000).
-
(2000)
Curr. Opin. Genet. Dev.
, vol.10
, pp. 668-674
-
-
Luzi, L.1
Confalonieri, S.2
Di Fiore, P.P.3
Pelicci, P.G.4
-
5
-
-
0030293986
-
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
-
van der Geer, P., Wiley, S., Gish, G. D.&Pawson, T. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions. Curr. Biol. 6, 1435-1444 (1996).
-
(1996)
Curr. Biol.
, vol.6
, pp. 1435-1444
-
-
Van Der Geer, P.1
Wiley, S.2
Gish, G.D.3
Pawson, T.4
-
6
-
-
33847718707
-
Dynamic control of signaling by modular adaptor proteins
-
Pawson, T. Dynamic control of signaling by modular adaptor proteins. Curr. Opin. Cell Biol. 19, 112-116 (2007).
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 112-116
-
-
Pawson, T.1
-
7
-
-
79960245388
-
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor
-
Bisson, N. et al. Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. Nature Biotechnol. 29, 653-658 (2011).
-
(2011)
Nature Biotechnol.
, vol.29
, pp. 653-658
-
-
Bisson, N.1
-
8
-
-
34447513028
-
Combinatorial ShcA docking interactions support diversity in tissue morphogenesis
-
Hardy, W. R. et al. Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science 317, 251-256 (2007).
-
(2007)
Science
, vol.317
, pp. 251-256
-
-
Hardy, W.R.1
-
9
-
-
0035137171
-
Grb2andShc adapter proteins play distinct roles inNeu(ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer
-
Dankort, D. et al. Grb2andShc adapter proteins play distinct roles inNeu(ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Mol. Cell. Biol. 21, 1540-1551 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 1540-1551
-
-
Dankort, D.1
-
10
-
-
40949130063
-
ShcA signalling is essential for tumour progression in mouse models of human breast cancer
-
Ursini-Siegel, J. et al. ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J. 27, 910-920 (2008).
-
(2008)
EMBO J
, vol.27
, pp. 910-920
-
-
Ursini-Siegel, J.1
-
11
-
-
79251616305
-
The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function
-
Vanderlaan, R. D. et al. The ShcA phosphotyrosine docking protein uses distinct mechanisms to regulate myocyte and global heart function. Circ. Res. 108, 184-193 (2011).
-
(2011)
Circ. Res.
, vol.108
, pp. 184-193
-
-
Vanderlaan, R.D.1
-
12
-
-
0029912575
-
Interaction of Shc with adaptor protein adaptins
-
Okabayashi, Y. et al. Interaction of Shc with adaptor protein adaptins. J. Biol. Chem. 271, 5265-5269 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5265-5269
-
-
Okabayashi, Y.1
-
13
-
-
0037119469
-
Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling
-
Faisal, A., el-Shemerly, M., Hess, D. & Nagamine, Y. Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling. J. Biol. Chem. 277, 30144-30152 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30144-30152
-
-
Faisal, A.1
El-Shemerly, M.2
Hess, D.3
Nagamine, Y.4
-
14
-
-
0034194470
-
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
-
Lai, K. M. & Pawson, T. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 14, 1132-1145 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 1132-1145
-
-
Lai, K.M.1
Pawson, T.2
-
15
-
-
77749297990
-
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kB
-
Min, J. et al. An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kB. Nature Med. 16, 286-294 (2010).
-
(2010)
Nature Med.
, vol.16
, pp. 286-294
-
-
Min, J.1
-
16
-
-
77954643220
-
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeletonand cancer progression.Proc.NatlAcad
-
Wang, Y. et al. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeletonand cancer progression.Proc.NatlAcad. Sci.USA107,10920-10925 (2010).
-
(2010)
Sci.USA
, vol.107
, pp. 10920-10925
-
-
Wang, Y.1
-
17
-
-
77951622782
-
ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients
-
Mü ller, T. et al. ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients. Oncogene 29, 2393-2403 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 2393-2403
-
-
Müller, T.1
-
18
-
-
0034074857
-
A new paxillin-binding protein, PAG3/Papa/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration
-
Kondo, A. et al. A new paxillin-binding protein, PAG3/Papa/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. Mol. Biol. Cell 11, 1315-1327 (2000).
-
(2000)
Mol. Biol. Cell
, vol.11
, pp. 1315-1327
-
-
Kondo, A.1
-
19
-
-
79956139704
-
The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation
-
Kuroiwa, M., Oneyama, C., Nada, S. & Okada, M. The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J. Cell Sci. 124, 1726-1738 (2011).
-
(2011)
J. Cell Sci.
, vol.124
, pp. 1726-1738
-
-
Kuroiwa, M.1
Oneyama, C.2
Nada, S.3
Okada, M.4
-
20
-
-
10744230322
-
Expression and molecular characterization of alternative transcripts of the ARHGEF5/TIM oncogene specific for human breast cancer
-
Debily, M. A. et al. Expression and molecular characterization of alternative transcripts of the ARHGEF5/TIM oncogene specific for human breast cancer. Hum. Mol. Genet. 13, 323-334 (2004).
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 323-334
-
-
Debily, M.A.1
-
21
-
-
33645721632
-
Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins
-
Anderson, L. & Hunter, C. L. Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins. Mol. Cell. Proteomics 5, 573-588 (2006).
-
(2006)
Mol. Cell. Proteomics
, vol.5
, pp. 573-588
-
-
Anderson, L.1
Hunter, C.L.2
-
22
-
-
43049090085
-
Targeted quantitative analysis of Streptococcus pyogenes virulence factors by multiple reaction monitoring
-
Lange, V. et al. Targeted quantitative analysis of Streptococcus pyogenes virulence factors by multiple reaction monitoring. Mol. Cell. Proteomics 7, 1489-1500 (2008).
-
(2008)
Mol. Cell. Proteomics
, vol.7
, pp. 1489-1500
-
-
Lange, V.1
-
23
-
-
68749094119
-
Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics
-
Picotti, P., Bodenmiller, B., Mueller, L. N., Domon, B. & Aebersold, R. Full dynamic range proteome analysis of S. cerevisiae by targeted proteomics. Cell 138, 795-806 (2009).
-
(2009)
Cell
, vol.138
, pp. 795-806
-
-
Picotti, P.1
Bodenmiller, B.2
Mueller, L.N.3
Domon, B.4
Aebersold, R.5
-
24
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110a in insulin signaling
-
Knight, Z. A. et al. A pharmacological map of the PI3-K family defines a role for p110a in insulin signaling. Cell 125, 733-747 (2006).
-
(2006)
Cell
, vol.125
, pp. 733-747
-
-
Knight, Z.A.1
-
25
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley, L. C. The phosphoinositide 3-kinase pathway. Science 296, 1655-1657 (2002).
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
26
-
-
9444287030
-
And distinct elements in cellular signaling via EGF and FGF receptors
-
Schlessinger, J. Common and distinct elements in cellular signaling via EGF and FGF receptors. Science 306, 1506-1507 (2004).
-
(2004)
Science
, vol.306
, pp. 1506-1507
-
-
Schlessinger, J.1
-
27
-
-
67749110266
-
GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling
-
Tashiro, K. et al. GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling. J. Biol. Chem. 284, 20206-20214 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20206-20214
-
-
Tashiro, K.1
-
28
-
-
0029939164
-
SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways
-
Chen, D., Waters, S. B., Holt, K. H. & Pessin, J. E. SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways. J. Biol. Chem. 271, 6328-6332 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6328-6332
-
-
Chen, D.1
Waters, S.B.2
Holt, K.H.3
Pessin, J.E.4
-
29
-
-
33744549035
-
Pragmin a novel effector of Rnd2 GTPase, stimulates RhoA activity
-
Tanaka, H., Katoh, H. & Negishi, M. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. J. Biol. Chem. 281, 10355-10364 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 10355-10364
-
-
Tanaka, H.1
Katoh, H.2
Negishi, M.3
-
30
-
-
0346728803
-
Functional diversity of protein phosphatase-1, a cellular economizer and reset button
-
Ceulemans, H. & Bollen, M. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol. Rev. 84, 1-39 (2004).
-
(2004)
Physiol. Rev.
, vol.84
, pp. 1-39
-
-
Ceulemans, H.1
Bollen, M.2
-
31
-
-
0033545617
-
Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells
-
Schmandt, R., Liu, S. K. & McGlade, C. J. Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Oncogene 18, 1867-1879 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 1867-1879
-
-
Schmandt, R.1
Liu, S.K.2
McGlade, C.J.3
-
32
-
-
0037453510
-
Assembly of cell regulatory systems through protein interaction domains
-
Pawson, T. & Nash, P. Assembly of cell regulatory systems through protein interaction domains. Science 300, 445-452 (2003).
-
(2003)
Science
, vol.300
, pp. 445-452
-
-
Pawson, T.1
Nash, P.2
-
33
-
-
0029988340
-
Phosphotyrosineindependent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity
-
Charest, A., Wagner, J., Jacob, S.,McGlade, C. J.&Tremblay, M. L. Phosphotyrosineindependent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity. J. Biol. Chem. 271, 8424-8429 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8424-8429
-
-
Charest, A.1
Wagner, J.2
Jacob, S.3
McGlade, C.J.4
Tremblay, M.L.5
-
34
-
-
79952292499
-
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
-
Sun, T. et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell 144, 703-718 (2011).
-
(2011)
Cell
, vol.144
, pp. 703-718
-
-
Sun, T.1
-
35
-
-
84875414367
-
Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway
-
Croucher, D. R. et al. Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway. Cancer Res. 73, 1969-1980 (2013).
-
(2013)
Cancer Res.
, vol.73
, pp. 1969-1980
-
-
Croucher, D.R.1
-
36
-
-
0030601940
-
Clonal nature of spontaneously immortalized 3T3 cells
-
Rittling, S. R. Clonal nature of spontaneously immortalized 3T3 cells. Exp. Cell Res. 229, 7-13 (1996).
-
(1996)
Exp. Cell Res.
, vol.229
, pp. 7-13
-
-
Rittling, S.R.1
-
37
-
-
33646033137
-
A lentiviral RNAi library for humanand mouse genes applied to an arrayed viral high-content screen
-
Moffat, J. et al. A lentiviral RNAi library for humanand mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283-1298 (2006).
-
(2006)
Cell
, vol.124
, pp. 1283-1298
-
-
Moffat, J.1
-
38
-
-
33644850529
-
Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein
-
Brummer, T. et al. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J. Biol. Chem. 281, 626-637 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 626-637
-
-
Brummer, T.1
-
39
-
-
66749165277
-
A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: Multiple reaction monitoring-initiated detection and sequencing (MIDAS)
-
Unwin, R. D., Griffiths, J. R. & Whetton, A. D. A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nature Protocols 4, 870-877 (2009).
-
(2009)
Nature Protocols
, vol.4
, pp. 870-877
-
-
Unwin, R.D.1
Griffiths, J.R.2
Whetton, A.D.3
-
40
-
-
84855199947
-
-
R Development Core Team R Foundation for Statistical Computing
-
R Development Core Team. A Language and Environment for Statistical Computing. R Foundation for Statistical Computing. http://www.R-project.org (2010).
-
(2010)
A Language and Environment for Statistical Computing
-
-
|