Caution when diagnosing your mouse with schizophrenia: The use and misuse of model animals for understanding psychiatric disorders

Biological Psychiatry

Volumn 79, Issue 1, 2016, Pages 32-38

  Wong, Albert H C ^a,b   Josselyn, Sheena A ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Animal model; Anxiety; Behavior; Depression; Mouse; Psychiatric disorder; Rat; Schizophrenia

Indexed keywords

DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; DISC1 PROTEIN, HUMAN; DISC1 PROTEIN, MOUSE; NERVE PROTEIN;

ANXIETY DISORDER; BRAIN DEVELOPMENT; BRAIN FUNCTION; DEPRESSION; ENDOPHENOTYPE; EXPERIMENTAL MOUSE; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETICALLY ENGINEERED MOUSE STRAIN; HUMAN; LOCOMOTION; MEMORY DISORDER; MENTAL DISEASE; MENTAL HEALTH RESEARCH; NEUROBIOLOGY; NONHUMAN; PHENOTYPE; PREPULSE INHIBITION; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; SPATIAL WORKING MEMORY IMPAIRMENT; ANIMAL; DISEASE MODEL; GENETICS; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PSYCHOLOGIC TEST; PSYCHOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOPHENOTYPES; HUMANS; MICE; NERVE TISSUE PROTEINS; PSYCHOLOGICAL TESTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84948446282     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2015.04.023     Document Type: Review

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