Role of glycogen phosphorylase in liver glycogen metabolism

Molecular Aspects of Medicine

Volumn 46, Issue , 2015, Pages 34-45

  Agius, Loranne ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Glucose; Glucose 6 phosphate; Glycogen targeting proteins; Insulin; Liver; Phosphorylase; PPP1R3B; PPP1R3C

Indexed keywords

ADENINE NUCLEOTIDE; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLUCOSE DERIVATIVE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN SYNTHASE; INSULIN; ISOENZYME; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLASE; PHOSPHORYLASE KINASE; PHOSPHORYLASE PHOSPHATASE; PYGB PROTEIN; PYGL PROTEIN; PYGM PROTEIN; UNCLASSIFIED DRUG; GLYCOGEN LIVER LEVEL;

ALLOSTERISM; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CIRCADIAN RHYTHM; ENDOCRINE FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME DEFICIENCY; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME REGULATION; ENZYME STRUCTURE; EXTRACELLULAR MATRIX; GENE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; HORMONE ACTION; HUMAN; INSULIN RESISTANCE; LIVER CELL; LIVER METABOLISM; METABOLITE; NEUROENDOCRINE SYSTEM; NONHUMAN; PORTAL VEIN BLOOD; PPP1R3B GENE; PROTEIN ACETYLATION; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; GLYCOGEN LIVER LEVEL; LIVER; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

GLUCOSE; GLYCOGEN PHOSPHORYLASE; HUMANS; LIVER; LIVER GLYCOGEN; PHOSPHORYLATION;

EID: 84948162378     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2015.09.002     Document Type: Review

References (113)

1. B. Adkins-Marshall, M.J. Pagliassotti, J.R. Asher, C.C. Connolly, D.W. Neal, P.E. Williams, and et al. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs Am. J. Physiol 262 1992 E679 E686
2. L. Agius Glucokinase and molecular aspects of liver glycogen metabolism Biochem. J. 414 1 2008 1 18
3. L. Agius Physiological control of liver glycogen metabolism: lessons from novel glycogen phosphorylase inhibitors Mini Rev. Med. Chem 10 12 2010 1175 1187
4. L. Agius Dietary carbohydrate and control of hepatic gene expression: mechanistic links from ATP and phosphate ester homeostasis to the carbohydrate-response element-binding protein Proc. Nutr. Soc 2015 1 9
5. L. Agius, M. Peak, and K.G. Alberti Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes Biochem. J. 266 1 1990 91 102
6. S. Aiston, and L. Agius Leptin enhances glycogen storage in hepatocytes by inhibition of phosphorylase and exerts an additive effect with insulin Diabetes 48 1 1999 15 20
7. S. Aiston, M. Peak, and L. Agius Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: the role of increased phosphorylase activity Diabetologia 43 5 2000 589 597
8. S. Aiston, L. Hampson, A.M. Gómez-Foix, J.J. Guinovart, and L. Agius Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis J. Biol. Chem 276 26 2001 23858 23866
9. S. Aiston, B. Andersen, and L. Agius Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase Diabetes 52 6 2003 1333 1339
10. S. Aiston, M.P. Coghlan, and L. Agius Inactivation of phosphorylase is a major component of the mechanism by which insulin stimulates hepatic glycogen synthesis Eur. J. Biochem 270 13 2003 2773 2781
11. S. Aiston, A. Green, M. Mukhtar, and L. Agius Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates the enzyme synergistically with glucose Biochem. J. 377 1 2004 195 204
12. S. Aiston, L.J. Hampson, C. Arden, P.B. Iynedjian, and L. Agius The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes Diabetologia 49 1 2006 174 182
13. S. Alemany, and P. Cohen Phosphorylase a is an allosteric inhibitor of the glycogen and microsomal forms of rat hepatic protein phosphatase-1 FEBS Lett 198 2 1986 194 202
14. B. Andersen, and N. Westergaard The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors Biochem. J. 367 2 2002 443 450
15. B. Andersen, A. Rassov, N. Westergaard, and K. Lundgren Inhibition of glycogenolysis in primary rat hepatocytes by 1, 4-dideoxy-1,4-imino-D-arabinitol Biochem. J. 342 3 1999 545 550
16. C. Arden, A.R. Green, L.J. Hampson, S. Aiston, L. Härndahl, C.C. Greenberg, and et al. Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats FEBS J. 273 9 2006 1989 1999
17. C.G. Armstrong, M.J. Doherty, and P.T. Cohen Identification of the separate domains in the hepatic glycogen-targeting subunit of protein phosphatase 1 that interact with phosphorylase a, glycogen and protein phosphatase 1 Biochem. J. 336 3 1998 699 704
18. H.K. Berman, R.M. O'Doherty, P. Anderson, and C.B. Newgard Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone- and substrate-mediated regulatory mechanisms J. Biol. Chem 273 1998 26421 26425
19. M. Board, M. Bollen, W. Stalmans, Y. Kim, G.W. Fleet, and L.N. Johnson Effects of C-1-substituted glucose analogue on the activation states of glycogen synthase and glycogen phosphorylase in rat hepatocytes Biochem. J. 311 3 1995 845 852
20. M. Board, M. Hadwen, and L.N. Johnson Effects of novel analogues of D-glucose on glycogen phosphorylase activities in crude extracts of liver and skeletal muscle Eur. J. Biochem 228 3 1995 753 761
21. M. Bollen, S. Keppens, and W. Stalmans Specific features of glycogen metabolism in the liver Biochem. J. 336 1 1998 19 31
22. F. Bosch, A.M. Gómez-Foix, J. Ariño, and J.J. Guinovart Effects of lithium ions on glycogen synthase and phosphorylase in rat hepatocytes J. Biol. Chem 261 36 1986 16927 16931
23. G.J. Browne, M. Delibegovic, S. Keppens, W. Stalmans, and P.T. Cohen The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats Biochem. J. 360 2 2001 449 459
24. B. Burwinkel, S. Shiomi, A. Al Zaben, and M.W. Kilimann Liver glycogenosis due to phosphorylase kinase deficiency: PHKG2 gene structure and mutations associated with cirrhosis Hum. Mol. Genet 7 1 1998 149 154
25. B. Burwinkel, Hu B., A. Schroers, P.R. Clemens, S.W. Moses, Y.S. Shin, and et al. Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases Eur. J. Hum. Genet 11 7 2003 516 526
26. J. Cadefau, M. Bollen, and W. Stalmans Glucose-induced glycogenesis in the liver involves the glucose-6-phosphate-dependent dephosphorylation of glycogen synthase Biochem. J. 322 3 1997 745 750
27. A. Carabaza, C.J. Ciudad, S. Baqué, and J.J. Guinovart Glucose has to be phosphorylated to activate glycogen synthase, but not to inactivate glycogen phosphorylase in hepatocytes FEBS Lett 296 2 1992 211 214
28. H. Ceulemans, W. Stalmans, and M. Bollen Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution Bioessays 24 4 2002 371 381
29. A.D. Cherrington Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo Diabetes 48 5 1999 1198 1214
30. C.J. Ciudad, A. Carabaza, and J.J. Guinovart Glucose 6-phosphate plays a central role in the activation of glycogen synthase by glucose in hepatocytes Biochem. Biophys. Res. Commun 141 3 1986 1195 1200
31. A.M. Danos, S. Osmanovic, and M.J. Brady Differential regulation of glycogenolysis by mutant protein phosphatase-1 glycogen-targeting subunits J. Biol. Chem 284 29 2009 19544 19553
32. H. De Wulf, W. Stalmans, and H.G. Hers The effect of glucose and of a treatment by glucocorticoids on the activation in vitro of liver glycogen synthetase Eur. J. Biochem 15 1970 1 8
33. M.J. Doherty, G. Moorhead, N. Morrice, P. Cohen, and P.T. Cohen Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1 FEBS Lett 375 3 1995 294 298
34. M. el-Salhy, R. Stenling, and L. Grimelius Peptidergic innervation and endocrine cells in the human liver Scand. J. Gastroenterol 28 9 1993 809 815
35. D.S. Edgerton, M. Lautz, M. Scott, C.A. Everett, K.M. Stettler, D.W. Neal, and et al. Insulin's direct effects on the liver dominate the control of hepatic glucose production J. Clin. Invest 116 2 2006 521 527
36. J.L. Ekstrom, T.A. Pauly, M.D. Carty, W.C. Soeller, J. Culp, D.E. Danley, and et al. Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase Chem. Biol 9 8 2002 915 924
37. J.M. Fernández-Novell, A. Roca, D. Bellido, S. Vilaró, and J.J. Guinovart Translocation and aggregation of hepatic glycogen synthase during the fasted-to-refed transition in rats Eur. J. Biochem 238 2 1996 570 575
38. J.C. Ferrer, C. Favre, R.R. Gomis, J.M. Fernández-Novell, M. García-Rocha, N. de la Iglesia, and et al. Control of glycogen deposition FEBS Lett 546 2003 127 132
39. R.J. Fletterick, and N.B. Madsen The structures and related functions of phosphorylase a Annu. Rev. Biochem 49 1980 31 61
40. N.M. Fong, T.C. Jensen, A.S. Shah, N.N. Parekh, A.R. Saltiel, and M.J. Brady Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism J. Biol. Chem 275 2000 35034 35039
41. K. Fosgerau, J. Breinholt, J.G. McCormack, and N. Westergaard Evidence against glycogen cycling of gluconeogenic substrates in various liver preparations J. Biol. Chem 277 32 2002 28648 28655
42. R. Gasa, P.B. Jensen, H.K. Berman, M.J. Brady, A.A. DePaoli-Roach, and C.B. Newgard Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM/RGl) expressed in hepatocytes J. Biol. Chem 275 34 2000 26396 26403
43. A.R. Green, S. Aiston, C.C. Greenberg, S. Freeman, S.M. Poucher, M.J. Brady, and et al. The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation J. Biol. Chem 279 45 2004 46474 46482
44. L.J. Hampson, and L. Agius Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism Diabetes 54 3 2005 617 623
45. L.J. Hampson, and L. Agius Acetylcholine exerts additive and permissive but not synergistic effects with insulin on glycogen synthesis in hepatocytes FEBS Lett 581 21 2007 3955 3960
46. L.J. Hampson, C. Arden, L. Agius, M. Ganotidis, M.N. Kosmopoulou, C. Tiraidis, and et al. Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site Bioorg. Med. Chem 14 2006 7835 7845
47. L.J. Hampson, P. Mackin, and L. Agius Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs Diabetologia 50 8 2007 1743 1751
48. L. Härndahl, D. Schmoll, A.W. Herling, and L. Agius The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism FEBS J. 273 2 2006 336 346
49. H.G. Hers The control of glycogen metabolism in the liver Annu. Rev. Biochem 45 1976 167 189
50. J.W. Hudson, K.L. Hefferon, and M.M. Crerar Comparative analysis of species-independent, isozyme-specific amino-acid substitutions in mammalian muscle, brain and liver glycogen phosphorylases Biochim. Biophys. Acta 1164 2 1993 197 208
51. J.W. Hudson, G.B. Golding, and M.M. Crerar Evolution of allosteric control in glycogen phosphorylase J. Mol. Biol 234 3 1993 700 721
52. L. Hue, F. Bontemps, and H. Hers The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations Biochem. J. 152 1 1975 105 114
53. L.N. Johnson Glycogen phosphorylase: control by phosphorylation and allosteric effectors FASEB J. 6 6 1992 2274 2282
54. L.N. Johnson, and D. Barford The effects of phosphorylation on the structure and function of proteins Annu. Rev. Biophys. Biomol. Struct 22 1993 199 232
55. L.N. Johnson, N.B. Madsen, J. Mosley, and K.S. Wilson The crystal structure of phosphorylase beta at 6 A resolution J. Mol. Biol 90 4 1974 703 717
56. L.N. Johnson, P. Snape, J.L. Martin, K.R. Acharya, D. Barford, and N.G. Oikonomakos Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b J. Mol. Biol 232 1 1993 253 267
57. P.J. Kasvinsky, S. Shechosky, and R.J. Fletterick Synergistic regulation of phosphorylase a by glucose and caffeine J. Biol. Chem 253 24 1978 9102 9106
58. P.J. Kasvinsky, R.J. Fletterick, and N.B. Madsen Regulation of the dephosphorylation of glycogen phosphorylase a and synthase b by glucose and caffeine in isolated hepatocytes Can. J. Biochem 59 6 1981 387 395
59. I.R. Kelsall, S. Munro, I. Hallyburton, J.L. Treadway, and P.T. Cohen The hepatic PP1 glycogen-targeting subunit interaction with phosphorylase a can be blocked by C-terminal tyrosine deletion or an indole drug FEBS Lett 581 24 2007 4749 4753
60. I.R. Kelsall, D. Rosenzweig, and P.T. Cohen Disruption of the allosteric phosphorylase a regulation of the hepatic glycogen-targeted protein phosphatase 1 improves glucose tolerance in vivo Cell. Signal 21 7 2009 1123 1134
61. I.R. Kelsall, M. Voss, S. Munro, D.J. Cuthbertson, and P.T. Cohen R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals J. Neurochem 118 4 2011 596 610
62. H.H. Klein, S. Ullmann, M. Drenckhan, T. Grimmsmann, K. Unthan-Fechner, and I. Probst Differential modulation of insulin actions by dexamethasone: studies in primary cultures of adult rat hepatocytes J. Hepatol 37 4 2002 432 440
63. M. Kobayashi, G. Soman, and D.J. Graves A comparison of the activator sites of liver and muscle glycogen phosphorylase b J. Biol. Chem 257 23 1982 14041 14047
64. E.G. Krebs, and E.H. Fischer The phosphorylase b to a converting enzyme of rabbit skeletal muscle Biochim. Biophys. Acta 20 1 1956 150 157
65. D.D. Lam, and L.K. Heisler Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes Expert Rev. Mol. Med 9 5 2007 1 24
66. T. Latsis, B. Andersen, and L. Agius Diverse effects of two allosteric inhibitors on the phosphorylation state of glycogen phosphorylase in hepatocytes Biochem. J. 368 1 2002 309 316
67. Lin K., V.L. Rath, Dai S.C., R.J. Fletterick, and P.K. Hwang A protein phosphorylation switch at the conserved allosteric site in GP Science 273 5281 1996 1539 1542
68. I. López-Soldado, D. Zafra, J. Duran, A. Adrover, J. Calbó, and J.J. Guinovart Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model Diabetes 64 3 2015 796 807
69. Lu B., D. Bridges, Yang Y., K. Fisher, Cheng A., Chang L., and et al. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity Diabetes 63 9 2014 2935 2948
70. Luo X., Zhang Y., Ruan X., Jiang X., Zhu L., Wang X., and et al. Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis Diabetes 60 5 2011 1435 1445
71. Ma L., L.N. Robinson, and H.C. Towle ChREBP∗Mlx is the principal mediator of glucose-induced gene expression in the liver J. Biol. Chem 281 39 2006 28721 28730
72. V.T. Maddaiah, and N.B. Madsen Kinetics of purified liver phosphorylase J. Biol. Chem 241 17 1966 3873 3881
73. T.M. Martensen, J.E. Brotherton, and D.J. Graves Kinetic studies of the activation of muscle phosphorylase phosphatase J. Biol. Chem 248 24 1973 8329 8336
74. W.H. Martin, D.J. Hoover, S.J. Armento, I.A. Stock, R.K. McPherson, D.E. Danley, and et al. Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo Proc. Natl. Acad. Sci. U.S.A. 95 4 1998 1776 1781
75. D. Massillon, M. Bollen, H. De Wulf, K. Overloop, F. Vanstapel, P. Van Hecke, and et al. Demonstration of a glycogen/glucose 1-phosphate cycle in hepatocytes from fasted rats. Selective inactivation of phosphorylase by 2-deoxy-2-fluoro-alpha-D-glucopyranosyl fluoride J. Biol. Chem 270 33 1995 19351 19356
76. A.E. Melpidou, and N.G. Oikonomakos Effect of glucose-6-P on the catalytic and structural properties of glycogen phosphorylase a FEBS Lett 154 1 1983 105 110
77. M. Montori-Grau, M. Guitart, C. García-Martínez, A. Orozco, and A.M. Gómez-Foix Differential pattern of glycogen accumulation after protein phosphatase 1 glycogen-targeting subunit PPP1R6 overexpression, compared to PPP1R3C and PPP1R3A, in skeletal muscle cells BMC Biochem 12 2011 57
78. M.C. Moore, W.B. Geho, M. Lautz, B. Farmer, D.W. Neal, and A.D. Cherrington Portal serotonin infusion and glucose disposal in conscious dogs Diabetes 53 2 2004 14 20
79. M.C. Moore, K.C. Coate, J.J. Winnick, An Z., and A.D. Cherrington Regulation of hepatic glucose uptake and storage in vivo Adv Nutr 3 3 2012 286 294
80. S. Munro, H. Ceulemans, M. Bollen, J. Diplexcito, and P.T. Cohen A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents FEBS J. 272 6 2005 1478 1489
81. C.B. Newgard, P.K. Hwang, and R.J. Fletterick The family of glycogen phosphorylases: structure and function Crit. Rev. Biochem. Mol. Biol 24 1 1989 69 99
82. R.M. O'Doherty, P.R. Anderson, Zhao A.Z., K.E. Bornfeldt, and C.B. Newgard Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition Am. J. Physiol 277 3 Pt 1 1999 E544 E550
83. N.G. Oikonomakos, S.E. Zographos, L.N. Johnson, A.C. Papageorgiou, and K.R. Acharya The binding of 2-deoxy-D-glucose 6-phosphate to glycogen phosphorylase b: kinetic and crystallographic studies J. Mol. Biol 254 5 1995 900 917
84. N.G. Oikonomakos, E.D. Chrysina, M.N. Kosmopoulou, and D.D. Leonidas Crystal structure of rabbit muscle glycogen phosphorylase a in complex with a potential hypoglycaemic drug at 2.0 A resolution Biochim. Biophys. Acta 1647 1-2 2003 325 332
85. N.G. Oikonomakos, M.N. Kosmopoulou, E.D. Chrysina, D.D. Leonidas, I.D. Kostas, K.U. Wendt, and et al. Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci 14 7 2005 1760 1771
86. N.G. Oikonomakos, C. Tiraidis, D.D. Leonidas, S.E. Zographos, M. Kristiansen, C.U. Jessen, and et al. Iminosugars as potential inhibitors of glycogenolysis: structural insights into the molecular basis of glycogen phosphorylase inhibition J. Med. Chem 49 19 2006 5687 5701
87. H. Ozen Glycogen storage diseases: new perspectives World J. Gastroenterol 13 18 2007 2541 2553
88. V. Parmenopoulou, A.L. Kantsadi, V.G. Tsirkone, D.S. Chatzileontiadou, S. Manta, S.E. Zographos, and et al. Structure based inhibitor design targeting glycogen phosphorylase B. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines Bioorg. Med. Chem 22 17 2014 4810 4825
89. A. Pautsch, N. Stadler, O. Wissdorf, E. Langkopf, W. Moreth, and R. Streicher Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylase J. Biol. Chem 283 14 2008 8913 8918
90. J.L. Petrie, Z.H. Al-Oanzi, C. Arden, S.J. Tudhope, J. Mann, J. Kieswich, and et al. Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter Mol. Cell. Biol 33 4 2013 725 738
91. V.L. Rath, M. Ammirati, P.K. LeMotte, K.F. Fennell, M.N. Mansour, D.E. Danley, and et al. Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core Mol. Cell 6 1 2000 139 148
92. V.L. Rath, M. Ammirati, D.E. Danley, J.L. Ekstrom, E.M. Gibbs, T.R. Hynes, and et al. Human liver glycogen phosphorylase inhibitors bind at a new allosteric site Chem. Biol 7 9 2000 677 682
93. P.J. Roach, A.A. Depaoli-Roach, T.D. Hurley, and V.S. Tagliabracci Glycogen and its metabolism: some new developments and old themes Biochem. J. 441 3 2012 763 787
94. S. Ros, D. Zafra, J. Valles-Ortega, M. García-Rocha, S. Forrow, J. Domínguez, and et al. Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis J. Biol. Chem 285 48 2010 37170 37177
95. K.R. Schwarz, S.M. Lanier, E.A. Carter, C.J. Homcy, and R.M. Graham Rapid reciprocal changes in adrenergic receptors in intact isolated hepatocytes during primary cell culture Mol. Pharmacol 27 2 1985 200 209
96. W. Stalmans, and G. Gevers The catalytic activity of phosphorylase b in the liver. With a note on the assay in the glycogenolytic direction Biochem. J. 200 2 1981 327 336
97. W. Stalmans, and H.G. Hers The stimulation of liver phosphorylase b by AMP, fluoride and sulfate. A technical note on the specific determination of the a and b forms of liver glycogen phosphorylase Eur. J. Biochem 54 2 1975 341 350
98. W. Stalmans, H. de Wulf, and H.G. Hers The control of liver glycogen synthetase phosphatase by phosphorylase Eur. J. Biochem 18 4 1971 582 587
99. W. Stalmans, H. De Wulf, L. Hue, and H.G. Hers The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose Eur. J. Biochem 41 1 1974 127 134
100. W. Stalmans, M. Laloux, and H.G. Hers The interaction of liver phosphorylase a with glucose and AMP Eur. J. Biochem 49 2 1974 415 427
101. J.L. Treadway, P. Mendys, and D.J. Hoover Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus Expert Opin. Investig. Drugs 10 3 2001 439 454
102. S.J. Tudhope, Wang C.C., J.L. Petrie, L. Potts, F. Malcomson, J. Kieswich, and et al. A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5 Diabetes 61 1 2012 49 60
103. U.S. Udoh, T.M. Swain, A.N. Filiano, K.L. Gamble, M.E. Young, and S.M. Bailey Chronic ethanol consumption disrupts diurnal rhythms of hepatic glycogen metabolism in mice Am. J. Physiol. Gastrointest. Liver Physiol 308 11 2015 G964 G974
104. G. van de Werve, L. Hue, and H.G. Hers Hormonal and ionic control of the glycogenolytic cascade in rat liver Biochem. J. 162 1 1977 135 142
105. A. von Wilamowitz-Moellendorff, R.W. Hunter, M. García-Rocha, Kang L., I. López-Soldado, L. Lantier, and et al. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis Diabetes 62 12 2013 4070 4082
106. G. Velho, K.F. Petersen, G. Perseghin, J.H. Hwang, D.L. Rothman, M.E. Pueyo, and et al. Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects J. Clin. Invest 98 8 1996 1755 1761
107. Wan M., K.F. Leavens, R.W. Hunter, S. Koren, A. von Wilamowitz-Moellendorff, Lu M., and et al. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition Cell Metab 18 1 2013 99 105
108. F. Zani, L. Breasson, B. Becattini, A. Vukolic, J.P. Montani, U. Albrecht, and et al. PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression Mol Metab 2 3 2013 292 305
109. Zhang T., Wang S., Lin Y., Xu W., Ye D., Xiong Y., and et al. Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1 Cell Metab 15 1 2012 75 87
110. Zhang Y., Xu D., Huang H., Chen S., Wang L., Zhu L., and et al. Regulation of glucose homeostasis and lipid metabolism by PPP1R3G-mediated hepatic glycogenesis Mol. Endocrinol 28 1 2014 116 126
111. Zhao A.Z., M.M. Shinohara, Huang D., M. Shimizu, H. Eldar-Finkelman, E.G. Krebs, and et al. Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes J. Biol. Chem 275 15 2000 11348 11354
112. D. Zibrova, R. Grempler, R. Streicher, and S.G. Kauschke Inhibition of the interaction between protein phosphatase 1 glycogen-targeting subunit and glycogen phosphorylase increases glycogen synthesis in primary rat hepatocytes Biochem. J. 412 2 2008 359 366
113. S.E. Zographos, N.G. Oikonomakos, K.E. Tsitsanou, D.D. Leonidas, E.D. Chrysina, V.T. Skamnaki, and et al. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor Structure 5 11 1997 1413 1425