Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model

Diabetes

Volumn 64, Issue 3, 2015, Pages 796-807

  López Soldado, Iliana ^a,b   Zafra, Delia ^a,b   Duran, Jordi ^a,b   Adrover, Anna ^a   Calbó, Joaquim ^a,b   Guinovart, Joan J ^a,b,c  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; LEPTIN; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; UNCOUPLING PROTEIN 1; CARRIER PROTEIN; GLYCOGEN LIVER LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CALORIMETRY; COMPARATIVE STUDY; CONTROLLED STUDY; DIET RESTRICTION; FAT MASS; FATTY LIVER; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLYCOGEN LIVER LEVEL; HOMOLOGOUS RECOMBINATION; HYPERINSULINEMIA; HYPERPHAGIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MOUSE; MOUSE MODEL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; ANIMAL; BLOOD; EATING; GENETICS; LIVER; METABOLISM; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CARRIER PROTEINS; DIET, HIGH-FAT; EATING; LEPTIN; LIVER; LIVER GLYCOGEN; MICE; OBESITY;

EID: 84928211440     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0728     Document Type: Article

References (50)

1. Roach PJ, Depaoli-Roach AA, Hurley TD, Tagliabracci VS. Glycogen and its metabolism: some new developments and old themes. Biochem J 2012;441: 763-787
2. Gomis RR, Ferrer JC, Guinovart JJ. Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase. Biochem J 2000;351:811-816
3. von Wilamowitz-Moellendorff A, Hunter RW, García-Rocha M, et al. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis. Diabetes 2013;62:4070-4082
4. Newgard CB, Brady MJ, O'Doherty RM, Saltiel AR. Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes 2000;49:1967-1977
5. Printen JA, Brady MJ, Saltiel AR. PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science 1997;275:1475-1478
6. Brady MJ, Printen JA, Mastick CC, Saltiel AR. Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity. J Biol Chem 1997;272:20198-20204
7. Berman HK, O'Doherty RM, Anderson P, Newgard CB. Overexpression of protein targeting to glycogen (PTG) in rat hepatocytes causes profound activation of glycogen synthesis independent of normal hormone-and substrate-mediated regulatory mechanisms. J Biol Chem 1998;273:26421-26425
8. O'Doherty RM, Jensen PB, Anderson P, et al. Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. J Clin Invest 2000;105:479-488
9. Yang R, Newgard CB. Hepatic expression of a targeting subunit of protein phosphatase-1 in streptozotocin-diabetic rats reverses hyperglycemia and hyperphagia despite depressed glucokinase expression. J Biol Chem 2003;278: 23418-23425
10. Ros S, García-Rocha M, Calbó J, Guinovart JJ. Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats. Diabetologia 2011; 54:2639-2648
11. Russek M. Participation of hepatic glucoreceptors in the control of intake of food. Nature 1963;197:79-80
12. Flatt JP. Carbohydrate balance and body-weight regulation. Proc Nutr Soc 1996;55:449-465
13. Emery PW, Carpenter TT, Obeid OA. Alterations in postprandial glycogen and lipid synthesis in cachectic tumor-bearing rats. Nutr Cancer 1993;20:231-240
14. Obeid OA, Powell-Tuck J, Emery PW. The postprandial rates of glycogen and lipid synthesis of lean and obese female Zucker rats. Int J Obes Relat Metab Disord 2000;24:508-513
15. Shetty PS, Prentice AM, Goldberg GR, et al. Alterations in fuel selection and voluntary food intake in response to isoenergetic manipulation of glycogen stores in humans. Am J Clin Nutr 1994;60:534-543
16. Snitker S, Larson DE, Tataranni PA, Ravussin E. Ad libitum food intake in humans after manipulation of glycogen stores. Am J Clin Nutr 1997;65:941-946
17. Ji H, Friedman MI. Compensatory hyperphagia after fasting tracks recovery of liver energy status. Physiol Behav 1999;68:181-186
18. Winzell MS, Ahrén B. The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 2004;53(Suppl. 3):S215-S219
19. Woods SC, Seeley RJ, Rushing PA, D'Alessio D, Tso P. A controlled high-fat diet induces an obese syndrome in rats. J Nutr 2003;133:1081-1087
20. García-Rocha M, Roca A, De La Iglesia N, et al. Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes. Biochem J 2001;357:17-24
21. Goodman MN, Berger M, Ruderman NB. Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids. Diabetes 1974;23:881-888
22. Salmon DM, Flatt JP. Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. Int J Obes 1985;9:443-449
23. Ros S, Zafra D, Valles-Ortega J, et al. Hepatic overexpression of a constitutively active form of liver glycogen synthase improves glucose homeostasis. J Biol Chem 2010;285:37170-37177
24. Chen Y, Heiman ML. Increased weight gain after ovariectomy is not a consequence of leptin resistance. Am J Physiol Endocrinol Metab 2001;280: E315-E322
25. Lu B, Bridges D, Yang Y, et al. Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes 2014;63:2935-2948
26. Savastano DM, Covasa M. Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats. J Nutr 2005;135:1953-1959
27. Nefti W, Chaumontet C, Fromentin G, Tomé D, Darcel N. A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice. Am J Physiol Regul Integr Comp Physiol 2009;296:R1681-R1686
28. Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science 2005; 307:375-379
29. Wang C, Chen Z, Li S, et al. Hepatic overexpression of ATP synthase b subunit activates PI3K/Akt pathway to ameliorate hyperglycemia of diabetic mice. Diabetes 2014;63:947-959
30. Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 1999;48:1198-1214
31. Lee YJ, Ko EH, Kim JE, et al. Nuclear receptor PPARg-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis. Proc Natl Acad Sci U S A 2012; 109:13656-13661
32. Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999;103:1489-1498
33. Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem 2000;275:28918-28928
34. Friedman MI. Fuel partitioning and food intake. Am J Clin Nutr 1998;67(Suppl.): 513S-518S
35. Friedman MI. Control of energy intake by energy metabolism. Am J Clin Nutr 1995;62(Suppl.):1096S-1100S
36. Langhans W, Scharrer E. Metabolic control of eating. World Rev Nutr Diet 1992;70:1-67
37. Grill HJ, Friedman MI, Norgren R, Scalera G, Seeley R. Parabrachial nucleus lesions impair feeding response elicited by 2,5-anhydro-D-mannitol. Am J Physiol 1995;268:R676-R682
38. Ritter S, Dinh TT, Friedman MI. Induction of Fos-like immunoreactivity (Fos-li) and stimulation of feeding by 2,5-anhydro-D-mannitol (2,5-AM) require the vagus nerve. Brain Res 1994;646:53-64
39. Gasa R, Clark C, Yang R, DePaoli-Roach AA, Newgard CB. Reversal of dietinduced glucose intolerance by hepatic expression of a variant glycogen-targeting subunit of protein phosphatase-1. J Biol Chem 2002;277:1524-1530
40. Yamauchi T, Waki H, Kamon J, et al. Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest 2001;108: 1001-1013
41. Vidal-Puig A, Jimenez-Liñan M, Lowell BB, et al. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest 1996;97:2553-2561
42. Horton JD, Bashmakov Y, Shimomura I, Shimano H. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci U S A 1998;95:5987-5992
43. Azzout-Marniche D, Bécard D, Guichard C, Foretz M, Ferré P, Foufelle F. Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes. Biochem J 2000;350:389-393
44. Iynedjian PB, Pilot PR, Nouspikel T, et al. Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. Proc Natl Acad Sci U S A 1989;86:7838-7842
45. Peter A, Stefan N, Cegan A, et al. Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans. J Clin Endocrinol Metab 2011;96:E1126-E1130
46. Shimomura I, Bashmakov Y, Horton JD. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 1999;274:30028-30032
47. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002; 109:1125-1131
48. Izumida Y, Yahagi N, Takeuchi Y, et al. Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization. Nat Commun 2013;4:2316
49. Crosson SM, Khan A, Printen J, Pessin JE, Saltiel AR. PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest 2003;111:1423-1432
50. Irimia JM, Meyer CM, Peper CL, et al. Impaired glucose tolerance and predisposition to the fasted state in liver glycogen synthase knock-out mice. J Biol Chem 2010;285:12851-12861