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Volumn 61, Issue 1, 2012, Pages 49-60

A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; GLUCOSE; GLYCOGEN PHOSPHORYLASE; INSULIN; NORADRENALIN; OLANZAPINE; PHOSPHORYLASE PHOSPHATASE; PROTEIN P35; ROSCOVITINE; SEROTONIN; SEROTONIN 1 AGONIST; SEROTONIN 1 RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN 2B RECEPTOR;

EID: 84555177974     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0870     Document Type: Article
Times cited : (33)

References (50)
  • 2
    • 0020043855 scopus 로고
    • Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for 'gut factor' involvement in hepatic glucose storage
    • Bergman RN, Beir JR, Hourigan PM. Intraportal glucose infusion matched to oral glucose absorption. Lack of evidence for "gut factor" involvement in hepatic glucose storage. Diabetes 1982;31:27-35 (Pubitemid 12254628)
    • (1982) Diabetes , vol.31 , Issue.1 , pp. 27-35
    • Bergman, R.N.1    Beir, J.R.2    Hourigan, P.M.3
  • 3
  • 4
    • 0033126490 scopus 로고    scopus 로고
    • Control of glucose uptake and release by the liver in vivo
    • DOI 10.2337/diabetes.48.5.1198
    • Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes 1999;48:1198-1214 (Pubitemid 29226371)
    • (1999) Diabetes , vol.48 , Issue.5 , pp. 1198-1214
    • Cherrington, A.D.1
  • 5
    • 16744368058 scopus 로고
    • Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs
    • Adkins-Marshall B, Pagliassotti MJ, Asher JR, et al. Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs. Am J Physiol 1992;262:E679-E686
    • (1992) Am J Physiol , vol.262
    • Adkins-Marshall, B.1    Pagliassotti, M.J.2    Asher, J.R.3
  • 6
    • 0020335147 scopus 로고
    • Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig
    • Niijima A. Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig. J Physiol 1982;332:315-323 (Pubitemid 13253455)
    • (1982) Journal of Physiology , vol.332 , pp. 315-323
    • Niijima, A.1
  • 7
    • 0019522385 scopus 로고
    • Central nervous system regulation of liver and adipose tissue metabolism
    • Shimazu T. Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia 1981;20(Suppl.):343-356 (Pubitemid 11159668)
    • (1981) Diabetologia , vol.20 , Issue.SUPPL. , pp. 343-356
    • Shimazu, T.1
  • 8
    • 0032533162 scopus 로고    scopus 로고
    • Specific features of glycogen metabolism in the liver
    • Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 1998;336:19-31 (Pubitemid 28532556)
    • (1998) Biochemical Journal , vol.336 , Issue.1 , pp. 19-31
    • Bollen, M.1    Keppens, S.2    Stalmans, W.3
  • 10
    • 0023066096 scopus 로고
    • Regulation of liver metabolism by the hepatic nerves
    • Jungermann K, Gardemann A, Beuers U, et al. Regulation of liver metabolism by the hepatic nerves. Adv Enzyme Regul 1987;26:63-88
    • (1987) Adv Enzyme Regul , vol.26 , pp. 63-88
    • Jungermann, K.1    Gardemann, A.2    Beuers, U.3
  • 11
    • 0015025933 scopus 로고
    • Factors modifying carbohydrate metabolism and effect of insulin in perfused rat liver
    • Mondon CE, Burton SD. Factors modifying carbohydrate metabolism and effect of insulin in perfused rat liver. Am J Physiol 1971;220:724-734
    • (1971) Am J Physiol , vol.220 , pp. 724-734
    • Mondon, C.E.1    Burton, S.D.2
  • 12
    • 0015211215 scopus 로고
    • Effect of acetylcholine on glycogen formation and the activity of glycogen synthetase in isolated, perfused rat liver
    • Ottolenghi C, Cania A, Barnabei O. Effect of acetylcholine on glycogen formation and the activity of glycogen synthetase in isolated, perfused rat liver. Nature 1971;229:420-422
    • (1971) Nature , vol.229 , pp. 420-422
    • Ottolenghi, C.1    Cania, A.2    Barnabei, O.3
  • 13
    • 0025043204 scopus 로고
    • Differential control of glycogenolysis and flow by arterial and portal acetylcholine in perfused rat liver
    • Gardemann A, Beck H, Jungermann K. Differential control of glycogenolysis and flow by arterial and portal acetylcholine in perfused rat liver. Biochem J 1990;271:599-604 (Pubitemid 20384589)
    • (1990) Biochemical Journal , vol.271 , Issue.3 , pp. 599-604
    • Gardemann, A.1    Beck, H.2    Jungermann, K.3
  • 14
    • 34547690994 scopus 로고    scopus 로고
    • Acetylcholine exerts additive and permissive but not synergistic effects with insulin on glycogen synthesis in hepatocytes
    • DOI 10.1016/j.febslet.2007.07.026, PII S001457930700796X
    • Hampson LJ, Agius L. Acetylcholine exerts additive and permissive but not synergistic effects with insulin on glycogen synthesis in hepatocytes. FEBS Lett 2007;581:3955-3960 (Pubitemid 47212101)
    • (2007) FEBS Letters , vol.581 , Issue.21 , pp. 3955-3960
    • Hampson, L.J.1    Agius, L.2
  • 16
    • 33847609962 scopus 로고    scopus 로고
    • Serotonin and energy balance: Molecular mechanisms and implications for type 2 diabetes
    • DOI 10.1017/S1462399407000245, PII S1462399407000245
    • Lam DD, Heisler LK. Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert Rev Mol Med 2007;9:1-24 (Pubitemid 46358401)
    • (2007) Expert Reviews in Molecular Medicine , vol.9 , Issue.5 , pp. 1-24
    • Lam, D.D.1    Heisler, L.K.2
  • 17
    • 0347990605 scopus 로고    scopus 로고
    • Portal Serotonin Infusion and Glucose Disposal in Conscious Dogs
    • DOI 10.2337/diabetes.53.1.14
    • Moore MC, Geho WB, Lautz M, Farmer B, Neal DW, Cherrington AD. Portal serotonin infusion and glucose disposal in conscious dogs. Diabetes 2004;53:14-20 (Pubitemid 38044692)
    • (2004) Diabetes , vol.53 , Issue.1 , pp. 14-20
    • Moore, M.C.1    Geho, W.B.2    Lautz, M.3    Farmer, B.4    Neal, D.W.5    Cherrington, A.D.6
  • 18
    • 53149111135 scopus 로고    scopus 로고
    • Molecular biology of 5-HT receptors
    • Hannon J, Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 2008;195:198-213
    • (2008) Behav Brain Res , vol.195 , pp. 198-213
    • Hannon, J.1    Hoyer, D.2
  • 19
    • 33645666489 scopus 로고    scopus 로고
    • Platelet-derived serotonin mediates liver regeneration
    • Lesurtel M, Graf R, Aleil B, et al. Platelet-derived serotonin mediates liver regeneration. Science 2006;312:104-107
    • (2006) Science , vol.312 , pp. 104-107
    • Lesurtel, M.1    Graf, R.2    Aleil, B.3
  • 20
    • 34447115914 scopus 로고    scopus 로고
    • Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs
    • DOI 10.1007/s00125-007-0696-y
    • Hampson LJ, Mackin P, Agius L. Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs. Diabetologia 2007;50:1743-1751 (Pubitemid 47036645)
    • (2007) Diabetologia , vol.50 , Issue.8 , pp. 1743-1751
    • Hampson, L.J.1    Mackin, P.2    Agius, L.3
  • 21
    • 63749126381 scopus 로고    scopus 로고
    • How can antipsychotics cause Diabetes Mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins
    • Starrenburg FC, Bogers JP. How can antipsychotics cause Diabetes Mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins. Eur Psychiatry 2009;24:164-170
    • (2009) Eur Psychiatry , vol.24 , pp. 164-170
    • Starrenburg, F.C.1    Bogers, J.P.2
  • 22
    • 41049098985 scopus 로고    scopus 로고
    • The association between antidepressant use and disturbances in glucose homeostasis: Evidence from spontaneous reports
    • Derijks HJ, Meyboom RH, Heerdink ER, et al. The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports. Eur J Clin Pharmacol 2008;64:531-538
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 531-538
    • Derijks, H.J.1    Meyboom, R.H.2    Heerdink, E.R.3
  • 23
    • 0017159024 scopus 로고
    • A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes
    • Chan TM, Exton JH. A rapid method for the determination of glycogen content and radioactivity in small quantities of tissue or isolated hepatocytes. Anal Biochem 1976;71:96-105
    • (1976) Anal Biochem , vol.71 , pp. 96-105
    • Chan, T.M.1    Exton, J.H.2
  • 24
    • 0035968302 scopus 로고    scopus 로고
    • Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: Evidence from metabolic control analysis
    • Aiston S, Hampson L, Gómez-Foix AM, Guinovart JJ, Agius L. Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis. J Biol Chem 2001;276:23858-23866
    • (2001) J Biol Chem , vol.276 , pp. 23858-23866
    • Aiston, S.1    Hampson, L.2    Gómez-Foix, A.M.3    Guinovart, J.J.4    Agius, L.5
  • 25
    • 13844271403 scopus 로고    scopus 로고
    • Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p
    • DOI 10.1016/j.bbrc.2005.01.106
    • Wilson WA, Wang Z, Roach PJ. Regulation of yeast glycogen phosphorylase by the cyclin-dependent protein kinase Pho85p. Biochem Biophys Res Commun 2005;329:161-167 (Pubitemid 40255435)
    • (2005) Biochemical and Biophysical Research Communications , vol.329 , Issue.1 , pp. 161-167
    • Wilson, W.A.1    Wang, Z.2    Roach, P.J.3
  • 26
    • 21344455074 scopus 로고    scopus 로고
    • Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes
    • DOI 10.2337/diabetes.54.7.1949
    • Payne VA, Arden C,Wu C, Lange AJ, Agius L. Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes. Diabetes 2005;54:1949-1957 (Pubitemid 40911256)
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1949-1957
    • Payne, V.A.1    Arden, C.2    Wu, C.3    Lange, A.J.4    Agius, L.5
  • 27
    • 0037984349 scopus 로고    scopus 로고
    • Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase
    • DOI 10.1074/jbc.M212151200
    • Gomis RR, Favre C, García-Rocha M, Fernández-Novell JM, Ferrer JC, Guinovart JJ. Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase. J Biol Chem 2003;278:9740-9746 (Pubitemid 36800472)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.11 , pp. 9740-9746
    • Gomis, R.R.1    Favre, C.2    Garcia-Rocha, M.3    Fernandez-Novell, J.M.4    Ferrer, J.C.5    Guinovart, J.J.6
  • 28
    • 0033531943 scopus 로고    scopus 로고
    • Serotonin (5-hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle
    • Hajduch E, Rencurel F, Balendran A, Batty IH, Downes CP, Hundal HS. Serotonin (5-hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle. J Biol Chem 1999;274:13563-13568
    • (1999) J Biol Chem , vol.274 , pp. 13563-13568
    • Hajduch, E.1    Rencurel, F.2    Balendran, A.3    Batty, I.H.4    Downes, C.P.5    Hundal, H.S.6
  • 29
    • 0036119338 scopus 로고    scopus 로고
    • Molecular, pharmacological and functional diversity of 5-HT receptors
    • DOI 10.1016/S0091-3057(01)00746-8, PII S0091305701007468
    • Hoyer D, Hannon JP, Martin GR. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 2002;71:533-554 (Pubitemid 34219205)
    • (2002) Pharmacology Biochemistry and Behavior , vol.71 , Issue.4 , pp. 533-554
    • Hoyer, D.1    Hannon, J.P.2    Martin, G.R.3
  • 31
    • 0032967875 scopus 로고    scopus 로고
    • 3, 5HT(2A) and muscarinic receptors
    • DOI 10.1007/s002130050834
    • Zhang W, Bymaster FP. The in vivo effects of olanzapine and other antipsychotic agents on receptor occupancy and antagonism of dopamine D1, D2, D3, 5HT2A and muscarinic receptors. Psychopharmacology (Berl) 1999;141:267-278 (Pubitemid 29196076)
    • (1999) Psychopharmacology , vol.141 , Issue.3 , pp. 267-278
    • Zhang, W.1    Bymaster, F.P.2
  • 32
    • 0034882360 scopus 로고    scopus 로고
    • 1D receptors
    • DOI 10.1016/S0893-133X(01)00237-8, PII S0893133X01002378
    • Audinot V, Newman-Tancredi A, Cussac D, Millan MJ. Inverse agonist properties of antipsychotic agents at cloned, human (h) serotonin (5-HT)(1B) and h5-HT(1D) receptors. Neuropsychopharmacology 2001;25:410-422 (Pubitemid 32780547)
    • (2001) Neuropsychopharmacology , vol.25 , Issue.3 , pp. 410-422
    • Audinot, V.1    Newman-Tancredi, A.2    Cussac, D.3    Millan, M.J.4
  • 33
    • 49649099805 scopus 로고    scopus 로고
    • Glucokinase and molecular aspects of liver glycogen metabolism
    • Agius L. Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J 2008;414:1-18
    • (2008) Biochem J , vol.414 , pp. 1-18
    • Agius, L.1
  • 34
    • 78549257789 scopus 로고    scopus 로고
    • Physiological control of liver glycogen metabolism: Lessons from novel glycogen phosphorylase inhibitors
    • Agius L. Physiological control of liver glycogen metabolism: lessons from novel glycogen phosphorylase inhibitors. Mini Rev Med Chem 2010;10:1175-1187
    • (2010) Mini Rev Med Chem , vol.10 , pp. 1175-1187
    • Agius, L.1
  • 35
    • 33645019549 scopus 로고    scopus 로고
    • The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism
    • Härndahl L, Schmoll D, Herling AW, Agius L. The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism. FEBS J 2006;273:336-346
    • (2006) FEBS J , vol.273 , pp. 336-346
    • Härndahl, L.1    Schmoll, D.2    Herling, A.W.3    Agius, L.4
  • 36
    • 36549040859 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: A further update
    • Bain J, Plater L, Elliott M, et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 2007;408:297-315
    • (2007) Biochem J , vol.408 , pp. 297-315
    • Bain, J.1    Plater, L.2    Elliott, M.3
  • 38
    • 0028866844 scopus 로고
    • Involvement of phosphorylase kinase inhibition in the effect of resorcinol and proglycosyn on glycogen metabolism in the liver
    • Van Schaftingen E. Involvement of phosphorylase kinase inhibition in the effect of resorcinol and proglycosyn on glycogen metabolism in the liver. Eur J Biochem 1995;234:301-307
    • (1995) Eur J Biochem , vol.234 , pp. 301-307
    • Van Schaftingen, E.1
  • 39
    • 2542461194 scopus 로고    scopus 로고
    • Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells
    • DOI 10.1210/en.2003-1522
    • Ubeda M, Kemp DM, Habener JF. Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells. Endocrinology 2004;145:3023-3031 (Pubitemid 38686252)
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 3023-3031
    • Ubeda, M.1    Kemp, D.M.2    Habener, J.F.3
  • 40
    • 34250312098 scopus 로고    scopus 로고
    • Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation
    • DOI 10.1074/jbc.M606347200
    • Li T, Chalifour LE, Paudel HK. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. J Biol Chem 2007;282:6619-6628 (Pubitemid 47100889)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.9 , pp. 6619-6628
    • Li, T.1    Chalifour, L.E.2    Paudel, H.K.3
  • 41
    • 0030034219 scopus 로고    scopus 로고
    • Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog
    • Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD. Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 1996;97:81-91 (Pubitemid 26021697)
    • (1996) Journal of Clinical Investigation , vol.97 , Issue.1 , pp. 81-91
    • Pagliassotti, M.J.1    Holste, L.C.2    Moore, M.C.3    Neal, D.W.4    Cherrington, A.D.5
  • 42
    • 0021227238 scopus 로고
    • 1- and beta-adrenergic receptors, but constant expression of glucagon receptor by rat hepatocytes during development and primary culture
    • Nakamura T, Tomomura A, Kato S, Noda C, Ichihara A. Reciprocal expressions of alpha 1- and beta-adrenergic receptors, but constant expression of glucagon receptor by rat hepatocytes during development and primary culture. J Biochem 1984;96:127-136 (Pubitemid 14089273)
    • (1984) Journal of Biochemistry , vol.96 , Issue.1 , pp. 127-136
    • Nakamura, T.1    Tomomura, A.2    Kato, S.3
  • 43
    • 0028168162 scopus 로고
    • Switching from alpha 1- To beta-subtypes in adrenergic response during primary culture of adult-rat hepatocytes as affected by the cell-to-cell interaction through plasma membranes
    • Kajiyama Y, Ui M. Switching from alpha 1- to beta-subtypes in adrenergic response during primary culture of adult-rat hepatocytes as affected by the cell-to-cell interaction through plasma membranes. Biochem J 1994;303:313-321
    • (1994) Biochem J , vol.303 , pp. 313-321
    • Kajiyama, Y.1    Ui, M.2
  • 45
    • 54049144285 scopus 로고    scopus 로고
    • New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function
    • Perry JR, Frayling TM. New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function. Curr Opin Clin Nutr Metab Care 2008;11:371-377
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 371-377
    • Perry, J.R.1    Frayling, T.M.2
  • 47
    • 44649091314 scopus 로고    scopus 로고
    • Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays
    • DOI 10.1002/pmic.200701063
    • Schnack C, Hengerer B, Gillardon F. Identification of novel substrates for Cdk5 and new targets for Cdk5 inhibitors using high-density protein microarrays. Proteomics 2008;8:1980-1986 (Pubitemid 351775778)
    • (2008) Proteomics , vol.8 , Issue.10 , pp. 1980-1986
    • Schnack, C.1    Hengerer, B.2    Gillardon, F.3
  • 50
    • 33644874489 scopus 로고    scopus 로고
    • Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal
    • Dicostanzo CA, Dardevet DP, Neal DW, et al. Role of the hepatic sympathetic nerves in the regulation of net hepatic glucose uptake and the mediation of the portal glucose signal. Am J Physiol Endocrinol Metab 2006;290:E9-E16
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Dicostanzo, C.A.1    Dardevet, D.P.2    Neal, D.W.3


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