-
1
-
-
77957745555
-
Type i interferon: Friend or foe?
-
Trinchieri, G. Type I interferon: friend or foe? J. Exp. Med. 207, 2053-2063 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2053-2063
-
-
Trinchieri, G.1
-
2
-
-
33748455338
-
Type i interferons in host defense
-
Stetson, D. B. & Medzhitov, R. Type I interferons in host defense. Immunity 25, 373-381 (2006).
-
(2006)
Immunity
, vol.25
, pp. 373-381
-
-
Stetson, D.B.1
Medzhitov, R.2
-
3
-
-
84876311772
-
Persistent LCMV infection is controlled by blockade of type i interferon signaling
-
Teijaro, J. R. et al. Persistent LCMV infection is controlled by blockade of type I interferon signaling. Science 340, 207-211 (2013).
-
(2013)
Science
, vol.340
, pp. 207-211
-
-
Teijaro, J.R.1
-
4
-
-
84876299371
-
Blockade of chronic type i interferon signaling to control persistent LCMV infection
-
Wilson, E. B. et al. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science 340, 202-207 (2013).
-
(2013)
Science
, vol.340
, pp. 202-207
-
-
Wilson, E.B.1
-
5
-
-
77749242510
-
The transcriptional code of human IFN-beta gene expression
-
Ford, E. & Thanos, D. The transcriptional code of human IFN-beta gene expression. Biochim. Biophys. Acta. 1799, 328-336 (2010).
-
(2010)
Biochim. Biophys. Acta.
, vol.1799
, pp. 328-336
-
-
Ford, E.1
Thanos, D.2
-
6
-
-
79953089398
-
IRF8 and IRF3 cooperatively regulate rapid interferon-beta induction in human blood monocytes
-
Li, P. et al. IRF8 and IRF3 cooperatively regulate rapid interferon-beta induction in human blood monocytes. Blood 117, 2847-2854 (2011).
-
(2011)
Blood
, vol.117
, pp. 2847-2854
-
-
Li, P.1
-
7
-
-
77954947887
-
The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
-
Kim, H. & Seed, B. The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3. Nat. Immunol. 11, 743-750 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 743-750
-
-
Kim, H.1
Seed, B.2
-
8
-
-
84455170015
-
Nuclear factor kappaB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated beta-interferon production via induction of transcriptional repressor protein YY1
-
Siednienko, J. et al. Nuclear factor kappaB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated beta-interferon production via induction of transcriptional repressor protein YY1. J. Biol. Chem. 286, 44750-44763 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 44750-44763
-
-
Siednienko, J.1
-
9
-
-
84861541407
-
Association of the interferon-beta gene with pericentromeric heterochromatin is dynamically regulated during virus infection through a YY1-dependent mechanism
-
Josse, T. et al. Association of the interferon-beta gene with pericentromeric heterochromatin is dynamically regulated during virus infection through a YY1-dependent mechanism. Nucleic. Acids. Res. 40, 4396-4411 (2012).
-
(2012)
Nucleic. Acids. Res.
, vol.40
, pp. 4396-4411
-
-
Josse, T.1
-
10
-
-
0037372113
-
Transcription factor YY1 binds to the murine beta interferon promoter and regulates its transcriptional capacity with a dual activator/repressor role
-
Weill, L., Shestakova, E. & Bonnefoy, E. Transcription factor YY1 binds to the murine beta interferon promoter and regulates its transcriptional capacity with a dual activator/repressor role. J. Virol. 77, 2903-2914 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 2903-2914
-
-
Weill, L.1
Shestakova, E.2
Bonnefoy, E.3
-
11
-
-
80054848955
-
TRIM proteins and cancer
-
Hatakeyama, S. TRIM proteins and cancer. Nat. Rev. Cancer 11, 792-804 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 792-804
-
-
Hatakeyama, S.1
-
12
-
-
80052971797
-
The TIF1alpha-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression
-
Herquel, B., Ouararhni, K. & Davidson, I. The TIF1alpha-related TRIM cofactors couple chromatin modifications to transcriptional regulation, signaling and tumor suppression. Transcription 2, 231-236 (2011).
-
(2011)
Transcription
, vol.2
, pp. 231-236
-
-
Herquel, B.1
Ouararhni, K.2
Davidson, I.3
-
13
-
-
84875214110
-
Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA
-
Herquel, B. et al. Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA. Nat. Struct. Mol. Biol. 20, 339-346 (2013).
-
(2013)
Nat. Struct. Mol. Biol.
, vol.20
, pp. 339-346
-
-
Herquel, B.1
-
14
-
-
84455167662
-
A poised chromatin platform for TGF-beta access to master regulators
-
Xi, Q. et al. A poised chromatin platform for TGF-beta access to master regulators. Cell 147, 1511-1524 (2011).
-
(2011)
Cell
, vol.147
, pp. 1511-1524
-
-
Xi, Q.1
-
15
-
-
79953839812
-
Adult hematopoiesis is regulated by TIF1gamma, a repressor of TAL1 and PU.1 transcriptional activity
-
Kusy, S. et al. Adult hematopoiesis is regulated by TIF1gamma, a repressor of TAL1 and PU.1 transcriptional activity. Cell Stem Cell 8, 412-425 (2011).
-
(2011)
Cell Stem Cell
, vol.8
, pp. 412-425
-
-
Kusy, S.1
-
16
-
-
77954301966
-
TIF1gamma controls erythroid cell fate by regulating transcription elongation
-
Bai, X. et al. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell 142, 133-143 (2010).
-
(2010)
Cell
, vol.142
, pp. 133-143
-
-
Bai, X.1
-
17
-
-
54949126675
-
TRIM family proteins and their emerging roles in innate immunity
-
Ozato, K., Shin, D. M., Chang, T. H. & Morse, 3rd H. C. TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol. 8, 849-860 (2008).
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 849-860
-
-
Ozato, K.1
Shin, D.M.2
Chang, T.H.3
Morse, H.C.4
-
18
-
-
79951669703
-
Tripartite-motif proteins and innate immune regulation
-
McNab, F. W., Rajsbaum, R., Stoye, J. P. & O'Garra, A. Tripartite-motif proteins and innate immune regulation. Curr. Opin. Immunol. 23, 46-56 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 46-56
-
-
McNab, F.W.1
Rajsbaum, R.2
Stoye, J.P.3
O'Garra, A.4
-
19
-
-
80053023388
-
Tripartite motif 24 (Trim24/Tif1 alpha) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor alpha (Rar alpha) inhibition
-
Tisserand, J. et al. Tripartite motif 24 (Trim24/Tif1 alpha) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor alpha (Rar alpha) inhibition. J. Biol. Chem. 286, 33369-33379 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 33369-33379
-
-
Tisserand, J.1
-
20
-
-
84907210913
-
The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation
-
Weng, L. et al. The E3 ubiquitin ligase tripartite motif 33 is essential for cytosolic RNA-induced NLRP3 inflammasome activation. J. Immunol. 193, 3676-3682 (2014).
-
(2014)
J. Immunol.
, vol.193
, pp. 3676-3682
-
-
Weng, L.1
-
21
-
-
84922527336
-
Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells
-
Squadrito, M. L. et al. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep. 8, 1432-1446 (2014).
-
(2014)
Cell Rep.
, vol.8
, pp. 1432-1446
-
-
Squadrito, M.L.1
-
22
-
-
84926100892
-
A novel virus-inducible enhancer of the interferon-beta gene with tightly linked promoter and enhancer activities
-
Banerjee, A. R., Kim, Y. J. & Kim, T. H. A novel virus-inducible enhancer of the interferon-beta gene with tightly linked promoter and enhancer activities. Nucleic Acids Res. 42, 12537-12554 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 12537-12554
-
-
Banerjee, A.R.1
Kim, Y.J.2
Kim, T.H.3
-
23
-
-
84872263381
-
Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes
-
Uhlenhaut, N. H. et al. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol. Cell 49, 158-171 (2013).
-
(2013)
Mol. Cell
, vol.49
, pp. 158-171
-
-
Uhlenhaut, N.H.1
-
24
-
-
84907419194
-
Immunogenetics. Chromatin state dynamics during blood formation
-
Lara-Astiaso, D. et al. Immunogenetics. Chromatin state dynamics during blood formation. Science 345, 943-949 (2014).
-
(2014)
Science
, vol.345
, pp. 943-949
-
-
Lara-Astiaso, D.1
-
25
-
-
77954204335
-
Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor
-
Bowers, E. M. et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem. Biol. 17, 471-482 (2010).
-
(2010)
Chem. Biol.
, vol.17
, pp. 471-482
-
-
Bowers, E.M.1
-
26
-
-
84929298301
-
Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection
-
Ng, C. T. et al. Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection. Cell Host Microbe 17, 653-661 (2015).
-
(2015)
Cell Host Microbe
, vol.17
, pp. 653-661
-
-
Ng, C.T.1
-
27
-
-
84878548127
-
Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia
-
Hogner, K. et al. Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia. PLoS Pathog. 9, e1003188 (2013).
-
(2013)
PLoS Pathog.
, vol.9
, pp. e1003188
-
-
Hogner, K.1
-
28
-
-
84905593782
-
Enhancer loops appear stable during development and are associated with paused polymerase
-
Ghavi-Helm, Y. et al. Enhancer loops appear stable during development and are associated with paused polymerase. Nature 512, 96-100 (2014).
-
(2014)
Nature
, vol.512
, pp. 96-100
-
-
Ghavi-Helm, Y.1
-
29
-
-
84887620842
-
A high-resolution map of the three-dimensional chromatin interactome in human cells
-
Jin, F. et al. A high-resolution map of the three-dimensional chromatin interactome in human cells. Nature 503, 290-294 (2013).
-
(2013)
Nature
, vol.503
, pp. 290-294
-
-
Jin, F.1
-
30
-
-
84925441397
-
Determining the specificities of TALENs Cas9 and other genome-editing enzymes
-
Pattanayak, V., Guilinger, J. P. & Liu, D. R. Determining the specificities of TALENs, Cas9, and other genome-editing enzymes. Methods Enzymol. 546, 47-78 (2014).
-
(2014)
Methods Enzymol.
, vol.546
, pp. 47-78
-
-
Pattanayak, V.1
Guilinger, J.P.2
Liu, D.R.3
-
31
-
-
84923221641
-
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
-
Wang, X. et al. Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat. Biotechnol. 33, 175-178 (2015).
-
(2015)
Nat. Biotechnol.
, vol.33
, pp. 175-178
-
-
Wang, X.1
-
32
-
-
84901834420
-
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
-
Kim, S., Kim, D., Cho, S. W., Kim, J. & Kim, J. S. Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins. Genome Res. 24, 1012-1019 (2014).
-
(2014)
Genome Res.
, vol.24
, pp. 1012-1019
-
-
Kim, S.1
Kim, D.2
Cho, S.W.3
Kim, J.4
Kim, J.S.5
-
33
-
-
84922998982
-
A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages
-
Mancino, A. et al. A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages. Genes Dev. 29, 394-408 (2015).
-
(2015)
Genes Dev.
, vol.29
, pp. 394-408
-
-
Mancino, A.1
-
34
-
-
84903647409
-
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated antiviral response
-
Rajsbaum, R. et al. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated antiviral response. Immunity 40, 880-895 (2014).
-
(2014)
Immunity
, vol.40
, pp. 880-895
-
-
Rajsbaum, R.1
-
35
-
-
79251550124
-
Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type i interferon induction
-
Inn, K. S. et al. Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type I interferon induction. Mol. Cell 41, 354-365 (2011).
-
(2011)
Mol. Cell
, vol.41
, pp. 354-365
-
-
Inn, K.S.1
-
36
-
-
49649125136
-
The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3
-
Higgs, R. et al. The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. J. Immunol. 181, 1780-1786 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 1780-1786
-
-
Higgs, R.1
-
37
-
-
78650214109
-
The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
-
Tsuchida, T. et al. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33, 765-776 (2010).
-
(2010)
Immunity
, vol.33
, pp. 765-776
-
-
Tsuchida, T.1
-
38
-
-
0031604766
-
Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription
-
Merika, M., Williams, A. J., Chen, G., Collins, T. & Thanos, D. Recruitment of CBP/p300 by the IFN beta enhanceosome is required for synergistic activation of transcription. Mol. Cell 1, 277-287 (1998).
-
(1998)
Mol. Cell
, vol.1
, pp. 277-287
-
-
Merika, M.1
Williams, A.J.2
Chen, G.3
Collins, T.4
Thanos, D.5
-
39
-
-
0033580224
-
And functional interactions between the transcription factor PU.1 and the coactivator CBP
-
Yamamoto, H., Kihara-Negishi, F., Yamada, T., Hashimoto, Y. & Oikawa, T. Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP. Oncogene 18, 1495-1501 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 1495-1501
-
-
Yamamoto, H.1
Kihara-Negishi, F.2
Yamada, T.3
Hashimoto, Y.4
Physical, O.T.5
-
40
-
-
26844546178
-
Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity
-
Bai, Y., Srinivasan, L., Perkins, L. & Atchison, M. L. Protein acetylation regulates both PU.1 transactivation and Ig kappa 3' enhancer activity. J. Immunol. 175, 5160-5169 (2005).
-
(2005)
J. Immunol.
, vol.175
, pp. 5160-5169
-
-
Bai, Y.1
Srinivasan, L.2
Perkins, L.3
Atchison, M.L.4
-
41
-
-
84875143934
-
Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions
-
Stadhouders, R. et al. Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions. Nat. Protoc. 8, 509-524 (2013).
-
(2013)
Nat. Protoc.
, vol.8
, pp. 509-524
-
-
Stadhouders, R.1
-
42
-
-
77957739847
-
NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia
-
Kusy, S. et al. NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia. J. Exp. Med. 207, 2141-2156 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2141-2156
-
-
Kusy, S.1
-
43
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz, S. et al. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
|