pH responsive granulocyte colony-stimulating factor variants with implications for treating Alzheimer's disease and other central nervous system disorders

Protein Engineering, Design and Selection

Volumn 28, Issue 10, 2015, Pages 481-489

  Heinzelman, Pete ^a   Schoborg, Jennifer A ^b   Jewett, Michael C ^b  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b Northwestern University   (United States)

Author keywords

Alzheimer's disease; blood brain barrier; cell free protein synthesis; granulocyte colony stimulating factor; yeast surface display

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; BINDING ENERGY; BINS; BIOSYNTHESIS; BLOOD; CELL CULTURE; CELLS; CYTOLOGY; DIAGNOSIS; ESCHERICHIA COLI; MOLECULAR BIOLOGY; NEURODEGENERATIVE DISEASES; NEUROLOGY; NEUROPHYSIOLOGY; PROTEINS; PURIFICATION; SURFACE PLASMON RESONANCE; SYNTHESIS (CHEMICAL); YEAST;

ALZHEIMER'S DISEASE; BLOOD-BRAIN BARRIER; CELL FREE PROTEIN SYNTHESIS; GRANULOCYTE-COLONY STIMULATING FACTOR; YEAST SURFACE DISPLAYS;

CEREBROSPINAL FLUID;

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; NEUROTROPHIC FACTOR; PROTEIN VARIANT; PEPTIDE LIBRARY;

ALZHEIMER DISEASE; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD BRAIN BARRIER; CELL INCLUSION; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL EFFECTIVENESS; CODON; EC50; ENDOCYTOSIS; IN VITRO STUDY; LIGAND BINDING; MOLECULAR WEIGHT; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SURFACE PLASMON RESONANCE; TRANSCYTOSIS; WILD TYPE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; LEUKOCYTE; METABOLISM; MOLECULAR CLONING; MOLECULAR MODEL; MUTATION; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PROTEIN SECONDARY STRUCTURE;

ALZHEIMER DISEASE; BLOOD-BRAIN BARRIER; CELL PROLIFERATION; CLONING, MOLECULAR; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; HYDROGEN-ION CONCENTRATION; LEUKOCYTES; MODELS, MOLECULAR; MUTATION; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; TRANSCYTOSIS;

EID: 84947934642     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzv022     Document Type: Article

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