Reengineering Granulocyte Colony-stimulating Factor for Enhanced Stability

Journal of Biological Chemistry

Volumn 276, Issue 36, 2001, Pages 33465-33470

  Bishop, Barney ^a   Koay, Debbie C ^b   Sartorelli, Alan C ^b   Regan, Lynne ^a  

^a YALE UNIVERSITY   (United States)

^b YALE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CELLS; PROTEINS;

THERAPEUTIC APPLICATIONS;

BIOCHEMISTRY;

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; HUMAN GROWTH HORMONE; GLYCINE;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BONE MARROW CELL; CANCER PATIENT; CELL PROLIFERATION; CIRCULAR DICHROISM; GENETIC ENGINEERING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; RESIDUE ANALYSIS; STEM CELL; THERMODYNAMICS; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEMATOPOIESIS; METABOLISM; MOLECULAR CLONING; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMID; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

MURINAE;

ANIMALS; CELL LINE; CIRCULAR DICHROISM; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; GLYCINE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIESIS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; MUTAGENESIS, SITE-DIRECTED; MYELOID CELLS; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; TRANSFECTION;

EID: 0035823594     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104494200     Document Type: Article

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