Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics

Protein Engineering, Design and Selection

Volumn 28, Issue 10, 2015, Pages 385-393

  Jacobs, Steven A ^a   Gibbs, Alan C ^a   Conk, Michelle ^a   Yi, Fang ^a   Maguire, Diane ^a   Kane, Colleen ^a   O'neil, Karyn T ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

albumin; half life extension; phamacokinetics; scaffold

Indexed keywords

BINDING ENERGY; EPITOPES; ESCHERICHIA COLI; PROTEINS; SCAFFOLDS; SCAFFOLDS (BIOLOGY);

ALBUMIN; ALBUMIN BINDINGS; CONSENSUS SEQUENCE; CYNOMOLGUS MONKEYS; PHAMACOKINETICS; PRECISE DEFINITION; SCAFFOLD PROTEIN; SOLUTION STRUCTURES;

MAMMALS;

ALBUMIN; SCAFFOLD PROTEIN; ALBUMINOID; HYBRID PROTEIN;

ALBUMIN BINDING DOMAIN; BINDING AFFINITY; EPITOPE MAPPING; ESCHERICHIA COLI; HUMAN; MUTATION; NONHUMAN; PLASMA HALF LIFE; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; TEMPERATURE; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONSENSUS SEQUENCE; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PROCEDURES; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE;

ALBUMINS; AMINO ACID SEQUENCE; ANIMALS; CONSENSUS SEQUENCE; ESCHERICHIA COLI; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 84947926446     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzv040     Document Type: Review

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