The albumin-binding domain as a scaffold for protein engineering

Computational and Structural Biotechnology Journal

Volumn 6, Issue 7, 2013, Pages e201303009-

  Nilvebrant, Johan ^a   Hober, Sophia ^a  

^a ALBANOVA UNIVERSITY CENTER   (Sweden)

Author keywords

Affinity maturation; Affinity protein; Albumin; Bispecific; Protein domain; Specificity

Indexed keywords

EID: 84902175200     PISSN: None     EISSN: 20010370     Source Type: Journal    
DOI: 10.5936/csbj.201303009     Document Type: Conference Paper

References (65)

1. Navarre WW, Schneewind O (1999) Surface proteins of grampositive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev 63:174-229. (Pubitemid 29116092)
2. Kronvall G, Simmons A, Myhre EB, Jonsson S (1979) Specific absorption of human serum albumin, immunoglobulin A, and immunoglobulin G with selected strains of group A and G streptococci. Infect Immun 25:1-10. (Pubitemid 9226933)
3. Myhre EB (1984) Surface receptors for human serum albumin in Peptococcus magnus strains. J Med Microbiol 18:189-195. (Pubitemid 14023794)
4. Johansson MU, Frick IM, Nilsson H, Kraulis PJ, Hober S, et al. (2002) Structure, specificity, and mode of interaction for bacterial albumin-binding modules. J Biol Chem 277:8114-8120. (Pubitemid 34975650)
5. de Chateau M, Bjorck L (1996) Identification of interdomain sequences promoting the intronless evolution of a bacterial protein family. Proc Natl Acad Sci U S A 93:8490-8495. (Pubitemid 26269586)
6. de Chateau M, Hoist E, Bjorck L (1996) Protein PAB, an albuminbinding bacterial surface protein promoting growth and virulence. J Biol Chem 271:26609-26615. (Pubitemid 26359063)
7. Clarke SR, Harris LG, Richards RG, Foster SJ (2002) Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus. Infect Immun 70:6680-6687. (Pubitemid 35387898)
8. Tanaka Y, Sakamoto S, Kuroda M, Coda S, Gao YG, et al. (2008) A helical string of alternately connected three-helix bundles for the cell wall-associated adhesion protein Ebh from Staphylococcus aureus. Structure 16:488-496. (Pubitemid 351324113)
9. Christner M, Franke GC, Schommer NN, Wendt U, Wegert K, et al. (2010) The giant extracellular matrix-binding protein of Staphylococcus epidermidis mediates biofilm accumulation and attachment to fibronectin. Mol Microbiol 75:187-207.
10. Egesten A, Frick IM, Morgelin M, Olin Al, Bjorck L (2011) Binding of albumin promotes bacterial survival at the epithelial surface. J Biol Chem 286:2469-2476.
11. Bjorck L, Kronvall G (1984) Purification and some properties of streptococcal protein G, a novel IgG-binding reagent. J Immunol 133:969-974. (Pubitemid 14093496)
12. Bjorck L, Kastern W, Lindahl G, Wideback K (1987) Streptococcal protein G, expressed by streptococci or by Escherichia coli, has separate binding sites for human albumin and IgG. Mol Immunol 24:1113-1122. (Pubitemid 17134646)
13. Reis KJ, Ayoub EM, Boyle MD (1984) Streptococcal Fc receptors. I. Isolation and partial characterization of the receptor from a group C streptococcus. J Immunol 132:3091-3097. (Pubitemid 14104275)
14. Akerstrom B, Nielsen E, Bjorck L (1987) Definition of IgG- and albumin-binding regions of streptococcal protein G. J Biol Chem 262:13388-13391.
15. Gronenborn AM, Filpula DR Essig NZ, Achari A, Whitlow M, et al. (1991) A novel, highly stable fold of the immunoglobulin binding domain of streptococcal protein G. Science 253:657-661. (Pubitemid 21917198)
16. Kraulis PJ, Jonasson P, Nygren PA, Uhlen M, Jendeberg L, et al. (1996) The serum albumin-binding domain of streptococcal protein G is a three-helical bundle: a heteronuclear NMR study. FEBS Lett 378:190-194. (Pubitemid 26015572)
17. Uhlen M, Guss B, Nilsson B, Gatenbeck S, Philipson L, et al. (1984) Complete sequence of the staphylococcal gene encoding protein A. A gene evolved through multiple duplications. J Biol Chem 259:1695-1702. (Pubitemid 14146555)
18. Gouda H, Torigoe H, Saito A, Sato M, Arata Y, et al. (1992) Three-dimensional solution structure of the B domain of staphylococcal protein A: comparisons of the solution and crystal structures. Biochemistry 31:9665-9672.
19. Johansson MU, de Chateau M, Bjorck L, Forsen S, Drakenberg T, et al. (1995) The GA module, a mobile albumin-binding bacterial domain, adopts a three-helix-bundle structure. FEBS Lett 374:257-261.
20. Grodzki AC, Berenstein E (2010) Antibody purification: affinity chromatography - protein A and protein G Sepharose. Methods Mol Biol 588:33-41.
21. Bostrom T, Nilvebrant J, Hober S (2012) Purification Systems Based on Bacterial Surface Proteins. In: Ahmad R, editor. Protein Purificaiton: InTech.
22. Stahl S, Nygren P-A (1997) The use of gene fusions to protein A and protein G in immunology and biotechnology. Pathol Biol (Paris) 45:66-76. (Pubitemid 27095125)
23. Konig T, Skerra A (1998) Use of an albumin-binding domain for the selective immobilisation of recombinant capture antibody fragments on ELISA plates. J Immunol Methods 218:73-83. (Pubitemid 28500134)
24. Nygren PA, Eliasson M, Abrahmsen L, Uhlen M, Palmcrantz E (1988) Analysis and use of the serum albumin binding domains of streptococcal protein G. J Mol Recognit 1:69-74.
25. de Chateau M, Bjorck L (1994) Protein PAB, a mosaic albuminbinding bacterial protein representing the first contemporary example of module shuffling. J Biol Chem 269:12147-12151. (Pubitemid 24196714)
26. Johansson MU, de Chateau M, Wikstrom M, Forsen S, Drakenberg T, et al. (1997) Solution structure of the albumin-binding GA module: a versatile bacterial protein domain. J Mol Biol 266:859-865. (Pubitemid 27122593)
27. Cramer JF, Nordberg PA, Hajdu J, Lejon S (2007) Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution. FEBS Lett 581:3178-3182. (Pubitemid 46977358)
28. Lejon S, Frick IM, Bjorck L, Wikstrom M, Svensson S (2004) Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin. J Biol Chem 279:42924-42928. (Pubitemid 39372183)
29. Lejon S, Cramer JF, Nordberg P (2008) Structural basis for the binding of naproxen to human serum albumin in the presence of fatty acids and the GA module. Acta Crystallogr Sect F Struct Biol Cryst Commun 64:64-69. (Pubitemid 351348062)
30. Linhult M, Binz HK, Uhlen M, Hober S (2002) Mutational analysis of the interaction between albumin-binding domain from streptococcal protein G and human serum albumin. Protein Sci 11:206-213. (Pubitemid 34075783)
31. Gulich S, Linhult M, Nygren P, Uhlen M, Hober S (2000) Stability towards alkaline conditions can be engineered into a protein ligand. J Biotechnol 80:169-178. (Pubitemid 30450150)
32. Rozak DA, Orban J, Bryan PN (2005) G148-GA3: a streptococcal virulence module with atypical thermodynamics of folding optimally binds human serum albumin at physiological temperatures. Biochim Biophys Acta 1753:226-233. (Pubitemid 41643155)
33. Nilsson B, Moks T, Jansson B, Abrahmsen L, Elmblad A, et al. (1987) A synthetic IgG-binding domain based on staphylococcal protein A. Protein Eng 1:107-113.
34. Rozak DA, Alexander PA, He Y, Chen Y, Orban J, et al. (2006) Using offset recombinant polymerase chain reaction to identify functional determinants in a common family of bacterial albumin binding domains. Biochemistry 45:3263-3271. (Pubitemid 43376345)
35. He Y, Rozak DA, Sari N, Chen Y, Bryan P, et al. (2006) Structure, dynamics, and stability variation in bacterial albumin binding modules: implications for species specificity. Biochemistry 45:10102-10109. (Pubitemid 44257404)
36. He Y, Chen Y, Rozak DA, Bryan PN, Orban J (2007) An artificially evolved albumin binding module facilitates chemical shift epitope mapping of GA domain interactions with phylogenetically diverse albumins. Protein Sci 16:1490-1494. (Pubitemid 46984883)
37. Kontermann RE (2011) Strategies for extended serum half-life of protein therapeutics. Curr Opin Biotechnol 22:868-876.
38. Sleep D, Cameron J, Evans LR (2013) Albumin as a versatile platform for drug half-life extension. Biochimica et Biophysica Acta.
39. Frejd F (2012) Half-Life Extension by Binding to Albumin through an Albumin Binding Domain. In: Kontermann R, editor. Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives. Weinheim: Wiley-VCH Verlag GmbH & Co.
40. Nygren P, Uhlen M, Flodby P, Anderson R, Wigzell H (1991) In vivo stabilization of a human recombinant CD4 derivative by fusion to a serum-albumin-binding receptor. Vaccines: Cold Spring Harbor Press, pp. 363-368.
41. Andersen JT, Dalhus B, Cameron J, Daba MB, Plumridge A, et al. (2012) Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor. Nat Commun 3:610.
42. Andersen JT, Pehrson R, Tolmachev V, Daba MB, Abrahmsen L, et al. (2011) Extending half-life by indirect targeting of the neonatal Fc receptor (FcRn) using a minimal albumin binding domain. J Biol Chem 286:5234-5241.
43. Stork R Campigna E, Robert B, Muller D, Kontermann RE (2009) Biodistribution of a bispecific single-chain diabody and its half-life extended derivatives. J Biol Chem 284:25612-25619.
44. Jonsson A, Dogan J, Heme N, Abrahmsen L, Nygren PA (2008) Engineering of a femtomolar affinity binding protein to human serum albumin. Protein Eng Des Sel 21:515-527. (Pubitemid 352019923)
45. Orlova A, Jonsson A, Rosik D, Lundqvist H, Lindborg M, et al. (2013) Site-Specific Radiometal Labeling and Improved Biodistribution Using ABY-027, A Novel HER2-Targeting Affibody Molecule-Albumin-Binding Domain Fusion Protein. Journal of Nuclear Medicine.
46. Hopp J, Hornig N, Zettlitz KA, Schwarz A, Fuss N, et al. (2010) The effects of affinity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein. Protein Eng Des Sel 23:827-834.
47. Nguyen A, Reyes AE, 2nd, Zhang M, McDonald P, Wong WL, et al. (2006) The pharmacokinetics of an albumin-binding Fab (AB. Fab) can be modulated as a function of affinity for albumin. Protein Eng Des Sel 19:291-297. (Pubitemid 43999639)
48. Linhult M, Gulich S, Graslund T, Nygren PA, Hober S (2003) Evaluation of different linker regions for multimerization and coupling chemistry for immobilization of a proteinaceous affinity ligand. Protein Eng 16:1147-1152. (Pubitemid 38292116)
49. Lofblom J, Feldwisch J, Tolmachev V, Carlsson J, Stahl S, et al. (2010) Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications. FEBS Lett 584:2670-2680.
50. Cyranka-Czaja A, Otewski J (2012) A novel, stable, helical scaffold as an alternative binder - construction of phage display libraries. Acta Biochimica Polonica 59:383-390.
51. Ahmad JN, Li J, Biedermannova L, Kuchar M, Sipova H, et al. (2012) Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G. Proteins 80:774-789.
52. Alm T, Yderland L, Nilvebrant J, Halldin A, Hober S (2010) A small bispecific protein selected for orthogonal affinity purification. Biotechnol J 5:605-617.
53. Nilvebrant J, Alm T, Hober S (2012) Orthogonal protein purification facilitated by a small bispecific affinity tag. J Vis Exp.
54. Nilvebrant J, Alm T, Hober S, Lofblom J (2011) Engineering bispeciflcity into a single albumin-binding domain. PLoS One 6:e25791.
55. Nilvebrant J, Astrand M, Lofblom J, Hober S (2013) Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3. Cell Mol Life Sci.
56. Bryan PN, Orban J (2010) Proteins that switch folds. Curr Opin Struct Biol 20:482-488.
57. Lei H, Duan Y (2007) Ab initio folding of albumin binding domain from all-atom molecular dynamics simulation. J Phys Chem Bill: 5458-5463. (Pubitemid 46854539)
58. Alexander PA, Rozak DA, Orban J, Bryan PN (2005) Directed evolution of highly homologous proteins with different folds by phage display: implications for the protein folding code. Biochemistry 44:14045-14054. (Pubitemid 41533030)
59. He Y, Yeh DC, Alexander P, Bryan PN, Orban J (2005) Solution NMR structures of IgG binding domains with artificially evolved high levels of sequence identity but different folds. Biochemistry 44:14055-14061. (Pubitemid 41533031)
60. Alexander PA, He Y, Chen Y, Orban J, Bryan PN (2007) The design and characterization of two proteins with 88% sequence identity but different structure and function. Proc Natl Acad Sci U S A 104:11963-11968. (Pubitemid 47185613)
61. He Y, Chen Y, Alexander P, Bryan PN, Orban J (2008) NMR structures of two designed proteins with high sequence identity but different fold and function. Proc Natl Acad Sci U S A 105:14412-14417.
62. Alexander PA, He Y, Chen Y, Orban J, Bryan PN (2009) A minimal sequence code for switching protein structure and function. Proc Natl Acad Sci U S A 106:21149-21154.
63. He Y, Chen Y, Alexander PA, Bryan PN, Orban J (2012) Mutational tipping points for switching protein folds and functions. Structure 20:283-291.
64. Bryan PN, Orban J (2013) Implications of protein fold switching. Curr Opin Struct Biol.
65. Shen Y, Bryan PN, He Y, Orban J, Baker D, et al. (2010) De novo structure generation using chemical shifts for proteins with highsequence identity but different folds. Protein Sci 19:349-356.