Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro

Oncotarget

Volumn 6, Issue 35, 2015, Pages 37758-37769

  Zhong, Yali ^a,b,c,d   Li, Xiaoran ^c,d   Yu, Dandan ^a   Li, Xiaoli ^a   Li, Yaqing ^a   Long, Yuan ^b   Yuan, Yuan ^e   Ji, Zhenyu ^b   Zhang, Mingzhi ^a   Wen, Jian Guo ^a   Nesland, Jahn M ^c,d   Suo, Zhenhe ^a,c,d  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Glycolysis; Mitochondrial dysfunction; MPC blocker; Stemness

Indexed keywords

2 CYANO 3 (1 PHENYLINDOL 3 YL)ACRYLIC ACID; MONOCARBOXYLATE TRANSPORTER; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; 2-CYANO-3-(1-PHENYLINDOL-3-YL)ACRYLATE; ACRYLIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; CARRIER PROTEIN; PYRUVATE TRANSPORT PROTEIN; REACTIVE OXYGEN METABOLITE;

ARTICLE; CHEMOSENSITIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RESISTANCE; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LNCAP CELL LINE; METABOLIC REGULATION; MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PROSTATE CANCER; PROTEIN EXPRESSION; SIDE POPULATION CELL; APOPTOSIS; CANCER STEM CELL; CELL CYCLE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; FLOW CYTOMETRY; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; PROSTATIC NEOPLASMS; TUMOR CELL CULTURE; WESTERN BLOTTING;

ACRYLATES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GLYCOLYSIS; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; NEOPLASTIC STEM CELLS; OXIDATIVE PHOSPHORYLATION; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 84947708408     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5386     Document Type: Article

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