Guanosine inhibits LPS-induced pro-inflammatory response and oxidative stress in hippocampal astrocytes through the heme oxygenase-1 pathway

Purinergic Signalling

Volumn 11, Issue 4, 2015, Pages 571-580

  Bellaver, Bruna ^a   Souza, Débora Guerini ^a   Bobermin, Larissa Daniele ^a   Gonçalves, Carlos Alberto ^a   Souza, Diogo Onofre ^a   Quincozes Santos, André ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Astrocytes; Glioprotection; Guanosine; HO 1; Neuroinflammation; NF B

Indexed keywords

GUANOSINE; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NITRITE; SUPEROXIDE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CYTOKINE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; INFLAMMATION; MALE; MICROGLIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; NERVOUS SYSTEM INFLAMMATION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN DETERMINATION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICALLY INDUCED; DRUG EFFECTS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ASTROCYTES; CYTOKINES; GUANOSINE; HEME OXYGENASE-1; HIPPOCAMPUS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84947611911     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-015-9475-2     Document Type: Article

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