Astrocytes from adult Wistar rats aged in vitro show changes in glial functions

Neurochemistry International

Volumn 90, Issue , 2015, Pages 93-97

  Souza, Débora Guerini ^a   Bellaver, Bruna ^a   Raupp, Gustavo Santos ^a   Souza, Diogo Onofre ^a   Quincozes Santos, André ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Adult astrocytes; Astrocytes aged in vitro; Brain aging; Glucose uptake; Glutamine synthetase activity; Glutathione

Indexed keywords

ANTIPORTER; CYSTINE GLUTAMATE ANTIPORTER; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; GLUTAMATE AMMONIA LIGASE; GLUTATHIONE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; ANTIOXIDANT; GLUTAMIC ACID; NERVE GROWTH FACTOR;

ADULT; AGED; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN; CELL AGING; CELL FUNCTION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GLIA CELL; GLUCOSE TRANSPORT; IN VITRO STUDY; METABOLIC PARAMETERS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; AGING; ANIMAL; CELL CULTURE; CYTOLOGY; GLIA; MALE; METABOLISM; WISTAR RAT;

AGING; ANIMALS; ANTIOXIDANTS; ASTROCYTES; BRAIN; CELLS, CULTURED; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; MALE; NERVE GROWTH FACTORS; NEUROGLIA; RATS, WISTAR;

EID: 84947043914     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.07.016     Document Type: Article

References (32)

1. C.M. Anderson, and R.A. Swanson Astrocyte glutamate transport: review of properties, regulation, and physiological functions Glia 32 2000 1 14
2. M. Belanger, I. Allaman, and P.J. Magistretti Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation Cell Metab. 14 2011 724 738
3. B. Bellaver, D.G. Souza, D.O. Souza, and A. Quincozes-Santos Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar rats Toxicol In Vitro 28 2014 479 484
4. E.E. Benarroch Glutamate transporters: diversity, function, and involvement in neurologic disease Neurology 74 2010 259 264
5. E.E. Benarroch Brain glucose transporters: implications for neurologic disease Neurology 82 2014 1374 1379
6. N.C. Danbolt Glutamate uptake Prog. Neurobiol. 65 2001 1 105
7. G.A. Dienel, and N.F. Cruz Contributions of glycogen to astrocytic energetics during brain activation Metab. Brain Dis. 30 2014 281 298
8. R. Dringen Metabolism and functions of glutathione in brain Prog. Neurobiol. 62 2000 649 671
9. C. Gottfried, F. Tramontina, D. Goncalves, C.A. Goncalves, E. Moriguchi, R.D. Dias, S.T. Wofchuk, and D.O. Souza Glutamate uptake in cultured astrocytes depends on age: a study about the effect of guanosine and the sensitivity to oxidative stress induced by H(2)O(2) Mech. Ageing Dev. 123 2002 1333 1340
10. T. Jiang, and E. Cadenas Astrocytic metabolic and inflammatory changes as a function of age Aging Cell 13 2014 1059 1067
11. F. Klamt, C. Gottfried, F. Tramontina, F. Dal-Pizzol, M.L. Da Frota Jr., J.C. Moreira, R.D. Dias, E. Moriguchi, S. Wofchuk, and D.O. Souza Time-related increase in mitochondrial superoxide production, biomolecule damage and antioxidant enzyme activities in cortical astrocyte cultures Neuroreport 13 2002 1515 1518
12. C.W. Kuzawa, H.T. Chugani, L.I. Grossman, L. Lipovich, O. Muzik, P.R. Hof, D.E. Wildman, C.C. Sherwood, W.R. Leonard, and N. Lange Metabolic costs and evolutionary implications of human brain development Proc. Natl. Acad. Sci. U. S. A. 111 2014 13010 13015
13. M. Lee, T. Cho, N. Jantaratnotai, Y.T. Wang, E. McGeer, and P.L. McGeer Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases FASEB J. 24 2010 2533 2545
14. c- protects from oxidative glutamate toxicity J. Neurochem. 98 2006 916 925
15. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
16. N.J. Maragakis, and J.D. Rothstein Mechanisms of Disease: astrocytes in neurodegenerative disease Nat. Clin. Pract. Neurol. 2 2006 679 689
17. J.M. Mates, C. Perez-Gomez, I. Nunez de Castro, M. Asenjo, and J. Marquez Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death Int. J. Biochem. Cell Biol. 34 2002 439 458
18. V. Menet, M. Gimenez y Ribotta, N. Chauvet, M.J. Drian, J. Lannoy, E. Colucci-Guyon, and A. Privat Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression J. Neurosci. 21 2001 6147 6158
19. J. Middeldorp, and E.M. Hol GFAP in health and disease Prog. Neurobiol. 93 2011 421 443
20. M. Nedergaard, B. Ransom, and S.A. Goldman New roles for astrocytes: redefining the functional architecture of the brain Trends Neurosci. 26 2003 523 530
21. V. Parpura, M.T. Heneka, V. Montana, S.H. Oliet, A. Schousboe, P.G. Haydon, R.F. Stout Jr., D.C. Spray, A. Reichenbach, T. Pannicke, M. Pekny, M. Pekna, R. Zorec, and A. Verkhratsky Glial cells in (patho)physiology J. Neurochem. 121 2012 4 27
22. L. Pellerin How astrocytes feed hungry neurons Mol. Neurobiol. 32 2005 59 72
23. G. Perea, M. Sur, and A. Araque Neuron-glia networks: integral gear of brain function Front. Cell Neurosci. 8 2014 378
24. M. Pertusa, S. Garcia-Matas, E. Rodriguez-Farre, C. Sanfeliu, and R. Cristofol Astrocytes aged in vitro show a decreased neuroprotective capacity J. Neurochem. 101 2007 794 805
25. H. Sato, M. Tamba, T. Ishii, and S. Bannai Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins J. Biol. Chem. 274 1999 11455 11458
26. A. Schousboe, H.M. Sickmann, L.K. Bak, I. Schousboe, F.S. Jajo, S.A. Faek, and H.S. Waagepetersen Neuron-glia interactions in glutamatergic neurotransmission: roles of oxidative and glycolytic adenosine triphosphate as energy source J. Neurosci. Res. 89 2011 1926 1934
27. A.L. Sheldon, and M.B. Robinson The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention Neurochem. Int. 51 2007 333 355
28. Y. Shen, H. Gao, X. Shi, N. Wang, D. Ai, J. Li, L. Ouyang, J. Yang, Y. Tian, and J. Lu Glutamine synthetase plays a role in d-galactose-induced astrocyte aging in vitro and in vivo Exp. Gerontol. 58 2014 166 173
29. D.G. Souza, B. Bellaver, D.O. Souza, and A. Quincozes-Santos Characterization of adult rat astrocyte cultures PLoS One 8 2013 e60282
30. N.M. Uwechue, M.C. Marx, Q. Chevy, and B. Billups Activation of glutamate transport evokes rapid glutamine release from perisynaptic astrocytes J. Physiol. 590 2012 2317 2331
31. D.D. Wang, and A. Bordey The astrocyte odyssey Prog. Neurobiol. 86 2008 342 367
32. Z.C. Ye, and H. Sontheimer Modulation of glial glutamate transport through cell interactions with the extracellular matrix Int. J. Dev. Neurosci. 20 2002 209 217