Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

Cell Reports

Volumn 13, Issue 9, 2015, Pages 1881-1894

  Alliouachene, Samira ^a   Bilanges, Benoit ^a   Chicanne, Gaëtan ^b   Anderson, Karen E ^c   Pearce, Wayne ^a   Ali, Khaled ^a,f   Valet, Colin ^b   Posor, York ^a   Low, Pei Ching ^a   Chaussade, Claire ^a,g   Scudamore, Cheryl L ^d   Salamon, Rachel S ^e   Backer, Jonathan M ^e   Stephens, Len ^c   Hawkins, Phill T ^c   Payrastre, Bernard ^b   Vanhaesebroeck, Bart ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSERM   (France)

^c BABRAHAM INSTITUTE   (United Kingdom)

^d Medical Research Council Harwell Institute   (United Kingdom)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f AMGEN INC   (United States)

^g Galderma R and D   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOSE; INSULIN; INSULIN RECEPTOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE C2 BETA; PROTEIN APPL1; PROTEIN KINASE B; SCAFFOLD PROTEIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; APPL1 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE 3 KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIN1 AMPHIPHYSIN RVS167 DOMAIN; CELL STRUCTURE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; EARLY ENDOSOMAL COMPARTMENT; EMBRYO; ENDOSOME; ENZYME ACTIVITY; ENZYME INACTIVATION; FATTY LIVER; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RECEPTOR TRAFFICKING; INSULIN SENSITIVITY; LIPID DIET; LIVER CELL; LIVER PROTECTION; MALE; METABOLIC REGULATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHOSPHOTYROSINE BINDING DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STARVATION; WILD TYPE; ANALYSIS; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CYTOLOGY; GENETICS; LIVER; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; BLOOD GLUCOSE; CELLS, CULTURED; CLASS II PHOSPHATIDYLINOSITOL 3-KINASES; DIET, HIGH-FAT; ENDOSOMES; FATTY LIVER; GENE KNOCK-IN TECHNIQUES; HEPATOCYTES; INSULIN; LIVER; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84947604001     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2015.10.052     Document Type: Article

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