Design, synthesis, and evaluation of orally available clioquinol-moracin M hybrids as multitarget-directed ligands for cognitive improvement in a rat model of neurodegeneration in Alzheimer's disease

Journal of Medicinal Chemistry

Volumn 58, Issue 21, 2015, Pages 8616-8637

  Wang, Zhiren ^a   Wang, Yali ^a   Wang, Bo ^a   Li, Wenrui ^a   Huang, Ling ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 (5 HYDROXYBENZOFURAN 2 YL) 7 IODOQUINOLIN 8 OL; AMYLOID BETA PROTEIN; CLIOQUINOL; MORACIN M; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG; WBQ 5187; ANTIOXIDANT; BENZOFURAN DERIVATIVE; LIGAND; NEUROPROTECTIVE AGENT; PHOSPHODIESTERASE IV; PROTEIN AGGREGATE; RESORCINOL DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; COGNITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; IC50; NERVE DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; INFLAMMATION; MALE; MEMORY; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; BENZOFURANS; CLIOQUINOL; COGNITION; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; INFLAMMATION; LIGANDS; MALE; MEMORY; MODELS, MOLECULAR; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHODIESTERASE 4 INHIBITORS; PROTEIN AGGREGATES; RATS; RATS, WISTAR; RESORCINOLS;

EID: 84947446079     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01222     Document Type: Article

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