Combination of Hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas

Pancreas

Volumn 41, Issue 2, 2012, Pages 222-229

  Bahra, Marcus ^a   Kamphues, Carsten ^a   Boas Knoop, Sabine ^a   Lippert, Steffen ^a   Esendik, Ulrike ^b   Schüller, Ulrich ^c   Hartmann, Wolfgang ^b   Waha, Andreas ^b   Neuhaus, Peter ^a   Heppner, Frank ^a   Pietsch, Torsten ^b   Koch, Arend ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

pancreatic cancer; signal blockage; Sonic Hedgehog

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPAMINE; GEMCITABINE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER SCREENING; CARCINOGENICITY; DRUG POTENTIATION; GENE MUTATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; PANCREAS ADENOCARCINOMA; PANCREAS CELL; PATHOPHYSIOLOGY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; XENOGRAFT;

ADENOCARCINOMA; AGED; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CELL PROLIFERATION; DEOXYCYTIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, NUDE; MIDDLE AGED; MUTATION; PANCREATIC NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR BURDEN; VERATRUM ALKALOIDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84857917917     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31822896dd     Document Type: Article

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