Antisense inhibition of microRNA-21 and microRNA-221 in tumor-initiating stem-like cells modulates tumorigenesis, metastasis, and chemotherapy resistance in pancreatic cancer

Targeted Oncology

Volumn 10, Issue 4, 2015, Pages 535-548

  Zhao, Yue ^a   Zhao, Lu ^b   Ischenko, Ivan ^b   Bao, Qi ^b   Schwarz, Bettina ^b   Nieß, Hanno ^b   Wang, Yan ^a   Renner, Andrea ^b   Mysliwietz, Josef ^c   Jauch, Karl Walter ^b   Nelson, Peter J ^b   Ellwart, Joachim W ^c   Bruns, Christiane J ^a   Camaj, Peter ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Chemotherapy resistance; Metastasis; miRNAs; Pancreatic cancer; Side population; Tumorigenesis

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FLUOROURACIL; GEMCITABINE; MICRORNA 21; MICRORNA 221; MICRORNA; MIRN21 MICRORNA, HUMAN; MIRN221 MICRORNA, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL DIFFERENTIATION; CELL FRACTIONATION; CELL INVASION; CELL PROLIFERATION; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME INHIBITION; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; SIDE POPULATION CELL; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CANCER STEM CELL; DRUG RESISTANCE; DRUG SCREENING; GENETIC TRANSFECTION; GENETICS; METABOLISM; METASTASIS; NUDE MOUSE; PANCREATIC NEOPLASMS; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; UPREGULATION;

ANIMALS; CARCINOGENESIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDES, ANTISENSE; PANCREATIC NEOPLASMS; TRANSFECTION; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84949097148     PISSN: 17762596     EISSN: 1776260X     Source Type: Journal    
DOI: 10.1007/s11523-015-0360-2     Document Type: Article

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