-
1
-
-
0026598056
-
Studies on the mechanism of the synergistic interaction between 2′-deoxy-5-azacytidine and cisplatin
-
Abbruzzese JL and Frost P (1992) Studies on the mechanism of the synergistic interaction between 2′-deoxy-5-azacytidine and cisplatin. Cancer Chem Pharmacol 30: 31-36
-
(1992)
Cancer Chem Pharmacol
, vol.30
, pp. 31-36
-
-
Abbruzzese, J.L.1
Frost, P.2
-
2
-
-
0025978216
-
A phase 1 clinical, plasma, and cellular pharmacology study of gemcitabine
-
Abbruzzese JL, Grunawald R, Weeks EA, Gravel D, Adams T, Nowak B, Mineishi S, Tarassoff P, Satterlee W, Raber MN and Plunkett W (1991) A phase 1 clinical, plasma, and cellular pharmacology study of gemcitabine. J Clin Oncol 9: 491-498
-
(1991)
J Clin Oncol
, vol.9
, pp. 491-498
-
-
Abbruzzese, J.L.1
Grunawald, R.2
Weeks, E.A.3
Gravel, D.4
Adams, T.5
Nowak, B.6
Mineishi, S.7
Tarassoff, P.8
Satterlee, W.9
Raber, M.N.10
Plunkett, W.11
-
3
-
-
0031032211
-
Weekly gemcitabine with monthly cisplatin: Effective chemotherapy for advanced non-small cell lung cancer
-
Abratt RP, Bezwoda WR, Goedhals L and Hacking DJ (1997) Weekly gemcitabine with monthly cisplatin: effective chemotherapy for advanced non-small cell lung cancer. J Clin Oncol 15: 744-749
-
(1997)
J Clin Oncol
, vol.15
, pp. 744-749
-
-
Abratt, R.P.1
Bezwoda, W.R.2
Goedhals, L.3
Hacking, D.J.4
-
4
-
-
0029875635
-
Interaction between cisplatin and gemcitabine in vitro
-
Bergman AM, Ruiz van Haperen VWT, Veerman G, Kuiper CM and Peters GJ (1996) Interaction between cisplatin and gemcitabine in vitro. Clin Cancer Res 2: 521-530
-
(1996)
Clin Cancer Res
, vol.2
, pp. 521-530
-
-
Bergman, A.M.1
Ruiz Van Haperen, V.W.T.2
Veerman, G.3
Kuiper, C.M.4
Peters, G.J.5
-
5
-
-
0019476174
-
Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation
-
Birnboim HC and Jeveak JJ (1981) Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res 41: 1889-1892
-
(1981)
Cancer Res
, vol.41
, pp. 1889-1892
-
-
Birnboim, H.C.1
Jeveak, J.J.2
-
6
-
-
0029593648
-
Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts
-
Braakhuis BJM, Ruiz van Haperen VWT, Welters MJP and Peters GJ (1995) Schedule-dependent therapeutic efficacy of the combination of gemcitabine and cisplatin in head and neck cancer xenografts. Eur J Cancer 31A: 1335-1340
-
(1995)
Eur J Cancer
, vol.31 A
, pp. 1335-1340
-
-
Braakhuis, B.J.M.1
Ruiz Van Haperen, V.W.T.2
Welters, M.J.P.3
Peters, G.J.4
-
7
-
-
0027018878
-
Inhibition of mammalian ribonucleotide reductase by cis-diamminedichloroplatinum(II)
-
Chiu CSM, Chan AK and Wright JA (1992) Inhibition of mammalian ribonucleotide reductase by cis-diamminedichloroplatinum(II). Biochem Cell Biol 70: 1132-1338.
-
(1992)
Biochem Cell Biol
, vol.70
, pp. 1132-1338
-
-
Chiu, C.S.M.1
Chan, A.K.2
Wright, J.A.3
-
8
-
-
0013554474
-
-
CalcuSyn, Windows Software for Dose Effect Analysis. Biosoft: Cambridge
-
Chou T-C and Hayball MP (1996) CalcuSyn, Windows Software for Dose Effect Analysis. Biosoft: Cambridge
-
(1996)
-
-
Chou, T.-C.1
Hayball, M.P.2
-
9
-
-
0021118703
-
Quantitative analysis of dose-effect relationship: The combined effects of multiple drugs on enzyme inhibitors
-
G. Weber (ed), pp. Pergamon Press: New York
-
Chou T-C and Talalay P (1983) Quantitative analysis of dose-effect relationship: the combined effects of multiple drugs on enzyme inhibitors. In Advances in Enzyme Regulation, G. Weber (ed), pp. 27-55. Pergamon Press: New York
-
(1983)
Advances in Enzyme Regulation
, pp. 27-55
-
-
Chou, T.-C.1
Talalay, P.2
-
10
-
-
0028153260
-
Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth; a rational approach to clinical protocol design
-
Chou T-C, Motzer RJ, Tong Y and Bosl GJ (1994) Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth; a rational approach to clinical protocol design. J Natl Cancer Inst 86: 1517-1524
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 1517-1524
-
-
Chou, T.-C.1
Motzer, R.J.2
Tong, Y.3
Bosl, G.J.4
-
11
-
-
17344384670
-
Cisplatin-gemcitabine combination in advanced non-small cell lung cancer: A phase II study
-
Crino L, Scagliotto G, Marangolo M, Figoli F, Clerici M, DeMarinis F, Salvati F, Cruciani G, Dagliotti L, Pucci F, Paccagnella A, Adamao V, Altavilla G, Incoronato P, Tripetti M, Mosconi AM, Santucci A, Sorbolini S, Oliva C and Tonato M (1997) Cisplatin-gemcitabine combination in advanced non-small cell lung cancer: a phase II study. J Clin Oncol 15: 297-303
-
(1997)
J Clin Oncol
, vol.15
, pp. 297-303
-
-
Crino, L.1
Scagliotto, G.2
Marangolo, M.3
Figoli, F.4
Clerici, M.5
DeMarinis, F.6
Salvati, F.7
Cruciani, G.8
Dagliotti, L.9
Pucci, F.10
Paccagnella, A.11
Adamao, V.12
Altavilla, G.13
Incoronato, P.14
Tripetti, M.15
Mosconi, A.M.16
Santucci, A.17
Sorbolini, S.18
Oliva, C.19
Tonato, M.20
more..
-
12
-
-
0027479992
-
2′-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation
-
Ellerhorst JA, Frost P, Abbruzzese JL, Newman RA and Chernajovsky Y (1993) 2′-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation. Br J Cancer 67: 209-215
-
(1993)
Br J Cancer
, vol.67
, pp. 209-215
-
-
Ellerhorst, J.A.1
Frost, P.2
Abbruzzese, J.L.3
Newman, R.A.4
Chernajovsky, Y.5
-
13
-
-
0028962811
-
Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid-chromatography with ultraviolet detection
-
Freeman KB, Anliker S, Hamilton M, Osborne D, Dhahir PH, Nelson R and Allerheiligen SRB (1995) Validated assays for the determination of gemcitabine in human plasma and urine using high-performance liquid-chromatography with ultraviolet detection. J Chromatogr Biomed Appl 665: 171-181
-
(1995)
J Chromatogr Biomed Appl
, vol.665
, pp. 171-181
-
-
Freeman, K.B.1
Anliker, S.2
Hamilton, M.3
Osborne, D.4
Dhahir, P.H.5
Nelson, R.6
Allerheiligen, S.R.B.7
-
14
-
-
0023783698
-
Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine
-
Heinemann V, Hertel LW, Grindey GB and Plunkett W (1988) Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine. Cancer Res 48: 4024-4031
-
(1988)
Cancer Res
, vol.48
, pp. 4024-4031
-
-
Heinemann, V.1
Hertel, L.W.2
Grindey, G.B.3
Plunkett, W.4
-
15
-
-
0023935362
-
Synthesis of 2′-deoxy-2′,2′-difluoro-D-ribose and 2′-deoxy-2′,2′-difluoro-D-ribofuranosyl nucleosides
-
Hertel LW, Kroin JS, Misner JW and Tustin JM (1988) Synthesis of 2′-deoxy-2′,2′-difluoro-D-ribose and 2′-deoxy-2′,2′-difluoro-D-ribofuranosyl nucleosides. J Org Chem 53: 2406-2409
-
(1988)
J Org Chem
, vol.53
, pp. 2406-2409
-
-
Hertel, L.W.1
Kroin, J.S.2
Misner, J.W.3
Tustin, J.M.4
-
16
-
-
0026324313
-
Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
-
Huang P, Chubb S, Hertel LW, Grindey GB and Plunkett W (1991) Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 51: 6110-6117
-
(1991)
Cancer Res
, vol.51
, pp. 6110-6117
-
-
Huang, P.1
Chubb, S.2
Hertel, L.W.3
Grindey, G.B.4
Plunkett, W.5
-
17
-
-
0003211707
-
Gemcitabine (Gemzar) in combination with cisplatin (CP) in advanced ovarian cancers (AOC): A phase II study
-
(abstract 1373)
-
Krakowski I, Petit T, Kayitalire L, Weber B, Beaudouin M, Canon JL, Janssens J, Martin C and Belpomine D (1998) Gemcitabine (Gemzar) in combination with cisplatin (CP) in advanced ovarian cancers (AOC): a phase II study. Proc Am Soc Clin Oncol 17: 356a (abstract 1373)
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Krakowski, I.1
Petit, T.2
Kayitalire, L.3
Weber, B.4
Beaudouin, M.5
Canon, J.L.6
Janssens, J.7
Martin, C.8
Belpomine, D.9
-
18
-
-
0023938053
-
Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid
-
Lu Y, Han J and Scanlon RJ (1988) Biochemical and molecular properties of cisplatin-resistant A2780 cells grown in folinic acid. J Biol Chem 263: 4891-4894
-
(1988)
J Biol Chem
, vol.263
, pp. 4891-4894
-
-
Lu, Y.1
Han, J.2
Scanlon, R.J.3
-
19
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
-
Monks A, Scudiero D, Skehan P, Shoemaker R, Paull K, Vistica D, Hose C, Langley J, Cronise P, Vaigro-Wolff A, Gray-Goodrich M, Campbell H, Mayo J and Boyd M (1991) Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83: 761-766
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 761-766
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
Shoemaker, R.4
Paull, K.5
Vistica, D.6
Hose, C.7
Langley, J.8
Cronise, P.9
Vaigro-Wolff, A.10
Gray-Goodrich, M.11
Campbell, H.12
Mayo, J.13
Boyd, M.14
-
20
-
-
0000036875
-
Gemcitabine combined with cisplatin first line: A phase II study in patients with advanced epithelial ovarian cancer
-
(abstract 1377)
-
Nogué M, Cirera L, Arcusa M, Tusquets I, Batiste-Alentorn E, Font A and Boto B (1998) Gemcitabine combined with cisplatin first line: a phase II study in patients with advanced epithelial ovarian cancer. Proc Am Soc Clin Oncol 17: 357a (abstract 1377)
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Nogué, M.1
Cirera, L.2
Arcusa, M.3
Tusquets, I.4
Batiste-Alentorn, E.5
Font, A.6
Boto, B.7
-
21
-
-
0025799467
-
Platinum DNA-damage in leucocyte DNA of patients receiving cisplatin and carboplatin chemotherapy, measured by atomic absorption spectrometry
-
Parker RJ, Gill I, Tarone R, Vionnet J, Grunberg S, Muggia F and Reed E (1991) Platinum DNA-damage in leucocyte DNA of patients receiving cisplatin and carboplatin chemotherapy, measured by atomic absorption spectrometry. Carcinogenesis 12: 1253-1258
-
(1991)
Carcinogenesis
, vol.12
, pp. 1253-1258
-
-
Parker, R.J.1
Gill, I.2
Tarone, R.3
Vionnet, J.4
Grunberg, S.5
Muggia, F.6
Reed, E.7
-
22
-
-
0023571156
-
Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity
-
Peters GJ, Laurensse E, Leyva A and Pinedo HM (1987) Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity. Eur J Cancer Clin Oncol 23: 1869-1881
-
(1987)
Eur J Cancer Clin Oncol
, vol.23
, pp. 1869-1881
-
-
Peters, G.J.1
Laurensse, E.2
Leyva, A.3
Pinedo, H.M.4
-
23
-
-
0027287554
-
Transformation of mouse fibroblasts with the oncogenes H-ras or trk is associated with pronounced changes in drug sensitivity and metabolism
-
Peters GJ, Wets M, Keepers YPAM, Oskam R, Van Ark-Otte J, Noordhuis P, Smid K and Pinedo HM (1993a) Transformation of mouse fibroblasts with the oncogenes H-ras or trk is associated with pronounced changes in drug sensitivity and metabolism. Int J Cancer 54: 450-455
-
(1993)
Int J Cancer
, vol.54
, pp. 450-455
-
-
Peters, G.J.1
Wets, M.2
Ypam, K.3
Oskam, R.4
Van Ark-Otte, J.5
Noordhuis, P.6
Smid, K.7
Pinedo, H.M.8
-
25
-
-
0027180521
-
2′,2′-Difluoro-deoxocytidine (Gemcitabine) incorporation into RNA and DNA of tumour cell lines
-
Ruiz van Haperen VWT, Veerman G, Vermorken JB and Peters GJ (1993) 2′,2′-Difluoro-deoxocytidine (Gemcitabine) incorporation into RNA and DNA of tumour cell lines. Biochem Pharmacol 46: 762-766
-
(1993)
Biochem Pharmacol
, vol.46
, pp. 762-766
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Vermorken, J.B.3
Peters, G.J.4
-
26
-
-
0028067217
-
Development and characterization of a 2′,2′-difluorodeoxycytidine-resistant variant of the human ovarian cancer cell line A2780
-
Ruiz van Haperen VWT, Veerman G, Eriksson S, Boven E, Stegmann APA, Hermsen M, Vermorken JB, Pinedo HM and Peters GJ (1994a) Development and characterization of a 2′,2′-difluorodeoxycytidine-resistant variant of the human ovarian cancer cell line A2780. Cancer Res 54: 4138-4143
-
(1994)
Cancer Res
, vol.54
, pp. 4138-4143
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Eriksson, S.3
Boven, E.4
Stegmann, A.P.A.5
Hermsen, M.6
Vermorken, J.B.7
Pinedo, H.M.8
Peters, G.J.9
-
27
-
-
0028105119
-
Schedule-dependence of sensitivity to 2′,2′-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumor cell lines and solid tumors
-
Ruiz van Haperen VWT, Veerman G, Boven E, Noordhuis P, Vermorken JB and Peters GJ (1994b) Schedule-dependence of sensitivity to 2′,2′-difluorodeoxycytidine (Gemcitabine) in relation to accumulation and retention of its triphosphate in solid tumor cell lines and solid tumors. Biochem Pharmacol 48: 1327-1339
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 1327-1339
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Boven, E.3
Noordhuis, P.4
Vermorken, J.B.5
Peters, G.J.6
-
28
-
-
0029990087
-
Regulation of deoxycytidine kinase from solid tumor cell lines by CTP and UTP
-
Ruiz van Haperen VWT, Veerman G, Vermorken JB, Pinedo HM and Peters GJ (1996) Regulation of deoxycytidine kinase from solid tumor cell lines by CTP and UTP. Biochem Pharmacol 51: 911-918
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 911-918
-
-
Ruiz Van Haperen, V.W.T.1
Veerman, G.2
Vermorken, J.B.3
Pinedo, H.M.4
Peters, G.J.5
-
30
-
-
0029848166
-
Phase I/II study of gemcitabine and cisplatin in non-small cell lung cancer: Preliminary results
-
Steward WP, Dunlop DJ, Dabouis G, Lacroix H and Talbot D (1996) Phase I/II study of gemcitabine and cisplatin in non-small cell lung cancer: preliminary results. Semin Oncol 5: 43-47
-
(1996)
Semin Oncol
, vol.5
, pp. 43-47
-
-
Steward, W.P.1
Dunlop, D.J.2
Dabouis, G.3
Lacroix, H.4
Talbot, D.5
-
31
-
-
0000125441
-
The coordination chemistry of platinum anticancer drugs and related compounds with DNA
-
Sundquist WI and Lippard SJ (1990) The coordination chemistry of platinum anticancer drugs and related compounds with DNA. Coord Chem Rev 100: 293-322
-
(1990)
Coord Chem Rev
, vol.100
, pp. 293-322
-
-
Sundquist, W.I.1
Lippard, S.J.2
-
32
-
-
0025363447
-
Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum
-
Terheggen PMAB, Emondt JY, Floot BGJ, Dijkman R, Schrier PI, Den Engelse L and Begg AC (1990) Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum. Cancer Res 50: 3556-3561
-
(1990)
Cancer Res
, vol.50
, pp. 3556-3561
-
-
Pmab, T.1
Emondt, J.Y.2
Floot, B.G.J.3
Dijkman, R.4
Schrier, P.I.5
Den Engelse, L.6
Begg, A.C.7
-
33
-
-
0026045802
-
Clinical pharmacology of carboplatin
-
Van der Vijgh WJF (1991) Clinical pharmacology of carboplatin. Clin Pharmacokin 21: 242-261
-
(1991)
Clin Pharmacokin
, vol.21
, pp. 242-261
-
-
Van Der Vijgh, W.J.F.1
-
34
-
-
0031105022
-
Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells
-
Van der Wilt CL, Smid K, Noordhuis P, Aherne GW and Peters GJ (1997) Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells. Eur J Cancer 33: 471-478
-
(1997)
Eur J Cancer
, vol.33
, pp. 471-478
-
-
Van Der Wilt, C.L.1
Smid, K.2
Noordhuis, P.3
Aherne, G.W.4
Peters, G.J.5
-
35
-
-
0027440968
-
In vitro antitumour activity of cis-and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils
-
Van der Wilt CL, Visser GWM, Braakhuis BJM, Wedzinga R, Noordhuis P, Smid K and Peters GJ (1993) In vitro antitumour activity of cis-and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils. Br J Cancer 68: 702-707
-
(1993)
Br J Cancer
, vol.68
, pp. 702-707
-
-
Van Der Wilt, C.L.1
Visser, G.W.M.2
Braakhuis, B.J.M.3
Wedzinga, R.4
Noordhuis, P.5
Smid, K.6
Peters, G.J.7
-
36
-
-
0030915362
-
Gemcitabine: Future prospects of single-agent and combination studies
-
Van Moorsel CJA, Peters GJ and Pinedo HM (1997) Gemcitabine: future prospects of single-agent and combination studies. Oncologist 2: 127-134
-
(1997)
Oncologist
, vol.2
, pp. 127-134
-
-
Van Moorsel, C.J.A.1
Peters, G.J.2
Pinedo, H.M.3
-
37
-
-
0033036665
-
Scheduling of gemcitabine and cisplatin in Lewis Lung tumour bearing mice
-
In press
-
Van Moorsel CJA, Pinedo HM, Veerman G, Vermorken JB, Postmus PE and Peters GJ (1999) Scheduling of gemcitabine and cisplatin in Lewis Lung tumour bearing mice. Eur J Cancer. In press
-
(1999)
Eur J Cancer.
-
-
Van Moorsel, C.J.A.1
Pinedo, H.M.2
Veerman, G.3
Vermorken, J.B.4
Postmus, P.E.5
Peters, G.J.6
-
38
-
-
0022570441
-
Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin
-
Vermorken JB, Van der Vijgh WJF, Klein I, Gall HE, Van Groeningen CJ and Pinedo HM (1984) Pharmacokinetics of free and total platinum species after rapid and prolonged infusions of cisplatin. Clin Pharmacol Ther 39: 136-144
-
(1984)
Clin Pharmacol Ther
, vol.39
, pp. 136-144
-
-
Vermorken, J.B.1
Van Der Vijgh, W.J.F.2
Klein, I.3
Gall, H.E.4
Van Groeningen, C.J.5
Pinedo, H.M.6
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