-
1
-
-
6044267987
-
The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine treated pancreas adenocarcinoma
-
Spratlin J, Sangha R, Glubrecht D, Dabbagh L, Young JD, Dumontet C, Cass C, Lai R and Mackey JR: The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine treated pancreas adenocarcinoma. Clin Cancer Res 10: 6956-6961, 2004.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6956-6961
-
-
Spratlin, J.1
Sangha, R.2
Glubrecht, D.3
Dabbagh, L.4
Young, J.D.5
Dumontet, C.6
Cass, C.7
Lai, R.8
Mackey, J.R.9
-
2
-
-
0142219312
-
Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2′,2,-difluorodeoxy-cytidine-induced cytotoxicity
-
Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A and Pastor-Anglada M: Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2′,2,-difluorodeoxy-cytidine-induced cytotoxicity. Clin Cancer Res 9: 5000-5008, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5000-5008
-
-
Garcia-Manteiga, J.1
Molina-Arcas, M.2
Casado, F.J.3
Mazo, A.4
Pastor-Anglada, M.5
-
3
-
-
0002831066
-
Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
-
Kroep JR, Loves WJ, van der Wilt CL, et al: Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 1: 371-376, 2002.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 371-376
-
-
Kroep, J.R.1
Loves, W.J.2
van der Wilt, C.L.3
-
4
-
-
0034792689
-
Tumor uptake and elimination of 2′,2,-difluorodeoxy-cytidine (gemcitabine) after deoxycytidine kinase gene transfer correlation with in vivo tumor response
-
Blackstock AW, Lightfoot H, Case LD, et al: Tumor uptake and elimination of 2′,2,-difluorodeoxy-cytidine (gemcitabine) after deoxycytidine kinase gene transfer correlation with in vivo tumor response. Clin Cancer Res 7: 3263-3268, 2001.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3263-3268
-
-
Blackstock, A.W.1
Lightfoot, H.2
Case, L.D.3
-
5
-
-
0029967966
-
Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine
-
Neff T and Blau CA: Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Exp Hematol 24: 1340-1346, 1996.
-
(1996)
Exp Hematol
, vol.24
, pp. 1340-1346
-
-
Neff, T.1
Blau, C.A.2
-
6
-
-
27144524050
-
In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant
-
Bergman AM, Eijk PP, Ruiz van Haperen VW, Smid K, Veerman G, Hubeek I, van den Ijssel P, Ylstra B and Peters GJ: In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant. Cancer Res 65: 9510-9516, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 9510-9516
-
-
Bergman, A.M.1
Eijk, P.P.2
Ruiz van Haperen, V.W.3
Smid, K.4
Veerman, G.5
Hubeek, I.6
van den Ijssel, P.7
Ylstra, B.8
Peters, G.J.9
-
7
-
-
33846958737
-
Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
-
Nakahira S, Nakamori S, Tsujie M, et al: Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer 120: 1355-1363, 2003.
-
(2003)
Int J Cancer
, vol.120
, pp. 1355-1363
-
-
Nakahira, S.1
Nakamori, S.2
Tsujie, M.3
-
8
-
-
0029924620
-
Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
-
Manome Y, Wen PY, Dong Y, Tanaka T, Mitchell BS, Kufe DW and Fine HA: Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med 2: 567-573, 1996.
-
(1996)
Nat Med
, vol.2
, pp. 567-573
-
-
Manome, Y.1
Wen, P.Y.2
Dong, Y.3
Tanaka, T.4
Mitchell, B.S.5
Kufe, D.W.6
Fine, H.A.7
-
9
-
-
0023277545
-
Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
-
Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
-
(1987)
Anal Biochem
, vol.162
, pp. 156-159
-
-
Chomczynski, P.1
Sacchi, N.2
-
10
-
-
2642535305
-
Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
-
Galmarini CM, Clarke ML, Jordheim L, Santos CL, Cros E, Mackey JR and Dumontet C: Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene. BMC Pharmacol 24: 4-8, 2004.
-
(2004)
BMC Pharmacol
, vol.24
, pp. 4-8
-
-
Galmarini, C.M.1
Clarke, M.L.2
Jordheim, L.3
Santos, C.L.4
Cros, E.5
Mackey, J.R.6
Dumontet, C.7
-
11
-
-
5044225419
-
Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
-
Achiwa H, Oguri T, Sato S, Maeda H, Niimi T and Ueda R: Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 95: 753-757, 2004.
-
(2004)
Cancer Sci
, vol.95
, pp. 753-757
-
-
Achiwa, H.1
Oguri, T.2
Sato, S.3
Maeda, H.4
Niimi, T.5
Ueda, R.6
-
12
-
-
33745712217
-
Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
-
Jordheim LP, Galmarini CM and Dumontet C: Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. Cancer Chemother Pharmacol 58: 547-554, 2006.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 547-554
-
-
Jordheim, L.P.1
Galmarini, C.M.2
Dumontet, C.3
-
13
-
-
23044435447
-
Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma
-
Bengala C, Guarneri V, Giovannetti E, et al: Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma. Br J Cancer 93: 35-40, 2005.
-
(2005)
Br J Cancer
, vol.93
, pp. 35-40
-
-
Bengala, C.1
Guarneri, V.2
Giovannetti, E.3
-
14
-
-
0027197028
-
Kinetic studies on 2′,2′-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase
-
Bouffard DY, Laliberté J and Momparler RL: Kinetic studies on 2′,2′-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase. Biochem Pharmacol 45: 1857-1861, 1993.
-
(1993)
Biochem Pharmacol
, vol.45
, pp. 1857-1861
-
-
Bouffard, D.Y.1
Laliberté, J.2
Momparler, R.L.3
-
15
-
-
33750440839
-
Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits
-
Smid K, Bergman AM, Eijk PP, et al: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Nucleosides Nucleotides Nucleic Acids 25: 1001-1007, 2006.
-
(2006)
Nucleosides Nucleotides Nucleic Acids
, vol.25
, pp. 1001-1007
-
-
Smid, K.1
Bergman, A.M.2
Eijk, P.P.3
-
16
-
-
34548580650
-
Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells
-
Mori R, Ishikawa T and Ichikawa Y: Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep 17: 1201-1205, 2007.
-
(2007)
Oncol Rep
, vol.17
, pp. 1201-1205
-
-
Mori, R.1
Ishikawa, T.2
Ichikawa, Y.3
-
17
-
-
33645731188
-
Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
-
Giovannetti E, Del Tacca M, Mey V, et al: Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 66: 3928-3935, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 3928-3935
-
-
Giovannetti, E.1
Del Tacca, M.2
Mey, V.3
-
18
-
-
28644447388
-
The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia
-
Hubeek I, Stam RW, Peters GJ, et al: The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia. Br J Cancer 93: 1388-1394, 2005.
-
(2005)
Br J Cancer
, vol.93
, pp. 1388-1394
-
-
Hubeek, I.1
Stam, R.W.2
Peters, G.J.3
-
19
-
-
0345688175
-
Nucleoside anticancer drugs: The role of nucleoside transporters in resistance to cancer chemotherapy
-
Damaraju VL, Damaraju S, Young JD, Baldwin SA, Mackey J, Sawyer MB and Cass CE: Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22: 7524-7536, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 7524-7536
-
-
Damaraju, V.L.1
Damaraju, S.2
Young, J.D.3
Baldwin, S.A.4
Mackey, J.5
Sawyer, M.B.6
Cass, C.E.7
-
20
-
-
0034984732
-
Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5(Prime)-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug
-
Mata JF, García-Manteiga JM, Lostao MP, et al: Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5(Prime)-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Mol Pharmacol 59: 1542-1548, 2001.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1542-1548
-
-
Mata, J.F.1
García-Manteiga, J.M.2
Lostao, M.P.3
-
21
-
-
0034327360
-
Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity
-
Rauchwerger DR, Firby PS, Hedley DW and Moore MJ: Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res 60: 6075-6079, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 6075-6079
-
-
Rauchwerger, D.R.1
Firby, P.S.2
Hedley, D.W.3
Moore, M.J.4
-
22
-
-
33846567414
-
Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo
-
Matthews DJ, Yakes FM, Chen J, et al: Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo. Cell Cycle 6: 104-110, 2007.
-
(2007)
Cell Cycle
, vol.6
, pp. 104-110
-
-
Matthews, D.J.1
Yakes, F.M.2
Chen, J.3
-
23
-
-
33746915066
-
In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients
-
Mey V, Giovannetti E, De Braud F, et al: In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients. Br J Cancer 95: 289-297, 2006.
-
(2006)
Br J Cancer
, vol.95
, pp. 289-297
-
-
Mey, V.1
Giovannetti, E.2
De Braud, F.3
-
24
-
-
33748374715
-
Enhanced killing of pancreatic cancer cells by expression of fusogenic membrane glycoproteins in combination with chemotherapy
-
Hoffmann D and Wildner O: Enhanced killing of pancreatic cancer cells by expression of fusogenic membrane glycoproteins in combination with chemotherapy. Mol Cancer Ther 5: 2013-2022, 2006.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2013-2022
-
-
Hoffmann, D.1
Wildner, O.2
-
25
-
-
33845789166
-
Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer
-
Bianco C, Giovannetti E, Ciardiello F, et al: Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer. Clin Cancer Res 12: 7099-7107, 2006.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7099-7107
-
-
Bianco, C.1
Giovannetti, E.2
Ciardiello, F.3
-
26
-
-
22344449812
-
Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small cell lung cancer cells
-
Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M and Danesi R: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small cell lung cancer cells. Mol Pharmacol 68: 110-118, 2005.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 110-118
-
-
Giovannetti, E.1
Mey, V.2
Nannizzi, S.3
Pasqualetti, G.4
Marini, L.5
Del Tacca, M.6
Danesi, R.7
-
27
-
-
33751020539
-
Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth
-
Vernejoul F, Ghénassia L, Souque A, et al: Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth. Mol Ther 14: 758-767, 2006.
-
(2006)
Mol Ther
, vol.14
, pp. 758-767
-
-
Vernejoul, F.1
Ghénassia, L.2
Souque, A.3
-
28
-
-
25144439138
-
Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells
-
Bocci G, Fioravanti A, Orlandi P, Bernardini N, Collecchi P, Del Tacca M and Danesi R: Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. Br J Cancer 93: 319-330, 2005.
-
(2005)
Br J Cancer
, vol.93
, pp. 319-330
-
-
Bocci, G.1
Fioravanti, A.2
Orlandi, P.3
Bernardini, N.4
Collecchi, P.5
Del Tacca, M.6
Danesi, R.7
-
29
-
-
24944563728
-
Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models
-
Yao B, He QM, Tian L, et al: Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models. Hum Gene Ther 16: 1075-1086, 2005.
-
(2005)
Hum Gene Ther
, vol.16
, pp. 1075-1086
-
-
Yao, B.1
He, Q.M.2
Tian, L.3
-
30
-
-
30744468831
-
MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells
-
Hamada S, Satoh K, Kimura K, Kanno A, Masamune A and Shimosegawa T: MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells. World J Gastroenterol 11: 6867-6870, 2005.
-
(2005)
World J Gastroenterol
, vol.11
, pp. 6867-6870
-
-
Hamada, S.1
Satoh, K.2
Kimura, K.3
Kanno, A.4
Masamune, A.5
Shimosegawa, T.6
-
31
-
-
1542742114
-
RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
-
Duxbury MS, Ito H, Zinner MJ, Ashley SW and Whang EE: RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 23: 1539-1548, 2004.
-
(2004)
Oncogene
, vol.23
, pp. 1539-1548
-
-
Duxbury, M.S.1
Ito, H.2
Zinner, M.J.3
Ashley, S.W.4
Whang, E.E.5
-
32
-
-
0037102999
-
The pemetrexed/gemcitabine combination in pancreatic cancer
-
Kindler HL: The pemetrexed/gemcitabine combination in pancreatic cancer. Cancer 95: 928-932, 2002.
-
(2002)
Cancer
, vol.95
, pp. 928-932
-
-
Kindler, H.L.1
|