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Volumn 23, Issue 2, 2010, Pages 471-475

Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?

Author keywords

Deoxycytidine deaminase; Deoxycytidine kinase; Gemcitabine; Pancreatic cancer; Tetra hydro uridine

Indexed keywords

DEOXYCYTIDINE KINASE; GEMCITABINE; TETRAHYDROURIDINE;

EID: 76649097360     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000657     Document Type: Article
Times cited : (28)

References (32)
  • 1
    • 6044267987 scopus 로고    scopus 로고
    • The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine treated pancreas adenocarcinoma
    • Spratlin J, Sangha R, Glubrecht D, Dabbagh L, Young JD, Dumontet C, Cass C, Lai R and Mackey JR: The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine treated pancreas adenocarcinoma. Clin Cancer Res 10: 6956-6961, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 6956-6961
    • Spratlin, J.1    Sangha, R.2    Glubrecht, D.3    Dabbagh, L.4    Young, J.D.5    Dumontet, C.6    Cass, C.7    Lai, R.8    Mackey, J.R.9
  • 2
    • 0142219312 scopus 로고    scopus 로고
    • Nucleoside transporter profiles in human pancreatic cancer cells: Role of hCNT1 in 2′,2,-difluorodeoxy-cytidine-induced cytotoxicity
    • Garcia-Manteiga J, Molina-Arcas M, Casado FJ, Mazo A and Pastor-Anglada M: Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2′,2,-difluorodeoxy-cytidine-induced cytotoxicity. Clin Cancer Res 9: 5000-5008, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 5000-5008
    • Garcia-Manteiga, J.1    Molina-Arcas, M.2    Casado, F.J.3    Mazo, A.4    Pastor-Anglada, M.5
  • 3
    • 0002831066 scopus 로고    scopus 로고
    • Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity
    • Kroep JR, Loves WJ, van der Wilt CL, et al: Pretreatment deoxycytidine kinase levels predict in vivo gemcitabine sensitivity. Mol Cancer Ther 1: 371-376, 2002.
    • (2002) Mol Cancer Ther , vol.1 , pp. 371-376
    • Kroep, J.R.1    Loves, W.J.2    van der Wilt, C.L.3
  • 4
    • 0034792689 scopus 로고    scopus 로고
    • Tumor uptake and elimination of 2′,2,-difluorodeoxy-cytidine (gemcitabine) after deoxycytidine kinase gene transfer correlation with in vivo tumor response
    • Blackstock AW, Lightfoot H, Case LD, et al: Tumor uptake and elimination of 2′,2,-difluorodeoxy-cytidine (gemcitabine) after deoxycytidine kinase gene transfer correlation with in vivo tumor response. Clin Cancer Res 7: 3263-3268, 2001.
    • (2001) Clin Cancer Res , vol.7 , pp. 3263-3268
    • Blackstock, A.W.1    Lightfoot, H.2    Case, L.D.3
  • 5
    • 0029967966 scopus 로고    scopus 로고
    • Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine
    • Neff T and Blau CA: Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine. Exp Hematol 24: 1340-1346, 1996.
    • (1996) Exp Hematol , vol.24 , pp. 1340-1346
    • Neff, T.1    Blau, C.A.2
  • 7
    • 33846958737 scopus 로고    scopus 로고
    • Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer
    • Nakahira S, Nakamori S, Tsujie M, et al: Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer 120: 1355-1363, 2003.
    • (2003) Int J Cancer , vol.120 , pp. 1355-1363
    • Nakahira, S.1    Nakamori, S.2    Tsujie, M.3
  • 8
    • 0029924620 scopus 로고    scopus 로고
    • Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo
    • Manome Y, Wen PY, Dong Y, Tanaka T, Mitchell BS, Kufe DW and Fine HA: Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Nat Med 2: 567-573, 1996.
    • (1996) Nat Med , vol.2 , pp. 567-573
    • Manome, Y.1    Wen, P.Y.2    Dong, Y.3    Tanaka, T.4    Mitchell, B.S.5    Kufe, D.W.6    Fine, H.A.7
  • 9
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
    • Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 10
    • 2642535305 scopus 로고    scopus 로고
    • Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene
    • Galmarini CM, Clarke ML, Jordheim L, Santos CL, Cros E, Mackey JR and Dumontet C: Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene. BMC Pharmacol 24: 4-8, 2004.
    • (2004) BMC Pharmacol , vol.24 , pp. 4-8
    • Galmarini, C.M.1    Clarke, M.L.2    Jordheim, L.3    Santos, C.L.4    Cros, E.5    Mackey, J.R.6    Dumontet, C.7
  • 11
    • 5044225419 scopus 로고    scopus 로고
    • Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer
    • Achiwa H, Oguri T, Sato S, Maeda H, Niimi T and Ueda R: Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer. Cancer Sci 95: 753-757, 2004.
    • (2004) Cancer Sci , vol.95 , pp. 753-757
    • Achiwa, H.1    Oguri, T.2    Sato, S.3    Maeda, H.4    Niimi, T.5    Ueda, R.6
  • 12
    • 33745712217 scopus 로고    scopus 로고
    • Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
    • Jordheim LP, Galmarini CM and Dumontet C: Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. Cancer Chemother Pharmacol 58: 547-554, 2006.
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 547-554
    • Jordheim, L.P.1    Galmarini, C.M.2    Dumontet, C.3
  • 13
    • 23044435447 scopus 로고    scopus 로고
    • Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma
    • Bengala C, Guarneri V, Giovannetti E, et al: Prolonged fixed dose rate infusion of gemcitabine with autologous haemopoietic support in advanced pancreatic adenocarcinoma. Br J Cancer 93: 35-40, 2005.
    • (2005) Br J Cancer , vol.93 , pp. 35-40
    • Bengala, C.1    Guarneri, V.2    Giovannetti, E.3
  • 14
    • 0027197028 scopus 로고
    • Kinetic studies on 2′,2′-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase
    • Bouffard DY, Laliberté J and Momparler RL: Kinetic studies on 2′,2′-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase. Biochem Pharmacol 45: 1857-1861, 1993.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1857-1861
    • Bouffard, D.Y.1    Laliberté, J.2    Momparler, R.L.3
  • 15
    • 33750440839 scopus 로고    scopus 로고
    • Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits
    • Smid K, Bergman AM, Eijk PP, et al: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Nucleosides Nucleotides Nucleic Acids 25: 1001-1007, 2006.
    • (2006) Nucleosides Nucleotides Nucleic Acids , vol.25 , pp. 1001-1007
    • Smid, K.1    Bergman, A.M.2    Eijk, P.P.3
  • 16
    • 34548580650 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells
    • Mori R, Ishikawa T and Ichikawa Y: Human equilibrative nucleoside transporter 1 is associated with the chemosensitivity of gemcitabine in human pancreatic adenocarcinoma and biliary tract carcinoma cells. Oncol Rep 17: 1201-1205, 2007.
    • (2007) Oncol Rep , vol.17 , pp. 1201-1205
    • Mori, R.1    Ishikawa, T.2    Ichikawa, Y.3
  • 17
    • 33645731188 scopus 로고    scopus 로고
    • Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine
    • Giovannetti E, Del Tacca M, Mey V, et al: Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine. Cancer Res 66: 3928-3935, 2006.
    • (2006) Cancer Res , vol.66 , pp. 3928-3935
    • Giovannetti, E.1    Del Tacca, M.2    Mey, V.3
  • 18
    • 28644447388 scopus 로고    scopus 로고
    • The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia
    • Hubeek I, Stam RW, Peters GJ, et al: The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia. Br J Cancer 93: 1388-1394, 2005.
    • (2005) Br J Cancer , vol.93 , pp. 1388-1394
    • Hubeek, I.1    Stam, R.W.2    Peters, G.J.3
  • 19
    • 0345688175 scopus 로고    scopus 로고
    • Nucleoside anticancer drugs: The role of nucleoside transporters in resistance to cancer chemotherapy
    • Damaraju VL, Damaraju S, Young JD, Baldwin SA, Mackey J, Sawyer MB and Cass CE: Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22: 7524-7536, 2003.
    • (2003) Oncogene , vol.22 , pp. 7524-7536
    • Damaraju, V.L.1    Damaraju, S.2    Young, J.D.3    Baldwin, S.A.4    Mackey, J.5    Sawyer, M.B.6    Cass, C.E.7
  • 20
    • 0034984732 scopus 로고    scopus 로고
    • Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5(Prime)-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug
    • Mata JF, García-Manteiga JM, Lostao MP, et al: Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5(Prime)-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug. Mol Pharmacol 59: 1542-1548, 2001.
    • (2001) Mol Pharmacol , vol.59 , pp. 1542-1548
    • Mata, J.F.1    García-Manteiga, J.M.2    Lostao, M.P.3
  • 21
    • 0034327360 scopus 로고    scopus 로고
    • Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity
    • Rauchwerger DR, Firby PS, Hedley DW and Moore MJ: Equilibrative-sensitive nucleoside transporter and its role in gemcitabine sensitivity. Cancer Res 60: 6075-6079, 2000.
    • (2000) Cancer Res , vol.60 , pp. 6075-6079
    • Rauchwerger, D.R.1    Firby, P.S.2    Hedley, D.W.3    Moore, M.J.4
  • 22
    • 33846567414 scopus 로고    scopus 로고
    • Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo
    • Matthews DJ, Yakes FM, Chen J, et al: Pharmacological abrogation of S-phase checkpoint enhances the anti-tumor activity of gemcitabine in vivo. Cell Cycle 6: 104-110, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 104-110
    • Matthews, D.J.1    Yakes, F.M.2    Chen, J.3
  • 23
    • 33746915066 scopus 로고    scopus 로고
    • In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients
    • Mey V, Giovannetti E, De Braud F, et al: In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients. Br J Cancer 95: 289-297, 2006.
    • (2006) Br J Cancer , vol.95 , pp. 289-297
    • Mey, V.1    Giovannetti, E.2    De Braud, F.3
  • 24
    • 33748374715 scopus 로고    scopus 로고
    • Enhanced killing of pancreatic cancer cells by expression of fusogenic membrane glycoproteins in combination with chemotherapy
    • Hoffmann D and Wildner O: Enhanced killing of pancreatic cancer cells by expression of fusogenic membrane glycoproteins in combination with chemotherapy. Mol Cancer Ther 5: 2013-2022, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2013-2022
    • Hoffmann, D.1    Wildner, O.2
  • 25
    • 33845789166 scopus 로고    scopus 로고
    • Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer
    • Bianco C, Giovannetti E, Ciardiello F, et al: Synergistic antitumor activity of ZD6474, an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, with gemcitabine and ionizing radiation against pancreatic cancer. Clin Cancer Res 12: 7099-7107, 2006.
    • (2006) Clin Cancer Res , vol.12 , pp. 7099-7107
    • Bianco, C.1    Giovannetti, E.2    Ciardiello, F.3
  • 26
    • 22344449812 scopus 로고    scopus 로고
    • Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small cell lung cancer cells
    • Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M and Danesi R: Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small cell lung cancer cells. Mol Pharmacol 68: 110-118, 2005.
    • (2005) Mol Pharmacol , vol.68 , pp. 110-118
    • Giovannetti, E.1    Mey, V.2    Nannizzi, S.3    Pasqualetti, G.4    Marini, L.5    Del Tacca, M.6    Danesi, R.7
  • 27
    • 33751020539 scopus 로고    scopus 로고
    • Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth
    • Vernejoul F, Ghénassia L, Souque A, et al: Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth. Mol Ther 14: 758-767, 2006.
    • (2006) Mol Ther , vol.14 , pp. 758-767
    • Vernejoul, F.1    Ghénassia, L.2    Souque, A.3
  • 28
    • 25144439138 scopus 로고    scopus 로고
    • Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells
    • Bocci G, Fioravanti A, Orlandi P, Bernardini N, Collecchi P, Del Tacca M and Danesi R: Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells. Br J Cancer 93: 319-330, 2005.
    • (2005) Br J Cancer , vol.93 , pp. 319-330
    • Bocci, G.1    Fioravanti, A.2    Orlandi, P.3    Bernardini, N.4    Collecchi, P.5    Del Tacca, M.6    Danesi, R.7
  • 29
    • 24944563728 scopus 로고    scopus 로고
    • Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models
    • Yao B, He QM, Tian L, et al: Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models. Hum Gene Ther 16: 1075-1086, 2005.
    • (2005) Hum Gene Ther , vol.16 , pp. 1075-1086
    • Yao, B.1    He, Q.M.2    Tian, L.3
  • 30
    • 30744468831 scopus 로고    scopus 로고
    • MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells
    • Hamada S, Satoh K, Kimura K, Kanno A, Masamune A and Shimosegawa T: MSX2 overexpression inhibits gemcitabine-induced caspase-3 activity in pancreatic cancer cells. World J Gastroenterol 11: 6867-6870, 2005.
    • (2005) World J Gastroenterol , vol.11 , pp. 6867-6870
    • Hamada, S.1    Satoh, K.2    Kimura, K.3    Kanno, A.4    Masamune, A.5    Shimosegawa, T.6
  • 31
    • 1542742114 scopus 로고    scopus 로고
    • RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW and Whang EE: RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine. Oncogene 23: 1539-1548, 2004.
    • (2004) Oncogene , vol.23 , pp. 1539-1548
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 32
    • 0037102999 scopus 로고    scopus 로고
    • The pemetrexed/gemcitabine combination in pancreatic cancer
    • Kindler HL: The pemetrexed/gemcitabine combination in pancreatic cancer. Cancer 95: 928-932, 2002.
    • (2002) Cancer , vol.95 , pp. 928-932
    • Kindler, H.L.1


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