The desmoplastic stroma plays an essential role in the accumulation and modulation of infiltrated immune cells in pancreatic adenocarcinoma

Clinical and Developmental Immunology

Volumn 2011, Issue , 2011, Pages

  Tjomsland, Vegard ^a   Niklasson, Lina ^a   Sandström, Per ^a   Borch, Kurt ^a   Druid, Henrik ^b   Bratthäll, Charlotte ^c   Messmer, Davorka ^d   Larsson, Marie ^a   Spångeus, Anna ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KALMAR COUNTY HOSPITAL   (Sweden)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYCLOOXYGENASE 2; INDOLEAMINE 2,3 DIOXYGENASE; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; AUTACOID; CD163 ANTIGEN; CELL SURFACE RECEPTOR; CYTOKINE; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ARTICLE; BIOACCUMULATION; BONE MARROW CELL; CANCER PATIENT; CANCER SURVIVAL; CANCER TISSUE; CELL DIFFERENTIATION; CELL INFILTRATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DESMOPLASTIC STROMA; FIBROBLAST; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; INFLAMMATION; MACROPHAGE; MONOCYTE; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT; CASE CONTROL STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MORTALITY; PANCREAS CARCINOMA; PANCREAS TUMOR; STROMA CELL;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA, PANCREATIC DUCTAL; CASE-CONTROL STUDIES; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; MACROPHAGES; PANCREATIC NEOPLASMS; RECEPTORS, CELL SURFACE; STROMAL CELLS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR MICROENVIRONMENT;

EID: 84855590868     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2011/212810     Document Type: Article

References (47)

1. Mantovani A., Allavena P., Sica A., Balkwill F., Cancer-related inflammation Nature 2008 454 7203 436 444
2. Kessenbrock K., Plaks V., Werb Z., Matrix Metalloproteinases: regulators of the Tumor Microenvironment Cell 2010 141 1 52 67
3. Le Bitoux M. A., Stamenkovic I., Tumor-host interactions: the role of inflammation Histochemistry and Cell Biology 2008 130 6 1079 1090
4. Morgan M. A., Parsels L. A., Zhao L., Parsels J. D., Davis M. A., Hassan M. C., Arumugarajah S., Hylander-Gans L., Morosini D., Simeone D. M., Canman C. E., Normolle D. P., Zabludoff S. D., Maybaum J., Lawrence T. S., Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair Cancer Research 2010 70 12 4972 4981
5. Korc M., Pancreatic cancer-associated stroma production American Journal of Surgery 2007 194 4 S84 S86
6. Mahadevan D., Von Hoff D. D., Tumor-stroma interactions in pancreatic ductal adenocarcinoma Molecular Cancer Therapeutics 2007 6 4 1186 1197 (Pubitemid 46711982)
7. Froeling F. E. M., Mirza T. A., Feakins R. M., Seedhar A., Elia G., Hart I. R., Kocher H. M., Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, -catenin, and ezrin expression in tumor cells American Journal of Pathology 2009 175 2 636 648
8. Omary M. B., Lugea A., Lowe A. W., Pandol S. J., The pancreatic stellate cell: a star on the rise in pancreatic diseases Journal of Clinical Investigation 2007 117 1 50 59 (Pubitemid 46048449)
9. Esposito I., Menicagli M., Funel N., Bergmann F., Boggi U., Mosca F., Bevilacqua G., Campani D., Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma Journal of Clinical Pathology 2004 57 6 630 636 (Pubitemid 38725766)
10. Fukunaga A., Miyamoto M., Cho Y., Murakami S., Kawarada Y., Oshikiri T., Kato K., Kurokawa T., Suzuoki M., Nakakubo Y., Hiraoka K., Itoh T., Morikawa T., Okushiba S., Kondo S., Katoh H., CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltrating lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma Pancreas 2004 28 1 e26 e31
11. Tassi E., Braga M., Longhi R., Gavazzi F., Parmiani G., Di Carlo V., Protti M. P., Non-redundant role for IL-12 and IL-27 in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients PLoS ONE 2009 4 10
12. Preynat-Seauve O., Schuler P., Contassot E., Beermann F., Huard B., French L. E., Tumor-infiltrating dendritic cells are potent antigen-presenting cells able to activate T cells and mediate tumor rejection Journal of Immunology 2006 176 1 61 67 (Pubitemid 43023249)
13. Nagorsen D., Voigt S., Berg E., Stein H., Thiel E., Loddenkemper C., Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival Journal of Translational Medicine 2007 5, article 62
14. Yanagimoto H., Takai S., Satoi S., Toyokawa H., Takahashi K., Terakawa N., Kwon A. H., Kamiyama Y., Impaired function of circulating dendritic cells in patients with pancreatic cancer Clinical Immunology 2005 114 1 52 60 (Pubitemid 39642790)
15. Takahashi K., Toyokawa H., Takai S., Satoi S., Yanagimoto H., Terakawa N., Araki H., Kwon A. H., Kamiyama Y., Surgical influence of pancreatectomy on the function and count of circulating dendritic cells in patients with pancreatic cancer Cancer Immunology, Immunotherapy 2006 55 7 775 784
16. Tjomsland V., Sandstrm P., Spngeus A., Messmer D., Emilsson J., Falkmer U., Falkmer S., Magnusson K. E., Borch K., Larsson M., Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity? BMC Cancer 2010 10, article 87
17. Steinman R. M., Banchereau J., Taking dendritic cells into medicine Nature 2007 449 7161 419 426 (Pubitemid 47509552)
18. Talmadge J. E., Donkor M., Scholar E., Inflammatory cell infiltration of tumors: jekyll or hyde Cancer and Metastasis Reviews 2007 26 3-4 373 400 (Pubitemid 350115102)
19. Tjomsland V., Spngeus A., Sandstrm P., Borch K., Messmer D., Larsson M., Semi mature blood dendritic cells exist in patients with ductal pancreatic adenocarcinoma owing to inflammatory factors released from the tumor PLoS ONE 2010 5 10, article e13441
20. Snoussi K., Strosberg A. D., Bouaouina N., Ahmed S. B., Chouchane L., Genetic variation in pro-inflammatory cytokines (interleukin-1, interleukin-1 and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma European Cytokine Network 2005 16 4 253 260 (Pubitemid 350056539)
21. Engels E. A., Wu X., Gu J., Dong Q., Liu J., Spitz M. R., Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer Cancer Research 2007 67 13 6520 6527 (Pubitemid 47037538)
22. Juuti A., Louhimo J., Nordling S., Ristimki A., Haglund C., Cyclooxygenase-2 expression correlates with poor prognosis in pancreatic cancer Journal of Clinical Pathology 2006 59 4 382 386
23. Von Bergwelt-Baildon M. S., Popov A., Saric T., Chemnitz J., Classen S., Stoffel M. S., Fiore F., Roth U., Beyer M., Debey S., Wickenhauser C., Hanisch F. G., Schultze J. L., CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition Blood 2006 108 1 228 237 (Pubitemid 43990633)
24. Mahic M., Yaqub S., Johansson C. C., Taskén K., Aandahl E. M., FOXP3+CD4+CD25+ adaptive regulatory T cells express cyclooxygenase-2 and suppress effector T cells by a prostaglandin E2-dependent mechanism Journal of Immunology 2006 177 1 246 254 (Pubitemid 43939136)
25. Obraztsova E. R., Sharova E. V., Zaitsev O. S., Voronov V. G., Skoriatina I. G., Particular aspects of bioelectric brain activity in post-traumatic Korsakoff syndrome Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 2003 103 59 65
26. Kamada N., Hisamatsu T., Honda H., Kobayashi T., Chinen H., Kitazume M. T., Takayama T., Okamoto S., Koganei K., Sugita A., Kanai T., Hibi T., Human CD14+ macrophages in intestinal lamina propria exhibit potent antigen-presenting ability Journal of Immunology 2009 183 3 1724 1731
27. Chung M. J., Kim H., Kim K. S., Park S., Chung J. B., Park S. W., Safety evaluation of self-expanding metallic biliary stents eluting gemcitabine in a porcine model. Journal of Gastroenterology and Hepatology. In press
28. Bakhru M. R., Foley P. L., Gatesman J., Schmitt T., Moskaluk C. A., Kahaleh M., Fully covered self-expanding metal stents placed temporarily in the bile duct: safety profile and histologic classification in a porcine model BMC Gastroenterology 2011 11, article 76
29. Lee D. K., Kim H. S., Kim K. S., Lee W. J., Kim H. K., Won Y. H., Byun Y. R., Kim M. Y., Baik S. K., Kwon S. O., The effect on porcine bile duct of a metallic stent covered with a paclitaxel-incorporated membrane Gastrointestinal Endoscopy 2005 61 2 296 301 (Pubitemid 40261091)
30. Calderon B., Suri A., Miller M. J., Unanue E. R., Dendritic cells in islets of Langerhans constitutively present cell-derived peptides bound to their class II MHC molecules Proceedings of the National Academy of Sciences of the United States of America 2008 105 16 6121 6126 (Pubitemid 351758409)
31. Dallal R. M., Christakos P., Lee K., Egawa S., Son Y. I., Lotze M. T., Paucity of dendritic cells in pancreatic cancer Surgery 2002 131 2 135 138 (Pubitemid 34169537)
32. Pashenkov M., Teleshova N., Kouwenhoven M., Smirnova T., Jin Y. P., Kostulas V., Huang Y. M., Pinegin B., Boiko A., Link H., Recruitment of dendritic cells to the cerebrospinal fluid in bacterial neuroinfections Journal of Neuroimmunology 2002 122 1-2 106 116 (Pubitemid 34075496)
33. Feijo E., Alfaro C., Mazzolini G., Serra P., Peuelas I., Arina A., Huarte E., Tirapu I., Palencia B., Murillo O., Ruiz J., Sangro B., Richter J. A., Prieto J., Melero I., Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8 International Journal of Cancer 2005 116 2 275 281 (Pubitemid 40967265)
34. Ladnyi A., Kiss J., Somlai B., Gilde K., Fejos Z., Mohos A., Gaudi I., Tmr J., Density of DC-LAMP+ mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor Cancer Immunology, Immunotherapy 2007 56 9 1459 1469 (Pubitemid 47024707)
35. Van Krinks C. H., Matyszak M. K., Hill Gaston J. S., Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid Rheumatology 2004 43 4 453 460 (Pubitemid 38489362)
36. Koshiba T., Hosotani R., Miyamoto Y., Ida J., Tsuji S., Nakajima S., Kawaguchi M., Kobayashi H., Doi R., Hori T., Fujii N., Imamura M., Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression Clinical Cancer Research 2000 6 9 3530 3535
37. Colonna M., Trinchieri G., Liu Y. J., Plasmacytoid dendritic cells in immunity Nature Immunology 2004 5 12 1219 1226 (Pubitemid 41057736)
38. Uyttenhove C., Pilotte L., Théate I., Stroobant V., Colau D., Parmentier N., Boon T., Van den Eynde B. J., Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase Nature Medicine 2003 9 10 1269 1274 (Pubitemid 37279849)
39. Lb S., Knigsrainer A., Zieker D., Brcher B. L.D.M., Rammensee H. -G., Opelz G., Terness P., IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism Cancer Immunology, Immunotherapy 2009 58 1 153 157
40. Basu G. D., Tinder T. L., Bradley J. M., Tu T., Hattrup C. L., Pockaj B. A., Mukherjee P., Cyclooxygenase-2 inhibitor enhances the efficacy of a breast cancer vaccine: role of IDO Journal of Immunology 2006 177 4 2391 2402 (Pubitemid 44201000)
41. Ghiringhelli F., Puig P. E., Roux S., Parcellier A., Schmitt E., Solary E., Kroemer G., Martin F., Chauffert B., Zitvogel L., Tumor cells convert immature myeloid dendritic cells into TGF- -secreting cells inducing CD4+CD25+ regulatory T cell proliferation Journal of Experimental Medicine 2005 202 7 919 929 (Pubitemid 41396892)
42. Coe D., Addey C., White M., Simpson E., Dyson J., Chai J. G., The roles of antigen-specificity, responsiveness to transforming growth factor- and antigen-presenting cell subsets in tumour-induced expansion of regulatory T cells Immunology 2010 131 4 556 569
43. Konishi J., Yamazaki K., Azuma M., Kinoshita I., Dosaka-Akita H., Nishimura M., B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression Clinical Cancer Research 2004 10 15 5094 5100 (Pubitemid 39106851)
44. Elliott B., Scolyer R. A., Suciu S., Lebecque S., Rimoldi D., Gugerli O., Musat E., Sharma R. N., Lienard D., Keilholz U., Testori A., Eggermont A., MacKie R., Robert C., Cook M., Thompson J. F., Angevin E., Spatz A., Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma Clinical Cancer Research 2007 13 13 3825 3830 (Pubitemid 47037587)
45. Monti P., Leone B. E., Marchesi F., Balzano G., Zerbi A., Scaltrini F., Pasquali C., Calori G., Pessi F., Sperti C., Di Carlo V., Allavena P., Piemonti L., The CC Chemokine MCP-1/CCL2 in Pancreatic Cancer Progression: regulation of Expression and Potential Mechanisms of Antimalignant Activity Cancer Research 2003 63 21 7451 7461 (Pubitemid 37413488)
46. Chomarat P., Banchereau J., Davoust J., Palucka A. K., IL-6 switches the differentiation of monocytes from dendritic cells to macrophages Nature Immunology 2000 1 6 510 514
47. Tjomsland V., Spngeus A., Vlil J., Sandstrm P., Borch K., Druid H., Falkmer S., Falkmer U., Messmer D., Larsson M., Interleukin 1 sustains the expression of inflammatory factors in human pancreatic cancer microenvironment by targeting cancer-associated fibroblasts Neoplasia 2011 13 8 664 675