Role of fatty acid synthase in gemcitabine and radiation resistance of pancreatic cancers

International Journal of Biochemistry and Molecular Biology

Volumn 2, Issue 1, 2011, Pages 89-98

  Yang, Youyun ^a   Liu, Hailan ^a   Li, Zhaomin ^a   Zhao, Zijin ^a   Yip Schneider, Michelle ^a   Fan, Qipeng ^a   Max Schmidt, C ^a,b   Gabriela Chiorean, E ^a,b   Xie, Jingwu ^a,b   Cheng, Liang ^a,b   Chen, Jey Hsin ^a,b   Zhang, Jian Ting ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gemcitabine; Human fatty acid synthase (FASN); Palmitate; Pancreatic cancers; Radiation treatments; Treatment resistance

Indexed keywords

FATTY ACID SYNTHASE; GEMCITABINE;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; DRUG RESISTANCE; ENZYME ACTIVITY; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RADIOSENSITIVITY; UPREGULATION;

EID: 79952136207     PISSN: None     EISSN: 21524114     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Alo PL, Amini M, Piro F, Pizzuti L, Sebastiani V, Botti C, Murari R, Zotti G and Di Tondo U. Immunohistochemical expression and prognostic significance of fatty acid synthase in pancreatic carcinoma. Anticancer Res 2007; 27: 2523-2527.
2. Witkiewicz AK, Nguyen KH, Dasgupta A, Kennedy EP, Yeo CJ, Lisanti MP and Brody JR. Coexpression of fatty acid synthase and caveolin-1 in pancreatic ductal adenocarcinoma: implications for tumor progression and clinical outcome. Cell Cycle 2008; 7: 3021-3025.
3. Liu H, Liu JY, Wu X and Zhang JT. Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis/prognosis marker. Int J Biochem Mol Biol 2010; 1: 69-89.
4. Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD and Pasternack GR. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci U S A 1994; 91: 6379-6383.
5. Shurbaji MS, Kalbfleisch JH and Thurmond TS. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol 1996; 27: 917-921.
6. Gansler TS, Hardman W, 3rd, Hunt DA, Schaffel S and Hennigar RA. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol 1997; 28: 686-692.
7. Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H, Heimburger DC and Grizzle WE. The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 2000; 31: 1068-1073.
8. Silva SD, Cunha IW, Rangel AL, Jorge J, Zecchin KG, Agostini M, Kowalski LP, Coletta RD and Graner E. Differential expression of fatty acid synthase (FAS) and ErbB2 in nonmalignant and malignant oral keratinocytes. Virchows Arch 2008; 453: 57-67.
9. Takahiro T, Shinichi K and Toshimitsu S. Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. Clin Cancer Res 2003; 9: 2204-2212.
10. Silva SD, Agostini M, Nishimoto IN, Coletta RD, Alves FA, Lopes MA, Kowalski LP and Graner E. Expression of fatty acid synthase, ErbB2 and Ki-67 in head and neck squamous cell carcinoma. A clinicopathological study. Oral Oncol 2004; 40: 688-696.
11. Sebastiani V, Visca P, Botti C, Santeusanio G, Galati GM, Piccini V, Capezzone de Joannon B, Di Tondo U and Alo PL. Fatty acid synthase is a marker of increased risk of recurrence in endometrial carcinoma. Gynecol Oncol 2004; 92: 101-105.
12. Ogino S, Nosho K, Meyerhardt JA, Kirkner GJ, Chan AT, Kawasaki T, Giovannucci EL, Loda M and Fuchs CS. Cohort study of fatty acid synthase expression and patient survival in colon cancer. J Clin Oncol 2008; 26: 5713-5720.
13. Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M and Hayakawa M. Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells. J Urol 2008; 180: 729-736.
14. Innocenzi D, Alo PL, Balzani A, Sebastiani V, Silipo V, La Torre G, Ricciardi G, Bosman C and Calvieri S. Fatty acid synthase expression in melanoma. J Cutan Pathol 2003; 30: 23-28.
15. Camassei FD, Jenkner A, Rava L, Bosman C, Francalanci P, Donfrancesco A, Alo PL and Boldrini R. Expression of the lipogenic enzyme fatty acid synthase (FAS) as a predictor of poor outcome in nephroblastoma: an interinstitutional study. Med Pediatr Oncol 2003; 40: 302-308.
16. Liu H, Liu Y and Zhang JT. A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction. Mol Cancer Ther 2008; 7: 263-270.
17. Yang L, He J, Huang S, Zhang X, Bian Y, He N, Zhang H and Xie J. Activation of hedgehog signaling is not a frequent event in ovarian cancers. Mol Cancer 2009; 8: 112.
18. Li Z, Dong Z, Myer D, Yip-Schneider M, Liu J, Cui P, Schmidt CM and Zhang JT. Role of 14-3-3sigma in poor prognosis and in radiation and drug resistance of human pancreatic cancers. BMC Cancer 2010; 10: 598.
19. Yang Y, Chen Q and Zhang JT. Structural and functional consequences of mutating cysteine residues in the amino terminus of human multidrug resistance-associated protein 1. J Biol Chem 2002; 277: 44268-44277.
20. Yang Y, Liu Y, Dong Z, Xu J, Peng H, Liu Z and Zhang JT. Regulation of function by dimerization through the amino-terminal membranespanning domain of human ABCC1/MRP1. J Biol Chem 2007; 282: 8821-8830.
21. Walter K, Hong SM, Nyhan S, Canto M, Fedarko N, Klein A, Griffith M, Omura N, Medghalchi S, Kuhajda F and Goggins M. Serum fatty acid synthase as a marker of pancreatic neoplasia. Cancer Epidemiol Biomarkers Prev 2009; 18: 2380-2385.
22. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE and Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321: 1801-1806.
23. Gao Y, Lin LP, Zhu CH, Chen Y, Hou YT and Ding J. Growth arrest induced by C75, A fatty acid synthase inhibitor, was partially modulated by p38 MAPK but not by p53 in human hepatocellular carcinoma. Cancer Biol Ther 2006; 5: 978-985.
24. Knowles LM, Axelrod F, Browne CD and Smith JW. A fatty acid synthase blockade induces tumor cell-cycle arrest by down-regulating Skp2. J Biol Chem 2004; 279: 30540-30545.
25. Li JN, Gorospe M, Chrest FJ, Kumaravel TS, Evans MK, Han WF and Pizer ES. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 2001; 61: 1493-1499.
26. Morikawa K, Ikeda C, Nonaka M and Suzuki I. Growth arrest and apoptosis induced by quercetin is not linked to adipogenic conversion of human preadipocytes. Metabolism 2007; 56: 1656-1665.